Tanvi Sinha, PhD, MS
Assistant Researcher
Cardiovascular Research Inst
School of Medicine

Publications (17)

Top publication keywords:
Enhancer Elements, GeneticCell LineageWnt-5a ProteinMyocytes, CardiacCell PolarityTranscription FactorsHeartEmbryonic Stem CellsEmbryonic DevelopmentDiGeorge SyndromeWnt ProteinsGene Regulatory NetworksMorphogenesisSinoatrial NodeBiological Clocks

• An injury-responsive mmp14b enhancer is required for heart regeneration.
  Science advances 2023 Zlatanova I, Sun F, Wu RS, Chen X, Lau BH, Colombier P, Sinha T, Celona B, Xu SM, Materna SC, Huang GN, Black BL
• ETV2 primes hematoendothelial gene enhancers prior to hematoendothelial fate commitment.
  Cell reports 2023 Steimle JD, Kim C, Rowton M, Nadadur RD, Wang Z, Stocker M, Hoffmann AD, Hanson E, Kweon J, Sinha T, Choi K, Black BL, Cunningham JM, Moskowitz IP, Ikegami K
• A Mesp1-dependent developmental breakpoint in transcriptional and epigenomic specification of early cardiac precursors.
  Development (Cambridge, England) 2023 Krup AL, Winchester SAB, Ranade SS, Agrawal A, Devine WP, Sinha T, Choudhary K, Dominguez MH, Thomas R, Black BL, Srivastava D, Bruneau BG
• An enhancer-based gene-therapy strategy for spatiotemporal control of cargoes during tissue repair.
  Cell stem cell 2022 Yan R, Cigliola V, Oonk KA, Petrover Z, DeLuca S, Wolfson DW, Vekstein A, Mendiola MA, Devlin G, Bishawi M, Gemberling MP, Sinha T, Sargent MA, York AJ, Shakked A, DeBenedittis P, Wendell DC, Ou J, …
• Differential Etv2 threshold requirement for endothelial and erythropoietic development.
  Cell reports 2022 Sinha T, Lammerts van Bueren K, Dickel DE, Zlatanova I, Thomas R, Lizama CO, Xu SM, Zovein AC, Ikegami K, Moskowitz IP, Pollard KS, Pennacchio LA, Black BL

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• ATAC-Seq Reveals an Isl1 Enhancer That Regulates Sinoatrial Node Development and Function.
  Circulation research 2020 Galang G, Mandla R, Ruan H, Jung C, Sinha T, Stone NR, Wu RS, Mannion BJ, Allu PKR, Chang K, Rammohan A, Shi MB, Pennacchio LA, Black BL, Vedantham V
• Genome-Wide Analysis Identifies an Essential Human TBX3 Pacemaker Enhancer.
  Circulation research 2020 van Eif VWW, Protze SI, Bosada FM, Yuan X, Sinha T, van Duijvenboden K, Ernault AC, Mohan RA, Wakker V, de Gier-de Vries C, Hooijkaas IB, Wilson MD, Verkerk AO, Bakkers J, Boukens BJ, Black BL, Scott …
• Cardiovascular development and survival require Mef2c function in the myocardial but not the endothelial lineage.
  Developmental biology 2018 Materna SC, Sinha T, Barnes RM, Lammerts van Bueren K, Black BL
• Cooperative activation of cardiac transcription through myocardin bridging of paired MEF2 sites.
  Development (Cambridge, England) 2017 Anderson CM, Hu J, Thomas R, Gainous TB, Celona B, Sinha T, Dickel DE, Heidt AB, Xu SM, Bruneau BG, Pollard KS, Pennacchio LA, Black BL
• Spatial regulation of cell cohesion by Wnt5a during second heart field progenitor deployment.
  Developmental biology 2016 Li D, Sinha T, Ajima R, Seo HS, Yamaguchi TP, Wang J
• MEF2C regulates outflow tract alignment and transcriptional control of Tdgf1.
  Development (Cambridge, England) 2016 Barnes RM, Harris IS, Jaehnig EJ, Sauls K, Sinha T, Rojas A, Schachterle W, McCulley DJ, Norris RA, Black BL
• Loss of tumor suppressive microRNA-31 enhances TRADD/NF-κB signaling in glioblastoma.
  Oncotarget 2015 Rajbhandari R, McFarland BC, Patel A, Gerigk M, Gray GK, Fehling SC, Bredel M, Berbari NF, Kim H, Marks MP, Meares GP, Sinha T, Chuang J, Benveniste EN, Nozell SE
• Mapping the dynamic expression of Wnt11 and the lineage contribution of Wnt11-expressing cells during early mouse development.
  Developmental biology 2014 Sinha T, Lin L, Li D, Davis J, Evans S, Wynshaw-Boris A, Wang J
• Loss of Wnt5a disrupts second heart field cell deployment and may contribute to OFT malformations in DiGeorge syndrome.
  Human molecular genetics 2014 Sinha T, Li D, Théveniau-Ruissy M, Hutson MR, Kelly RG, Wang J
• Disheveled mediated planar cell polarity signaling is required in the second heart field lineage for outflow tract morphogenesis.
  Developmental biology 2012 Sinha T, Wang B, Evans S, Wynshaw-Boris A, Wang J
• Wnt signaling in mammalian development: lessons from mouse genetics.
  Cold Spring Harbor perspectives in biology 2012 Wang J, Sinha T, Wynshaw-Boris A
• Disruption of PCP signaling causes limb morphogenesis and skeletal defects and may underlie Robinow syndrome and brachydactyly type B.
  Human molecular genetics 2010 Wang B, Sinha T, Jiao K, Serra R, Wang J