Terumi Kohwi-Shigematsu, PhD
Professor
Orofacial Sciences
School of Dentistry

Publications (101)

Top publication keywords:
Nuclear ProteinsGenomeAmelogenesisThymocytesMatrix Attachment Region Binding ProteinsDental EnamelAmeloblastsDNA-Binding ProteinsChromatinAntigens, NuclearDNA, SuperhelicalDNADNA HelicasesNucleic Acid ConformationNuclear Matrix

• Genome organization by SATB1 binding to base-unpairing regions (BURs) provides a scaffold for SATB1-regulated gene expression.
  eLife 2025 Kohwi Y, Wong X, Grange M, Sexton T, Richards HW, Kitagawa Y, Sakaguchi S, Liang YC, Chuong CM, Botchkarev VA, Taniuchi I, Reddy KL, Kohwi-Shigematsu T
• Genome organization by SATB1 binding to base-unpairing regions (BURs) provides a scaffold for SATB1-regulated gene expression.
  eLife 2025 Yoshinori Kohwi, Xianrong Wong, Mari Grange, Thomas Sexton, Hunter W Richards, Yohko Kitagawa, Shimon Sakaguchi, Ya-Chen Liang, Cheng-Ming Chuong, Vladimir A Botchkarev, Ichiro Taniuchi, Karen L Reddy…
• SATB1 is a key regulator of quiescence in stem-like CD8+ T cells.
  Nature immunology 2025 Lin S, Niu H, Zhang Y, Gai K, Brown R, Brown A, Shen J, Xu Z, Shah RK, Schmeling JL, Vargas-Cortes M, Zamora AE, Kohwi-Shigematsu T, Fan J, Zhang B, Cui W
• The therapeutically actionable long non-coding RNA 'T-RECS' is essential to cancer cells' survival in NRAS/MAPK-driven melanoma.
  Molecular cancer 2024 Feichtenschlager V, Chen L, Zheng YJ, Ho W, Sanlorenzo M, Vujic I, Fewings E, Lee A, Chen C, Callanan C, Lin K, Qu T, Hohlova D, Vujic M, Hwang Y, Lai K, Chen S, Nguyen T, Muñoz DP, Kohwi Y, Posch C, …
• The therapeutically actionable long non-coding RNA 'T-RECS' is essential to cancer cells' survival in NRAS/MAPK-driven melanoma.
  Research square 2023 Feichtenschlager V, Chen L, Zheng YJ, Ho W, Sanlorenzo M, Vujic I, Fewings E, Lee A, Chen C, Callanan C, Lin K, Qu T, Hohlova D, Vujic M, Hwang Y, Lai K, Chen S, Nguyen T, Muñoz DP, Kohwi Y, Posch C, …

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• Crucial Roles of SATB1 in Regulation of Thymocyte Migration after Positive Selection.
  Journal of immunology (Baltimore, Md. : 1950) 2023 Naito T, Ise M, Tanaka Y, Kohwi-Shigematsu T, Kondo M
• Chromatin organizer SATB1 controls the cell identity of CD4+ CD8+ double-positive thymocytes by regulating the activity of super-enhancers.
  Nature communications 2022 Feng D, Chen Y, Dai R, Bian S, Xue W, Zhu Y, Li Z, Yang Y, Zhang Y, Zhang J, Bai J, Qin L, Kohwi Y, Shi W, Kohwi-Shigematsu T, Ma J, Liao S, Hao B
• SATB1-dependent mitochondrial ROS production controls TCR signaling in CD4 T cells.
  Life science alliance 2021 Kuwabara T, Ishikawa F, Ikeda M, Ide T, Kohwi-Shigematsu T, Tanaka Y, Kondo M
• Increased Indoleamine 2,3-Dioxygenase Levels at the Onset of Sjögren's Syndrome in SATB1-Conditional Knockout Mice.
  International journal of molecular sciences 2021 Tanaka Y, Onozato M, Mikami T, Kohwi-Shigematsu T, Fukushima T, Kondo M
• Withdrawal: Selective cleavage of BLM, the Bloom syndrome protein, during apoptotic cell death.
  The Journal of biological chemistry 2020 Bischof O, Galande S, Farzaneh F, Kohwi-Shigematsu T, Campisi J
• Runx-mediated regulation of CCL5 via antagonizing two enhancers influences immune cell function and anti-tumor immunity.
  Nature communications 2020 Seo W, Shimizu K, Kojo S, Okeke A, Kohwi-Shigematsu T, Fujii SI, Taniuchi I
• SATB1 establishes ameloblast cell polarity and regulates directional amelogenin secretion for enamel formation.
  BMC biology 2019 Zhang Y, Zheng L, Le M, Nakano Y, Chan B, Huang Y, Torbaty PM, Kohwi Y, Marcucio R, Habelitz S, Den Besten PK, Kohwi-Shigematsu T
• Satb1 regulates the effector program of encephalitogenic tissue Th17 cells in chronic inflammation.
  Nature communications 2019 Yasuda K, Kitagawa Y, Kawakami R, Isaka Y, Watanabe H, Kondoh G, Kohwi-Shigematsu T, Sakaguchi S, Hirota K
• Variable SATB1 Levels Regulate Hematopoietic Stem Cell Heterogeneity with Distinct Lineage Fate.
  Cell reports 2018 Doi Y, Yokota T, Satoh Y, Okuzaki D, Tokunaga M, Ishibashi T, Sudo T, Ueda T, Shingai Y, Ichii M, Tanimura A, Ezoe S, Shibayama H, Kohwi-Shigematsu T, Takeda J, Oritani K, Kanakura Y
• 671 Cross-talk between covalent DNA modifications and chromatin architecture: DNA dioxygenase Tet2 mediates the effects of chromatin architectural protein CTCF on epidermal barrier maintenance, inflammation and tumorigenesis.
  Journal of Investigative Dermatology 2018 I. Malashchuk, J. Rudolf, T. Vafaee, K. Poterlowicz, A. Sharov, M. Fessing, T. Kohwi-Shigematsu, G. Xu, A. Mardaryev, V. Botchkarev
• Addendum: Guidance of regulatory T cell development by Satb1-dependent super-enhancer establishment.
  Nature immunology 2017 Kitagawa Y, Ohkura N, Kidani Y, Vandenbon A, Hirota K, Kawakami R, Yasuda K, Motooka D, Nakamura S, Kondo M, Taniuchi I, Kohwi-Shigematsu T, Sakaguchi S
• 091 5C analysis reveals distinct spatial contact networks between gene-rich and gene-poor TADs at the Epidermal Differentiation Complex in skin epithelial cells.
  Journal of Investigative Dermatology 2017 K. Poterlowicz, J. Yarker, I. Malashchuk, A.N. Mardaryev, M.R. Gdula, A. sharov, T. Kohwi-Shigematsu, V. Botchkarev, M.Y. Fessing
• 5C analysis of the Epidermal Differentiation Complex locus reveals distinct chromatin interaction networks between gene-rich and gene-poor TADs in skin epithelial cells.
  PLoS genetics 2017 Poterlowicz K, Yarker JL, Malashchuk I, Lajoie BR, Mardaryev AN, Gdula MR, Sharov AA, Kohwi-Shigematsu T, Botchkarev VA, Fessing MY
• Erratum: Guidance of regulatory T cell development by Satb1-dependent super-enhancer establishment.
  Nature immunology 2017 Kitagawa Y, Ohkura N, Kidani Y, Vandenbon A, Hirota K, Kawakami R, Yasuda K, Motooka D, Nakamura S, Kondo M, Taniuchi I, Kohwi-Shigematsu T, Sakaguchi S
• Guidance of regulatory T cell development by Satb1-dependent super-enhancer establishment.
  Nature immunology 2016 Kitagawa Y, Ohkura N, Kidani Y, Vandenbon A, Hirota K, Kawakami R, Yasuda K, Motooka D, Nakamura S, Kondo M, Taniuchi I, Kohwi-Shigematsu T, Sakaguchi S
• SATB1 Expression Helps in Identification of the Lymphoid-Lineage-Biased Trajectory of Functionally Fluctuating Hematopoietic Stem Cells.
  Blood 2016 Yukiko Doi, Takafumi Yokota, Yusuke Satoh, Tomoaki Ueda, Yasuhiro Shingai, Michiko Ichii, Akira Tanimura, Sachiko Ezoe, Hirohiko Shibayama, Kenji Oritani, Terumi Kohwi-Shigematsu, Yuzuru Kanakura
• Satb2 Is Required for the Development of a Spinal Exteroceptive Microcircuit that Modulates Limb Position.
  Neuron 2016 Hilde KL, Levine AJ, Hinckley CA, Hayashi M, Montgomery JM, Gullo M, Driscoll SP, Grosschedl R, Kohwi Y, Kohwi-Shigematsu T, Pfaff SL
• Correction: SATB1 Plays a Critical Role in Establishment of Immune Tolerance.
  Journal of immunology (Baltimore, Md. : 1950) 2016 Kondo M, Tanaka Y, Kuwabara T, Naito T, Kohwi-Shigematsu T, Watanabe A
• SATB1 Plays a Critical Role in Establishment of Immune Tolerance.
  Journal of immunology (Baltimore, Md. : 1950) 2015 Kondo M, Tanaka Y, Kuwabara T, Naito T, Kohwi-Shigematsu T, Watanabe A
• An anti-silencer- and SATB1-dependent chromatin hub regulates Rag1 and Rag2 gene expression during thymocyte development.
  The Journal of experimental medicine 2015 Hao B, Naik AK, Watanabe A, Tanaka H, Chen L, Richards HW, Kondo M, Taniuchi I, Kohwi Y, Kohwi-Shigematsu T, Krangel MS
• Required enhancer-matrin-3 network interactions for a homeodomain transcription program.
  Nature 2014 Skowronska-Krawczyk D, Ma Q, Schwartz M, Scully K, Li W, Liu Z, Taylor H, Tollkuhn J, Ohgi KA, Notani D, Kohwi Y, Kohwi-Shigematsu T, Rosenfeld MG
• The Satb1 protein directs hematopoietic stem cell differentiation toward lymphoid lineages.
  Immunity 2013 Satoh Y, Yokota T, Sudo T, Kondo M, Lai A, Kincade PW, Kouro T, Iida R, Kokame K, Miyata T, Habuchi Y, Matsui K, Tanaka H, Matsumura I, Oritani K, Kohwi-Shigematsu T, Kanakura Y
• ATM suppresses SATB1-induced malignant progression in breast epithelial cells.
  PloS one 2012 Ordinario E, Han HJ, Furuta S, Heiser LM, Jakkula LR, Rodier F, Spellman PT, Campisi J, Gray JW, Bissell MJ, Kohwi Y, Kohwi-Shigematsu T
• A network of genetic repression and derepression specifies projection fates in the developing neocortex.
  Proceedings of the National Academy of Sciences of the United States of America 2012 Srinivasan K, Leone DP, Bateson RK, Dobreva G, Kohwi Y, Kohwi-Shigematsu T, Grosschedl R, McConnell SK
• SATB1-mediated functional packaging of chromatin into loops.
  Methods (San Diego, Calif.) 2012 Kohwi-Shigematsu T, Kohwi Y, Takahashi K, Richards HW, Ayers SD, Han HJ, Cai S
• Genome organizing function of SATB1 in tumor progression.
  Seminars in cancer biology 2012 Kohwi-Shigematsu T, Poterlowicz K, Ordinario E, Han HJ, Botchkarev VA, Kohwi Y
• Satb1 Determines Hematopoietic Stem Cell Differentiation Toward the Lymphoid Lineages.
  Blood 2011 Yusuke Satoh, Takafumi Yokota, Motonari Kondo, Paul W. Kincade, Taku Kouro, Ryuji Iida, Koichi Kokame, Toshiyuki Miyata, Takao Sudo, Hirokazu Tanaka, Itaru Matsumura, Kenji Oritani, Terumi Kohwi-…
• Satb1 ablation alters temporal expression of immediate early genes and reduces dendritic spine density during postnatal brain development.
  Molecular and cellular biology 2011 Balamotis MA, Tamberg N, Woo YJ, Li J, Davy B, Kohwi-Shigematsu T, Kohwi Y
• SATB1 (SATB homeobox 1).
  Atlas of Genetics and Cytogenetics in Oncology and Haematology 2011 H Richards, T Kohwi-Shigematsu
• p63 regulates Satb1 to control tissue-specific chromatin remodeling during development of the epidermis.
  The Journal of cell biology 2011 Fessing MY, Mardaryev AN, Gdula MR, Sharov AA, Sharova TY, Rapisarda V, Gordon KB, Smorodchenko AD, Poterlowicz K, Ferone G, Kohwi Y, Missero C, Kohwi-Shigematsu T, Botchkarev VA
• Re: The role of SATB1 in breast cancer pathogenesis.
  Journal of the National Cancer Institute 2010 Kohwi-Shigematsu T, Han HJ, Russo J, Kohwi Y
• Satb1 and Satb2 regulate embryonic stem cell differentiation and Nanog expression.
  Genes & development 2009 Savarese F, Dávila A, Nechanitzky R, De La Rosa-Velazquez I, Pereira CF, Engelke R, Takahashi K, Jenuwein T, Kohwi-Shigematsu T, Fisher AG, Grosschedl R
• SATB1 defines the developmental context for gene silencing by Xist in lymphoma and embryonic cells.
  Developmental cell 2009 Agrelo R, Souabni A, Novatchkova M, Haslinger C, Leeb M, Komnenovic V, Kishimoto H, Gresh L, Kohwi-Shigematsu T, Kenner L, Wutz A
• New advances in breast cancer metastasis.
  Women's health (London, England) 2008 Russo J, Han HJ, Kohwi Y, Kohwi-Shigematsu T
• DLX5 expression is monoallelic and Dlx5 is up-regulated in the Mecp2-null frontal cortex.
  Journal of cellular and molecular medicine 2008 Miyano M, Horike S, Cai S, Oshimura M, Kohwi-Shigematsu T
• SATB1 reprogrammes gene expression to promote breast tumour growth and metastasis.
  Nature 2008 Han HJ, Russo J, Kohwi Y, Kohwi-Shigematsu T
• A Distal Single Nucleotide Polymorphism Disrupts Development-Dependent Long-Range Transcriptional Regulation of the PU.1 Gene through the Chromatin-Remodeling Protein SATB1 in Acute Myeloid Leukemia.
  Blood 2007 Ulrich Steidl, Christian Steidl, Alexander Ebralidze, Bjoern Chapuy, Hye-Jung Han, Britta Will, Frank Rosenbauer, Annegret Becker, Katharina Wagner, Steffen Koschmieder, Susumu Kobayashi, Daniel B. …
• A distal single nucleotide polymorphism alters long-range regulation of the PU.1 gene in acute myeloid leukemia.
  The Journal of clinical investigation 2007 Steidl U, Steidl C, Ebralidze A, Chapuy B, Han HJ, Will B, Rosenbauer F, Becker A, Wagner K, Koschmieder S, Kobayashi S, Costa DB, Schulz T, O'Brien KB, Verhaak RG, Delwel R, Haase D, Trümper L, …
• SATB1 packages densely looped, transcriptionally active chromatin for coordinated expression of cytokine genes.
  Nature genetics 2006 Cai S, Lee CC, Kohwi-Shigematsu T
• A nuclear targeting determinant for SATB1, a genome organizer in the T cell lineage.
  Cell cycle (Georgetown, Tex.) 2005 Nakayama Y, Mian IS, Kohwi-Shigematsu T, Ogawa T
• SATB1 family protein expressed during early erythroid differentiation modifies globin gene expression.
  Blood 2004 Wen J, Huang S, Rogers H, Dickinson LA, Kohwi-Shigematsu T, Noguchi CT
• Loss of silent-chromatin looping and impaired imprinting of DLX5 in Rett syndrome.
  Nature genetics 2004 Horike S, Cai S, Miyano M, Cheng JF, Kohwi-Shigematsu T
• Tissue-specific nuclear architecture and gene expression regulated by SATB1.
  Nature genetics 2003 Cai S, Han HJ, Kohwi-Shigematsu T
• Mapping the initial DNA breaks in apoptotic Jurkat cells using ligation-mediated PCR.
  Cell death and differentiation 2003 Liu QY, Ribecco-Lutkiewicz M, Carson C, Testolin L, Bergeron D, Kohwi-Shigematsu T, Walker PR, Sikorska M
• SATB1 targets chromatin remodelling to regulate genes over long distances.
  Nature 2002 Yasui D, Miyano M, Cai S, Varga-Weisz P, Kohwi-Shigematsu T
• Identification of a candidate regulatory region in the human CD8 gene complex by colocalization of DNase I hypersensitive sites and matrix attachment regions which bind SATB1 and GATA-3.
  Journal of immunology (Baltimore, Md. : 1950) 2002 Kieffer LJ, Greally JM, Landres I, Nag S, Nakajima Y, Kohwi-Shigematsu T, Kavathas PB
• Matrix Attachment Regions.
  Wiley Encyclopedia of Molecular Medicine 2002 Terumi Kohwi-Shigematsu, Yoshinori Kohwi
• The Bloom Syndrome Protein BLM Is Selectively Cleaved during Apoptotic Cell Death.
  TheScientificWorldJournal 2001 Bischof O, Galande S, Kohwi-Shigematsu T, Campisi J, Dejean A
• The matrix attachment region-binding protein SATB1 interacts with multiple elements within the gp91phox promoter and is down-regulated during myeloid differentiation.
  The Journal of biological chemistry 2001 Hawkins SM, Kohwi-Shigematsu T, Skalnik DG
• SATB1 cleavage by caspase 6 disrupts PDZ domain-mediated dimerization, causing detachment from chromatin early in T-cell apoptosis.
  Molecular and cellular biology 2001 Galande S, Dickinson LA, Mian IS, Sikorska M, Kohwi-Shigematsu T
• Selective cleavage of BLM, the bloom syndrome protein, during apoptotic cell death.
  The Journal of biological chemistry 2001 Bischof O, Galande S, Farzaneh F, Kohwi-Shigematsu T, Campisi J
• THE BLOOM SYNDROME PROTEIN BLM IS SELECTIVELY CLEAVED DURING APOPTOTIC CELL DEATH.
  The Scientific World JOURNAL 2001 Oliver Bischof, Sanjeev Galande, Terumi Kohwi-Shigematsu, Judith Campisi, Anne Dejean
• Ku acts in a unique way at the mammalian telomere to prevent end joining.
  Genes & development 2000 Hsu HL, Gilley D, Galande SA, Hande MP, Allen B, Kim SH, Li GC, Campisi J, Kohwi-Shigematsu T, Chen DJ
• The MAR-binding protein SATB1 orchestrates temporal and spatial expression of multiple genes during T-cell development.
  Genes & development 2000 Alvarez JD, Yasui DH, Niida H, Joh T, Loh DY, Kohwi-Shigematsu T
• Modulated binding of SATB1, a matrix attachment region protein, to the AT-rich sequence flanking the major breakpoint region of BCL2.
  Molecular and cellular biology 2000 Ramakrishnan M, Liu WM, DiCroce PA, Posner A, Zheng J, Kohwi-Shigematsu T, Krontiris TG
• Caught in the act: binding of Ku and PARP to MARs reveals novel aspects of their functional interaction.
  Critical reviews in eukaryotic gene expression 2000 Galande S, Kohwi-Shigematsu T
• Linking chromatin architecture to cellular phenotype: BUR-binding proteins in cancer.
  Journal of cellular biochemistry. Supplement 2000 Galande S, Kohwi-Shigematsu T
• HMG-I(Y) recognizes base-unpairing regions of matrix attachment sequences and its increased expression is directly linked to metastatic breast cancer phenotype.
  Cancer research 1999 Liu WM, Guerra-Vladusic FK, Kurakata S, Lupu R, Kohwi-Shigematsu T
• Intranuclear relocalization of matrix binding sites during T cell activation detected by amplified fluorescence in situ hybridization.
  Methods (San Diego, Calif.) 1999 Cai S, Kohwi-Shigematsu T
• Poly(ADP-ribose) polymerase and Ku autoantigen form a complex and synergistically bind to matrix attachment sequences.
  The Journal of biological chemistry 1999 Galande S, Kohwi-Shigematsu T
• The genomic sequences bound to special AT-rich sequence-binding protein 1 (SATB1) in vivo in Jurkat T cells are tightly associated with the nuclear matrix at the bases of the chromatin loops.
  The Journal of cell biology 1998 de Belle I, Cai S, Kohwi-Shigematsu T
• Identification of base-unpairing region-binding proteins and characterization of their in vivo binding sequences.
  Methods in cell biology 1998 Kohwi-Shigematsu T, deBelle I, Dickinson LA, Galande S, Kohwi Y
• Stress-induced duplex DNA destabilization in scaffold/matrix attachment regions.
  Journal of molecular biology 1997 Benham C, Kohwi-Shigematsu T, Bode J
• A thymocyte factor SATB1 suppresses transcription of stably integrated matrix-attachment region-linked reporter genes.
  Biochemistry 1997 Kohwi-Shigematsu T, Maass K, Bode J
• Subnuclear localization of S/MAR-binding proteins is differently affected by in vitro stabilization with heat or Cu2+.
  Chromosoma 1997 Neri LM, Fackelmayer FO, Zweyer M, Kohwi-Shigematsu T, Martelli AM
• An atypical homeodomain in SATB1 promotes specific recognition of the key structural element in a matrix attachment region.
  The Journal of biological chemistry 1997 Dickinson LA, Dickinson CD, Kohwi-Shigematsu T
• Association of nuclear matrix proteins with granular and threaded nuclear bodies in cell lines undergoing apoptosis.
  Experimental cell research 1997 Zweyer M, Riederer BM, Ochs RL, Fackelmayer FO, Kohwi-Shigematsu T, Bareggi R, Narducci P, Martelli AM
• 4 High Unwinding Capability of Matrix Attachment Regions and ATC-Sequence Context-Specific MAR-Binding Proteins.
  Nuclear Structure and Gene Expression 1997 Terumi Kohwi-Shigematsu, Yoshinori Kohwi
• Contrasting effects of the SATB1 core nuclear matrix attachment region and flanking sequences of the keratin 18 gene in transgenic mice.
  Molecular biology of the cell 1996 Neznanov N, Kohwi-Shigematsu T, Oshima RG
• A matrix attachment region (MAR)-binding activity due to a p114 kilodalton protein is found only in human breast carcinomas and not in normal and benign breast disease tissues.
  Cancer research 1996 Yanagisawa J, Ando J, Nakayama J, Kohwi Y, Kohwi-Shigematsu T
• A novel matrix attachment region DNA binding motif identified using a random phage peptide library.
  The Journal of biological chemistry 1995 Wang B, Dickinson LA, Koivunen E, Ruoslahti E, Kohwi-Shigematsu T
• [Biological significance of nuclear matrix attachment regions (MAR) and tissue specific MAR-DNA binding proteins].
  Seikagaku. The Journal of Japanese Biochemical Society 1995 Kohwi Y, Kohwi-Shigematsu T
• Nucleolin is a matrix attachment region DNA-binding protein that specifically recognizes a region with high base-unpairing potential.
  Molecular and cellular biology 1995 Dickinson LA, Kohwi-Shigematsu T
• A Novel DNA-Binding Motif in the Nuclear Matrix Attachment DNA-Binding Protein SATB1.
  Molecular and Cellular Biology 1994 K. Nakagomi, Y. Kohwi, L. A. Dickinson, T. Kohwi-Shigematsu
• A novel DNA-binding motif in the nuclear matrix attachment DNA-binding protein SATB1.
  Molecular and Cellular Biology 1994 K Nakagomi, Y Kohwi, L A Dickinson, T Kohwi-Shigematsu
• A novel DNA-binding motif in the nuclear matrix attachment DNA-binding protein SATB1.
  Molecular and cellular biology 1994 Nakagomi K, Kohwi Y, Dickinson LA, Kohwi-Shigematsu T
• The non-B-DNA structure of d(CA/TG)n differs from that of Z-DNA.
  Proceedings of the National Academy of Sciences of the United States of America 1994 Kladde MP, Kohwi Y, Kohwi-Shigematsu T, Gorski J
• A single trinucleotide, 5'AGC3'/5'GCT3', of the triplet-repeat disease genes confers metal ion-induced non-B DNA structure.
  Nucleic acids research 1993 Kohwi Y, Wang H, Kohwi-Shigematsu T
• Structural polymorphism of homopurine-homopyrimidine sequences at neutral pH.
  Journal of molecular biology 1993 Kohwi Y, Kohwi-Shigematsu T
• A tissue-specific MAR/SAR DNA-binding protein with unusual binding site recognition.
  Cell 1992 Dickinson LA, Joh T, Kohwi Y, Kohwi-Shigematsu T
• Intramolecular dG.dG.dC triplex detected in Escherichia coli cells.
  Journal of molecular biology 1992 Kohwi Y, Malkhosyan SR, Kohwi-Shigematsu T
• Biological significance of unwinding capability of nuclear matrix-associating DNAs.
  Science (New York, N.Y.) 1992 Bode J, Kohwi Y, Dickinson L, Joh T, Klehr D, Mielke C, Kohwi-Shigematsu T
• Detection of non-B-DNA structures at specific sites in supercoiled plasmid DNA and chromatin with haloacetaldehyde and diethyl pyrocarbonate.
  Methods in enzymology 1992 Kohwi-Shigematsu T, Kohwi Y
• Altered gene expression correlates with DNA structure.
  Genes & development 1991 Kohwi Y, Kohwi-Shigematsu T
• Detection of triple-helix related structures adopted by poly(dG)-poly(dC) sequences in supercoiled plasmid DNA.
  Nucleic acids research 1991 Kohwi-Shigematsu T, Kohwi Y
• Torsional stress stabilizes extended base unpairing in suppressor sites flanking immunoglobulin heavy chain enhancer.
  Biochemistry 1990 Kohwi-Shigematsu T, Kohwi Y
• Hierarchical binding of DNA fragments derived from scaffold-attached regions: correlation of properties in vitro and function in vivo.
  Biochemistry 1990 Mielke C, Kohwi Y, Kohwi-Shigematsu T, Bode J
• Magnesium ion-dependent triple-helix structure formed by homopurine-homopyrimidine sequences in supercoiled plasmid DNA.
  Proceedings of the National Academy of Sciences of the United States of America 1988 Kohwi Y, Kohwi-Shigematsu T
• An ultimate chemical carcinogen, N-acetoxy-2-acetylaminofluorene, detects non-B DNA structures that are reactive with chloroacetaldehyde in supercoiled plasmid DNA.
  Carcinogenesis 1988 Kohwi-Shigematsu T, Scribner N, Kohwi Y
• The chemical carcinogen, chloroacetaldehyde, modifies a specific site within the regulatory sequence of human cytomegalovirus major immediate early gene in vivo.
  Molecular carcinogenesis 1988 Kohwi-Shigematsu T, Nelson JA
• Unusual conformational effect exerted by Z-DNA upon its neighboring sequences.
  Proceedings of the National Academy of Sciences of the United States of America 1987 Kohwi-Shigematsu T, Manes T, Kohwi Y
• Poly(dG)-poly(dC) sequences, under torsional stress, induce an altered DNA conformation upon neighboring DNA sequences.
  Cell 1985 Kohwi-Shigematsu T, Kohwi Y
• Human fetal to adult hemoglobin switching: changes in chromatin structure of the beta-globin gene locus.
  Proceedings of the National Academy of Sciences of the United States of America 1983 Groudine M, Kohwi-Shigematsu T, Gelinas R, Stamatoyannopoulos G, Papayannopoulou T
• Detection of an altered DNA conformation at specific sites in chromatin and supercoiled DNA.
  Proceedings of the National Academy of Sciences of the United States of America 1983 Kohwi-Shigematsu T, Gelinas R, Weintraub H
• Hydrogen-exchange study of a nucleosome.
  FEBS letters 1980 Mitane Y, Nakanishi M, Tsuboi M, Kohwi-Shigematsu T, Enomoto T, Yamada MA
• Exposure of DNA bases induced by the interaction of DNA and calf thymus DNA helix-destabilizing protein.
  Proceedings of the National Academy of Sciences of the United States of America 1978 Kohwi-Shigematsu T, Enomoto T, Yamada MA, Nakanishi M, Tsuboi M