Suzanne Noble, MD, PhD
Associate Professor
Microbiology and Immunology
School of Medicine

Education & Training

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• M.D. Medicine University of California, San Francisco 1997
• Ph.D. Graduate Division (Biochemistry) University of California, San Francisco 1995
• Postdoctoral Studies Graduate Division University of California, San Francisco

Websites

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• Profile at UCSF Biomedical Sciences (bms.ucsf.edu)

Grants and Projects

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• Treatment and Prevention of Systemic Candidiasis, NIH, 2016-2021
• Exploring Paneth Cell Peptide YY (PYY), a unique anti-microbial peptide that maintains fungal commensalism, in the pathogenesis of ileal Crohn?s Disease, NIH, 2017-2021
• Signals and switches for Candida albicans commensalism, NIH, 2013-2020
• Treatment and Prevention of Systemic Candidiasis, NIH, 2016-2018
• Comprehensive Biology: Exploiting the Yeast Genome, NIH, 1996-2016
• The Candida albicans commensal program, NIH, 2012-2015
• A Genetic Approach to Virulence in C. albicans, NIH, 2005-2010

Publications (31)

Top publication keywords:
VirulenceCandida albicansHyphaeFungal ProteinsSymbiosisInterleukin-17Gene Expression Regulation, FungalRNA SplicingCell PlasticityGastrointestinal TractCentromere Protein AGeneticsIn Situ Hybridization, FluorescenceGenes, FungalChromosome Segregation

• Peptide YY: A Paneth cell antimicrobial peptide that maintains Candida gut commensalism.
  Science (New York, N.Y.) 2023 Pierre JF, Peters BM, La Torre D, Sidebottom AM, Tao Y, Zhu X, Cham CM, Wang L, Kambal A, Harris KG, Silva JF, Zaborina O, Alverdy JC, Herzog H, Witchley J, Noble SM, Leone VA, Chang EB
• Multifactor transcriptional control of alternative oxidase induction integrates diverse environmental inputs to enable fungal virulence.
  Nature communications 2023 Liu Z, Basso P, Hossain S, Liston SD, Robbins N, Whitesell L, Noble SM, Cowen LE
• Ent2 Governs Morphogenesis and Virulence in Part through Regulation of the Cdc42 Signaling Cascade in the Fungal Pathogen Candida albicans.
  mBio 2023 Lash E, Prudent V, Stogios PJ, Savchenko A, Noble SM, Robbins N, Cowen LE
• Deep tissue infection by an invasive human fungal pathogen requires lipid-based suppression of the IL-17 response.
  Cell host & microbe 2022 Basso P, Dang EV, Urisman A, Cowen LE, Madhani HD, Noble SM
• Christine Guthrie (1945-2022).
  Science (New York, N.Y.) 2022 Noble S, Burgess SM, Strauss E

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• Candida albicans oscillating UME6 expression during intestinal colonization primes systemic Th17 protective immunity.
  Cell reports 2022 Shao TY, Kakade P, Witchley JN, Frazer C, Murray KL, Ene IV, Haslam DB, Hagan T, Noble SM, Bennett RJ, Way SS
• Leveraging machine learning essentiality predictions and chemogenomic interactions to identify antifungal targets.
  Nature communications 2021 Fu C, Zhang X, Veri AO, Iyer KR, Lash E, Xue A, Yan H, Revie NM, Wong C, Lin ZY, Polvi EJ, Liston SD, VanderSluis B, Hou J, Yashiroda Y, Gingras AC, Boone C, O'Meara TR, O'Meara MJ, Noble S, Robbins N…
• Adaptive immunity induces mutualism between commensal eukaryotes.
  Nature 2021 Ost KS, O'Meara TR, Stephens WZ, Chiaro T, Zhou H, Penman J, Bell R, Catanzaro JR, Song D, Singh S, Call DH, Hwang-Wong E, Hanson KE, Valentine JF, Christensen KA, O'Connell RM, Cormack B, Ibrahim AS,…
• Recording of DNA-binding events reveals the importance of a repurposed Candida albicans regulatory network for gut commensalism.
  Cell host & microbe 2021 Witchley JN, Basso P, Brimacombe CA, Abon NV, Noble SM
• Visualization of Candida albicans in the Murine Gastrointestinal Tract Using Fluorescent In Situ Hybridization.
  Journal of visualized experiments : JoVE 2019 Witchley JN, Penumetcha PM, Noble SM
• A natural histone H2A variant lacking the Bub1 phosphorylation site and regulated depletion of centromeric histone CENP-A foster evolvability in Candida albicans.
  PLoS biology 2019 Brimacombe CA, Burke JE, Parsa JY, Catania S, O'Meara TR, Witchley JN, Burrack LS, Madhani HD, Noble SM
• Candida albicans Morphogenesis Programs Control the Balance between Gut Commensalism and Invasive Infection.
  Cell host & microbe 2019 Witchley JN, Penumetcha P, Abon NV, Woolford CA, Mitchell AP, Noble SM
• High-Throughput Screening Identifies Genes Required for Candida albicans Induction of Macrophage Pyroptosis.
  mBio 2018 O'Meara TR, Duah K, Guo CX, Maxson ME, Gaudet RG, Koselny K, Wellington M, Powers ME, MacAlpine J, O'Meara MJ, Veri AO, Grinstein S, Noble SM, Krysan D, Gray-Owen SD, Cowen LE
• Genome-wide association and HLA region fine-mapping studies identify susceptibility loci for multiple common infections.
  Nature communications 2017 Tian C, Hromatka BS, Kiefer AK, Eriksson N, Noble SM, Tung JY, Hinds DA
• Candida albicans cell-type switching and functional plasticity in the mammalian host.
  Nature reviews. Microbiology 2016 Noble SM, Gianetti BA, Witchley JN
• Impact of a transposon insertion in phzF2 on the specialized metabolite production and interkingdom interactions of Pseudomonas aeruginosa.
  Journal of bacteriology 2014 Phelan VV, Moree WJ, Aguilar J, Cornett DS, Koumoutsi A, Noble SM, Pogliano K, Guerrero CA, Dorrestein PC
• Candida albicans specializations for iron homeostasis: from commensalism to virulence.
  Current opinion in microbiology 2013 Noble SM
• Passage through the mammalian gut triggers a phenotypic switch that promotes Candida albicans commensalism.
  Nature genetics 2013 Pande K, Chen C, Noble SM
• Post-transcriptional regulation of the Sef1 transcription factor controls the virulence of Candida albicans in its mammalian host.
  PLoS pathogens 2012 Chen C, Noble SM
• An iron homeostasis regulatory circuit with reciprocal roles in Candida albicans commensalism and pathogenesis.
  Cell host & microbe 2011 Chen C, Pande K, French SD, Tuch BB, Noble SM
• Systematic screens of a Candida albicans homozygous deletion library decouple morphogenetic switching and pathogenicity.
  Nature genetics 2010 Noble SM, French S, Kohn LA, Chen V, Johnson AD
• Genetics and molecular biology in Candida albicans.
  Methods in enzymology 2010 Hernday AD, Noble SM, Mitrovich QM, Johnson AD
• A phenotypic profile of the Candida albicans regulatory network.
  PLoS genetics 2009 Homann OR, Dea J, Noble SM, Johnson AD
• An RNA transport system in Candida albicans regulates hyphal morphology and invasive growth.
  PLoS genetics 2009 Elson SL, Noble SM, Solis NV, Filler SG, Johnson AD
• Systematic genetic analysis of virulence in the human fungal pathogen Cryptococcus neoformans.
  Cell 2008 Liu OW, Chun CD, Chow ED, Chen C, Madhani HD, Noble SM
• Genetics of Candida albicans, a diploid human fungal pathogen.
  Annual review of genetics 2007 Noble SM, Johnson AD
• Transcriptional response of Candida albicans to nitric oxide and the role of the YHB1 gene in nitrosative stress and virulence.
  Molecular biology of the cell 2005 Hromatka BS, Noble SM, Johnson AD
• Strains and strategies for large-scale gene deletion studies of the diploid human fungal pathogen Candida albicans.
  Eukaryotic cell 2005 Noble SM, Johnson AD
• Essential yeast protein with unexpected similarity to subunits of mammalian cleavage and polyadenylation specificity factor (CPSF).
  Science (New York, N.Y.) 1996 Chanfreau G, Noble SM, Guthrie C
• Transcriptional pulse-chase analysis reveals a role for a novel snRNP-associated protein in the manufacture of spliceosomal snRNPs.
  The EMBO journal 1996 Noble SM, Guthrie C
• Identification of novel genes required for yeast pre-mRNA splicing by means of cold-sensitive mutations.
  Genetics 1996 Noble SM, Guthrie C