Thiennu Vu, MD, PhD
Professor
Medicine
School of Medicine

She was the principal investigator of a research program focusing on the molecular mechanisms of lung development and the biology of lung progenitor and stem cells from 2000 to 2016. She currently practices pulmonary medicine at the UCSF Mt Zion Pulmonary clinic.

• Integrin α6β4 identifies an adult distal lung epithelial population with regenerative potential in mice.
  The Journal of clinical investigation 2011 Chapman HA, Li X, Alexander JP, Brumwell A, Lorizio W, Tan K, Sonnenberg A, Wei Y, Vu TH
• Complementary interplay between matrix metalloproteinase-9, vascular endothelial growth factor and osteoclast function drives endochondral bone formation.
  Disease models & mechanisms 2010 Ortega N, Wang K, Ferrara N, Werb Z, Vu TH
• Ablation of lung epithelial cells deregulates FGF-10 expression and impairs lung branching morphogenesis.
  Anatomical record (Hoboken, N.J. : 2007) 2009 Kim N, Yamamoto H, Pauling MH, Lorizio W, Vu TH
• P311 functions in an alternative pathway of lipid accumulation that is induced by retinoic acid.
  Journal of cell science 2008 Leung JK, Cases S, Vu TH
• Epithelial-vascular cross talk mediated by VEGF-A and HGF signaling directs primary septae formation during distal lung morphogenesis.
  Developmental biology 2007 Yamamoto H, Yun EJ, Gerber HP, Ferrara N, Whitsett JA, Vu TH
• Parabronchial smooth muscle cells and alveolar myofibroblasts in lung development.
  Birth defects research. Part C, Embryo today : reviews 2006 Kim N, Vu TH
• Identification of P311 as a potential gene regulating alveolar generation.
  American journal of respiratory cell and molecular biology 2006 Zhao L, Leung JK, Yamamoto H, Goswami S, Kheradmand F, Vu TH
• Epidermal development and wound healing in matrix metalloproteinase 13-deficient mice.
  The Journal of investigative dermatology 2006 Hartenstein B, Dittrich BT, Stickens D, Heyer B, Vu TH, Teurich S, Schorpp-Kistner M, Werb Z, Angel P
• Vascular endothelial growth factor co-ordinates proper development of lung epithelium and vasculature.
  Mechanisms of development 2005 Zhao L, Wang K, Ferrara N, Vu TH
• Epidermal growth factor receptor-deficient mice have delayed primary endochondral ossification because of defective osteoclast recruitment.
  The Journal of biological chemistry 2004 Wang K, Yamamoto H, Chin JR, Werb Z, Vu TH
• Mechanisms and regulation of lung vascular development.
  Current topics in developmental biology 2004 Pauling MH, Vu TH
• New insights into saccular development and vascular formation in lung allografts under the renal capsule.
  Mechanisms of development 2003 Vu TH, Alemayehu Y, Werb Z
• Don't mess with the matrix.
  Nature genetics 2001 Vu TH
• Matrix metalloproteinase 9 and vascular endothelial growth factor are essential for osteoclast recruitment into developing long bones.
  The Journal of cell biology 2000 Engsig MT, Chen QJ, Vu TH, Pedersen AC, Therkidsen B, Lund LR, Henriksen K, Lenhard T, Foged NT, Werb Z, Delaissé JM
• Matrix metalloproteinase-9 triggers the angiogenic switch during carcinogenesis.
  Nature cell biology 2000 Bergers G, Brekken R, McMahon G, Vu TH, Itoh T, Tamaki K, Tanzawa K, Thorpe P, Itohara S, Werb Z, Hanahan D
• Biology and Regulation of the Matrix Metalloproteinases.
  Matrix Metalloproteinase Inhibitors in Cancer Therapy 2000 Mark D. Sternlicht, Lisa M. Coussens, Thiennu H. Vu, Zena Werb
• Matrix metalloproteinases: effectors of development and normal physiology.
  Genes & development 2000 Vu TH, Werb Z
• Proteinases in bone resorption: obvious and less obvious roles.
  Clinica chimica acta; international journal of clinical chemistry 2000 Delaissé JM, Engsig MT, Everts V, del Carmen Ovejero M, Ferreras M, Lund L, Vu TH, Werb Z, Winding B, Lochter A, Karsdal MA, Troen T, Kirkegaard T, Lenhard T, Heegaard AM, Neff L, Baron R, Foged NT
• VEGF couples hypertrophic cartilage remodeling, ossification and angiogenesis during endochondral bone formation.
  Nature medicine 1999 Gerber HP, Vu TH, Ryan AM, Kowalski J, Werb Z, Ferrara N
• Matrix-degrading proteases and angiogenesis during development and tumor formation.
  APMIS : acta pathologica, microbiologica, et immunologica Scandinavica 1999 Werb Z, Vu TH, Rinkenberger JL, Coussens LM
• Gelatinase B-deficient mice are resistant to experimental bullous pemphigoid.
  The Journal of experimental medicine 1998 Liu Z, Shipley JM, Vu TH, Zhou X, Diaz LA, Werb Z, Senior RM
• MMP-9/gelatinase B is a key regulator of growth plate angiogenesis and apoptosis of hypertrophic chondrocytes.
  Cell 1998 Vu TH, Shipley JM, Bergers G, Berger JE, Helms JA, Hanahan D, Shapiro SD, Senior RM, Werb Z
• Gelatinase B: Structure, Regulation, and Function.
  Matrix Metalloproteinases 1998 Thiennu H. Vu, Zena Werb