Synthia Mellon, PhD
Professor
Ob/Gyn, Reproductive Sciences
School of Medicine

Grants and Projects

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• Integrated Training in Reproductive Sciences, NIH, 1983-2024
• Center for Research, Innovation and Training in Reproduction and Infertility, NIH, 2007-2023
• Cell Aging in Major Depression, NIH, 2008-2021
• Origins and Biological Consequences of Human Infertility, NIH, 2007-2017
• Neurosteroids in health and disease, NIH, 2005-2012
• General Clinical Research Center, NIH, 1974-2009
• Regulation of Reproduction, NIH, 1991-2006
• Hormonal Regulation of Steroidogenesis, NIH, 1986-1991
• Hormonal Regulation of Steroidogenesis, NIH, 1986-1989

Publications (141)

Top publication keywords:
VeteransCell-Free Nucleic AcidsDNA, MitochondrialCholesterol Side-Chain Cleavage EnzymeSteroidsDehydroepiandrosterone SulfateSteroid 17-alpha-HydroxylaseDehydroepiandrosteroneCytochrome P-450 Enzyme SystemAntidepressive AgentsStress Disorders, Post-TraumaticCombat DisordersDepressive Disorder, MajorPregnanoloneBrain-Derived Neurotrophic Factor

• Circulating cell-free mitochondrial DNA levels and glucocorticoid sensitivity in a cohort of male veterans with and without combat-related PTSD.
  Translational psychiatry 2024 Blalock ZN, Wu GWY, Lindqvist D, Trumpff C, Flory JD, Lin J, Reus VI, Rampersaud R, Hammamieh R, Gautam A, SBPBC, Doyle FJ, Marmar CR, Jett M, Yehuda R, Wolkowitz OM, Mellon SH
• Integrated analysis of proteomics, epigenomics and metabolomics data revealed divergent pathway activation patterns in the recent versus chronic post-traumatic stress disorder.
  Brain, behavior, and immunity 2023 Muhie S, Gautam A, Misganaw B, Yang R, Mellon SH, Hoke A, Flory J, Daigle B, Swift K, PTSD Systems Biology Consortium, Hood L, Doyle FJ, Wolkowitz OM, Marmar CR, Ressler K, Yehuda R, Hammamieh R, Jett…
• Shorter telomere length predicts poor antidepressant response and poorer cardiometabolic indices in major depression.
  Scientific reports 2023 Rampersaud R, Wu GWY, Reus VI, Lin J, Blackburn EH, Epel ES, Hough CM, Mellon SH, Wolkowitz OM
• Molecular signatures of post-traumatic stress disorder in war-zone-exposed veteran and active-duty soldiers.
  Cell reports. Medicine 2023 Muhie S, Gautam A, Yang R, Misganaw B, Daigle BJ, Mellon SH, Flory JD, Abu-Amara D, Lee I, Wang K, Rampersaud R, PTSD Systems Biology Consortium, Hood L, Yehuda R, Marmar CR, Wolkowitz OM, Ressler KJ,…
• The Genetic Basis for the Increased Prevalence of Metabolic Syndrome among Post-Traumatic Stress Disorder Patients.
  International journal of molecular sciences 2022 Misganaw B, Yang R, Gautam A, Muhie S, Mellon SH, Wolkowitz OM, Ressler KJ, Doyle FJ, Marmar CR, Jett M, Hammamieh R

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• Dimensions of childhood adversity differentially affect biological aging in major depression.
  Translational psychiatry 2022 Rampersaud R, Protsenko E, Yang R, Reus V, Hammamieh R, Wu GWY, Epel E, Jett M, Gautam A, Mellon SH, Wolkowitz OM
• Blood-based mitochondrial respiratory chain function in major depression.
  Translational psychiatry 2021 Fernström J, Mellon SH, McGill MA, Picard M, Reus VI, Hough CM, Lin J, Epel ES, Wolkowitz OM, Lindqvist D
• Abnormal levels of mitochondrial proteins in plasma neuronal extracellular vesicles in major depressive disorder.
  Molecular psychiatry 2021 Goetzl EJ, Wolkowitz OM, Srihari VH, Reus VI, Goetzl L, Kapogiannis D, Heninger GR, Mellon SH
• Correction: A DNA methylation clock associated with age-related illnesses and mortality is accelerated in men with combat PTSD.
  Molecular psychiatry 2021 Yang R, Wu GWY, Verhoeven JE, Gautam A, Reus VI, Kang JI, Flory JD, Abu-Amara D, PTSD Systems Biology Consortium, Hood L, Doyle FJ, Yehuda R, Marmar CR, Jett M, Hammamieh R, Mellon SH, Wolkowitz OM
• Serum brain-derived neurotrophic factor remains elevated after long term follow-up of combat veterans with chronic post-traumatic stress disorder.
  Psychoneuroendocrinology 2021 Wu GWY, Wolkowitz OM, Reus VI, Kang JI, Elnar M, Sarwal R, Flory JD, Abu-Amara D, Hammamieh R, Gautam A, Doyle FJ, Yehuda R, Marmar CR, Jett M, Mellon SH, SBPBC
• Utilization of machine learning for identifying symptom severity military-related PTSD subtypes and their biological correlates.
  Translational psychiatry 2021 Siegel CE, Laska EM, Lin Z, Xu M, Abu-Amara D, Jeffers MK, Qian M, Milton N, Flory JD, Hammamieh R, Daigle BJ, Gautam A, Dean KR, Reus VI, Wolkowitz OM, Mellon SH, Ressler KJ, Yehuda R, Wang K, Hood L…
• "GrimAge," an epigenetic predictor of mortality, is accelerated in major depressive disorder.
  Translational psychiatry 2021 Protsenko E, Yang R, Nier B, Reus V, Hammamieh R, Rampersaud R, Wu GWY, Hough CM, Epel E, Prather AA, Jett M, Gautam A, Mellon SH, Wolkowitz OM
• Epigenetic biotypes of post-traumatic stress disorder in war-zone exposed veteran and active duty males.
  Molecular psychiatry 2020 Yang R, Gautam A, Getnet D, Daigle BJ, Miller S, Misganaw B, Dean KR, Kumar R, Muhie S, Wang K, Lee I, Abu-Amara D, Flory JD, PTSD Systems Biology Consortium, Hood L, Wolkowitz OM, Mellon SH, Doyle FJ…
• Pre-deployment risk factors for PTSD in active-duty personnel deployed to Afghanistan: a machine-learning approach for analyzing multivariate predictors.
  Molecular psychiatry 2020 Schultebraucks K, Qian M, Abu-Amara D, Dean K, Laska E, Siegel C, Gautam A, Guffanti G, Hammamieh R, Misganaw B, Mellon SH, Wolkowitz OM, Blessing EM, Etkin A, Ressler KJ, Doyle FJ, Jett M, Marmar CR
• Pre-treatment allostatic load and metabolic dysregulation predict SSRI response in major depressive disorder: a preliminary report.
  Psychological medicine 2020 Hough CM, Bersani FS, Mellon SH, Morford AE, Lindqvist D, Reus VI, Epel ES, Wolkowitz OM
• A DNA methylation clock associated with age-related illnesses and mortality is accelerated in men with combat PTSD.
  Molecular psychiatry 2020 Yang R, Wu GWY, Verhoeven JE, Gautam A, Reus VI, Kang JI, Flory JD, Abu-Amara D, PTSD Systems Biology Consortium, Hood L, Doyle FJ, Yehuda R, Marmar CR, Jett M, Hammamieh R, Mellon SH, Wolkowitz OM
• Role of enhanced glucocorticoid receptor sensitivity in inflammation in PTSD: insights from computational model for circadian-neuroendocrine-immune interactions.
  American journal of physiology. Endocrinology and metabolism 2020 Somvanshi PR, Mellon SH, Yehuda R, Flory JD, Makotkine I, Bierer L, Marmar C, Jett M, Doyle FJ
• Effect of Combat Exposure and Posttraumatic Stress Disorder on Telomere Length and Amygdala Volume.
  Biological psychiatry. Cognitive neuroscience and neuroimaging 2020 Kang JI, Mueller SG, Wu GWY, Lin J, Ng P, Yehuda R, Flory JD, Abu-Amara D, Reus VI, Gautam A, PTSD Systems Biology Consortium, Hammamieh R, Doyle FJ, Jett M, Marmar CR, Mellon SH, Wolkowitz OM
• Vitamin D and inflammation in major depressive disorder.
  Journal of affective disorders 2020 Grudet C, Wolkowitz OM, Mellon SH, Malm J, Reus VI, Brundin L, Nier BM, Dhabhar FS, Hough CM, Westrin Å, Lindqvist D
• Novel Pharmacological Targets for Combat PTSD-Metabolism, Inflammation, The Gut Microbiome, and Mitochondrial Dysfunction.
  Military medicine 2020 Bersani FS, Mellon SH, Lindqvist D, Kang JI, Rampersaud R, Somvanshi PR, Doyle FJ, Hammamieh R, Jett M, Yehuda R, Marmar CR, Wolkowitz OM
• Multi-omic biomarker identification and validation for diagnosing warzone-related post-traumatic stress disorder.
  Molecular psychiatry 2019 Dean KR, Hammamieh R, Mellon SH, Abu-Amara D, Flory JD, Guffanti G, Wang K, Daigle BJ, Gautam A, Lee I, Yang R, Almli LM, Bersani FS, Chakraborty N, Donohue D, Kerley K, Kim TK, Laska E, Young Lee M, …
• Accelerated aging in serious mental disorders.
  Current opinion in psychiatry 2019 Bersani FS, Mellon SH, Reus VI, Wolkowitz OM
• Cortisol, moderated by age, is associated with antidepressant treatment outcome and memory improvement in Major Depressive Disorder: A retrospective analysis.
  Psychoneuroendocrinology 2019 Jain FA, Connolly CG, Reus VI, Meyerhoff DJ, Yang TT, Mellon SH, Mackin S, Hough CM, Morford A, Wolkowitz OM
• Mechanistic inferences on metabolic dysfunction in posttraumatic stress disorder from an integrated model and multiomic analysis: role of glucocorticoid receptor sensitivity.
  American journal of physiology. Endocrinology and metabolism 2019 Somvanshi PR, Mellon SH, Flory JD, Abu-Amara D, PTSD Systems Biology Consortium;, Wolkowitz OM, Yehuda R, Jett M, Hood L, Marmar C, Doyle FJ
• Accelerating research on biological aging and mental health: Current challenges and future directions.
  Psychoneuroendocrinology 2019 Han LKM, Verhoeven JE, Tyrka AR, Penninx BWJH, Wolkowitz OM, Månsson KNT, Lindqvist D, Boks MP, Révész D, Mellon SH, Picard M
• Metabolomic analysis of male combat veterans with post traumatic stress disorder.
  PloS one 2019 Mellon SH, Bersani FS, Lindqvist D, Hammamieh R, Donohue D, Dean K, Jett M, Yehuda R, Flory J, Reus VI, Bierer LM, Makotkine I, Abu Amara D, Henn Haase C, Coy M, Doyle FJ, Marmar C, Wolkowitz OM
• Low serum brain-derived neurotrophic factor is associated with suicidal ideation in major depressive disorder.
  Psychiatry research 2019 Khan MS, Wu GWY, Reus VI, Hough CM, Lindqvist D, Westrin Å, Nier BM, Wolkowitz OM, Mellon SH
• Epigenetic Age in Male Combat-Exposed War Veterans: Associations with Posttraumatic Stress Disorder Status.
  Molecular neuropsychiatry 2018 Verhoeven JE, Yang R, Wolkowitz OM, Bersani FS, Lindqvist D, Mellon SH, Yehuda R, Flory JD, Lin J, Abu-Amara D, Makotkine I, Marmar C, Jett M, Hammamieh R
• Posttraumatic stress disorder, symptoms, and white matter abnormalities among combat-exposed veterans.
  Brain imaging and behavior 2018 Aschbacher K, Mellon SH, Wolkowitz OM, Henn-Haase C, Yehuda R, Flory JD, Bierer LM, Abu-Amara D, Marmar CR, Mueller SG
• Metabolism, Metabolomics, and Inflammation in Posttraumatic Stress Disorder.
  Biological psychiatry 2018 Mellon SH, Gautam A, Hammamieh R, Jett M, Wolkowitz OM
• Circulating cell-free mitochondrial DNA, but not leukocyte mitochondrial DNA copy number, is elevated in major depressive disorder.
  Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 2018 Lindqvist D, Wolkowitz OM, Picard M, Ohlsson L, Bersani FS, Fernström J, Westrin Å, Hough CM, Lin J, Reus VI, Epel ES, Mellon SH
• Increased circulating blood cell counts in combat-related PTSD: Associations with inflammation and PTSD severity.
  Psychiatry research 2017 Lindqvist D, Mellon SH, Dhabhar FS, Yehuda R, Grenon SM, Flory JD, Bierer LM, Abu-Amara D, Coy M, Makotkine I, Reus VI, Aschbacher K, Bersani FS, Marmar CR, Wolkowitz OM
• Whole-genome DNA methylation status associated with clinical PTSD measures of OIF/OEF veterans.
  Translational psychiatry 2017 Hammamieh R, Chakraborty N, Gautam A, Muhie S, Yang R, Donohue D, Kumar R, Daigle BJ, Zhang Y, Amara DA, Miller SA, Srinivasan S, Flory J, Yehuda R, Petzold L, Wolkowitz OM, Mellon SH, Hood L, Doyle …
• Telomere length is inversely correlated with urinary stress hormone levels in healthy controls but not in un-medicated depressed individuals-preliminary findings.
  Journal of psychosomatic research 2017 Fair B, Mellon SH, Epel ES, Lin J, Révész D, Verhoeven JE, Penninx BW, Reus VI, Rosser R, Hough CM, Mahan L, Burke HM, Blackburn EH, Wolkowitz OM
• Severity of anxiety- but not depression- is associated with oxidative stress in Major Depressive Disorder.
  Journal of affective disorders 2017 Steenkamp LR, Hough CM, Reus VI, Jain FA, Epel ES, James SJ, Morford AE, Mellon SH, Wolkowitz OM, Lindqvist D
• Biological predictors of insulin resistance associated with posttraumatic stress disorder in young military veterans.
  Psychoneuroendocrinology 2017 Blessing EM, Reus V, Mellon SH, Wolkowitz OM, Flory JD, Bierer L, Lindqvist D, Dhabhar F, Li M, Qian M, Abu-Amara D, Galatzer-Levy I, Yehuda R, Marmar CR
• Higher serum DHEA concentrations before and after SSRI treatment are associated with remission of major depression.
  Psychoneuroendocrinology 2016 Hough CM, Lindqvist D, Epel ES, Denis MS, Reus VI, Bersani FS, Rosser R, Mahan L, Burke HM, Wolkowitz OM, Mellon SH
• Oxidative stress, inflammation and treatment response in major depression.
  Psychoneuroendocrinology 2016 Lindqvist D, Dhabhar FS, James SJ, Hough CM, Jain FA, Bersani FS, Reus VI, Verhoeven JE, Epel ES, Mahan L, Rosser R, Wolkowitz OM, Mellon SH
• Increased pro-inflammatory milieu in combat related PTSD - A new cohort replication study.
  Brain, behavior, and immunity 2016 Lindqvist D, Dhabhar FS, Mellon SH, Yehuda R, Grenon SM, Flory JD, Bierer LM, Abu-Amara D, Coy M, Makotkine I, Reus VI, Bersani FS, Marmar CR, Wolkowitz OM
• Cortisol/DHEA ratio and hippocampal volume: A pilot study in major depression and healthy controls.
  Psychoneuroendocrinology 2016 Jin RO, Mason S, Mellon SH, Epel ES, Reus VI, Mahan L, Rosser RL, Hough CM, Burke HM, Mueller SG, Wolkowitz OM
• Leukocyte telomere length predicts SSRI response in major depressive disorder: A preliminary report.
  Molecular neuropsychiatry 2016 Hough CM, Bersani FS, Mellon SH, Epel ES, Reus VI, Lindqvist D, Lin J, Mahan L, Rosser R, Burke H, Coetzee J, Nelson JC, Blackburn EH, Wolkowitz OM
• Alterations in leukocyte transcriptional control pathway activity associated with major depressive disorder and antidepressant treatment.
  Translational psychiatry 2016 Mellon SH, Wolkowitz OM, Schonemann MD, Epel ES, Rosser R, Burke HB, Mahan L, Reus VI, Stamatiou D, Liew CC, Cole SW
• A population of atypical CD56(-)CD16(+) natural killer cells is expanded in PTSD and is associated with symptom severity.
  Brain, behavior, and immunity 2016 Bersani FS, Wolkowitz OM, Milush JM, Sinclair E, Eppling L, Aschbacher K, Lindqvist D, Yehuda R, Flory J, Bierer LM, Matokine I, Abu-Amara D, Reus VI, Coy M, Hough CM, Marmar CR, Mellon SH
• Neuroscience-informed Auditory Training in Schizophrenia: A Final Report of the Effects on Cognition and Serum Brain-Derived Neurotrophic Factor.
  Schizophrenia research. Cognition 2016 Fisher M, Mellon SH, Wolkowitz O, Vinogradov S
• Association of dimensional psychological health measures with telomere length in male war veterans.
  Journal of affective disorders 2015 Bersani FS, Lindqvist D, Mellon SH, Epel ES, Yehuda R, Flory J, Henn-Hasse C, Bierer LM, Makotkine I, Abu-Amara D, Coy M, Reus VI, Lin J, Blackburn EH, Marmar C, Wolkowitz OM
• Global arginine bioavailability, a marker of nitric oxide synthetic capacity, is decreased in PTSD and correlated with symptom severity and markers of inflammation.
  Brain, behavior, and immunity 2015 Bersani FS, Wolkowitz OM, Lindqvist D, Yehuda R, Flory J, Bierer LM, Makotine I, Abu-Amara D, Coy M, Reus VI, Epel ES, Marmar C, Mellon SH
• Evidence for disrupted gray matter structural connectivity in posttraumatic stress disorder.
  Psychiatry research 2015 Mueller SG, Ng P, Neylan T, Mackin S, Wolkowitz O, Mellon S, Yan X, Flory J, Yehuda R, Marmar CR, Weiner MW
• Telomerase activation as a possible mechanism of action for psychopharmacological interventions.
  Drug discovery today 2015 Bersani FS, Lindqvist D, Mellon SH, Penninx BW, Verhoeven JE, Révész D, Reus VI, Wolkowitz OM
• Mitochondrial DNA copy number is reduced in male combat veterans with PTSD.
  Progress in neuro-psychopharmacology & biological psychiatry 2015 Bersani FS, Morley C, Lindqvist D, Epel ES, Picard M, Yehuda R, Flory J, Bierer LM, Makotkine I, Abu-Amara D, Coy M, Reus VI, Lin J, Blackburn EH, Marmar C, Wolkowitz OM, Mellon SH
• Psychiatric disorders and leukocyte telomere length: Underlying mechanisms linking mental illness with cellular aging.
  Neuroscience and biobehavioral reviews 2015 Lindqvist D, Epel ES, Mellon SH, Penninx BW, Révész D, Verhoeven JE, Reus VI, Lin J, Mahan L, Hough CM, Rosser R, Bersani FS, Blackburn EH, Wolkowitz OM
• PBMC telomerase activity, but not leukocyte telomere length, correlates with hippocampal volume in major depression.
  Psychiatry research 2015 Wolkowitz OM, Mellon SH, Lindqvist D, Epel ES, Blackburn EH, Lin J, Reus VI, Burke H, Rosser R, Mahan L, Mackin S, Yang T, Weiner M, Mueller S
• Peripheral antioxidant markers are associated with total hippocampal and CA3/dentate gyrus volume in MDD and healthy controls-preliminary findings.
  Psychiatry research 2014 Lindqvist D, Mueller S, Mellon SH, Su Y, Epel ES, Reus VI, Rosser R, Mahan L, Mackin RS, Yang TT, Wolkowitz OM
• Adverse childhood experiences and leukocyte telomere maintenance in depressed and healthy adults.
  Journal of affective disorders 2014 Chen SH, Epel ES, Mellon SH, Lin J, Reus VI, Rosser R, Kupferman E, Burke H, Mahan L, Blackburn EH, Wolkowitz OM
• Proinflammatory milieu in combat-related PTSD is independent of depression and early life stress.
  Brain, behavior, and immunity 2014 Lindqvist D, Wolkowitz OM, Mellon S, Yehuda R, Flory JD, Henn-Haase C, Bierer LM, Abu-Amara D, Coy M, Neylan TC, Makotkine I, Reus VI, Yan X, Taylor NM, Marmar CR, Dhabhar FS
• Dysregulated relationship of inflammation and oxidative stress in major depression.
  Brain, behavior, and immunity 2012 Rawdin BJ, Mellon SH, Dhabhar FS, Epel ES, Puterman E, Su Y, Burke HM, Reus VI, Rosser R, Hamilton SP, Nelson JC, Wolkowitz OM
• A culture system to study oligodendrocyte myelination processes using engineered nanofibers.
  Nature methods 2012 Lee S, Leach MK, Redmond SA, Chong SY, Mellon SH, Tuck SJ, Feng ZQ, Corey JM, Chan JR
• Expression of P450c17 in the human fetal nervous system.
  Endocrinology 2012 Schonemann MD, Muench MO, Tee MK, Miller WL, Mellon SH
• Oligogenesis and oligodendrocyte progenitor maturation vary in different brain regions and partially correlate with local angiogenesis after ischemic stroke.
  Translational stroke research 2011 Jiang L, Shen F, Degos V, Schonemann M, Pleasure SJ, Mellon SH, Young WL, Su H
• Serum BDNF levels before treatment predict SSRI response in depression.
  Progress in neuro-psychopharmacology & biological psychiatry 2011 Wolkowitz OM, Wolf J, Shelly W, Rosser R, Burke HM, Lerner GK, Reus VI, Nelson JC, Epel ES, Mellon SH
• Leukocyte telomere length in major depression: correlations with chronicity, inflammation and oxidative stress--preliminary findings.
  PloS one 2011 Wolkowitz OM, Mellon SH, Epel ES, Lin J, Dhabhar FS, Su Y, Reus VI, Rosser R, Burke HM, Kupferman E, Compagnone M, Nelson JC, Blackburn EH
• Resting leukocyte telomerase activity is elevated in major depression and predicts treatment response.
  Molecular psychiatry 2011 Wolkowitz OM, Mellon SH, Epel ES, Lin J, Reus VI, Rosser R, Burke H, Compagnone M, Nelson JC, Dhabhar FS, Blackburn EH
• Of sound mind and body: depression, disease, and accelerated aging.
  Dialogues in clinical neuroscience 2011 Wolkowitz OM, Reus VI, Mellon SH
• Estrogen receptor beta-selective agonists stimulate calcium oscillations in human and mouse embryonic stem cell-derived neurons.
  PloS one 2010 Zhang L, Blackman BE, Schonemann MD, Zogovic-Kapsalis T, Pan X, Tagliaferri M, Harris HA, Cohen I, Pera RA, Mellon SH, Weiner RI, Leitman DC
• Serum brain-derived neurotrophic factor predicts responses to escitalopram in chronic posttraumatic stress disorder.
  Progress in neuro-psychopharmacology & biological psychiatry 2010 Berger W, Mehra A, Lenoci M, Metzler TJ, Otte C, Tarasovsky G, Mellon SH, Wolkowitz OM, Marmar CR, Neylan TC
• Depression gets old fast: do stress and depression accelerate cell aging?
  Depression and anxiety 2010 Wolkowitz OM, Epel ES, Reus VI, Mellon SH
• Analyses and comparisons of telomerase activity and telomere length in human T and B cells: insights for epidemiology of telomere maintenance.
  Journal of immunological methods 2009 Lin J, Epel E, Cheon J, Kroenke C, Sinclair E, Bigos M, Wolkowitz O, Mellon S, Blackburn E
• Low serum IL-10 concentrations and loss of regulatory association between IL-6 and IL-10 in adults with major depression.
  Journal of psychiatric research 2009 Dhabhar FS, Burke HM, Epel ES, Mellon SH, Rosser R, Reus VI, Wolkowitz OM
• Is serum brain-derived neurotrophic factor a biomarker for cognitive enhancement in schizophrenia?
  Biological psychiatry 2009 Vinogradov S, Fisher M, Holland C, Shelly W, Wolkowitz O, Mellon SH
• Neurobiological and neuropsychiatric effects of dehydroepiandrosterone (DHEA) and DHEA sulfate (DHEAS).
  Frontiers in neuroendocrinology 2008 Maninger N, Wolkowitz OM, Reus VI, Epel ES, Mellon SH
• Regulation of P450c17 expression in the early embryo depends on GATA factors.
  Endocrinology 2008 Shi Y, Schonemann MD, Mellon SH
• Oxidative stress in NPC1 deficient cells: protective effect of allopregnanolone.
  Journal of cellular and molecular medicine 2008 Zampieri S, Mellon SH, Butters TD, Nevyjel M, Covey DF, Bembi B, Dardis A
• When blue turns to grey: do stress and depression accelerate cell aging?
  The world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry 2008 Wolkowitz OM, Epel ES, Mellon S
• Neurosteroid regulation of central nervous system development.
  Pharmacology & therapeutics 2007 Mellon SH
• Endogenous and synthetic neurosteroids in treatment of Niemann-Pick Type C disease.
  Brain research reviews 2007 Mellon SH, Gong W, Schonemann MD
• Translin coactivates steroidogenic factor-1-stimulated transcription.
  Molecular endocrinology (Baltimore, Md.) 2006 Mellon SH, Bair SR, Depoix C, Vigne JL, Hecht NB, Brake PB
• Pregnane X receptor (PXR) activation: a mechanism for neuroprotection in a mouse model of Niemann-Pick C disease.
  Proceedings of the National Academy of Sciences of the United States of America 2006 Langmade SJ, Gale SE, Frolov A, Mohri I, Suzuki K, Mellon SH, Walkley SU, Covey DF, Schaffer JE, Ory DS
• DNA sequence-dependent regulation of SF-1-mediated transcription.
  DNA and cell biology 2005 Brake PB, Bair SR, Mellon SH
• Niemann pick type C disease as a model for defects in neurosteroidogenesis.
  Endocrine research 2004 Mellon S, Gong W, Griffin LD
• Niemann-Pick type C disease involves disrupted neurosteroidogenesis and responds to allopregnanolone.
  Nature medicine 2004 Griffin LD, Gong W, Verot L, Mellon SH
• Deletion of the mouse P450c17 gene causes early embryonic lethality.
  Molecular and cellular biology 2004 Bair SR, Mellon SH
• The Endocrine Society Ethics Advisory Committee: ethical aspects of conflicts of interests, October 2003.
  Endocrinology 2004 Komesaroff PA, Bach MA, Danoff A, Grumbach MM, Kaplan S, Lakoski JM, Leitman D, Mellon S, Underwood LE, Leupen S, Endocrine Society Ethics Advisory Committee
• Molecular mechanism of suppression of testicular steroidogenesis by proinflammatory cytokine tumor necrosis factor alpha.
  Molecular and cellular biology 2004 Hong CY, Park JH, Ahn RS, Im SY, Choi HS, Soh J, Mellon SH, Lee K
• Transcriptional regulation of P450scc gene expression in the embryonic rodent nervous system.
  Endocrinology 2003 Hammer F, Compagnone NA, Vigne JL, Bair SR, Mellon SH
• Synthesis, regulation, and function of neurosteroids.
  Endocrine research 2002 Mellon SH, Griffin LD
• Dietary phosphorus transcriptionally regulates 25-hydroxyvitamin D-1alpha-hydroxylase gene expression in the proximal renal tubule.
  Endocrinology 2002 Zhang MY, Wang X, Wang JT, Compagnone NA, Mellon SH, Olson JL, Tenenhouse HS, Miller WL, Portale AA
• Neurosteroids: biochemistry and clinical significance.
  Trends in endocrinology and metabolism: TEM 2002 Mellon SH, Griffin LD
• Biosynthesis and action of neurosteroids.
  Brain research. Brain research reviews 2001 Mellon SH, Griffin LD, Compagnone NA
• Biosynthesis of the neurosteroid 3 alpha-hydroxy-4-pregnen-20-one (3 alpha hp), a specific inhibitor of FSH release.
  Endocrinology 2001 Griffin LD, Mellon SH
• Developmental gonadal expression of the transcription factor SET and its target gene, P450c17 (17alpha-hydroxylase/c17,20 lyase).
  DNA and cell biology 2001 Zhang P, Compagnone NA, Fiore C, Vigne JL, Culp P, Musci TJ, Mellon SH
• Regulation of uterine gamma-aminobutyric acid(A) receptor subunit expression throughout pregnancy.
  Endocrinology 2001 Fujii E, Mellon SH
• Opposing early inhibitory and late stimulatory effects of insulin-like growth factor-I on myogenin gene transcription.
  Journal of cellular biochemistry 2000 Adi S, Cheng ZQ, Zhang PL, Wu NY, Mellon SH, Rosenthal SM
• Novel role for the nuclear phosphoprotein SET in transcriptional activation of P450c17 and initiation of neurosteroidogenesis.
  Molecular endocrinology (Baltimore, Md.) 2000 Compagnone NA, Zhang P, Vigne JL, Mellon SH
• Autocrine and paracrine Müllerian inhibiting substance hormone signaling in reproduction.
  Recent progress in hormone research 2000 Ingraham HA, Hirokawa Y, Roberts LM, Mellon SH, McGee E, Nachtigal MW, Visser JA
• Neurosteroids: biosynthesis and function of these novel neuromodulators.
  Frontiers in neuroendocrinology 2000 Compagnone NA, Mellon SH
• Selective serotonin reuptake inhibitors directly alter activity of neurosteroidogenic enzymes.
  Proceedings of the National Academy of Sciences of the United States of America 1999 Griffin LD, Mellon SH
• Ku autoimmune antigen is involved in placental regulation of rat P450c17 gene transcription.
  DNA and cell biology 1999 Zhang P, Hammer F, Bair S, Wang J, Reeves WH, Mellon SH
• Orphan receptors, proto-oncogenes and other nuclear factors regulate P450C17 gene transcription.
  Endocrine research 1998 Mellon SH, Compagnone NA, Zhang P
• 25-Hydroxycholesterol is not a ligand for the orphan nuclear receptor steroidogenic factor-1 (SF-1).
  Endocrinology 1998 Mellon SH, Bair SR
• Dehydroepiandrosterone: a potential signalling molecule for neocortical organization during development.
  Proceedings of the National Academy of Sciences of the United States of America 1998 Compagnone NA, Mellon SH
• Polyribonucleotide phosphorylase is a double-stranded DNA-binding protein.
  DNA and cell biology 1998 Zhang P, Vigne JL, Mellon SH
• Expression of steroid sulfatase during embryogenesis.
  Endocrinology 1997 Compagnone NA, Salido E, Shapiro LJ, Mellon SH
• Multiple orphan nuclear receptors converge to regulate rat P450c17 gene transcription: novel mechanisms for orphan nuclear receptor action.
  Molecular endocrinology (Baltimore, Md.) 1997 Zhang P, Mellon SH
• Characterization of adrenocortical cell lines produced by genetically targeted tumorigenesis in transgenic mice.
  Steroids 1997 Compagnone NA, Bair SR, Mellon SH
• The testis and the adrenal are (transcriptionally) the same.
  Steroids 1997 Mellon SH, Zhang P
• Enzymatic properties of transplanted glomerulosa cells.
  World journal of surgery 1996 Scheumann GF, Heitmann P, Teebken OE, Mössinger E, Mellon SH, Pichlmayr R
• Cytochrome P450 17 alpha-hydroxylase gene expression in differentiating rat trophoblast cells.
  The Journal of endocrinology 1996 Yamamoto T, Chapman BM, Johnson DC, Givens CR, Mellon SH, Soares MJ
• Expression of the gene for cytochrome P-450 17 alpha-hydroxylase/C17-20 lyase (CYP17) in porcine Leydig cells: identification of a DNA sequence that mediates cAMP response.
  Biochimica et biophysica acta 1996 Zhang P, Han XG, Mellon SH, Hall PF
• The orphan nuclear receptor steroidogenic factor-1 regulates the cyclic adenosine 3',5'-monophosphate-mediated transcriptional activation of rat cytochrome P450c17 (17 alpha-hydroxylase/c17-20 lyase).
  Molecular endocrinology (Baltimore, Md.) 1996 Zhang P, Mellon SH
• Steroidogenic enzyme P450c17 is expressed in the embryonic central nervous system.
  Endocrinology 1995 Compagnone NA, Bulfone A, Rubenstein JL, Mellon SH
• Transcriptional regulation of P450scc gene expression in neural and steroidogenic cells: implications for regulation of neurosteroidogenesis.
  Molecular endocrinology (Baltimore, Md.) 1995 Zhang P, Rodriguez H, Mellon SH
• Targeted ablation of pituitary pre-proopiomelanocortin cells by herpes simplex virus-1 thymidine kinase differentially regulates mRNAs encoding the adrenocorticotropin receptor and aldosterone synthase in the mouse adrenal gland.
  Molecular endocrinology (Baltimore, Md.) 1995 Allen RG, Carey C, Parker JD, Mortrud MT, Mellon SH, Low MJ
• Molecular variants in the P450c11AS gene as determinants of aldosterone synthase activity in the Dahl rat model of hypertension.
  The Journal of biological chemistry 1995 Cover CM, Wang JM, St Lezin E, Kurtz TW, Mellon SH
• Chronic dexamethasone treatment suppresses hypertension development in the transgenic rat TGR(mREN2)27.
  Journal of hypertension 1995 Djavidani B, Sander M, Kreutz R, Zeh K, Bader M, Mellon SH, Vecsei P, Peters J, Ganten D
• Expression of the steroidogenic enzyme P450scc in the central and peripheral nervous systems during rodent embryogenesis.
  Endocrinology 1995 Compagnone NA, Bulfone A, Rubenstein JL, Mellon SH
• Artificial mutations in P450c11AS (aldosterone synthase) can increase enzymatic activity: a model for low-renin hypertension?
  The Journal of clinical endocrinology and metabolism 1995 Fardella CE, Rodriguez H, Hum DW, Mellon SH, Miller WL
• P450c11B3 mRNA, transcribed from a third P450c11 gene, is expressed in a tissue-specific, developmentally, and hormonally regulated fashion in the rodent adrenal and encodes a protein with both 11-hydroxylase and 18-hydroxylase activities.
  The Journal of biological chemistry 1995 Mellon SH, Bair SR, Monis H
• Prenatal diagnosis of congenital lipoid adrenal hyperplasia.
  The Journal of clinical endocrinology and metabolism 1995 Saenger P, Klonari Z, Black SM, Compagnone N, Mellon SH, Fleischer A, Abrams CA, Shackelton CH, Miller WL
• Rodent models for studying steroids and hypertension: from fetal development to cells in culture.
  Steroids 1995 Mellon SH, Compagnone N, Sander M, Cover C, Ganten D, Djavidani B
• Transcriptional regulation of rat cytochrome P450c17 expression in mouse Leydig MA-10 and adrenal Y-1 cells: identification of a single protein that mediates both basal and cAMP-induced activities.
  DNA and cell biology 1994 Givens CR, Zhang P, Bair SR, Mellon SH
• Neurosteroids: biochemistry, modes of action, and clinical relevance.
  The Journal of clinical endocrinology and metabolism 1994 Mellon SH
• Role of adrenal renin in the regulation of adrenal steroidogenesis by corticotropin.
  Proceedings of the National Academy of Sciences of the United States of America 1994 Sander M, Ganten D, Mellon SH
• Steroidogenic adrenocortical cell lines produced by genetically targeted tumorigenesis in transgenic mice.
  Molecular endocrinology (Baltimore, Md.) 1994 Mellon SH, Miller WL, Bair SR, Moore CC, Vigne JL, Weiner RI
• Neurosteroid biosynthesis: genes for adrenal steroidogenic enzymes are expressed in the brain.
  Brain research 1993 Mellon SH, Deschepper CF
• Structure and function of the hepatic form of 11 beta-hydroxysteroid dehydrogenase in the squirrel monkey, an animal model of glucocorticoid resistance.
  Endocrinology 1993 Moore CC, Mellon SH, Murai J, Siiteri PK, Miller WL
• Tenascin-X: a novel extracellular matrix protein encoded by the human XB gene overlapping P450c21B.
  The Journal of cell biology 1993 Bristow J, Tee MK, Gitelman SE, Mellon SH, Miller WL
• Mitogenic action, regulation, and localization of insulin-like growth factors in the human fetal adrenal gland.
  The Journal of clinical endocrinology and metabolism 1993 Mesiano S, Mellon SH, Jaffe RB
• Basic fibroblast growth factor expression is regulated by corticotropin in the human fetal adrenal: a model for adrenal growth regulation.
  Proceedings of the National Academy of Sciences of the United States of America 1991 Mesiano S, Mellon SH, Gospodarowicz D, Di Blasio AM, Jaffe RB
• Expression and regulation of adrenodoxin and P450scc mRNA in rodent tissues.
  DNA and cell biology 1991 Mellon SH, Kushner JA, Vaisse C
• Zone-specific regulation of two messenger RNAs for P450c11 in the adrenals of pregnant and nonpregnant rats.
  Proceedings of the National Academy of Sciences of the United States of America 1991 Malee MP, Mellon SH
• Human proopiomelanocortin-(79-96), a proposed androgen stimulatory hormone, does not affect steroidogenesis in cultured human fetal adrenal cells.
  The Journal of clinical endocrinology and metabolism 1991 Mellon SH, Shively JE, Miller WL
• Tissue-specific, cyclic adenosine 3',5'-monophosphate-induced, and phorbol ester-repressed transcription from the human P450c17 promoter in mouse cells.
  Molecular endocrinology (Baltimore, Md.) 1990 Brentano ST, Picado-Leonard J, Mellon SH, Moore CC, Miller WL
• Effect of extracellular matrix on prolactin secretion and mRNA accumulation in GH3 cells.
  DNA and cell biology 1990 Elias KA, Weiner RI, Mellon SH
• Extraadrenal steroid 21-hydroxylation is not mediated by P450c21.
  The Journal of clinical investigation 1989 Mellon SH, Miller WL
• cAMP regulates P450scc gene expression by a cycloheximide-insensitive mechanism in cultured mouse Leydig MA-10 cells.
  Proceedings of the National Academy of Sciences of the United States of America 1989 Mellon SH, Vaisse C
• Cell-specific expression of transfected brain identifier repetitive DNAs.
  Nucleic acids research 1988 Mellon SH, Baxter JD, Gutierrez-Hartmann A
• In situ hybridization identifies renin mRNA in the rat corpus luteum.
  Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology 1987 Lightman A, Deschepper CF, Mellon SH, Ganong WF, Naftolin F
• Interaction of a tissue-specific factor with an essential rat growth hormone gene promoter element.
  Molecular and cellular biology 1987 West BL, Catanzaro DF, Mellon SH, Cattini PA, Baxter JD, Reudelhuber TL
• Analysis by immunocytochemistry and in situ hybridization of renin and its mRNA in kidney, testis, adrenal, and pituitary of the rat.
  Proceedings of the National Academy of Sciences of the United States of America 1986 Deschepper CF, Mellon SH, Cumin F, Baxter JD, Ganong WF
• An approach to the molecular biology of congenital adrenal hyperplasia.
  Annals of the New York Academy of Sciences 1985 Chung BC, Matteson KJ, Morin JE, Mellon SH, Miller WL
• Expression and hormonal regulation of the rat growth hormone gene in transfected mouse L cells.
  DNA (Mary Ann Liebert, Inc.) 1984 Karin M, Eberhardt NL, Mellon SH, Malich N, Richards RI, Slater EP, Barta A, Martial JA, Baxter JD, Cathala G
• Growth hormone gene transcription is regulated by thyroid and glucocorticoid hormones in cultured rat pituitary tumor cells.
  The Journal of biological chemistry 1982 Spindler SR, Mellon SH, Baxter JD