Takeshi Tsusaka, PhD
Postdoctoral Scholar
Physiology
School of Medicine

Publications (14)

Top publication keywords:
MethylationGene SilencingCCAAT-Enhancer-Binding ProteinsPhosphoglycerate Mutasep300-CBP Transcription FactorsSirtuin 2PhosphoproteinsCell NucleusProtein Processing, Post-TranslationalUbiquitinationDNA Ligase ATPRepressor ProteinsHEK293 CellsFibronectin Type III DomainHistone-Lysine N-Methyltransferase

• Reversible histone deacetylase activity catalyzes lysine acylation.
  bioRxiv : the preprint server for biology 2023 Tsusaka T, Najar MA, Schwarz B, Bohrnsen E, Oses-Prieto JA, Lee C, Burlingame AL, Bosio CM, Burslem GM, Goldberg EL
• Non-specific recognition of histone modifications by H3K9bhb antibody.
  iScience 2023 Tsusaka T, Oses-Prieto JA, Lee C, DeFelice BC, Burlingame AL, Goldberg EL
• Non-specific recognition of histone modifications by H3K9bhb antibody.
  bioRxiv : the preprint server for biology 2023 Tsusaka T, Oses-Prieto JA, Lee C, DeFelice BC, Burlingame AL, Goldberg E
• IL-33 causes thermogenic failure in aging by expanding dysfunctional adipose ILC2.
  Cell metabolism 2021 Goldberg EL, Shchukina I, Youm YH, Ryu S, Tsusaka T, Young KC, Camell CD, Dlugos T, Artyomov MN, Dixit VD
• The fibronectin type-III (FNIII) domain of ATF7IP contributes to efficient transcriptional silencing mediated by the SETDB1 complex.
  Epigenetics & chromatin 2020 Tsusaka T, Fukuda K, Shimura C, Kato M, Shinkai Y

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• ATF7IP regulates SETDB1 nuclear localization and increases its ubiquitination.
  EMBO reports 2019 Tsusaka T, Shimura C, Shinkai Y
• Structure of the UHRF1 Tandem Tudor Domain Bound to a Methylated Non-histone Protein, LIG1, Reveals Rules for Binding and Regulation.
  Structure (London, England : 1993) 2019 Kori S, Ferry L, Matano S, Jimenji T, Kodera N, Tsusaka T, Matsumura R, Oda T, Sato M, Dohmae N, Ando T, Shinkai Y, Defossez PA, Arita K
• Tri-methylation of ATF7IP by G9a/GLP recruits the chromodomain protein MPP8.
  Epigenetics & chromatin 2018 Tsusaka T, Kikuchi M, Shimazu T, Suzuki T, Sohtome Y, Akakabe M, Sodeoka M, Dohmae N, Umehara T, Shinkai Y
• Histone H3 Methylated at Arginine 17 Is Essential for Reprogramming the Paternal Genome in Zygotes.
  Cell reports 2017 Hatanaka Y, Tsusaka T, Shimizu N, Morita K, Suzuki T, Machida S, Satoh M, Honda A, Hirose M, Kamimura S, Ogonuki N, Nakamura T, Inoue K, Hosoi Y, Dohmae N, Nakano T, Kurumizaka H, Matsumoto K, Shinkai…
• Methylation of DNA Ligase 1 by G9a/GLP Recruits UHRF1 to Replicating DNA and Regulates DNA Methylation.
  Molecular cell 2017 Ferry L, Fournier A, Tsusaka T, Adelmant G, Shimazu T, Matano S, Kirsh O, Amouroux R, Dohmae N, Suzuki T, Filion GJ, Deng W, de Dieuleveult M, Fritsch L, Kudithipudi S, Jeltsch A, Leonhardt H, Hajkova…
• The STAR protein QKI-7 recruits PAPD4 to regulate post-transcriptional polyadenylation of target mRNAs.
  Nucleic acids research 2016 Yamagishi R, Tsusaka T, Mitsunaga H, Maehata T, Hoshino S
• Deacetylation of phosphoglycerate mutase in its distinct central region by SIRT2 down-regulates its enzymatic activity.
  Genes to cells : devoted to molecular & cellular mechanisms 2014 Tsusaka T, Guo T, Yagura T, Inoue T, Yokode M, Inagaki N, Kondoh H
• Senescence-inducing stress promotes proteolysis of phosphoglycerate mutase via ubiquitin ligase Mdm2.
  The Journal of cell biology 2014 Mikawa T, Maruyama T, Okamoto K, Nakagama H, Lleonart ME, Tsusaka T, Hori K, Murakami I, Izumi T, Takaori-Kondo A, Yokode M, Peters G, Beach D, Kondoh H
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  Kagaku To Seibutsu 2014 Takeshi TSUSAKA, Hiroshi KONDOH