Tara Sigdel, PhD
Associate Professor
Surgery
School of Medicine

My research is driven by two major factors. First, there is an unprecedented pressure to deliver new and improved diagnostic and treatment options to patients. Second, due to improved understanding of biological intricacies with ever improving molecular assays have placed us in a much better position to look for disease specific biomarkers that once validated can be used in the clinics in order to provide timely and accurate assessment of health status of patients.

Awards

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• Pediatric Research Fund – CHRP Award, Stanford University, Stanford, CA, 2009-2010
• Pediatric Research Fund – CHRP Award, Stanford University, Stanford, CA, 2008-2009
• Deans Postdoctoral Fellowship, Stanford University, Stanford, CA, 2007-2008
• Doctoral-Undergraduate Opportunities in Scholarship (DUOS) award for two consecutive years (2003 and, Miami University, Oxford, OH, 2003-2005
• William Hale Charch Graduate Fellowship, Miami University, Oxford, OH, 2002-2003

Interests

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• New Onset of Diabetes after Transplantation (NODAT)
• Liver Cancer
• ELISA
• Proteomics
• QPCR
• Immunology
• Biomarker validation
• SNP analysis
• Digital PCR
• Diabetes
• Biomarker Discovery
• Cell-Free DNA
• Biomarker
• Transcriptomics
• Kidney Transplant Rejection
• Sequencing
• Genomics
• Bioinformatics
• Peptidomics
• Protein Arrays
• Non-HLA Antibody Profiling
• Pancreatic and Islet Transplantation
• BKV nephritis
• Solid Organ Transplantation
• Liver Transplantation
• Microarrays
• Kidney Disease

Websites

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• The Sarwal Lab (sarwallab.surgery.ucsf.edu)

Publications (98)

Top publication keywords:
Electrophoresis, Gel, Two-DimensionalBiomarkersAntibodiesSerpinsAllograftsOrgan TransplantationWest Nile virusTransplantation, HomologousProteomeProteomicsChromatography, AgaroseKidney TransplantationProtein Array AnalysisKidneyGraft Rejection

• Proteome Analysis for Inflammation Related to Acute and Convalescent Infection.
  Inflammation 2023 Sigdel TK, Sur S, Boada P, McDermott SM, Arlehamn CSL, Murray KO, Bockenstedt LK, Kerwin M, Reed EF, Harris E, Stuart K, Peters B, Sesma A, Montgomery RR, Sarwal MM
• Transcriptional and spatial profiling of the kidney allograft unravels a central role for FcyRIII+ innate immune cells in rejection.
  Nature communications 2023 Lamarthée B, Callemeyn J, Van Herck Y, Antoranz A, Anglicheau D, Boada P, Becker JU, Debyser T, De Smet F, De Vusser K, Eloudzeri M, Franken A, Gwinner W, Koshy P, Kuypers D, Lambrechts D, Marquet P, …
• Plasma proteome perturbation for CMV DNAemia in kidney transplantation.
  PloS one 2023 Sigdel TK, Boada P, Kerwin M, Rashmi P, Gjertson D, Rossetti M, Sur S, Munar D, Cimino J, Ahn R, Pickering H, Sen S, Parmar R, Fatou B, Steen H, Schaenman J, Bunnapradist S, Reed EF, Sarwal MM, CMV …
• Perturbations in podocyte transcriptome and biological pathways induced by FSGS associated circulating factors.
  Annals of translational medicine 2023 Rashmi P, Sigdel TK, Rychkov D, Damm I, Da Silva AA, Vincenti F, Lourenco AL, Craik CS, Reiser J, Sarwal MM
• Longitudinal serum proteomics analyses identify unique and overlapping host response pathways in Lyme disease and West Nile virus infection.
  Frontiers in immunology 2022 Boada P, Fatou B, Belperron AA, Sigdel TK, Smolen KK, Wurie Z, Levy O, Ronca SE, Murray KO, Liberto JM, Rashmi P, Kerwin M, Montgomery RR, Bockenstedt LK, Steen H, Sarwal MM

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• Perturbations of the T-cell immune repertoire in kidney transplant rejection.
  Frontiers in immunology 2022 Sigdel TK, Fields PA, Liberto J, Damm I, Kerwin M, Hood J, Towfighi P, Sirota M, Robins HS, Sarwal MM
• A reference tissue atlas for the human kidney.
  Science advances 2022 Hansen J, Sealfon R, Menon R, Eadon MT, Lake BB, Steck B, Anjani K, Parikh S, Sigdel TK, Zhang G, Velickovic D, Barwinska D, Alexandrov T, Dobi D, Rashmi P, Otto EA, Rivera M, Rose MP, Anderton CR, …
• Mass cytometry reveals single-cell kinetics of cytotoxic lymphocyte evolution in CMV-infected renal transplant patients.
  Proceedings of the National Academy of Sciences of the United States of America 2022 Ishiyama K, Arakawa-Hoyt J, Aguilar OA, Damm I, Towfighi P, Sigdel T, Tamaki S, Babdor J, Spitzer MH, Reed EF, Sarwal MM, Lanier LL, CMV Systems Immunobiology Group
• Multiplexed droplet single-cell sequencing (Mux-Seq) of normal and transplant kidney.
  American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 2021 Rashmi P, Sur S, Sigdel TK, Boada P, Schroeder AW, Damm I, Kretzler M, Hodgin J, Hartoularos G, Jimmie Ye C, Sarwal MM, Kidney Precision Medicine Project
• FcER1: A Novel Molecule Implicated in the Progression of Human Diabetic Kidney Disease.
  Frontiers in immunology 2021 Sur S, Nguyen M, Boada P, Sigdel TK, Sollinger H, Sarwal MM
• A Comprehensive Urine Proteome Database Generated From Patients With Various Renal Conditions and Prostate Cancer.
  Frontiers in medicine 2021 Swensen AC, He J, Fang AC, Ye Y, Nicora CD, Shi T, Liu AY, Sigdel TK, Sarwal MM, Qian WJ
• Use of the Tissue Common Rejection Module Score in Kidney Transplant as an Objective Measure of Allograft Inflammation.
  Frontiers in immunology 2021 Zarinsefat A, Guerra JMA, Sigdel T, Damm I, Sarwal R, Chan-On C, Szabo G, Aguilar-Frasco JL, Ixtlapale-Carmona X, Salinas-Ramos C, Ramirez-Martinez L, Ramirez C, Vilatoba M, Morales Buenrostro LE, …
• Corrigendum: Near-Single-Cell Proteomics Profiling of the Proximal Tubular and Glomerulus of the Normal Human Kidney.
  Frontiers in medicine 2021 Sigdel TK, Piehowski PD, Roy S, Liberto J, Hansen JR, Swensen AC, Zhao R, Zhu Y, Rashmi P, Schroeder A, Damm I, Sur S, Luo J, Yang Y, Qian WJ, Sarwal MM
• A multimodal and integrated approach to interrogate human kidney biopsies with rigor and reproducibility: guidelines from the Kidney Precision Medicine Project.
  Physiological genomics 2020 El-Achkar TM, Eadon MT, Menon R, Lake BB, Sigdel TK, Alexandrov T, Parikh S, Zhang G, Dobi D, Dunn KW, Otto EA, Anderton CR, Carson JM, Luo J, Park C, Hamidi H, Zhou J, Hoover P, Schroeder A, Joanes M…
• Near-Single-Cell Proteomics Profiling of the Proximal Tubular and Glomerulus of the Normal Human Kidney.
  Frontiers in medicine 2020 Sigdel TK, Piehowski PD, Roy S, Liberto J, Hansen JR, Swensen AC, Zhao R, Zhu Y, Rashmi P, Schroeder A, Damm I, Sur S, Luo J, Yang Y, Qian WJ, Sarwal MM, Kidney Precision Medicine Project (KPMP) …
• Peripheral Blood RNA Sequencing Unravels a Differential Signature of Coding and Noncoding Genes by Types of Kidney Allograft Rejection.
  Kidney international reports 2020 Pineda S, Sur S, Sigdel T, Nguyen M, Crespo E, Torija A, Meneghini M, Gomà M, Sirota M, Bestard O, Sarwal MM
• Targeted Urine Metabolomics for Monitoring Renal Allograft Injury and Immunosuppression in Pediatric Patients.
  Journal of clinical medicine 2020 Sigdel TK, Schroeder AW, Yang JYC, Sarwal RD, Liberto JM, Sarwal MM
• Avoidance of CNI and steroids using belatacept-Results of the Clinical Trials in Organ Transplantation 16 trial.
  American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 2020 Mannon RB, Armstrong B, Stock PG, Mehta AK, Farris AB, Watson N, Morrison Y, Sarwal M, Sigdel T, Bridges N, Robien M, Newell KA, Larsen CP
• A urine score for noninvasive accurate diagnosis and prediction of kidney transplant rejection.
  Science translational medicine 2020 Yang JYC, Sarwal RD, Sigdel TK, Damm I, Rosenbaum B, Liberto JM, Chan-On C, Arreola-Guerra JM, Alberu J, Vincenti F, Sarwal MM
• Assessment of 19 Genes and Validation of CRM Gene Panel for Quantitative Transcriptional Analysis of Molecular Rejection and Inflammation in Archival Kidney Transplant Biopsies.
  Frontiers in medicine 2019 Sigdel T, Nguyen M, Liberto J, Dobi D, Junger H, Vincenti F, Laszik Z, Sarwal MM
• A urinary Common Rejection Module (uCRM) score for non-invasive kidney transplant monitoring.
  PloS one 2019 Sigdel TK, Yang JYC, Bestard O, Schroeder A, Hsieh SC, Liberto JM, Damm I, Geraedts ACM, Sarwal MM
• A Modified Injector and Sample Acquisition Protocol Can Improve Data Quality and Reduce Inter-Instrument Variability of the Helios Mass Cytometer.
  Cytometry. Part A : the journal of the International Society for Analytical Cytology 2019 Lee BH, Kelly G, Bradford S, Davila M, Guo XV, Amir ED, Thrash EM, Solga MD, Lannigan J, Sellers B, Candia J, Tsang J, Montgomery RR, Tamaki SJ, Sigdel TK, Sarwal MM, Lanier LL, Tian Y, Kim C, Hinz D,…
• Characterizing pre-transplant and post-transplant kidney rejection risk by B cell immune repertoire sequencing.
  Nature communications 2019 Pineda S, Sigdel TK, Liberto JM, Vincenti F, Sirota M, Sarwal MM
• A Novel Multi-Biomarker Assay for Non-Invasive Quantitative Monitoring of Kidney Injury.
  Journal of clinical medicine 2019 Watson D, Yang JYC, Sarwal RD, Sigdel TK, Liberto JM, Damm I, Louie V, Sigdel S, Livingstone D, Soh K, Chakraborty A, Liang M, Lin PC, Sarwal MM
• Cell-Free DNA and CXCL10 Derived from Bronchoalveolar Lavage Predict Lung Transplant Survival.
  Journal of clinical medicine 2019 Yang JYC, Verleden SE, Zarinsefat A, Vanaudenaerde BM, Vos R, Verleden GM, Sarwal RD, Sigdel TK, Liberto JM, Damm I, Watson D, Sarwal MM
• Optimizing Detection of Kidney Transplant Injury by Assessment of Donor-Derived Cell-Free DNA via Massively Multiplex PCR.
  Journal of clinical medicine 2018 Sigdel TK, Archila FA, Constantin T, Prins SA, Liberto J, Damm I, Towfighi P, Navarro S, Kirkizlar E, Demko ZP, Ryan A, Sigurjonsson S, Sarwal RD, Hseish SC, Chan-On C, Zimmermann B, Billings PR, …
• The common rejection module in chronic rejection post lung transplantation.
  PloS one 2018 Sacreas A, Yang JYC, Vanaudenaerde BM, Sigdel TK, Liberto JM, Damm I, Verleden GM, Vos R, Verleden SE, Sarwal MM
• Urinary Virome Perturbations in Kidney Transplantation.
  Frontiers in medicine 2018 Sigdel TK, Mercer N, Nandoe S, Nicora CD, Burnum-Johnson K, Qian WJ, Sarwal MM
• Targeted Transcriptional Profiling of Kidney Transplant Biopsies.
  Kidney international reports 2018 Sigdel TK, Nguyen M, Dobi D, Hsieh SC, Liberto JM, Vincenti F, Sarwal MM, Laszik Z
• Corrigendum: Novel Non-Histocompatibility Antigen Mismatched Variants Improve the Ability to Predict Antibody-Mediated Rejection Risk in Kidney Transplant.
  Frontiers in immunology 2018 Pineda S, Sigdel TK, Chen J, Jackson AM, Sirota M, Sarwal MM
• Discovery of Immune Reactive Human Proteins by High-Density Protein Arrays and Customized Validation of Potential Biomarkers by ELISA.
  Methods in molecular biology (Clifton, N.J.) 2018 Sigdel TK, Sarwal MM
• Fractionation of Soluble Proteins Using DEAE-Sepharose, SP-Sepharose, and Phenyl Sepharose Chromatographies for Proteomics.
  Methods in molecular biology (Clifton, N.J.) 2018 Towfighi P, Shaw J, Sigdel T
• LC-SRM-Based Targeted Quantification of Urinary Protein Biomarkers.
  Methods in molecular biology (Clifton, N.J.) 2018 Gao Y, Wang H, Nicora CD, Shi T, Smith RD, Sigdel TK, Sarwal MM, Camp DG, Qian WJ
• Optimization for Peptide Sample Preparation for Urine Peptidomics.
  Methods in molecular biology (Clifton, N.J.) 2018 Sigdel TK, Nicora CD, Qian WJ, Sarwal MM
• Novel Non-Histocompatibility Antigen Mismatched Variants Improve the Ability to Predict Antibody-Mediated Rejection Risk in Kidney Transplant.
  Frontiers in immunology 2017 Pineda S, Sigdel TK, Chen J, Jackson AM, Sirota M, Sarwal MM
• Expression of Mitochondrial-Encoded Genes in Blood Differentiate Acute Renal Allograft Rejection.
  Frontiers in medicine 2017 Roedder S, Sigdel T, Hsieh SC, Cheeseman J, Metes D, Macedo C, Reed EF, Gritsch HA, Zeevi A, Shapiro R, Kirk AD, Sarwal MM
• Polyclonal Regulatory T Cell Therapy for Control of Inflammation in Kidney Transplants.
  American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 2017 Chandran S, Tang Q, Sarwal M, Laszik ZG, Putnam AL, Lee K, Leung J, Nguyen V, Sigdel T, Tavares EC, Yang JYC, Hellerstein M, Fitch M, Bluestone JA, Vincenti F
• Assessment of Circulating Protein Signatures for Kidney Transplantation in Pediatric Recipients.
  Frontiers in medicine 2017 Sigdel TK, Sarwal MM
• Molecular and Functional Noninvasive Immune Monitoring in the ESCAPE Study for Prediction of Subclinical Renal Allograft Rejection.
  Transplantation 2017 Crespo E, Roedder S, Sigdel T, Hsieh SC, Luque S, Cruzado JM, Tran TQ, Grinyó JM, Sarwal MM, Bestard O
• Prevalence and pattern of dyslipidemia in Nepalese individuals with type 2 diabetes.
  BMC research notes 2017 Pokharel DR, Khadka D, Sigdel M, Yadav NK, Acharya S, Kafle R, Sapkota RM, Sigdel T
• A combined biomarker and clinical panel for chronic graft versus host disease diagnosis.
  The journal of pathology. Clinical research 2016 Pidala J, Sigdel TK, Wang A, Hsieh S, Inamoto Y, Martin PJ, Flowers ME, Hansen JA, Lee SJ, Sarwal MM
• Advances in diagnostics for transplant rejection.
  Expert review of molecular diagnostics 2016 Nasr M, Sigdel T, Sarwal M
• Intragraft Antiviral-Specific Gene Expression as a Distinctive Transcriptional Signature for Studies in Polyomavirus-Associated Nephropathy.
  Transplantation 2016 Sigdel TK, Bestard O, Salomonis N, Hsieh SC, Torras J, Naesens M, Tran TQ, Roedder S, Sarwal MM
• Self-antigens and rejection: a proteomic analysis.
  Current opinion in organ transplantation 2016 Yang JY, Sigdel TK, Sarwal MM
• Mining the human urine proteome for monitoring renal transplant injury.
  Kidney international 2016 Sigdel TK, Gao Y, He J, Wang A, Nicora CD, Fillmore TL, Shi T, Webb-Robertson BJ, Smith RD, Qian WJ, Salvatierra O, Camp DG, Sarwal MM
• Circulating CD40 autoantibody and suPAR synergy drives glomerular injury.
  Annals of translational medicine 2015 Wei C, Sigdel TK, Sarwal MM, Reiser J
• A Computational Gene Expression Score for Predicting Immune Injury in Renal Allografts.
  PloS one 2015 Sigdel TK, Bestard O, Tran TQ, Hsieh SC, Roedder S, Damm I, Vincenti F, Sarwal MM
• Transcriptional Perturbations in Graft Rejection.
  Transplantation 2015 Vitalone MJ, Sigdel TK, Salomonis N, Sarwal RD, Hsieh SC, Sarwal MM
• Perturbations in the urinary exosome in transplant rejection.
  Frontiers in medicine 2015 Sigdel TK, Ng YW, Lee S, Nicora CD, Qian WJ, Smith RD, Camp DG, Sarwal MM
• Mapping novel immunogenic epitopes in IgA nephropathy.
  Clinical journal of the American Society of Nephrology : CJASN 2014 Woo SH, Sigdel TK, Dinh VT, Vu MT, Sarwal MM, Lafayette RA
• A Three-Gene Assay for Monitoring Immune Quiescence in Kidney Transplantation.
  Journal of the American Society of Nephrology : JASN 2014 Roedder S, Li L, Alonso MN, Hsieh SC, Vu MT, Dai H, Sigdel TK, Bostock I, Macedo C, Metes D, Zeevi A, Shapiro R, Salvatierra O, Scandling J, Alberu J, Engleman E, Sarwal MM
• The kSORT assay to detect renal transplant patients at high risk for acute rejection: results of the multicenter AART study.
  PLoS medicine 2014 Roedder S, Sigdel T, Salomonis N, Hsieh S, Dai H, Bestard O, Metes D, Zeevi A, Zeevi A, Gritsch A, Cheeseman J, Macedo C, Peddy R, Medeiros M, Vincenti F, Asher N, Salvatierra O, Shapiro R, Kirk A, …
• Endothelial cell antibodies associated with novel targets and increased rejection.
  Journal of the American Society of Nephrology : JASN 2014 Jackson AM, Sigdel TK, Delville M, Hsieh SC, Dai H, Bagnasco S, Montgomery RA, Sarwal MM
• A circulating antibody panel for pretransplant prediction of FSGS recurrence after kidney transplantation.
  Science translational medicine 2014 Delville M, Sigdel TK, Wei C, Li J, Hsieh SC, Fornoni A, Burke GW, Bruneval P, Naesens M, Jackson A, Alachkar N, Canaud G, Legendre C, Anglicheau D, Reiser J, Sarwal MM
• Optimization for peptide sample preparation for urine peptidomics.
  Clinical proteomics 2014 Sigdel TK, Nicora CD, Hsieh SC, Dai H, Qian WJ, Camp DG, Sarwal MM
• Identification of common blood gene signatures for the diagnosis of renal and cardiac acute allograft rejection.
  PloS one 2013 Li L, Khush K, Hsieh SC, Ying L, Luikart H, Sigdel T, Roedder S, Yang A, Valantine H, Sarwal MM
• The identification of novel potential injury mechanisms and candidate biomarkers in renal allograft rejection by quantitative proteomics.
  Molecular & cellular proteomics : MCP 2013 Sigdel TK, Salomonis N, Nicora CD, Ryu S, He J, Dinh V, Orton DJ, Moore RJ, Hsieh SC, Dai H, Thien-Vu M, Xiao W, Smith RD, Qian WJ, Camp DG, Sarwal MM
• Moving beyond HLA: a review of nHLA antibodies in organ transplantation.
  Human immunology 2013 Sigdel TK, Sarwal MM
• A rapid noninvasive assay for the detection of renal transplant injury.
  Transplantation 2013 Sigdel TK, Vitalone MJ, Tran TQ, Dai H, Hsieh SC, Salvatierra O, Sarwal MM
• Multicenter evaluation of a standardized protocol for noninvasive gene expression profiling.
  American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 2013 Keslar KS, Lin M, Zmijewska AA, Sigdel TK, Tran TQ, Ma L, Bhasin M, Rao P, Ding R, Iklé DN, Mannon RB, Sarwal MM, Strom TB, Reed EF, Heeger PS, Suthanthiran M, Fairchild RL
• Immune response profiling identifies autoantibodies specific to Moyamoya patients.
  Orphanet journal of rare diseases 2013 Sigdel TK, Shoemaker LD, Chen R, Li L, Butte AJ, Sarwal MM, Steinberg GK
• The clinical impact of humoral immunity in pediatric renal transplantation.
  Journal of the American Society of Nephrology : JASN 2013 Chaudhuri A, Ozawa M, Everly MJ, Ettenger R, Dharnidharka V, Benfield M, Mathias R, Portale A, McDonald R, Harmon W, Kershaw D, Vehaskari VM, Kamil E, Baluarte HJ, Warady B, Li L, Sigdel TK, Hsieh SC,…
• A common blood gene assay predates clinical and histological rejection in kidney and heart allografts.
  Clinical transplants 2013 Sarwal M, Sigdel T
• Discovery and customized validation of antibody targets by protein arrays and indirect ELISA.
  Methods in molecular biology (Clifton, N.J.) 2013 Sigdel TK, Sarwal MM
• A peripheral blood diagnostic test for acute rejection in renal transplantation.
  American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 2012 Li L, Khatri P, Sigdel TK, Tran T, Ying L, Vitalone MJ, Chen A, Hsieh S, Dai H, Zhang M, Naesens M, Zarkhin V, Sansanwal P, Chen R, Mindrinos M, Xiao W, Benfield M, Ettenger RB, Dharnidharka V, …
• Complete steroid avoidance is effective and safe in children with renal transplants: a multicenter randomized trial with three-year follow-up.
  American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 2012 Sarwal MM, Ettenger RB, Dharnidharka V, Benfield M, Mathias R, Portale A, McDonald R, Harmon W, Kershaw D, Vehaskari VM, Kamil E, Baluarte HJ, Warady B, Tang L, Liu J, Li L, Naesens M, Sigdel T, …
• Protein and peptide biomarkers in organ transplantation.
  Biomarkers in medicine 2012 Sigdel TK, Gao X, Sarwal MM
• Non-HLA antibodies to immunogenic epitopes predict the evolution of chronic renal allograft injury.
  Journal of the American Society of Nephrology : JASN 2012 Sigdel TK, Li L, Tran TQ, Khatri P, Naesens M, Sansanwal P, Dai H, Hsieh SC, Sarwal MM
• Cell-free DNA as a measure of transplant injury.
  Clinical transplants 2012 Sigdel TK, Sarwal MM
• Characterization of Zn(II)-responsive ribosomal proteins YkgM and L31 in E. coli.
  Journal of inorganic biochemistry 2011 Hensley MP, Gunasekera TS, Easton JA, Sigdel TK, Sugarbaker SA, Klingbeil L, Breece RM, Tierney DL, Crowder MW
• Profiling of autoantibodies in IgA nephropathy, an integrative antibiomics approach.
  Clinical journal of the American Society of Nephrology : CJASN 2011 Sigdel TK, Woo SH, Dai H, Khatri P, Li L, Myers B, Sarwal MM, Lafayette RA
• Recent advances in biomarker discovery in solid organ transplant by proteomics.
  Expert review of proteomics 2011 Sigdel TK, Sarwal MM
• The dual role of epithelial-to-mesenchymal transition in chronic allograft injury in pediatric renal transplantation.
  Transplantation 2011 Vitalone MJ, Naesens M, Sigdel T, Li L, Hseih S, Sarwal MM
• Functional proteogenomics--embracing complexity.
  Seminars in immunology 2011 Sarwal MM, Sigdel TK, Salomon DR
• Progressive histological damage in renal allografts is associated with expression of innate and adaptive immunity genes.
  Kidney international 2011 Naesens M, Khatri P, Li L, Sigdel TK, Vitalone MJ, Chen R, Butte AJ, Salvatierra O, Sarwal MM
• Profiling the proteome in renal transplantation.
  Proteomics. Clinical applications 2011 Sigdel TK, Lee S, Sarwal MM
• Protein microarrays discover angiotensinogen and PRKRIP1 as novel targets for autoantibodies in chronic renal disease.
  Molecular & cellular proteomics : MCP 2010 Butte AJ, Sigdel TK, Wadia PP, Miklos DB, Sarwal MM
• Differential immunogenicity and clinical relevance of kidney compartment specific antigens after renal transplantation.
  Journal of proteome research 2010 Li L, Sigdel T, Vitalone M, Lee SH, Sarwal M
• Differentially expressed RNA from public microarray data identifies serum protein biomarkers for cross-organ transplant rejection and other conditions.
  PLoS computational biology 2010 Chen R, Sigdel TK, Li L, Kambham N, Dudley JT, Hsieh SC, Klassen RB, Chen A, Caohuu T, Morgan AA, Valantine HA, Khush KK, Sarwal MM, Butte AJ
• Compartmental localization and clinical relevance of MICA antibodies after renal transplantation.
  Transplantation 2010 Li L, Chen A, Chaudhuri A, Kambham N, Sigdel T, Chen R, Sarwal MM
• Integrative urinary peptidomics in renal transplantation identifies biomarkers for acute rejection.
  Journal of the American Society of Nephrology : JASN 2010 Ling XB, Sigdel TK, Lau K, Ying L, Lau I, Schilling J, Sarwal MM
• Shotgun proteomics identifies proteins specific for acute renal transplant rejection.
  Proteomics. Clinical applications 2010 Sigdel TK, Kaushal A, Gritsenko M, Norbeck AD, Qian WJ, Xiao W, Camp DG, Smith RD, Sarwal MM
• Protein microarrays identify antibodies to protein kinase Czeta that are associated with a greater risk of allograft loss in pediatric renal transplant recipients.
  Kidney international 2009 Sutherland SM, Li L, Sigdel TK, Wadia PP, Miklos DB, Butte AJ, Sarwal MM
• Expression of complement components differs between kidney allografts from living and deceased donors.
  Journal of the American Society of Nephrology : JASN 2009 Naesens M, Li L, Ying L, Sansanwal P, Sigdel TK, Hsieh SC, Kambham N, Lerut E, Salvatierra O, Butte AJ, Sarwal MM
• Identifying compartment-specific non-HLA targets after renal transplantation by integrating transcriptome and "antibodyome" measures.
  Proceedings of the National Academy of Sciences of the United States of America 2009 Li L, Wadia P, Chen R, Kambham N, Naesens M, Sigdel TK, Miklos DB, Sarwal MM, Butte AJ
• Interpreting the proteome and peptidome in transplantation.
  Advances in clinical chemistry 2009 Sigdel TK, Klassen RB, Sarwal MM
• A randomized, prospective trial of rituximab for acute rejection in pediatric renal transplantation.
  American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 2008 Zarkhin V, Li L, Kambham N, Sigdel T, Salvatierra O, Sarwal MM
• The proteogenomic path towards biomarker discovery.
  Pediatric transplantation 2008 Sigdel TK, Sarwal MM
• Optimizing protein recovery for urinary proteomics, a tool to monitor renal transplantation.
  Clinical transplantation 2008 Sigdel TK, Lau K, Schilling J, Sarwal M
• Interference of globin genes with biomarker discovery for allograft rejection in peripheral blood samples.
  Physiological genomics 2007 Li L, Ying L, Naesens M, Xiao W, Sigdel T, Hsieh S, Martin J, Chen R, Liu K, Mindrinos M, Davis R, Sarwal M
• Probing the adaptive response of Escherichia coli to extracellular Zn(II).
  Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine 2006 Sigdel TK, Cilliers R, Gursahaney PR, Thompson P, Easton JA, Crowder MW
• Transcriptional response of Escherichia coli to TPEN.
  Journal of bacteriology 2006 Sigdel TK, Easton JA, Crowder MW
• Phosphinate, sulfonate, and sulfonamidate dipeptides as potential inhibitors of Escherichia coli aminopeptidase N.
  Bioorganic & medicinal chemistry letters 2005 Yang KW, Golich FC, Sigdel TK, Crowder MW
• A five-coordinate metal center in Co(II)-substituted VanX.
  The Journal of biological chemistry 2005 Breece RM, Costello A, Bennett B, Sigdel TK, Matthews ML, Tierney DL, Crowder MW
• Fractionation of soluble proteins in Escherichia coli using DEAE-, SP-, and phenyl sepharose chromatographies.
  Journal of biomolecular techniques : JBT 2004 Sigdel TK, Cilliers R, Gursahaney PR, Crowder MW
• L-alanine-p-nitroanilide is not a substrate for VanX.
  Analytical biochemistry 2004 Golich FC, Sigdel T, Breece RM, Detar L, Herron LR, Crowder MW
• Over-expression, purification, and characterization of metallo-beta-lactamase ImiS from Aeromonas veronii bv. sobria.
  Protein expression and purification 2004 Crawford PA, Sharma N, Chandrasekar S, Sigdel T, Walsh TR, Spencer J, Crowder MW
• In vivo folding of recombinant metallo-beta-lactamase L1 requires the presence of Zn(II).
  Protein science : a publication of the Protein Society 2004 Periyannan G, Shaw PJ, Sigdel T, Crowder MW