Susanna Fryer, PhD
Associate Professor
Psychiatry
School of Medicine

Education & Training

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• PhD subfield: neuropsychology SDUS/UCSF Joint Doctoral Program in Clinical Psychology 2009
• Clinical Psychology Internship San Francisco VA Medical Center 2009
• B.A. Human Biology Stanford University 00

Grants and Projects

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• Reward processing and depressive subtypes: Identifying neural biotypes related to suicide risk, resilience, and treatment response, VA, 2020-2024
• Reward processing and depressive subtypes: Identifying neural biotypes related to suicide risk, resilience, and treatment response, NIH, 2020-2024
• Using electrophysiology to index non-invasive brain stimulation effects on reward system neurobiology in depression, NIH, 2021-2023
• Multimodal Neural Investigation of Reward Processing in Schizophrenia, NIH, 2014-2019
• Default mode connectivity in typical development & the schizophrenia prodrome, NIH, 2012-2014
• Brain Imaging in Fetal Alcohol Exposed Delinquents, NIH, 2005-2008

Publications (61)

Top publication keywords:
Prenatal Exposure Delayed EffectsCorpus CallosumConnectomeSchizophreniaFetal Alcohol Spectrum DisordersMindfulnessRewardTime PerceptionReaction TimePsychomotor PerformanceBrain WavesNeurobiologyAnticipation, PsychologicalPsychotic DisordersGambling

• 466. Reduced Visual Cortex Suppression During Reward Processing is Associated With Less Emotional Well-Being in Schizophrenia.
  Biological Psychiatry 2023 Susanna Fryer, Ken Lau, Samantha Abram, Spero Nicholas, Judith Ford, Daniel Mathalon
• Cortical and subcortical brain morphometry abnormalities in youth at clinical high-risk for psychosis and individuals with early illness schizophrenia.
  Psychiatry research. Neuroimaging 2023 Hua JPY, Loewy RL, Stuart B, Fryer SL, Niendam TA, Carter CS, Vinogradov S, Mathalon DH
• Rich-club connectivity and structural connectome organization in youth at clinical high-risk for psychosis and individuals with early illness schizophrenia.
  Schizophrenia research 2023 Hua JPY, Cummings J, Roach BJ, Fryer SL, Loewy RL, Stuart BK, Ford JM, Vinogradov S, Mathalon DH
• Alpha Event-Related Desynchronization During Reward Processing in Schizophrenia.
  Biological psychiatry. Cognitive neuroscience and neuroimaging 2023 Fryer SL, Marton TF, Roach BJ, Holroyd CB, Abram SV, Lau KJ, Ford JM, McQuaid JR, Mathalon DH
• Advanced brain age correlates with greater rumination and less mindfulness in schizophrenia.
  NeuroImage. Clinical 2022 Abram SV, Roach BJ, Hua JPY, Han LKM, Mathalon DH, Ford JM, Fryer SL

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• Dysfunctional Cortical Gradient Topography in Treatment-Resistant Major Depressive Disorder.
  Biological psychiatry. Cognitive neuroscience and neuroimaging 2022 Pasquini L, Fryer SL, Eisendrath SJ, Segal ZV, Lee AJ, Brown JA, Saggar M, Mathalon DH
• Validation of ketamine as a pharmacological model of thalamic dysconnectivity across the illness course of schizophrenia.
  Molecular psychiatry 2022 Abram SV, Roach BJ, Fryer SL, Calhoun VD, Preda A, van Erp TGM, Bustillo JR, Lim KO, Loewy RL, Stuart BK, Krystal JH, Ford JM, Mathalon DH
• Psychological Dimensions Relevant to Motivation and Pleasure in Schizophrenia.
  Frontiers in behavioral neuroscience 2022 Abram SV, Weittenhiller LP, Bertrand CE, McQuaid JR, Mathalon DH, Ford JM, Fryer SL
• Age affects temporal response, but not durability, to serial ketamine infusions for treatment refractory depression.
  Psychopharmacology 2021 Pennybaker S, Roach BJ, Fryer SL, Badathala A, Wallace AW, Mathalon DH, Marton TF
• Advanced Brain Age Corresponds With Increased Rumination and Decreased Mindfulness in Schizophrenia.
  Biological Psychiatry 2021 Samantha Abram, Brian Roach, Jessica Hua, Daniel Mathalon, Judith Ford, Susanna Fryer
• Cortical and Subcortical Brain Morphometry Abnormalities in Youth at Clinical High Risk for Psychosis and Individuals With Early Illness Schizophrenia.
  Biological Psychiatry 2021 Jessica Hua, Brian Roach, Susanna Fryer, Rachel Loewy, Sophia Vinogradov, Cameron Carter, Tara Niendam, Daniel Mathalon
• Response to targeted cognitive training may be neuroprotective in patients with early schizophrenia.
  Psychiatry research. Neuroimaging 2021 Ramsay IS, Fryer S, Roach BJ, Boos A, Fisher M, Loewy R, Ford JM, Vinogradov S, Mathalon DH
• Thalamic dysconnectivity in the psychosis risk syndrome and early illness schizophrenia.
  Psychological medicine 2021 Fryer SL, Ferri JM, Roach BJ, Loewy RL, Stuart BK, Anticevic A, Ford JM, Mathalon DH
• Electrophysiological investigation of reward anticipation and outcome evaluation during slot machine play.
  NeuroImage 2021 Fryer SL, Roach BJ, Holroyd CB, Paulus MP, Sargent K, Boos A, Ford JM, Mathalon DH
• Doubling Down on Developing Reward System Neurobiology Markers of Antidepressant Treatment Response.
  Biological psychiatry. Cognitive neuroscience and neuroimaging 2021 Fryer SL
• Reward processing electrophysiology in schizophrenia: Effects of age and illness phase.
  NeuroImage. Clinical 2020 Abram SV, Roach BJ, Holroyd CB, Paulus MP, Ford JM, Mathalon DH, Fryer SL
• Deficits in auditory predictive coding in individuals with the psychosis risk syndrome: Prediction of conversion to psychosis.
  Journal of abnormal psychology 2020 Fryer SL, Roach BJ, Hamilton HK, Bachman P, Belger A, Carrión RE, Duncan E, Johannesen J, Light GA, Niznikiewicz M, Addington J, Bearden CE, Cadenhead KS, Cannon TD, Cornblatt BA, McGlashan TH, …
• Deficits in Auditory Predictive Coding in Individuals With the Psychosis Risk Syndrome: Prediction of Conversion to Psychosis.
  Biological Psychiatry 2020 Susanna Fryer, Brian Roach, Holly Hamilton, Peter Bachman, Aysenil Belger, Ricardo Carrion, Erica Duncan, Jason Johannesen, Gregory Light, Margaret Niznikiewicz, Jean Addington, Carrie Bearden, …
• Reward Processing Electrophysiology in Schizophrenia Depends on Age and Illness Phase.
  Biological Psychiatry 2020 Samantha Abram, Brian Roach, Clay Holroyd, Martin Paulus, Judith Ford, Daniel Mathalon, Susanna Fryer
• Increased global cognition correlates with increased thalamo-temporal connectivity in response to targeted cognitive training for recent onset schizophrenia.
  Schizophrenia research 2020 Ramsay IS, Roach BJ, Fryer S, Fisher M, Loewy R, Ford JM, Vinogradov S, Mathalon DH
• O17. Mindfulness-Based Cognitive Therapy Modulates Functional Brain Activation During Affective Distraction in Treatment-Resistant Depression: A Randomized Controlled Study.
  Biological Psychiatry 2019 Susanna Fryer, Stuart Eisendrath, Zindel Segal, Brian Roach, Judith Ford, Daniel Mathalon, Erin Gillung
• O8.2. CHANGES IN FRONTAL AND TEMPORAL CORTICAL THICKNESS CORRELATE WITH GLOBAL COGNITIVE CHANGES FOLLOWING TARGETED COGNITIVE TRAINING IN SCHIZOPHRENIA.
  Schizophrenia Bulletin 2019 Ian Ramsay, Susanna Fryer, Brian Roach, Alison Boos, Melissa Fisher, Rachel Loewy, Judith Ford, Sophia Vinogradov, Daniel Mathalon
• Should I Stay or Should I Go? FMRI Study of Response Inhibition in Early Illness Schizophrenia and Risk for Psychosis.
  Schizophrenia bulletin 2019 Fryer SL, Roach BJ, Ford JM, Donaldson KR, Calhoun VD, Pearlson GD, Kiehl KA, Srihari VH, McGlashan TH, Woods SW, Mathalon DH
• Transient Patterns of Functional Dysconnectivity in Clinical High Risk and Early Illness Schizophrenia Individuals Compared with Healthy Controls.
  Brain connectivity 2018 Mennigen E, Fryer SL, Rashid B, Damaraju E, Du Y, Loewy RL, Stuart BK, Calhoun VD, Mathalon DH
• Reduced higher-dimensional resting state fMRI dynamism in clinical high-risk individuals for schizophrenia identified by meta-state analysis.
  Schizophrenia research 2018 Mennigen E, Miller RL, Rashid B, Fryer SL, Loewy RL, Stuart BK, Mathalon DH, Calhoun VD
• F224. Thalamic Dysconnectivity in the Psychosis Risk Syndrome and Early Illness Schizophrenia.
  Biological Psychiatry 2018 Judith Ford, Jamie Ferri, Brian Roach, Susanna Fryer, Barbara Stuart, Rachel Loewy, Daniel Mathalon
• T217. Measures of Neural Oscillation Synchrony During Reward Processing in Schizophrenia.
  Biological Psychiatry 2018 Susanna Fryer, Brian Roach, Judith Ford, Nemra Gokbayrak, Alison Boos, Daniel Mathalon
• T258. Increased Thalamo-Temporal Connectivity Following Targeted Cognitive Training in Schizophrenia.
  Biological Psychiatry 2018 Ian Ramsay, Brian Roach, Susanna Fryer, Melissa Fisher, Rachel Loewy, Sophia Vinogradov, Daniel Mathalon
• Blunted amygdala activity is associated with depression severity in treatment-resistant depression.
  Cognitive, affective & behavioral neuroscience 2017 Ferri J, Eisendrath SJ, Fryer SL, Gillung E, Roach BJ, Mathalon DH
• Identifying functional network changing patterns in individuals at clinical high-risk for psychosis and patients with early illness schizophrenia: A group ICA study.
  NeuroImage. Clinical 2017 Du Y, Fryer SL, Lin D, Sui J, Yu Q, Chen J, Stuart B, Loewy RL, Calhoun VD, Mathalon DH
• Dynamic functional connectivity impairments in early schizophrenia and clinical high-risk for psychosis.
  NeuroImage 2017 Du Y, Fryer SL, Fu Z, Lin D, Sui J, Chen J, Damaraju E, Mennigen E, Stuart B, Loewy RL, Mathalon DH, Calhoun VD
• Response to Targeted Cognitive Training Correlates with Change in Thalamic Volume in a Randomized Trial for Early Schizophrenia.
  Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 2017 Ramsay IS, Fryer S, Boos A, Roach BJ, Fisher M, Loewy R, Vinogradov S, Mathalon DH
• 76. fMRI Response During Error Processing in Clinical High Risk and Early Illness Schizophrenia.
  Schizophrenia Bulletin 2017 Susanna Fryer, Jennifer D. Townsend, Judith M. Ford, Brian J. Roach, Vince D. Calhoun, Godfrey D. Pearlson, Kent A. Kiehl, Vinod H. Srihari, Scott W. Woods, Thomas H. McGlashan, Daniel H. Mathalon
• 77. Thalamic Dysconnectivity in Individuals at Clinically High Risk for Schizophrenia and During Early Illness.
  Schizophrenia Bulletin 2017 Jamie Ferri, Susanna Fryer, Brian J. Roach, Rachel Loewy, Judith M. Ford, Daniel Mathalon
• 90. Targeted Cognitive Training is Neuroprotective Against Thalamic Volume Loss in Early Schizophrenia.
  Schizophrenia Bulletin 2017 Ian Ramsay, Susanna Fryer, Alison Boos, Brian J. Roach, Melissa Fisher, Rachel Loewy, Sophia Vinogradov, Daniel Mathalon
• Exposure to Teratogens as a Risk Factor for Psychopathology.
  Child and Adolescent Psychopathology, Third Edition 2017 Lauren R. Doyle, Nicole A. Crocker, Susanna L. Fryer, Sarah N. Mattson
• Action-based predictive coding is abnormal in psychotic patients.
  International Journal of Psychophysiology 2016 Judith Ford, Vanessa Palzes, Brian J. Roach, Susanna L. Fryer, Daniel H. Mathalon
• Reduced Amplitude of Low-Frequency Brain Oscillations in the Psychosis Risk Syndrome and Early Illness Schizophrenia.
  Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 2016 Fryer SL, Roach BJ, Wiley K, Loewy RL, Ford JM, Mathalon DH
• The effect of cognitive challenge on delay discounting.
  NeuroImage 2015 Aranovich GJ, McClure SM, Fryer S, Mathalon DH
• Relating Intrinsic Low-Frequency BOLD Cortical Oscillations to Cognition in Schizophrenia.
  Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 2015 Fryer SL, Roach BJ, Ford JM, Turner JA, van Erp TG, Voyvodic J, Preda A, Belger A, Bustillo J, O'Leary D, Mueller BA, Lim KO, McEwen SC, Calhoun VD, Diaz M, Glover G, Greve D, Wible CG, Vaidya J, …
• Deficient Suppression of Default Mode Regions during Working Memory in Individuals with Early Psychosis and at Clinical High-Risk for Psychosis.
  Frontiers in psychiatry 2013 Fryer SL, Woods SW, Kiehl KA, Calhoun VD, Pearlson GD, Roach BJ, Ford JM, Srihari VH, McGlashan TH, Mathalon DH
• Differential brain response to alcohol cue distractors across stages of alcohol dependence.
  Biological psychology 2012 Fryer SL, Jorgensen KW, Yetter EJ, Daurignac EC, Watson TD, Shanbhag H, Krystal JH, Mathalon DH
• Effect of predictive cuing on response inhibition in children with heavy prenatal alcohol exposure.
  Alcoholism, clinical and experimental research 2012 O'Brien JW, Norman AL, Fryer SL, Tapert SF, Paulus MP, Jones KL, Riley EP, Mattson SN
• Associations of Cigarette Smoking and Polymorphisms in Brain-Derived Neurotrophic Factor and Catechol-O-Methyltransferase with Neurocognition in Alcohol Dependent Individuals during Early Abstinence.
  Frontiers in pharmacology 2012 Durazzo TC, Hutchison KE, Fryer SL, Mon A, Meyerhoff DJ
• Another step forward in relating facial and brain dysmorphologies associated with prenatal alcohol exposure.
  Alcoholism, clinical and experimental research 2012 Fryer SL
• Caudate volume predicts neurocognitive performance in youth with heavy prenatal alcohol exposure.
  Alcoholism, clinical and experimental research 2012 Fryer SL, Mattson SN, Jernigan TL, Archibald SL, Jones KL, Riley EP
• Cortical thickness, surface area, and volume of the brain reward system in alcohol dependence: relationships to relapse and extended abstinence.
  Alcoholism, clinical and experimental research 2011 Durazzo TC, Tosun D, Buckley S, Gazdzinski S, Mon A, Fryer SL, Meyerhoff DJ
• Measures of learning, memory and processing speed accurately predict smoking status in short-term abstinent treatment-seeking alcohol-dependent individuals.
  Alcohol and alcoholism (Oxford, Oxfordshire) 2010 Durazzo TC, Fryer SL, Rothlind JC, Vertinski M, Gazdzinski S, Mon A, Meyerhoff DJ
• Cingulate gyrus morphology in children and adolescents with fetal alcohol spectrum disorders.
  Psychiatry research 2010 Bjorkquist OA, Fryer SL, Reiss AL, Mattson SN, Riley EP
• BOLD response during spatial working memory in youth with heavy prenatal alcohol exposure.
  Alcoholism, clinical and experimental research 2009 Spadoni AD, Bazinet AD, Fryer SL, Tapert SF, Mattson SN, Riley EP
• Characterization of white matter microstructure in fetal alcohol spectrum disorders.
  Alcoholism, clinical and experimental research 2008 Fryer SL, Schweinsburg BC, Bjorkquist OA, Frank LR, Mattson SN, Spadoni AD, Riley EP
• Microstructural integrity of the corpus callosum linked with neuropsychological performance in adolescents.
  Brain and cognition 2008 Fryer SL, Frank LR, Spadoni AD, Theilmann RJ, Nagel BJ, Schweinsburg AD, Tapert SF
• Deficits in social problem solving in adolescents with prenatal exposure to alcohol.
  The American journal of drug and alcohol abuse 2008 McGee CL, Fryer SL, Bjorkquist OA, Mattson SN, Riley EP
• Prenatal alcohol exposure affects frontal-striatal BOLD response during inhibitory control.
  Alcoholism, clinical and experimental research 2007 Fryer SL, Tapert SF, Mattson SN, Paulus MP, Spadoni AD, Riley EP
• Evaluation of psychopathological conditions in children with heavy prenatal alcohol exposure.
  Pediatrics 2007 Fryer SL, McGee CL, Matt GE, Riley EP, Mattson SN
• Neuroimaging and fetal alcohol spectrum disorders.
  Neuroscience and biobehavioral reviews 2006 Spadoni AD, McGee CL, Fryer SL, Riley EP
• Influence of Alcohol on Structure of the Developing Human Brain.
  2006 Susanna L. Fryer, Christie L. McGee, Andrea D. Spadoni, Edward P. Riley
• Lessons Learned.
  Human Developmental Neurotoxicology 2006 Susanna Fryer, Christie McGee, Sarah Mattson
• ADAPTIVE FUNCTIONING DIFFERENCES BY ASCERTAINMENT METHOD IN CHILDREN PRENATALLY EXPOSED TO ALCOHOL.
  Alcoholism Clinical and Experimental Research 2004 C L. McGee, S L. Fryer, E P. Riley, C D. Coles, P Kodituwakku, P A. May, W Kalberg, S N. Mattson
• Investigation of neuroanatomical differences between autism and Asperger syndrome.
  Archives of general psychiatry 2004 Lotspeich LJ, Kwon H, Schumann CM, Fryer SL, Goodlin-Jones BL, Buonocore MH, Lammers CR, Amaral DG, Reiss AL
• Corpus callosum and posterior fossa development in monozygotic females: a morphometric MRI study of Turner syndrome.
  Developmental medicine and child neurology 2003 Fryer SL, Kwon H, Eliez S, Reiss AL