Teresa Sparks, MD, MAS
Associate Professor
Ob/Gyn, Reproductive Sciences
School of Medicine

These reasons may include fetal birth defects, fetal genetic diseases, maternal genetic or non-genetic diseases, and many others. I am also Program Director for the Maternal-Fetal Medicine Fellowship at UCSF, and serve as Medical Director for the Prenatal Diagnosis Center at UCSF Benioff Children's Physicians (UBCP). In my role as a physician scientist, I am a Chan Zuckerberg Biohub Investigator as well as an Investigator for the UCSF Center for Maternal-Fetal Precision Medicine, Co-Director of the Women's Reproductive Health Research (WRHR)/K12 Program at UCSF, and serve as the alternate PI for the Maternal-Fetal Medicine Units (MFMU) Network award at UCSF. My research program is focused on developing a precision-based approach to care for non-immune hydrops fetalis (NIHF) and other fetal anomalies by establishing multicenter NIHF data over many years, performing genomic sequencing and other testing to discover the breadth of underlying causes, refining clinical testing algorithms, and developing novel in utero treatment approaches.

• Trust in prenatal exome sequencing for expectant families facing unexplained fetal anomalies.
  Prenatal diagnosis 2023 Rothschild HT, Lianoglou BR, Sahin Hodoglugil NN, Tick K, Brown JEH, Sparks TN
• Monogenic conditions and central nervous system anomalies: A prospective study, systematic review and meta-analysis.
  Prenatal diagnosis 2023 Blayney GV, Laffan E, Jacob PA, Baptiste CD, Gabriel H, Sparks TN, Yaron Y, Norton ME, Diderich K, Wang Y, Chong K, Chitayat D, Saini N, Aggarwal S, Pauta M, Borrell A, Gilmore K, Chandler NJ, Allen S…
• The Medical Action Ontology: A tool for annotating and analyzing treatments and clinical management of human disease.
  Med (New York, N.Y.) 2023 Carmody LC, Gargano MA, Toro S, Vasilevsky NA, Adam MP, Blau H, Chan LE, Gomez-Andres D, Horvath R, Kraus ML, Ladewig MS, Lewis-Smith D, Lochmüller H, Matentzoglu NA, Munoz-Torres MC, Schuetz C, Seitz…
• Author Correction: Diagnostic yield of pediatric and prenatal exome sequencing in a diverse population.
  NPJ genomic medicine 2023 Slavotinek A, Rego S, Sahin-Hodoglugil N, Kvale M, Lianoglou B, Yip T, Hoban H, Outram S, Anguiano B, Chen F, Michelson J, Cilio RM, Curry C, Gallagher RC, Gardner M, Kuperman R, Mendelsohn B, Sherr E…
• Optimal timing of delivery for growth restricted fetuses with gastroschisis: A decision analysis.
  Prenatal diagnosis 2023 Packer CH, Pilliod RA, Caughey AB, Sparks TN
• Access to prenatal exome sequencing for fetal malformations: A qualitative landscape analysis in the US.
  Prenatal diagnosis 2023 Sahin-Hodoglugil NN, Lianoglou BR, Ackerman S, Sparks TN, Norton ME
• The utility of gene sequencing in identifying an underlying genetic disorder in prenatally suspected lower urinary tract obstruction.
  Prenatal diagnosis 2023 Brar BK, Blakemore K, Hertenstein C, Miller JL, Miller KA, Shamseldin H, Maddirevula S, Hays T, Lianoglou B, Dukhovny S, Baker LA, Sparks TN, Wapner R, Alkuraya FS, Norton ME, Jelin AC, Fetal …
• The Medical Action Ontology: A Tool for Annotating and Analyzing Treatments and Clinical Management of Human Disease.
  medRxiv : the preprint server for health sciences 2023 Carmody LC, Gargano MA, Toro S, Vasilevsky NA, Adam MP, Blau H, Chan LE, Gomez-Andres D, Horvath R, Kraus ML, Ladewig MS, Lewis-Smith D, Lochmüller H, Matentzoglu NA, Munoz-Torres MC, Schuetz C, Seitz…
• Diagnostic yield of pediatric and prenatal exome sequencing in a diverse population.
  NPJ genomic medicine 2023 Slavotinek A, Rego S, Sahin-Hodoglugil N, Kvale M, Lianoglou B, Yip T, Hoban H, Outram S, Anguiano B, Chen F, Michelson J, Cilio RM, Curry C, Gallagher RC, Gardner M, Kuperman R, Mendelsohn B, Sherr E…
• A systematic review and meta-analysis of cell-free DNA testing for detection of fetal sex chromosome aneuploidy.
  Prenatal diagnosis 2023 Shear MA, Swanson K, Garg R, Jelin AC, Boscardin J, Norton ME, Sparks TN
• Prenatal phenotyping of fetal tubulinopathies: A multicenter retrospective case series.
  Prenatal diagnosis 2022 Brar BK, Thompson MG, Vora NL, Gilmore K, Blakemore K, Miller KA, Giordano J, Dufke A, Wong B, Stover S, Lianoglou B, Van den Veyver I, Dempsey E, Rosner M, Chong K, Chitayat D, Sparks TN, Norton ME, …
• Obstetrical and neonatal outcomes of cardio-facio-cutaneous syndrome: Prenatal consequences of Ras/MAPK dysregulation.
  American journal of medical genetics. Part A 2022 Jelin AC, Mahle A, Tran SH, Sparks TN, Rauen KA
• Prenatal Somatic Cell Gene Therapies: Charting a Path Toward Clinical Applications (Proceedings of the CERSI-FDA Meeting).
  Journal of clinical pharmacology 2022 Herzeg A, Almeida-Porada G, Charo RA, David AL, Gonzalez-Velez J, Gupta N, Lapteva L, Lianoglou B, Peranteau W, Porada C, Sanders SJ, Sparks TN, Stitelman DH, Struble E, Sumner CJ, MacKenzie TC
• Prenatal phenotyping: A community effort to enhance the Human Phenotype Ontology.
  American journal of medical genetics. Part C, Seminars in medical genetics 2022 Dhombres F, Morgan P, Chaudhari BP, Filges I, Sparks TN, Lapunzina P, Roscioli T, Agarwal U, Aggarwal S, Beneteau C, Cacheiro P, Carmody LC, Collardeau-Frachon S, Dempsey EA, Dufke A, Duyzend MH, El …
• The utility of pathologic examination and comprehensive phenotyping for accurate diagnosis with perinatal exome sequencing.
  Prenatal diagnosis 2022 Swanson K, Norton ME, Lianoglou BR, Jelin AC, Hodoglugil U, Van Ziffle J, Devine P, Sparks TN
• "Let's Just Wait Until She's Born": Temporal Factors That Shape Decision-Making for Prenatal Genomic Sequencing Amongst Families Underrepresented in Genomic Research.
  Frontiers in genetics 2022 Brown JEH, Zamora AN, Outram S, Sparks TN, Lianoglou BR, Norstad M, Sahin Hodoglugil NN, Norton ME, Ackerman SL
• Perspectives and preferences regarding genomic secondary findings in underrepresented prenatal and pediatric populations: A mixed-methods approach.
  Genetics in medicine : official journal of the American College of Medical Genetics 2022 Rego S, Hoban H, Outram S, Zamora AN, Chen F, Sahin-Hodoglugil N, Anguiano B, Norstad M, Yip T, Lianoglou B, Sparks TN, Norton ME, Koenig BA, Slavotinek AM, Ackerman SL
• Disparities in the acceptance of chromosomal microarray at the time of prenatal genetic diagnosis.
  Prenatal diagnosis 2022 Swanson K, Loeliger KB, Chetty SP, Sparks TN, Norton ME
• Prenatal presentation of multiple anomalies associated with haploinsufficiency for ARID1A.
  European journal of medical genetics 2021 Slavotinek A, Lefebvre M, Brehin AC, Thauvin C, Patrier S, Sparks TN, Norton M, Yu J, Huang E
• Prenatal phenotype of 47, XXY (Klinefelter syndrome).
  Prenatal diagnosis 2021 Swanson K, Bishop JC, Al-Kouatly HB, Makhamreh M, Felton T, Vora NL, Sparks TN, Jelin AC
• The Current State and Future of Fetal Therapies.
  Clinical obstetrics and gynecology 2021 Sparks TN
• Response to "Further genetic testing in prenatal cases of nonimmune hydrops fetalis with a normal array: a targeted panel or exome?"
  American journal of obstetrics and gynecology 2021 Norton ME, Sparks TN
• Correction to: Screening for autosomal recessive and X-linked conditions during pregnancy and preconception: a practice resource of the American College of Medical Genetics and Genomics (ACMG).
  Genetics in medicine : official journal of the American College of Medical Genetics 2021 Gregg AR, Aarabi M, Klugman S, Leach NT, Bashford MT, Goldwaser T, Chen E, Sparks TN, Reddi HV, Rajkovic A, Dungan JS, ACMG Professional Practice and Guidelines Committee
• Hypospadias.
  American journal of obstetrics and gynecology 2021 Society for Maternal-Fetal Medicine (SMFM), Sparks TN
• SMFM Fetal Anomalies Consult Series #4: Genitourinary anomalies.
  American journal of obstetrics and gynecology 2021 Society for Maternal-Fetal Medicine (SMFM). Electronic address: pubs@smfm.org, Norton ME, Cheng Y, Chetty S, Chyu JK, Connolly K, Ghaffari N, Hopkins LM, Jelin A, Mardy A, Osmundson SS, Sparks TN, …
• Twin chorionicity and zygosity both vary with maternal age.
  Prenatal diagnosis 2021 Yeaton-Massey A, Sparks TN, Norton ME, Jelliffe-Pawlowski L, Currier RJ
• Preference for secondary findings in prenatal and pediatric exome sequencing.
  Prenatal diagnosis 2021 Swanson K, Sparks TN, Lianoglou BR, Chen F, Downum S, Patel S, Rego S, Yip T, Van Ziffle J, Koenig BA, Slavotinek AM, Norton ME
• Interval growth across gestation in pregnancies with fetal gastroschisis.
  American journal of obstetrics & gynecology MFM 2021 Zhang-Rutledge K, Jacobs M, Patberg E, Field N, Holliman K, Strobel KM, Murphy A, Robles D, Rangwala N, Gonzalez JM, Sparks TN, University of California Fetal-Maternal Consortium
• Outcomes of Monochorionic, Diamniotic Twin Pregnancies with Prenatally Diagnosed Intertwin Weight Discordance.
  American journal of perinatology 2020 Sobhani NC, Sparks TN, Gosnell KA, Rand L, Gonzalez JM, Feldstein VA
• Variants of uncertain significance in prenatal microarrays: a retrospective cohort study.
  BJOG : an international journal of obstetrics and gynaecology 2020 Mardy AH, Wiita AP, Wayman BV, Drexler K, Sparks TN, Norton ME
• The utility of exome sequencing for fetal pleural effusions.
  Prenatal diagnosis 2020 Jelin AC, Sobreira N, Wohler E, Solomon B, Sparks T, Sagaser KG, Forster KR, Miller J, Witmer PD, Hamosh A, Valle D, Blakemore K
• Utility of chromosomal microarray for diagnosis in cases of nonimmune hydrops fetalis.
  Prenatal diagnosis 2020 Mardy AH, Rangwala N, Hernandez-Cruz Y, Gosnell KA, Gonzalez JM, Norton ME, Sparks TN
• Anthropogenic control over wintertime oxidation of atmospheric pollutants.
  Geophysical research letters 2019 Haskins JD, Lopez-Hilfiker FD, Lee BH, Shah V, Wolfe GM, DiGangi J, Fibiger D, McDuffie EE, Veres P, Schroder JC, Campuzano-Jost P, Day DA, Jimenez JL, Weinheimer A, Sparks T, Cohen RC, Campos T, …
• The utility of nuchal translucency ultrasound in identifying rare chromosomal abnormalities not detectable by cell-free DNA screening.
  Prenatal diagnosis 2019 Berger VK, Norton ME, Sparks TN, Flessel M, Baer RJ, Currier RJ
• Expanded carrier screening: counseling and considerations.
  Human genetics 2019 Sparks TN
• Cell-free fetal DNA screening for detection of microdeletion syndromes: a cost-effectiveness analysis.
  The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians 2019 Avram CM, Shaffer BL, Sparks TN, Allen AJ, Caughey AB
• A system-based approach to the genetic etiologies of non-immune hydrops fetalis.
  Prenatal diagnosis 2019 Mardy AH, Chetty SP, Norton ME, Sparks TN
• Nonimmune hydrops fetalis: identifying the underlying genetic etiology.
  Genetics in medicine : official journal of the American College of Medical Genetics 2018 Sparks TN, Thao K, Lianoglou BR, Boe NM, Bruce KG, Datkhaeva I, Field NT, Fratto VM, Jolley J, Laurent LC, Mardy AH, Murphy AM, Ngan E, Rangwala N, Rottkamp CAM, Wilson L, Wu E, Uy CC, Valdez Lopez P,…
• Fetal Congenital Pulmonary Airway Malformation: The Role of an Objective Measurement of Cardiomediastinal Shift.
  American journal of perinatology 2018 Shulman R, Sparks TN, Gosnell K, Blat C, Norton ME, Lee H, Gonzalez-Velez J, Goldstein RB
• How should costs and cost-effectiveness be considered in prenatal genetic testing?
  Seminars in perinatology 2018 Sparks TN, Caughey AB
• Stage I Twin-Twin Transfusion Syndrome: Outcomes of Expectant Management and Prognostic Features.
  American journal of perinatology 2018 Washburn EE, Sparks TN, Gosnell KA, Rand L, Gonzalez JM, Feldstein VA
• Prenatal Diagnosis of Congenital Diaphragmatic Hernia: Does Laterality Predict Perinatal Outcomes?
  American journal of perinatology 2018 Sperling JD, Sparks TN, Berger VK, Farrell JA, Gosnell K, Keller RL, Norton ME, Gonzalez JM
• Utility of chromosomal microarray in anomalous fetuses.
  Prenatal diagnosis 2018 Parchem JG, Sparks TN, Gosnell K, Norton ME
• Polyhydramnios Affecting a Recipient-like Twin: Risk of Progression to Twin-Twin Transfusion Syndrome and Outcomes.
  American journal of perinatology 2017 Washburn EE, Sparks TN, Gosnell KA, Rand L, Gonzalez JM, Feldstein VA
• Non-Immune Hydrops Fetalis: Do Placentomegaly and Polyhydramnios Matter?
  Journal of ultrasound in medicine : official journal of the American Institute of Ultrasound in Medicine 2017 Berger VK, Sparks TN, Jelin AC, Derderian C, Jeanty C, Gosnell K, Mackenzie T, Gonzalez JM
• The growth-restricted fetus: risk of mortality by each additional week of expectant management.
  The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians 2017 Pilliod RA, Page JM, Sparks TN, Caughey AB
• Potential Role of Genomic Sequencing in the Early Diagnosis of Treatable Genetic Conditions.
  The Journal of pediatrics 2017 Zahed H, Sparks TN, Li B, Alsadah A, Shieh JTC
• Mosaic trisomy 16: what are the obstetric and long-term childhood outcomes?
  Genetics in medicine : official journal of the American College of Medical Genetics 2017 Sparks TN, Thao K, Norton ME
• Observed Rate of Down Syndrome in Twin Pregnancies.
  Obstetrics and gynecology 2016 Sparks TN, Norton ME, Flessel M, Goldman S, Currier RJ
• Gastroschisis: mortality risks with each additional week of expectant management.
  American journal of obstetrics and gynecology 2016 Sparks TN, Shaffer BL, Page J, Caughey AB
• Maternal arrhythmia and perinatal outcomes.
  Journal of perinatology : official journal of the California Perinatal Association 2016 Henry D, Gonzalez JM, Harris IS, Sparks TN, Killion M, Thiet MP, Bianco K
• Hypertension in dichorionic twin gestations: how is birthweight affected?
  The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians 2016 Sparks TN, Nakagawa S, Gonzalez JM
• Down syndrome: perinatal mortality risks with each additional week of expectant management.
  Prenatal diagnosis 2016 Sparks TN, Griffin E, Page J, Pilliod R, Shaffer BL, Caughey AB
• How do maternal views of delivery outcomes vary by demographics and preferred mode of delivery?
  American journal of perinatology 2014 Sparks TN, Yeaton-Massey A, Granados JM, Handler SJ, Meyer M, Caughey AB
• Preference toward future mode of delivery: how do antepartum preferences and prior delivery experience contribute?
  The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians 2014 Sparks TN, Yeaton-Massey A, Granados JM, Handler SJ, Meyer MR, Caughey AB
• Predictors of cesarean delivery in women undergoing labor induction with a Foley balloon.
  The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians 2014 Delaney S, Shaffer BL, Cheng YW, Vargas J, Sparks TN, Paul K, Caughey AB
• Racial/ethnic variations in perineal length and association with perineal lacerations: a prospective cohort study.
  The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians 2014 Yeaton-Massey A, Wong L, Sparks TN, Handler SJ, Meyer MR, Granados JM, Stasenko M, Sit A, Caughey AB
• The cost-effectiveness of repeat HIV testing during pregnancy in a resource-limited setting.
  Journal of acquired immune deficiency syndromes (1999) 2013 Kim LH, Cohan DL, Sparks TN, Pilliod RA, Arinaitwe E, Caughey AB
• Does risk of preeclampsia differ by twin chorionicity?
  The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians 2013 Sparks TN, Cheng YW, Phan N, Caughey AB
• Impending macrosomia: will induction of labour modify the risk of caesarean delivery?
  BJOG : an international journal of obstetrics and gynaecology 2012 Cheng YW, Sparks TN, Laros RK, Nicholson JM, Caughey AB
• Treating mild gestational diabetes mellitus: a cost-effectiveness analysis.
  American journal of obstetrics and gynecology 2011 Ohno MS, Sparks TN, Cheng YW, Caughey AB
• Patient counseling increases postpartum follow-up in women with gestational diabetes mellitus.
  American journal of obstetrics and gynecology 2011 Stasenko M, Liddell J, Cheng YW, Sparks TN, Killion M, Caughey AB
• The effect of cesarean delivery rates on the future incidence of placenta previa, placenta accreta, and maternal mortality.
  The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians 2011 Solheim KN, Esakoff TF, Little SE, Cheng YW, Sparks TN, Caughey AB
• Diagnosis and morbidity of placenta accreta.
  Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology 2011 Esakoff TF, Sparks TN, Kaimal AJ, Kim LH, Feldstein VA, Goldstein RB, Cheng YW, Caughey AB
• Fundal height: a useful screening tool for fetal growth?
  The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians 2010 Sparks TN, Cheng YW, McLaughlin B, Esakoff TF, Caughey AB
• Labor induction with a Foley balloon inflated to 30 mL compared with 60 mL: a randomized controlled trial.
  Obstetrics and gynecology 2010 Delaney S, Shaffer BL, Cheng YW, Vargas J, Sparks TN, Paul K, Caughey AB
• The association between birthweight 4000 g or greater and perinatal outcomes in patients with and without gestational diabetes mellitus.
  American journal of obstetrics and gynecology 2009 Esakoff TF, Cheng YW, Sparks TN, Caughey AB