Tatsuya Tsukui, PhD
Assistant Professor
Medicine
School of Medicine
Awards
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- Jo Rae Wright Early Career Investigator Award, American Thoracic Society, 2020
- Scholarship Award, Keystone Symposia: Fibrosis and Tissue Repair, 2020
- Tadamitsu Kishimoto International Travel Award, Japanese Society for Immunology, 2015
- International Travel Award, The Japanese Society of Inflammation and Regeneration, 2015
Education & Training
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- Postdoc Medicine UCSF 2021
- PhD Medicine The University of Tokyo 2016
- MSc Medicine The University of Tokyo 2012
- BA Pharmaceutical Sciences The University of Tokyo 2010
Websites
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- Twitter (twitter.com)
- Google Scholar (scholar.google.com)
Grants and Projects
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- Cellular and molecular delineation of pathologic fibroblasts in pulmonary fibrosis, NIH, 2023-2026
- Cellular and molecular delineation of pathologic fibroblasts in pulmonary fibrosis, NIH, 2021-2023
- , California Foundation for Molecular Biology, 2019-2020
- , Japan Society for the Promotion of Science, 2017-2019
- , Uehara Memorial Foundation, 2016-2017
- , Mochida Memorial Foundation for Medical and Pharmaceutical Research, 2017
- , Japan Society for the Promotion of Science, 2013-2016
Publications (24)
Top publication keywords:
Embryo ImplantationFibroblastsCicatrixPulmonary FibrosisIdiopathic Pulmonary FibrosisCollagenMyofibroblastsZinc Finger Protein GLI1Green Fluorescent ProteinsLungMice, Inbred C57BLPulmonary AlveoliConnexin 43BleomycinUp-Regulation
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An in vivo screening platform identifies senolytic compounds that target p16INK4a+ fibroblasts in lung fibrosis.
The Journal of clinical investigation 2024 Lee JY, Reyes NS, Ravishankar S, Zhou M, Krasilnikov M, Ringler C, Pohan G, Wilson C, Ang KK, Wolters PJ, Tsukui T, Sheppard D, Arkin MR, Peng T -
Impaired Myofibroblast Proliferation is a Central Feature of Pathologic Post-Natal Alveolar Simplification.
bioRxiv : the preprint server for biology 2023 Khan IS, Molina C, Ren X, Auyeung VC, Cohen M, Tsukui T, Atakilit A, Sheppard D -
An immune-based tool platform for in vivo cell clearance.
Life science alliance 2023 Zhang J, Tsukui T, Wu X, Brito A, Trumble JM, Caraballo JC, Allen GM, Zavala-Solorio J, Zhang C, Paw J, Lim WA, Geng J, Kutskova Y, Freund A, Kolumam G, Sheppard D, Cohen RL -
Unique Glycoform-Dependent Monoclonal Antibodies for Mouse Mucin 21.
International journal of molecular sciences 2022 Nishida J, Shichino S, Tsukui T, Hoshino M, Okada T, Okada K, Yi Y, Toraya-Brown S, Mochizuki M, Koizumi R, Ishii-Schrade K, Denda-Nagai K, Irimura T -
Macrophage Cx43 Is Necessary for Fibroblast Cytosolic Calcium and Lung Fibrosis After Injury.
Frontiers in immunology 2022 Bhattacharyya A, Torre P, Yadav P, Boostanpour K, Chen TY, Tsukui T, Sheppard D, Muramatsu R, Seed RI, Nishimura SL, Jung JB, Tang XZ, Allen CDC, Bhattacharya M
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Mucin 21 confers resistance to apoptosis in an O-glycosylation-dependent manner.
Cell death discovery 2022 Tian Y, Denda-Nagai K, Tsukui T, Ishii-Schrade KB, Okada K, Nishizono Y, Matsuzaki K, Hafley M, Bresalier RS, Irimura T -
Gene silencing by EZH2 suppresses TGF-β activity within the decidua to avert pregnancy-adverse wound healing at the maternal-fetal interface.
Cell reports 2022 Osokine I, Siewiera J, Rideaux D, Ma S, Tsukui T, Erlebacher A -
Integrin αvβ8 on T cells suppresses anti-tumor immunity in multiple models and is a promising target for tumor immunotherapy.
Cell reports 2021 Dodagatta-Marri E, Ma HY, Liang B, Li J, Meyer DS, Chen SY, Sun KH, Ren X, Zivak B, Rosenblum MD, Headley MB, Pinzas L, Reed NI, Del Cid JS, Hann BC, Yang S, Giddabasappa A, Noorbehesht K, Yang B, Dal… -
Gli1+ mesenchymal stromal cells form a pathological niche to promote airway progenitor metaplasia in the fibrotic lung.
Nature cell biology 2020 Cassandras M, Wang C, Kathiriya J, Tsukui T, Matatia P, Matthay M, Wolters P, Molofsky A, Sheppard D, Chapman H, Peng T -
Collagen-producing lung cell atlas identifies multiple subsets with distinct localization and relevance to fibrosis.
Nature communications 2020 Tsukui T, Sun KH, Wetter JB, Wilson-Kanamori JR, Hazelwood LA, Henderson NC, Adams TS, Schupp JC, Poli SD, Rosas IO, Kaminski N, Matthay MA, Wolters PJ, Sheppard D -
Broadly conserved roles of TMEM131 family proteins in intracellular collagen assembly and secretory cargo trafficking.
Science advances 2020 Zhang Z, Bai M, Barbosa GO, Chen A, Wei Y, Luo S, Wang X, Wang B, Tsukui T, Li H, Sheppard D, Kornberg TB, Ma DK -
CXCR6 regulates localization of tissue-resident memory CD8 T cells to the airways.
The Journal of experimental medicine 2019 Wein AN, McMaster SR, Takamura S, Dunbar PR, Cartwright EK, Hayward SL, McManus DT, Shimaoka T, Ueha S, Tsukui T, Masumoto T, Kurachi M, Matsushima K, Kohlmeier JE -
Gli signaling pathway modulates fibroblast activation and facilitates scar formation in pulmonary fibrosis.
Biochemical and biophysical research communications 2019 Tsukui T, Ueha S, Shichino S, Hashimoto S, Nakajima T, Shiraishi K, Kihara M, Kiyonari H, Inagaki Y, Matsushima K -
Engraftment and proliferation potential of embryonic lung tissue cells in irradiated mice with emphysema.
Scientific reports 2019 Shiraishi K, Shichino S, Tsukui T, Hashimoto S, Ueha S, Matsushima K -
Transcriptome network analysis identifies protective role of the LXR/SREBP-1c axis in murine pulmonary fibrosis.
JCI insight 2019 Shichino S, Ueha S, Hashimoto S, Otsuji M, Abe J, Tsukui T, Deshimaru S, Nakajima T, Kosugi-Kanaya M, Shand FH, Inagaki Y, Shimano H, Matsushima K -
Lung fibroblasts express a miR-19a-19b-20a sub-cluster to suppress TGF-β-associated fibroblast activation in murine pulmonary fibrosis.
Scientific reports 2018 Souma K, Shichino S, Hashimoto S, Ueha S, Tsukui T, Nakajima T, Suzuki HI, Shand FHW, Inagaki Y, Nagase T, Matsushima K -
Fra-2 negatively regulates postnatal alveolar septation by modulating myofibroblast function.
American journal of physiology. Lung cellular and molecular physiology 2017 Tsujino K, Li JT, Tsukui T, Ren X, Bakiri L, Wagner E, Sheppard D -
Heat Shock Protein 27 Plays a Pivotal Role in Myofibroblast Differentiation and in the Development of Bleomycin-Induced Pulmonary Fibrosis.
PloS one 2016 Park AM, Kanai K, Itoh T, Sato T, Tsukui T, Inagaki Y, Selman M, Matsushima K, Yoshie O -
Intratracheal cell transfer demonstrates the profibrotic potential of resident fibroblasts in pulmonary fibrosis.
The American journal of pathology 2015 Tsukui T, Ueha S, Shichino S, Inagaki Y, Matsushima K -
Reduced supply of monocyte-derived macrophages leads to a transition from nodular to diffuse lesions and tissue cell activation in silica-induced pulmonary fibrosis in mice.
The American journal of pathology 2015 Shichino S, Abe J, Ueha S, Otsuji M, Tsukui T, Kosugi-Kanaya M, Shand FH, Hashimoto S, Suzuki HI, Morikawa T, Inagaki Y, Matsushima K -
Tracking of intertissue migration reveals the origins of tumor-infiltrating monocytes.
Proceedings of the National Academy of Sciences of the United States of America 2014 Shand FH, Ueha S, Otsuji M, Koid SS, Shichino S, Tsukui T, Kosugi-Kanaya M, Abe J, Tomura M, Ziogas J, Matsushima K -
Qualitative rather than quantitative changes are hallmarks of fibroblasts in bleomycin-induced pulmonary fibrosis.
The American journal of pathology 2013 Tsukui T, Ueha S, Abe J, Hashimoto S, Shichino S, Shimaoka T, Shand FH, Arakawa Y, Oshima K, Hattori M, Inagaki Y, Tomura M, Matsushima K -
Mucin 21 in esophageal squamous epithelia and carcinomas: analysis with glycoform-specific monoclonal antibodies.
Glycobiology 2012 Tian Y, Denda-Nagai K, Kamata-Sakurai M, Nakamori S, Tsukui T, Itoh Y, Okada K, Yi Y, Irimura T -
Chemokine receptor CXCR3 facilitates CD8(+) T cell differentiation into short-lived effector cells leading to memory degeneration.
The Journal of experimental medicine 2011 Kurachi M, Kurachi J, Suenaga F, Tsukui T, Abe J, Ueha S, Tomura M, Sugihara K, Takamura S, Kakimi K, Matsushima K