Swetansu Hota, PhD
Visiting Scientist
Business Service Ctr
Chancellor/EVC/FAS

Awards

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• Distinguished Achievement in Science Award, Gladstone Institutes, 2020
• Career Advancement Award, Gladstone Institutes, 2018
• Poster Prize, UCSF/CVRI, 2018
• Solver award, Innocentive.com, 2003
• Initiative Award, AstraZeneca, 2002

Education & Training

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• PhD Biochemistry Southern Illinois University 2011
• Postdoc Developmental Biology, Genomics, Biochemistry Gladstone Institutes

Grants and Projects

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• Dissecting the function of BAF chromatin remodeling ATPases during cardiogenesis, American Heart Association, 2021-2024
• Dissecting the functions of cardiac specific BAF complexes in cardiac gene regulation, NIH, 2017-2018
• Chromatin remodellers Brg1 and Baf60c in heart development, Tobacco Related Disease Research Program, 2015-2016
• Molecular and genomic function of the chromatin remodeling factor Baf60c in heart development, American Heart Association, 2013-2015

Publications (16)

Top publication keywords:
Adenosine TriphosphatasesMyocytes, CardiacCell LineageDNA, FungalOrganogenesisChromatinMultiprotein ComplexesTranscription FactorsMesodermNucleosomesDNA HelicasesChromatin Assembly and DisassemblySaccharomyces cerevisiaeAdenosine TriphosphateProtein Subunits

• A disrupted compartment boundary underlies abnormal cardiac patterning and congenital heart defects.
  bioRxiv : the preprint server for biology 2024 Kathiriya IS, Dominguez MH, Rao KS, Muncie-Vasic JM, Devine WP, Hu KM, Hota SK, Garay BI, Quintero D, Goyal P, Matthews MN, Thomas R, Sukonnik T, Miguel-Perez D, Winchester S, Brower EF, Forjaz A, Wu …
• Brahma safeguards canalization of cardiac mesoderm differentiation.
  Nature 2022 Hota SK, Rao KS, Blair AP, Khalilimeybodi A, Hu KM, Thomas R, So K, Kameswaran V, Xu J, Polacco BJ, Desai RV, Chatterjee N, Hsu A, Muncie JM, Blotnick AM, Winchester SAB, Weinberger LS, Hüttenhain R, …
• Modeling Human TBX5 Haploinsufficiency Predicts Regulatory Networks for Congenital Heart Disease.
  Developmental cell 2020 Kathiriya IS, Rao KS, Iacono G, Devine WP, Blair AP, Hota SK, Lai MH, Garay BI, Thomas R, Gong HZ, Wasson LK, Goyal P, Sukonnik T, Hu KM, Akgun GA, Bernard LD, Akerberg BN, Gu F, Li K, Speir ML, …
• Dinucleosome specificity and allosteric switch of the ISW1a ATP-dependent chromatin remodeler in transcription regulation.
  Nature communications 2020 Bhardwaj SK, Hailu SG, Olufemi L, Brahma S, Kundu S, Hota SK, Persinger J, Bartholomew B
• Dynamic BAF chromatin remodeling complex subunit inclusion promotes temporally distinct gene expression programs in cardiogenesis.
  Development (Cambridge, England) 2019 Hota SK, Johnson JR, Verschueren E, Thomas R, Blotnick AM, Zhu Y, Sun X, Pennacchio LA, Krogan NJ, Bruneau BG

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• Histone Octamer Structure Is Altered Early in ISW2 ATP-Dependent Nucleosome Remodeling.
  Cell reports 2019 Hada A, Hota SK, Luo J, Lin YC, Kale S, Shaytan AK, Bhardwaj SK, Persinger J, Ranish J, Panchenko AR, Bartholomew B
• Cardiac-enriched BAF chromatin-remodeling complex subunit Baf60c regulates gene expression programs essential for heart development and function.
  Biology open 2018 Sun X, Hota SK, Zhou YQ, Novak S, Miguel-Perez D, Christodoulou D, Seidman CE, Seidman JG, Gregorio CC, Henkelman RM, Rossant J, Bruneau BG
• ATP-dependent chromatin remodeling during mammalian development.
  Development (Cambridge, England) 2016 Hota SK, Bruneau BG
• Brg1 modulates enhancer activation in mesoderm lineage commitment.
  Development (Cambridge, England) 2015 Alexander JM, Hota SK, He D, Thomas S, Ho L, Pennacchio LA, Bruneau BG
• ISWI remodelers slide nucleosomes with coordinated multi-base-pair entry steps and single-base-pair exit steps.
  Cell 2013 Deindl S, Hwang WL, Hota SK, Blosser TR, Prasad P, Bartholomew B, Zhuang X
• Nucleosome mobilization by ISW2 requires the concerted action of the ATPase and SLIDE domains.
  Nature structural & molecular biology 2013 Hota SK, Bhardwaj SK, Deindl S, Lin YC, Zhuang X, Bartholomew B
• Disparity in the DNA translocase domains of SWI/SNF and ISW2.
  Nucleic acids research 2012 Dechassa ML, Hota SK, Sen P, Chatterjee N, Prasad P, Bartholomew B
• Approaches for studying nucleosome movement by ATP-dependent chromatin remodeling complexes.
  Methods in molecular biology (Clifton, N.J.) 2012 Hota SK, Bartholomew B
• Mapping protein-DNA and protein-protein interactions of ATP-dependent chromatin remodelers.
  Methods in molecular biology (Clifton, N.J.) 2012 Hota SK, Dechassa ML, Prasad P, Bartholomew B
• An assay for exogenous sources of purified MurG, enabled by the complementation of Escherichia coli murG(Ts) by the Mycobacterium tuberculosis homologue.
  FEMS microbiology letters 2011 Jha RK, Katagihallimath N, Hota SK, Das KS, de Sousa SM
• Diversity of operation in ATP-dependent chromatin remodelers.
  Biochimica et biophysica acta 2011 Hota SK, Bartholomew B