Thea Tlsty, PhD
Professor
Pathology
School of Medicine
Dr. Tlsty has over 25 years of experience in studying human cells and the earliest responses to injury. She has lead multi-disciplinary groups that address both the epithelial and stromal contributions to wound healing and malignancy. The model systems the Tlsty laboratory has developed and the applied translational insights obtained have great potential to contribute to clinical utility.
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Our work was the first to develop biomarkers for risk stratification of ductal carcinoma in situ, a pre-malignant lesion of breast cancer. Our recent work has identified molecular aspects of stromal-epithelial stress responses and the interactions that facilitate tumor progression in breast, prostate and other cancers. These analyses have enabled us to identify cell-extrinsic consequences of epithelial stress that lead to the activation of pro-tumorigenic stromal phenotypes. One of the most profound phenotypes involves the activation of a multicellular stromal program shared by high mammographic density and desmoplastic tumor tissues, characterized by repression of CD36. While studying these interactions we unexpectedly found a rare population of cells within disease-free tissue that has the potential to attain pluripotency. These cells have the ability to create functional tissues of all three germ layers which we hypothesize may be involved in metaplasia and inflammatory diseases. A single pluripotent cell can generate beating cardiomyocytes, lactating breast, bone, cartilage, vasculature, adipocytes, pancreas, and intestinal cells. We hypothesize that these cells may be the cell-of-origin for metaplastic cancers and provide insights for the identification of novel therapeutic targets. Similarly, these cells may be responsible for a wide collection of phenotypes that are initiated by chronic stress and defective in a wide spectrum of cancers. Our current studies, couched in a large multi-disciplinary, multi-investigator grant, are aimed at investigating the role of chronic inflammation in increased cancer incidence with the intent of developing preventive and therapeutic solutions.
Websites
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- Profile at UCSF Cancer Center (cancer.ucsf.edu)
Videos
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- Cancer Biology 101 (youtube.com)
Grants and Projects
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- Cancer Center Support Grant, NIH, 1999-2023
- Plastic States Associated with Cellular Stress and Malignancy: Insights for Prevention and Treatment of Lethal Metaplastic Cancers, NIH, 2016-2022
- CD36-dependent stromal signaling orchestrates acquisition of pro-tumorigenic phenotypes, NIH, 2015
- Using Stromal Markers to Improve Risk Stratification of Ductal Carcinoma in Situ, NIH, 2015
- Regulation of Genomic Instability in Early Breast Cancer, NIH, 2002-2015
- Explosive Evolution Under Stress: The Driving Forces of Cancer Dynamics (Main), NIH, 2009-2014
- Biological Basis of Breast Density and Cancer Risk, NIH, 2006-2013
- Characterizing the Evolution of Pre-malignant Tissues at High Risk for Malignancy, NIH, 2008-2011
- Regulation of DNA hypermethylation in human mammary cells, NIH, 2006-2010
- Fibroblast Regulation of Human Prostatic Carcinogenesis, NIH, 2000-2004
- Mechanisms of Radiation--Induced Genomic Instability, NIH, 1997-2002
- Cycle-dependent Mechanisms of Chemical Carcinogenesis, NIH, 1988-2001
- 10Th International P53 Workshop, NIH, 2000-2001
- Gene Amplification to Study Neoplasia, NIH, 1990-1998
- Control of Genomic Fluidity in Cancer Cells, NIH, 1993-1997
- Cellular Adaptation and Environmental Carcinogenesis, NIH, 1987-1990
Publications (118)
Top publication keywords:
Precancerous ConditionsCyclooxygenase 2Breast NeoplasmsCyclin-Dependent Kinase Inhibitor p16ActivinsGene AmplificationStromal CellsFibroblastsCell Transformation, NeoplasticCarcinoma, Intraductal, NoninfiltratingDNA DamageEpithelial CellsBreastCell PlasticityMammary Glands, Human
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Extracellular Matrix Orchestration of Tissue Remodeling in the Chronically Inflamed Mouse Colon.
Cellular and molecular gastroenterology and hepatology 2024 Moutin EB, Bons J, Giavara G, Lourenco F, Pan D, Burton JB, Shah S, Colombé M, Gascard P, Tlsty T, Schilling B, Winton DJ -
Loss of PPARγ activity characterizes early protumorigenic stromal reprogramming and dictates the therapeutic window of opportunity.
Proceedings of the National Academy of Sciences of the United States of America 2023 Caruso JA, Wang X, Murrow LM, Rodriguez CI, Chen-Tanyolac C, Vu L, Chen YY, Gascard P, Gartner ZJ, Kerlikowske K, Tlsty TD -
Concerted epithelial and stromal changes during progression of Barrett's Esophagus to invasive adenocarcinoma exposed by multi-scale, multi-omics analysis.
bioRxiv : the preprint server for biology 2023 Strasser MK, Gibbs DL, Gascard P, Bons J, Hickey JW, Schürch CM, Tan Y, Black S, Chu P, Ozkan A, Basisty N, Sangwan V, Rose J, Shah S, Camilleri-Broet S, Fiset PO, Bertos N, Berube J, Djambazian H, Li… -
Apposition of Fibroblasts With Metaplastic Gastric Cells Promotes Dysplastic Transition.
Gastroenterology 2023 Lee SH, Contreras Panta EW, Gibbs D, Won Y, Min J, Zhang C, Roland JT, Hong SH, Sohn Y, Krystofiak E, Jang B, Ferri L, Sangwan V, Ragoussis J, Camilleri-Broët S, Caruso J, Chen-Tanyolac C, Strasser M,… -
Data-independent acquisition and quantification of extracellular matrix from human lung in chronic inflammation-associated carcinomas.
Proteomics 2022 Bons J, Pan D, Shah S, Bai R, Chen-Tanyolac C, Wang X, Elliott DRF, Urisman A, O'Broin A, Basisty N, Rose J, Sangwan V, Camilleri-Broët S, Tankel J, Gascard P, Ferri L, Tlsty TD, Schilling B
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Antigen-Dependent Inducible T-Cell Reporter System for PET Imaging of Breast Cancer and Glioblastoma.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine 2022 Shin J, Parker MFL, Zhu I, Alanizi A, Rodriguez CI, Liu R, Watchmaker PB, Kalita M, Blecha J, Luu J, Wright B, Lapi SE, Flavell RR, Okada H, Tlsty TD, Roybal KT, Wilson DM -
Mapping hormone-regulated cell-cell interaction networks in the human breast at single-cell resolution.
Cell systems 2022 Murrow LM, Weber RJ, Caruso JA, McGinnis CS, Phong K, Gascard P, Rabadam G, Borowsky AD, Desai TA, Thomson M, Tlsty T, Gartner ZJ -
Remaining true to one's identity.
Nature aging 2021 Caruso JA, Tlsty TD -
A framework for advancing our understanding of cancer-associated fibroblasts.
Nature reviews. Cancer 2020 Sahai E, Astsaturov I, Cukierman E, DeNardo DG, Egeblad M, Evans RM, Fearon D, Greten FR, Hingorani SR, Hunter T, Hynes RO, Jain RK, Janowitz T, Jorgensen C, Kimmelman AC, Kolonin MG, Maki RG, Powers … -
Stromal directives can control cancer.
Science (New York, N.Y.) 2019 Tlsty TD, Gascard P -
Introducing cancer convergence.
Cancer convergence 2017 Blagoev KB, Ting DT, Levine H, Saenger Y, Tlsty TD, Sun B -
Metastatic State of Cancer Cells May Be Indicated by Adhesion Strength.
Biophysical journal 2017 Fuhrmann A, Banisadr A, Beri P, Tlsty TD, Engler AJ -
SOX2, OCT3/4 and NANOG expression and cellular plasticity in rare human somatic cells requires CD73.
Cellular signalling 2016 Pan D, Roy S, Gascard P, Zhao J, Chen-Tanyolac C, Tlsty TD -
Risk prediction for local versus regional/metastatic tumors after initial ductal carcinoma in situ diagnosis treated by lumpectomy.
Breast cancer research and treatment 2016 Molinaro AM, Sison JD, Ljung BM, Tlsty TD, Kerlikowske K -
Carcinoma-associated fibroblasts: orchestrating the composition of malignancy.
Genes & development 2016 Gascard P, Tlsty TD -
Novel insights from 3D models: the pivotal role of physical symmetry in epithelial organization.
Scientific reports 2015 Kurup A, Ravindranath S, Tran T, Keating M, Gascard P, Valdevit L, Tlsty TD, Botvinick EL -
Towards aspirin-inspired self-immolating molecules which target the cyclooxygenases.
Organic & biomolecular chemistry 2015 Drake CR, Estévez-Salmerón L, Gascard P, Shen Y, Tlsty TD, Jones EF -
Integrative analysis of 111 reference human epigenomes.
Nature 2015 Roadmap Epigenomics Consortium, Kundaje A, Meuleman W, Ernst J, Bilenky M, Yen A, Heravi-Moussavi A, Kheradpour P, Zhang Z, Wang J, Ziller MJ, Amin V, Whitaker JW, Schultz MD, Ward LD, Sarkar A, Quon … -
Epigenetic and transcriptional determinants of the human breast.
Nature communications 2015 Gascard P, Bilenky M, Sigaroudinia M, Zhao J, Li L, Carles A, Delaney A, Tam A, Kamoh B, Cho S, Griffith M, Chu A, Robertson G, Cheung D, Li I, Heravi-Moussavi A, Moksa M, Mingay M, Hussainkhel A, … -
Intermediate DNA methylation is a conserved signature of genome regulation.
Nature communications 2015 Elliott G, Hong C, Xing X, Zhou X, Li D, Coarfa C, Bell RJ, Maire CL, Ligon KL, Sigaroudinia M, Gascard P, Tlsty TD, Harris RA, Schalkwyk LC, Bilenky M, Mill J, Farnham PJ, Kellis M, Marra MA, … -
Regulatory network decoded from epigenomes of surface ectoderm-derived cell types.
Nature communications 2014 Lowdon RF, Zhang B, Bilenky M, Mauro T, Li D, Gascard P, Sigaroudinia M, Farnham PJ, Bastian BC, Tlsty TD, Marra MA, Hirst M, Costello JF, Wang T, Cheng JB -
Stress signaling from human mammary epithelial cells contributes to phenotypes of mammographic density.
Cancer research 2014 DeFilippis RA, Fordyce C, Patten K, Chang H, Zhao J, Fontenay GV, Kerlikowske K, Parvin B, Tlsty TD -
Evolutionary game theory for physical and biological scientists. I. Training and validating population dynamics equations.
Interface focus 2014 Liao D, Tlsty TD -
Evolutionary game theory for physical and biological scientists. II. Population dynamics equations can be associated with interpretations.
Interface focus 2014 Liao D, Tlsty TD -
Game theory in the death galaxy: interaction of cancer and stromal cells in tumour microenvironment.
Interface focus 2014 Wu A, Liao D, Tlsty TD, Sturm JC, Austin RH -
Cell motility and drug gradients in the emergence of resistance to chemotherapy.
Proceedings of the National Academy of Sciences of the United States of America 2013 Wu A, Loutherback K, Lambert G, Estévez-Salmerón L, Tlsty TD, Austin RH, Sturm JC -
Functional DNA methylation differences between tissues, cell types, and across individuals discovered using the M&M algorithm.
Genome research 2013 Zhang B, Zhou Y, Lin N, Lowdon RF, Hong C, Nagarajan RP, Cheng JB, Li D, Stevens M, Lee HJ, Xing X, Zhou J, Sundaram V, Elliott G, Gu J, Shi T, Gascard P, Sigaroudinia M, Tlsty TD, Kadlecek T, Weiss A… -
DNA hypomethylation within specific transposable element families associates with tissue-specific enhancer landscape.
Nature genetics 2013 Xie M, Hong C, Zhang B, Lowdon RF, Xing X, Li D, Zhou X, Lee HJ, Maire CL, Ligon KL, Gascard P, Sigaroudinia M, Tlsty TD, Kadlecek T, Weiss A, O'Geen H, Farnham PJ, Madden PA, Mungall AJ, Tam A, Kamoh… -
Coordinate transcriptional and translational repression of p53 by TGF-β1 impairs the stress response.
Molecular cell 2013 López-Díaz FJ, Gascard P, Balakrishnan SK, Zhao J, Del Rincon SV, Spruck C, Tlsty TD, Emerson BM -
Rare somatic cells from human breast tissue exhibit extensive lineage plasticity.
Proceedings of the National Academy of Sciences of the United States of America 2013 Roy S, Gascard P, Dumont N, Zhao J, Pan D, Petrie S, Margeta M, Tlsty TD -
Breast fibroblasts modulate early dissemination, tumorigenesis, and metastasis through alteration of extracellular matrix characteristics.
Neoplasia (New York, N.Y.) 2013 Dumont N, Liu B, Defilippis RA, Chang H, Rabban JT, Karnezis AN, Tjoe JA, Marx J, Parvin B, Tlsty TD -
A physical sciences network characterization of non-tumorigenic and metastatic cells.
Scientific reports 2013 Physical Sciences - Oncology Centers Network, Agus DB, Alexander JF, Arap W, Ashili S, Aslan JE, Austin RH, Backman V, Bethel KJ, Bonneau R, Chen WC, Chen-Tanyolac C, Choi NC, Curley SA, Dallas M, … -
Cell-extrinsic consequences of epithelial stress: activation of protumorigenic tissue phenotypes.
Breast cancer research : BCR 2012 Fordyce CA, Patten KT, Fessenden TB, DeFilippis R, Hwang ES, Zhao J, Tlsty TD -
Hello out there...is anybody listening?
Cancer discovery 2012 DeFilippis RA, Tlsty TD -
Conceptualizing a tool to optimize therapy based on dynamic heterogeneity.
Physical biology 2012 Liao D, Estévez-Salmerón L, Tlsty TD -
Generalized principles of stochasticity can be used to control dynamic heterogeneity.
Physical biology 2012 Liao D, Estévez-Salmerón L, Tlsty TD -
CD36 repression activates a multicellular stromal program shared by high mammographic density and tumor tissues.
Cancer discovery 2012 DeFilippis RA, Chang H, Dumont N, Rabban JT, Chen YY, Fontenay GV, Berman HK, Gauthier ML, Zhao J, Hu D, Marx JJ, Tjoe JA, Ziv E, Febbraio M, Kerlikowske K, Parvin B, Tlsty TD -
The clonal and mutational evolution spectrum of primary triple-negative breast cancers.
Nature 2012 Shah SP, Roth A, Goya R, Oloumi A, Ha G, Zhao Y, Turashvili G, Ding J, Tse K, Haffari G, Bashashati A, Prentice LM, Khattra J, Burleigh A, Yap D, Bernard V, McPherson A, Shumansky K, Crisan A, … -
p16(INK4a) expression and breast cancer risk in women with atypical hyperplasia.
Cancer prevention research (Philadelphia, Pa.) 2011 Radisky DC, Santisteban M, Berman HK, Gauthier ML, Frost MH, Reynolds CA, Vierkant RA, Pankratz VS, Visscher DW, Tlsty TD, Hartmann LC -
Tissue states provide novel insights into attributes that drive metastasis.
Cancer cell 2011 Tlsty TD -
An analogy between the evolution of drug resistance in bacterial communities and malignant tissues.
Nature reviews. Cancer 2011 Lambert G, Estévez-Salmeron L, Oh S, Liao D, Emerson BM, Tlsty TD, Austin RH -
Tumor microenvironment and progression.
Journal of surgical oncology 2011 Dvorak HF, Weaver VM, Tlsty TD, Bergers G -
A twist of cell fate.
Cell stem cell 2011 Tlsty TD -
Biomarker expression and risk of subsequent tumors after initial ductal carcinoma in situ diagnosis.
Journal of the National Cancer Institute 2010 Kerlikowske K, Molinaro AM, Gauthier ML, Berman HK, Waldman F, Bennington J, Sanchez H, Jimenez C, Stewart K, Chew K, Ljung BM, Tlsty TD -
Premalignant breast neoplasia: a paradigm of interlesional and intralesional molecular heterogeneity and its biological and clinical ramifications.
Cancer prevention research (Philadelphia, Pa.) 2010 Berman HK, Gauthier ML, Tlsty TD -
Primary cilia regulate branching morphogenesis during mammary gland development.
Current biology : CB 2010 McDermott KM, Liu BY, Tlsty TD, Pazour GJ -
Unprecedented opportunities and promise for cancer prevention research.
Cancer prevention research (Philadelphia, Pa.) 2010 Blackburn EH, Tlsty TD, Lippman SM -
DNA damage drives an activin a-dependent induction of cyclooxygenase-2 in premalignant cells and lesions.
Cancer prevention research (Philadelphia, Pa.) 2009 Fordyce C, Fessenden T, Pickering C, Jung J, Singla V, Berman H, Tlsty T -
Human mammary cancer progression model recapitulates methylation events associated with breast premalignancy.
Breast cancer research : BCR 2009 Dumont N, Crawford YG, Sigaroudinia M, Nagrani SS, Wilson MB, Buehring GC, Turashvili G, Aparicio S, Gauthier ML, Fordyce CA, McDermott KM, Tlsty TD -
Reflections on miR-ing effects in metastasis.
Cancer cell 2009 Dumont N, Tlsty TD -
Sustained induction of epithelial to mesenchymal transition activates DNA methylation of genes silenced in basal-like breast cancers.
Proceedings of the National Academy of Sciences of the United States of America 2008 Dumont N, Wilson MB, Crawford YG, Reynolds PA, Sigaroudinia M, Tlsty TD -
Graphical methods for quantifying macromolecules through bright field imaging.
Bioinformatics (Oxford, England) 2008 Chang H, DeFilippis RA, Tlsty TD, Parvin B -
Cancer: whispering sweet somethings.
Nature 2008 Tlsty T -
Morphologically normal-appearing mammary epithelial cells obtained from high-risk women exhibit methylation silencing of INK4a/ARF.
Clinical cancer research : an official journal of the American Association for Cancer Research 2007 Bean GR, Bryson AD, Pilie PG, Goldenberg V, Baker JC, Ibarra C, Brander DM, Paisie C, Case NR, Gauthier M, Reynolds PA, Dietze E, Ostrander J, Scott V, Wilke LG, Yee L, Kimler BF, Fabian CJ, Zalles CM… -
Abrogated response to cellular stress identifies DCIS associated with subsequent tumor events and defines basal-like breast tumors.
Cancer cell 2007 Gauthier ML, Berman HK, Miller C, Kozakeiwicz K, Chew K, Moore D, Rabban J, Chen YY, Kerlikowske K, Tlsty TD -
Stratification of breast cancer risk in women with atypia: a Mayo cohort study.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2007 Degnim AC, Visscher DW, Berman HK, Frost MH, Sellers TA, Vierkant RA, Maloney SD, Pankratz VS, de Groen PC, Lingle WL, Ghosh K, Penheiter L, Tlsty T, Melton LJ, Reynolds CA, Hartmann LC -
Inactivation of p53 function in cultured human mammary epithelial cells turns the telomere-length dependent senescence barrier from agonescence into crisis.
Cell cycle (Georgetown, Tex.) 2007 Garbe JC, Holst CR, Bassett E, Tlsty T, Stampfer MR -
Luminal cells GATA have it.
Nature cell biology 2007 Tlsty TD -
p16INK4a modulates p53 in primary human mammary epithelial cells.
Cancer research 2006 Zhang J, Pickering CR, Holst CR, Gauthier ML, Tlsty TD -
Simulating properties of in vitro epithelial cell morphogenesis.
PLoS computational biology 2006 Grant MR, Mostov KE, Tlsty TD, Hunt CA -
Tumor suppressor p16INK4A regulates polycomb-mediated DNA hypermethylation in human mammary epithelial cells.
The Journal of biological chemistry 2006 Reynolds PA, Sigaroudinia M, Zardo G, Wilson MB, Benton GM, Miller CJ, Hong C, Fridlyand J, Costello JF, Tlsty TD -
p16(INK4a) prevents centrosome dysfunction and genomic instability in primary cells.
PLoS biology 2006 McDermott KM, Zhang J, Holst CR, Kozakiewicz BK, Singla V, Tlsty TD -
Tumor stroma and regulation of cancer development.
Annual review of pathology 2006 Tlsty TD, Coussens LM -
Benign breast disease and the risk of breast cancer.
The New England journal of medicine 2005 Hartmann LC, Sellers TA, Frost MH, Lingle WL, Degnim AC, Ghosh K, Vierkant RA, Maloney SD, Pankratz VS, Hillman DW, Suman VJ, Johnson J, Blake C, Tlsty T, Vachon CM, Melton LJ, Visscher DW -
p38 regulates cyclooxygenase-2 in human mammary epithelial cells and is activated in premalignant tissue.
Cancer research 2005 Gauthier ML, Pickering CR, Miller CJ, Fordyce CA, Chew KL, Berman HK, Tlsty TD -
Genetic and epigenetic changes in mammary epithelial cells identify a subpopulation of cells involved in early carcinogenesis.
Cold Spring Harbor symposia on quantitative biology 2005 Berman H, Zhang J, Crawford YG, Gauthier ML, Fordyce CA, McDermott KM, Sigaroudinia M, Kozakiewicz K, Tlsty TD -
Genetic and epigenetic changes in mammary epithelial cells may mimic early events in carcinogenesis.
Journal of mammary gland biology and neoplasia 2004 Tlsty TD, Crawford YG, Holst CR, Fordyce CA, Zhang J, McDermott K, Kozakiewicz K, Gauthier ML -
Histologically normal human mammary epithelia with silenced p16(INK4a) overexpress COX-2, promoting a premalignant program.
Cancer cell 2004 Crawford YG, Gauthier ML, Joubel A, Mantei K, Kozakiewicz K, Afshari CA, Tlsty TD -
Cyclooxygenase-2 expression is related to nuclear grade in ductal carcinoma in situ and is increased in its normal adjacent epithelium.
Cancer research 2003 Shim V, Gauthier ML, Sudilovsky D, Mantei K, Chew KL, Moore DH, Cha I, Tlsty TD, Esserman LJ -
Methylation of p16(INK4a) promoters occurs in vivo in histologically normal human mammary epithelia.
Cancer research 2003 Holst CR, Nuovo GJ, Esteller M, Chew K, Baylin SB, Herman JG, Tlsty TD -
Functions of p53 suppress critical consequences of damage and repair in the initiation of cancer.
Cancer cell 2002 Tlsty TD -
Induction of tubulogenesis in telomerase-immortalized human microvascular endothelial cells by glioblastoma cells.
Experimental cell research 2002 Venetsanakos E, Mirza A, Fanton C, Romanov SR, Tlsty T, McMahon M -
Minichromosome maintenance protein 2 expression in prostate: characterization and association with outcome after therapy for cancer.
Clinical cancer research : an official journal of the American Association for Cancer Research 2001 Meng MV, Grossfeld GD, Williams GH, Dilworth S, Stoeber K, Mulley TW, Weinberg V, Carroll PR, Tlsty TD -
Stromal cells can contribute oncogenic signals.
Seminars in cancer biology 2001 Tlsty TD -
Know thy neighbor: stromal cells can contribute oncogenic signals.
Current opinion in genetics & development 2001 Tlsty TD, Hein PW -
Searching for targets: the power of somatic cell genetics.
Genome research 2001 Tlsty TD -
Overexpression of MYC causes p53-dependent G2 arrest of normal fibroblasts.
Proceedings of the National Academy of Sciences of the United States of America 2000 Felsher DW, Zetterberg A, Zhu J, Tlsty T, Bishop JM -
Human mammary epithelial cells exhibit a differential p53-mediated response following exposure to ionizing radiation or UV light.
Oncogene 1999 Meyer KM, Hess SM, Tlsty TD, Leadon SA -
Carcinoma-associated fibroblasts direct tumor progression of initiated human prostatic epithelium.
Cancer research 1999 Olumi AF, Grossfeld GD, Hayward SW, Carroll PR, Tlsty TD, Cunha GR -
A molecular blueprint for targeting cancer?
Nature genetics 1999 Tlsty TD -
Telomerase expression in human somatic cells does not induce changes associated with a transformed phenotype.
Nature genetics 1999 Jiang XR, Jimenez G, Chang E, Frolkis M, Kusler B, Sage M, Beeche M, Bodnar AG, Wahl GM, Tlsty TD, Chiu CP -
A novel coculture technique demonstrates that normal human prostatic fibroblasts contribute to tumor formation of LNCaP cells by retarding cell death.
Cancer research 1998 Olumi AF, Dazin P, Tlsty TD -
Cell-adhesion-dependent influences on genomic instability and carcinogenesis.
Current opinion in cell biology 1998 Tlsty TD -
Attenuation of G1 checkpoint function by the non-genotoxic carcinogen phenobarbital.
Carcinogenesis 1998 Gonzales AJ, Christensen JG, Preston RJ, Goldsworthy TL, Tlsty TD, Fox TR -
Genetic and epigenetic influences in prostatic carcinogenesis (review).
International journal of oncology 1998 Hayward SW, Grossfeld GD, Tlsty TD, Cunha GR -
An oncogenic form of p53 confers a dominant, gain-of-function phenotype that disrupts spindle checkpoint control.
Proceedings of the National Academy of Sciences of the United States of America 1998 Gualberto A, Aldape K, Kozakiewicz K, Tlsty TD -
Identification of additional complementation groups that regulate genomic instability.
Genes, chromosomes & cancer 1997 Hall IJ, Gioeli D, Weissman BE, Tlsty TD -
Cellular adhesion regulates p53 protein levels in primary human keratinocytes.
Cancer research 1997 Nigro JM, Aldape KD, Hess SM, Tlsty TD -
Genomic instability and its role in neoplasia.
Current topics in microbiology and immunology 1997 Tlsty TD -
Separate pathways for p53 induction by ionizing radiation and N-(phosphonoacetyl)-L-aspartate.
Cancer research 1996 Chen CY, Hall I, Lansing TJ, Gilmer TM, Tlsty TD, Kastan MB -
Alteration of cell cycle kinase complexes in human papillomavirus E6- and E7-expressing fibroblasts precedes neoplastic transformation.
Journal of virology 1996 Xiong Y, Kuppuswamy D, Li Y, Livanos EM, Hixon M, White A, Beach D, Tlsty TD -
Regulation of genomic instability in preneoplastic cells.
Cancer surveys 1996 Tlsty TD -
Genomic instability and cancer.
Mutation research 1995 Tlsty TD, Briot A, Gualberto A, Hall I, Hess S, Hixon M, Kuppuswamy D, Romanov S, Sage M, White A -
Defective G2 checkpoint function in cells from individuals with familial cancer syndromes.
Cancer research 1995 Paules RS, Levedakou EN, Wilson SJ, Innes CL, Rhodes N, Tlsty TD, Galloway DA, Donehower LA, Tainsky MA, Kaufmann WK -
Analysis of cell cycle checkpoint status in mammalian cells.
Methods in enzymology 1995 Tlsty T, Briot A, Poulose B -
Clonal variation of tumorigenic potential in v-Ha-ras-transformed human bronchial epithelial cells: relationship to ras oncogene expression and CAD gene amplification.
Molecular carcinogenesis 1994 Forrester K, Kispert J, Sanchez JH, Gerwin BI, Tlsty TD, Harris CC -
p53-dependent inhibition of cyclin-dependent kinase activities in human fibroblasts during radiation-induced G1 arrest.
Cell 1994 Dulic V, Kaufmann WK, Wilson SJ, Tlsty TD, Lees E, Harper JW, Elledge SJ, Reed SI -
Differential disruption of genomic integrity and cell cycle regulation in normal human fibroblasts by the HPV oncoproteins.
Genes & development 1994 White AE, Livanos EM, Tlsty TD -
Genomic integrity and the genetics of cancer.
Cold Spring Harbor symposia on quantitative biology 1994 Tlsty TD, White A, Livanos E, Sage M, Roelofs H, Briot A, Poulose B -
Multiple mechanisms of N-(phosphonoacetyl)-L-aspartate drug resistance in SV40-infected precrisis human fibroblasts.
Cancer research 1993 Schaefer DI, Livanos EM, White AE, Tlsty TD -
Amplification potential in preneoplastic and neoplastic Syrian hamster embryo fibroblasts transformed by various carcinogens.
Cancer research 1993 Jonczyk P, White A, Lum K, Barrett JC, Tlsty TD -
Loss of chromosomal integrity in neoplasia.
Cold Spring Harbor symposia on quantitative biology 1993 Tlsty TD, Jonczyk P, White A, Sage M, Hall I, Schaefer D, Briot A, Livanos E, Roelofs H, Poulose B -
Altered cell cycle arrest and gene amplification potential accompany loss of wild-type p53.
Cell 1992 Livingstone LR, White A, Sprouse J, Livanos E, Jacks T, Tlsty TD -
Suppression of gene amplification in human cell hybrids.
Science (New York, N.Y.) 1992 Tlsty TD, White A, Sanchez J -
Replication of the dihydrofolate reductase genes on double minute chromosomes in a murine cell line.
Experimental cell research 1990 Tlsty TD, Adams P -
Normal diploid human and rodent cells lack a detectable frequency of gene amplification.
Proceedings of the National Academy of Sciences of the United States of America 1990 Tlsty TD -
Differences in the rates of gene amplification in nontumorigenic and tumorigenic cell lines as measured by Luria-Delbrück fluctuation analysis.
Proceedings of the National Academy of Sciences of the United States of America 1989 Tlsty TD, Margolin BH, Lum K -
1-beta-D-arabinofuranosylcytosine enhancement of resistance to several antineoplastic drugs in mammalian tissue culture cells.
Molecular pharmacology 1989 Goz B, Carl PL, Tlsty TD -
Increased incidence of CAD gene amplification in tumorigenic rat lines as an indicator of genomic instability of neoplastic cells.
The Journal of biological chemistry 1989 Otto E, McCord S, Tlsty TD -
Rapid emergence of methotrexate resistance in cultured mouse cells.
Cancer research 1984 Rath H, Tlsty T, Schimke RT -
UV radiation facilitates methotrexate resistance and amplification of the dihydrofolate reductase gene in cultured 3T6 mouse cells.
Molecular and cellular biology 1984 Tlsty TD, Brown PC, Schimke RT -
Gene amplification in the lac region of E. coli.
Cell 1984 Tlsty TD, Albertini AM, Miller JH -
Enhancement of methotrexate resistance and dihydrofolate reductase gene amplification by treatment of mouse 3T6 cells with hydroxyurea.
Molecular and cellular biology 1983 Brown PC, Tlsty TD, Schimke RT -
Analysis of spontaneous deletions and gene amplification in the lac region of Escherichia coli.
Cold Spring Harbor symposia on quantitative biology 1983 Albertini AM, Hofer M, Calos MP, Tlsty TD, Miller JH -
Insertion, excision, and inversion of Tn5.
Cold Spring Harbor symposia on quantitative biology 1981 Berg DE, Egner C, Hirschel BJ, Howard J, Johnsrud L, Jorgensen RA, Tlsty TD -
The distribution of DNA repair synthesis in chromatin and its rearrangement following damage with N-acetoxy-2-acetylaminofluorene.
Nucleic acids research 1978 Tlsty TD, Lieberman MW -
Distribution of ultraviolet-induced DNA repair synthesis in nuclease sensitive and resistant regions of human chromatin.
Biochemistry 1978 Smerdon MJ, Tlsty TD, Lieberman MW -
The inhibition of ribosomal RNA synthesis and maturation in Novikoff hepatoma cells by 5-fluorouridine.
Cancer research 1975 Wilkinson DS, Tlsty TD, Hanas RJ