Takashi Mikawa, PhD
Professor
Cardiovascular Research Inst
School of Medicine

Grants and Projects

Show all (13) Hide

• Induction and Patterning of Cardiogenic Fields, NIH, 2020-2024
• Development of Vascular Smooth Muscle Stem Cell Niche, NIH, 2019-2023
• Atrioventricular Junction Development, NIH, 2016-2021
• Coronary Vascular Cell Development, NIH, 2004-2020
• Heart Field Development, NIH, 2014-2019
• Cardiac Pacemaker Development, NIH, 2011-2016
• Cardiac Conduction System Development, NIH, 2008-2013
• Vascular Differentiation and Patterning, NIH, 2008-2012
• Induction of Coronary Endothelial Cell Lineage, NIH, 2004-2009
• Regulation of Cardiac Conduction System Development, NIH, 1999-2009
• Negative Regulation of Blood Vessel Formation, NIH, 2004-2009
• Molecular Regulation of Coronary Vessel Development, NIH, 2001-2008
• Regulation of Purkinje Fiber Development in the Heart, NIH, 1996-2007

Publications (101)

Top publication keywords:
ChromosomesMyocardiumRetroviridaeQuailSinoatrial NodeHeartChick EmbryoMesodermBody PatterningEmbryonic InductionPurkinje FibersChickensPericardiumNotochordMitosis

• Programmed cell death along the midline axis patterns ipsilaterality in gastrulation.
  Science (New York, N.Y.) 2020 Maya-Ramos L, Mikawa T
• Mitotic antipairing of homologous and sex chromosomes via spatial restriction of two haploid sets.
  Proceedings of the National Academy of Sciences of the United States of America 2018 Hua LL, Mikawa T
• Early mesodermal cues assign avian cardiac pacemaker fate potential in a tertiary heart field.
  Science (New York, N.Y.) 2013 Bressan M, Liu G, Mikawa T
• Coupling and uncoupling of midline morphogenesis and cell flow in amniote gastrulation.
  bioRxiv : the preprint server for biology 2024 Asai R, Prakash VN, Sinha S, Prakash M, Mikawa T
• Population Analysis of Daptomycin-non-Susceptible Methicillin-Resistant Staphylococcus aureus Reveals the Presence of Variants That Contribute to Daptomycin Resistance.
  Current microbiology 2024 Kanesaka I, Yabuta J, Jitsukawa T, Fujisaki S, Morita M, Mikawa T, Kanayama Katsuse A, Takahashi H, Ohno A, Kobayashi I

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• Ipsilateral restriction of chromosome movement along a centrosome, and apical-basal axis during the cell cycle.
  bioRxiv : the preprint server for biology 2023 Cai P, Casas CJ, Hua LL, Mikawa T
• Mitotic Antipairing of Homologous Chromosomes.
  Results and problems in cell differentiation 2022 Hua LL, Casas CJ, Mikawa T
• Avians as a Model System of Vascular Development.
  Methods in molecular biology (Clifton, N.J.) 2021 Asai R, Bressan M, Mikawa T
• Body Cavity Development Is Guided by Morphogen Transfer between Germ Layers.
  Cell reports 2018 Schlueter J, Mikawa T
• Dynamic Cellular Integration Drives Functional Assembly of the Heart's Pacemaker Complex.
  Cell reports 2018 Bressan M, Henley T, Louie JD, Liu G, Christodoulou D, Bai X, Taylor J, Seidman CE, Seidman JG, Mikawa T
• Chick cranial neural crest cells use progressive polarity refinement, not contact inhibition of locomotion, to guide their migration.
  Developmental biology 2018 Genuth MA, Allen CDC, Mikawa T, Weiner OD
• Chromosome Painting of Mouse Chromosomes.
  Methods in molecular biology (Clifton, N.J.) 2018 Hua LL, Mikawa T
• Avians as a model system of vascular development.
  Methods in molecular biology (Clifton, N.J.) 2015 Bressan M, Mikawa T
• Hemodynamic forces regulate developmental patterning of atrial conduction.
  PloS one 2014 Bressan MC, Louie JD, Mikawa T
• Early divergence of central and peripheral neural retina precursors during vertebrate eye development.
  Developmental dynamics : an official publication of the American Association of Anatomists 2014 Venters SJ, Mikawa T, Hyer J
• Reciprocal myocardial-endocardial interactions pattern the delay in atrioventricular junction conduction.
  Development (Cambridge, England) 2014 Bressan M, Yang PB, Louie JD, Navetta AM, Garriock RJ, Mikawa T
• Microtubules coordinate VEGFR2 signaling and sorting.
  PloS one 2013 Czeisler C, Mikawa T
• Induction of the Proepicardium.
  Journal of developmental biology 2013 Maya-Ramos L, Cleland J, Bressan M, Mikawa T
• Isolation and culture of mouse proepicardium using serum-free conditions.
  Methods (San Diego, Calif.) 2013 Garriock RJ, Mikawa T, Yamaguchi TP
• Central and peripheral retina arise through distinct developmental paths.
  PloS one 2013 Venters SJ, Mikawa T, Hyer J
• Early arterial differentiation and patterning in the avian embryo model.
  Seminars in cell & developmental biology 2011 Garriock RJ, Mikawa T
• A dual role for ErbB2 signaling in cardiac trabeculation.
  Development (Cambridge, England) 2010 Liu J, Bressan M, Hassel D, Huisken J, Staudt D, Kikuchi K, Poss KD, Mikawa T, Stainier DY
• An anteroposterior wave of vascular inhibitor downregulation signals aortae fusion along the embryonic midline axis.
  Development (Cambridge, England) 2010 Garriock RJ, Czeisler C, Ishii Y, Navetta AM, Mikawa T
• Eph regulates dorsoventral asymmetry of the notochord plate and convergent extension-mediated notochord formation.
  PloS one 2010 Oda-Ishii I, Ishii Y, Mikawa T
• BMP signals promote proepicardial protrusion necessary for recruitment of coronary vessel and epicardial progenitors to the heart.
  Developmental cell 2010 Ishii Y, Garriock RJ, Navetta AM, Coughlin LE, Mikawa T
• Morphogenesis and cytodifferentiation of the avian retinal pigmented epithelium require downregulation of Group B1 Sox genes.
  Development (Cambridge, England) 2009 Ishii Y, Weinberg K, Oda-Ishii I, Coughlin L, Mikawa T
• FGFR-1 is required by epicardium-derived cells for myocardial invasion and correct coronary vascular lineage differentiation.
  Developmental biology 2009 Pennisi DJ, Mikawa T
• Notochord-derived BMP antagonists inhibit endothelial cell generation and network formation.
  Developmental biology 2008 Bressan M, Davis P, Timmer J, Herzlinger D, Mikawa T
• Endothelial cell lineages of the heart.
  Cell and tissue research 2008 Ishii Y, Langberg J, Rosborough K, Mikawa T
• Induction of proepicardial marker gene expression by the liver bud.
  Development (Cambridge, England) 2007 Ishii Y, Langberg JD, Hurtado R, Lee S, Mikawa T
• Development of the cardiac conduction system.
  Seminars in cell & developmental biology 2007 Mikawa T, Hurtado R
• FGF-mediated induction of ciliary body tissue in the chick eye.
  Developmental biology 2006 Dias da Silva MR, Tiffin N, Mima T, Mikawa T, Hyer J
• Bone marrow Oct3/4+ cells differentiate into cardiac myocytes via age-dependent paracrine mechanisms.
  Circulation research 2006 Pallante BA, Duignan I, Okin D, Chin A, Bressan MC, Mikawa T, Edelberg JM
• Enhanced sensitivity and stability in two-color in situ hybridization by means of a novel chromagenic substrate combination.
  Developmental dynamics : an official publication of the American Association of Anatomists 2006 Hurtado R, Mikawa T
• TrkB/BDNF signaling regulates photoreceptor progenitor cell fate decisions.
  Developmental biology 2006 Turner BA, Sparrow J, Cai B, Monroe J, Mikawa T, Hempstead BL
• VEGF family members regulate myocardial tubulogenesis and coronary artery formation in the embryo.
  Circulation research 2006 Tomanek RJ, Ishii Y, Holifield JS, Sjogren CL, Hansen HK, Mikawa T
• Normal patterning of the coronary capillary plexus is dependent on the correct transmural gradient of FGF expression in the myocardium.
  Developmental biology 2005 Pennisi DJ, Mikawa T
• Somatic transgenesis in the avian model system.
  Birth defects research. Part C, Embryo today : reviews 2005 Ishii Y, Mikawa T
• Developmental transitions in electrical activation patterns in chick embryonic heart.
  The anatomical record. Part A, Discoveries in molecular, cellular, and evolutionary biology 2004 Sedmera D, Reckova M, Bigelow MR, Dealmeida A, Stanley CP, Mikawa T, Gourdie RG, Thompson RP
• A role for Tbx5 in proepicardial cell migration during cardiogenesis.
  Physiological genomics 2004 Hatcher CJ, Diman NY, Kim MS, Pennisi D, Song Y, Goldstein MM, Mikawa T, Basson CT
• Negative regulation of midline vascular development by the notochord.
  Developmental cell 2004 Reese DE, Hall CE, Mikawa T
• Folding of the tectal cortex by local remodeling of neural differentiation.
  Developmental dynamics : an official publication of the American Association of Anatomists 2004 Mima T, Mikawa T
• Induction and patterning of the primitive streak, an organizing center of gastrulation in the amniote.
  Developmental dynamics : an official publication of the American Association of Anatomists 2004 Mikawa T, Poh AM, Kelly KA, Ishii Y, Reese DE
• Somatic transgenesis using retroviral vectors in the chicken embryo.
  Developmental dynamics : an official publication of the American Association of Anatomists 2004 Ishii Y, Reese DE, Mikawa T
• Platelet-derived growth factor-AB promotes the generation of adult bone marrow-derived cardiac myocytes.
  Circulation research 2004 Xaymardan M, Tang L, Zagreda L, Pallante B, Zheng J, Chazen JL, Chin A, Duignan I, Nahirney P, Rafii S, Mikawa T, Edelberg JM
• Hemodynamic-dependent patterning of endothelin converting enzyme 1 expression and differentiation of impulse-conducting Purkinje fibers in the embryonic heart.
  Development (Cambridge, England) 2004 Hall CE, Hurtado R, Hewett KW, Shulimovich M, Poma CP, Reckova M, Justus C, Pennisi DJ, Tobita K, Sedmera D, Gourdie RG, Mikawa T
• Epicardium is required for the full rate of myocyte proliferation and levels of expression of myocyte mitogenic factors FGF2 and its receptor, FGFR-1, but not for transmural myocardial patterning in the embryonic chick heart.
  Developmental dynamics : an official publication of the American Association of Anatomists 2003 Pennisi DJ, Ballard VL, Mikawa T
• Evidence for an extracellular matrix bridge guiding proepicardial cell migration to the myocardium of chick embryos.
  Developmental dynamics : an official publication of the American Association of Anatomists 2003 Nahirney PC, Mikawa T, Fischman DA
• Optic cup morphogenesis requires pre-lens ectoderm but not lens differentiation.
  Developmental biology 2003 Hyer J, Kuhlman J, Afif E, Mikawa T
• Fibroblast growth factor (FGF)-4 can induce proliferation of cardiac cushion mesenchymal cells during early valve leaflet formation.
  Developmental biology 2003 Sugi Y, Ito N, Szebenyi G, Myers K, Fallon JF, Mikawa T, Markwald RR
• His-Purkinje lineages and development.
  Novartis Foundation symposium 2003 Gourdie RG, Harris BS, Bond J, Edmondson AM, Cheng G, Sedmera D, O'Brien TX, Mikawa T, Thompson RP
• Induction and patterning of the Purkinje fibre network.
  Novartis Foundation symposium 2003 Mikawa T, Gourdie RG, Takebayashi-Suzuki K, Kanzawa N, Hyer J, Pennisi DJ, Poma CP, Shulimovich M, Diaz KG, Layliev J, Prasad A
• Constitutive expression of preproendothelin in the cardiac neural crest selectively promotes expansion of the adventitia of the great vessels in vivo.
  Developmental biology 2002 Ballard VL, Mikawa T
• Development of the coronary vessel system.
  Circulation research 2002 Reese DE, Mikawa T, Bader DM
• Induction and patterning of the cardiac conduction system.
  The International journal of developmental biology 2002 Pennisi DJ, Rentschler S, Gourdie RG, Fishman GI, Mikawa T
• Competency of embryonic cardiomyocytes to undergo Purkinje fiber differentiation is regulated by endothelin receptor expression.
  Development (Cambridge, England) 2002 Kanzawa N, Poma CP, Takebayashi-Suzuki K, Diaz KG, Layliev J, Mikawa T
• Cell death along the embryo midline regulates left-right sidedness.
  Developmental dynamics : an official publication of the American Association of Anatomists 2002 Kelly KA, Wei Y, Mikawa T
• TBX5 transcription factor regulates cell proliferation during cardiogenesis.
  Developmental biology 2001 Hatcher CJ, Kim MS, Mah CS, Goldstein MM, Wong B, Mikawa T, Basson CT
• Fate diversity of primitive streak cells during heart field formation in ovo.
  Developmental dynamics : an official publication of the American Association of Anatomists 2000 Wei Y, Mikawa T
• Trk C receptor signaling regulates cardiac myocyte proliferation during early heart development in vivo.
  Developmental biology 2000 Lin MI, Das I, Schwartz GM, Tsoulfas P, Mikawa T, Hempstead BL
• Axonal growth of the spinal cord interneurons expressing a homophilic adhesion molecule SC1 ectopically.
  Neuroscience research 2000 Fujii T, Funahashi J, Matsuura R, Izaki T, Nakamura H, Mikawa T, Tanaka H
• In vivo induction of cardiac Purkinje fiber differentiation by coexpression of preproendothelin-1 and endothelin converting enzyme-1.
  Development (Cambridge, England) 2000 Takebayashi-Suzuki K, Yanagisawa M, Gourdie RG, Kanzawa N, Mikawa T
• Trk C signaling is required for retinal progenitor cell proliferation.
  The Journal of neuroscience : the official journal of the Society for Neuroscience 2000 Das I, Sparrow JR, Lin MI, Shih E, Mikawa T, Hempstead BL
• Stable transfectants of smooth muscle cell line lacking the expression of myosin light chain kinase and their characterization with respect to the actomyosin system.
  The Journal of biological chemistry 2000 Kishi H, Mikawa T, Seto M, Sasaki Y, Kanayasu-Toyoda T, Yamaguchi T, Imamura M, Ito M, Karaki H, Bao J, Nakamura A, Ishikawa R, Kohama K
• Formation of the avian primitive streak from spatially restricted blastoderm: evidence for polarized cell division in the elongating streak.
  Development (Cambridge, England) 2000 Wei Y, Mikawa T
• Retroviral cell lineage analysis in the developing chick heart.
  Methods in molecular biology (Clifton, N.J.) 2000 Gourdie RG, Cheng G, Thompson RP, Mikawa T
• Induction of Purkinje fiber differentiation by coronary arterialization.
  Proceedings of the National Academy of Sciences of the United States of America 1999 Hyer J, Johansen M, Prasad A, Wessels A, Kirby ML, Gourdie RG, Mikawa T
• Development of the cardiac conduction system involves recruitment within a multipotent cardiomyogenic lineage.
  Development (Cambridge, England) 1999 Cheng G, Litchenberg WH, Cole GJ, Mikawa T, Thompson RP, Gourdie RG
• Identification of chick rax/rx genes with overlapping patterns of expression during early eye and brain development.
  Mechanisms of development 1999 Ohuchi H, Tomonari S, Itoh H, Mikawa T, Noji S
• Adenovirus-mediated gene transfer of a truncated form of fibroblast growth factor receptor inhibits growth of glioma cells both in vitro and in vivo.
  Journal of neuro-oncology 1999 Saiki M, Mima T, Takahashi JC, Tani S, Yukawa H, Ueno H, Mikawa T, Itoh N, Kikuchi H, Hashimoto N, Miyatake S
• Conducting the embryonic heart: orchestrating development of specialized cardiac tissues.
  Trends in cardiovascular medicine 1999 Gourdie RG, Kubalak S, Mikawa T
• Neural crest cells in outflow tract septation of the embryonic chicken heart: differentiation and apoptosis.
  Developmental dynamics : an official publication of the American Association of Anatomists 1998 Poelmann RE, Mikawa T, Gittenberger-de Groot AC
• Endothelin-induced conversion of embryonic heart muscle cells into impulse-conducting Purkinje fibers.
  Proceedings of the National Academy of Sciences of the United States of America 1998 Gourdie RG, Wei Y, Kim D, Klatt SC, Mikawa T
• FGF1 patterns the optic vesicle by directing the placement of the neural retina domain.
  Development (Cambridge, England) 1998 Hyer J, Mima T, Mikawa T
• Trabecular myocytes of the embryonic heart require N-cadherin for migratory unit identity.
  Developmental biology 1998 Ong LL, Kim N, Mima T, Cohen-Gould L, Mikawa T
• Isoform-specific interaction of the myosin-binding proteins (MyBPs) with skeletal and cardiac myosin is a property of the C-terminal immunoglobulin domain.
  The Journal of biological chemistry 1997 Alyonycheva TN, Mikawa T, Reinach FC, Fischman DA
• Retroviral techniques for studying organogenesis with a focus on heart development.
  Molecular and cellular biochemistry 1997 Hyer J, Mikawa T
• Skeletal muscle-specific myosin binding protein-H is expressed in Purkinje fibers of the cardiac conduction system.
  Circulation research 1997 Alyonycheva T, Cohen-Gould L, Siewert C, Fischman DA, Mikawa T
• The use of replication-defective retroviruses for cell lineage studies of myogenic cells.
  Methods in cell biology 1997 Fischman DA, Mikawa T
• Ependymal/subependymal zone cells of postnatal and adult songbird brain generate both neurons and nonneuronal siblings in vitro and in vivo.
  Journal of neurobiology 1996 Goldman SA, Zukhar A, Barami K, Mikawa T, Niedzwiecki D
• The fate diversity of mesodermal cells within the heart field during chicken early embryogenesis.
  Developmental biology 1996 Cohen-Gould L, Mikawa T
• Smooth muscle alpha-actin downregulation in cultured chick aortic smooth muscle and neural crest cells is associated with altered cell shape.
  Experimental cell research 1996 Mishima N, Mikawa T, Kirby ML
• Retroviral vectors to study cardiovascular development.
  Trends in cardiovascular medicine 1996 Mikawa T, Hyer J, Itoh N, Wei Y
• Pericardial mesoderm generates a population of coronary smooth muscle cells migrating into the heart along with ingrowth of the epicardial organ.
  Developmental biology 1996 Mikawa T, Gourdie RG
• Loss of fibroblast growth factor receptors is necessary for terminal differentiation of embryonic limb muscle.
  Development (Cambridge, England) 1996 Itoh N, Mima T, Mikawa T
• The carboxyl terminus of myosin binding protein C (MyBP-C, C-protein) specifies incorporation into the A-band of striated muscle.
  Journal of cell science 1996 Gilbert R, Kelly MG, Mikawa T, Fischman DA
• The polyclonal origin of myocyte lineages.
  Annual review of physiology 1996 Mikawa T, Fischman DA
• Terminal diversification of the myocyte lineage generates Purkinje fibers of the cardiac conduction system.
  Development (Cambridge, England) 1995 Gourdie RG, Mima T, Thompson RP, Mikawa T
• An additional limb can be induced from the flank of the chick embryo by FGF4.
  Biochemical and biophysical research communications 1995 Ohuchi H, Nakagawa T, Yamauchi M, Ohata T, Yoshioka H, Kuwana T, Mima T, Mikawa T, Nohno T, Noji S
• Retroviral targeting of FGF and FGFR in cardiomyocytes and coronary vascular cells during heart development.
  Annals of the New York Academy of Sciences 1995 Mikawa T
• Antisense suppression of skeletal muscle myosin light chain-1 biosynthesis impairs myofibrillogenesis in cultured myotubes.
  Journal of muscle research and cell motility 1995 Nawrotzki R, Fischman DA, Mikawa T
• FGF can induce outgrowth of somatic mesoderm both inside and outside of limb-forming regions.
  Developmental biology 1995 Mima T, Ohuchi H, Noji S, Mikawa T
• Fibroblast growth factor receptor is required for in vivo cardiac myocyte proliferation at early embryonic stages of heart development.
  Proceedings of the National Academy of Sciences of the United States of America 1995 Mima T, Ueno H, Fischman DA, Williams LT, Mikawa T
• Mapping the origin of the avian enteric nervous system with a retroviral marker.
  Developmental dynamics : an official publication of the American Association of Anatomists 1994 Epstein ML, Mikawa T, Brown AM, McFarlin DR
• The major myosin-binding domain of skeletal muscle MyBP-C (C protein) resides in the COOH-terminal, immunoglobulin C2 motif.
  The Journal of cell biology 1993 Okagaki T, Weber FE, Fischman DA, Vaughan KT, Mikawa T, Reinach FC
• Retroviral analysis of cardiac morphogenesis: discontinuous formation of coronary vessels.
  Proceedings of the National Academy of Sciences of the United States of America 1992 Mikawa T, Fischman DA
• Clonal analysis of cardiac morphogenesis in the chicken embryo using a replication-defective retrovirus. III: Polyclonal origin of adjacent ventricular myocytes.
  Developmental dynamics : an official publication of the American Association of Anatomists 1992 Mikawa T, Cohen-Gould L, Fischman DA
• Metanephric mesenchyme contains multipotent stem cells whose fate is restricted after induction.
  Development (Cambridge, England) 1992 Herzlinger D, Koseki C, Mikawa T, al-Awqati Q
• Clonal analysis of cardiac morphogenesis in the chicken embryo using a replication-defective retrovirus: I. Formation of the ventricular myocardium.
  Developmental dynamics : an official publication of the American Association of Anatomists 1992 Mikawa T, Borisov A, Brown AM, Fischman DA
• In vivo analysis of a new lacZ retrovirus vector suitable for cell lineage marking in avian and other species.
  Experimental cell research 1991 Mikawa T, Fischman DA, Dougherty JP, Brown AM
• Changes in myosin isozymes during development of chicken breast muscle.
  Journal of biochemistry 1982 Takano-Ohmuro H, Obinata T, Masaki T, Mikawa T