Susan Noworolski, PhD
Professor
Radiology
School of Medicine

Dr. Noworolski’s research focuses on developing magnetic resonance imaging techniques and quantitative analyses to enable robust interpretation of MR measures to characterize the anatomy, physiology, and pathology studied. She has been focused primarily on studying prostate cancer and metabolic health.

In the prostate cancer area, she has characterized MR signatures of the heterogeneous benign and cancerous tissues of the prostate through correlation of multiparametric MR imaging measures with histopathology of the prostate and has developed quantitative, multiparametric models to generate risk maps of cancer and of aggressive cancer in the prostate. She is currently leveraging these findings to facilitate characterizing the risk for men considering active surveillance of their prostate cancer. Her lab has been automating our tools and transitioning some of our analyses from traditional machine learning approaches to deep learning approaches when appropriate. Through this research, we are initiating translating these resources so they can be used clinically.

In the metabolic health area, she has extended earlier research covering diagnostic evaluation of fat, inflammation and fibrosis in the liver to characterize disease in individuals with HIV and hepatitis C infection and to assess interventions. With collaborators, she has demonstrated effects of short-term dietary changes on de novo lipogenesis and lipid storage in the livers of normal subjects and subjects, including children, with obesity and/or metabolic syndrome. Through traditional image processing and via convolutional neural network algorithms, her lab has automated the analyses of some of our more established metrics of fatty liver disease. Her lab is pursuing novel imaging techniques to aid in characterizing the effects of sleep apnea on mitochondrial function, in addition to other metabolic syndrome effects, and is studying the role of MR to characterize ectopic fat and fibrosis and their roles in metabolic health and as predictors of Type II diabetes.

• Abstract 16511: Isocaloric Fructose Restriction Improves Postprandial Chylomicron and VLDL Excursions in Adolescents With Obesity by Reducing Angiopoietin-Like Protein 3 and Apolipoprotein CIII.
  Circulation 2020 Yasmin Bains, Ayca Erkin-Cakmak, Russell Caccavello, Kathleen Mulligan, Susan Noworolski, Jean-Marc Schwarz, Robert Lustig, Alejandro Gugliucci
• Short-Term Isocaloric Fructose Restriction Improves Postprandial Lipoprotein Subclass Profiles.
  Atherosclerosis 2019 A. Gugliucci, Y. Bains, R. Caccavello, M. Wen, A. Erkin-Cakmak, K. Mulligan, R. Lustig, S. Noworolski, J.M. Schwarz
• Isocaloric Fructose Restriction Reduces Serum d-Lactate Concentration in Children With Obesity and Metabolic Syndrome.
  The Journal of clinical endocrinology and metabolism 2019 Erkin-Cakmak A, Bains Y, Caccavello R, Noworolski SM, Schwarz JM, Mulligan K, Lustig RH, Gugliucci A
• Quantitative imaging biomarkers alliance (QIBA) recommendations for improved precision of DWI and DCE-MRI derived biomarkers in multicenter oncology trials.
  Journal of Magnetic Resonance Imaging 2019 Amita Shukla-Dave, Nancy A. Obuchowski, Thomas L. Chenevert, Sachin Jambawalikar, Lawrence H. Schwartz, Dariya Malyarenko, Wei Huang, Susan M. Noworolski, Robert J. Young, Mark S. Shiroishi, Harrison …
• Hypoenhancing prostate cancers on dynamic contrast-enhanced MRI are associated with poor outcomes in high-risk patients: results of a hypothesis generating study.
  Abdominal radiology (New York) 2019 Muglia VF, Reis RB, Rocha TO, Silva AR, Noworolski S, Westphalen AC
• Phase I Study of CTT1057, an 18F-Labeled Imaging Agent with Phosphoramidate Core Targeting Prostate-Specific Membrane Antigen in Prostate Cancer.
  Journal of nuclear medicine : official publication, Society of Nuclear Medicine 2018 Behr SC, Aggarwal R, VanBrocklin HF, Flavell RR, Gao K, Small EJ, Blecha J, Jivan S, Hope TA, Simko JP, Kurhanewicz J, Noworolski SM, Korn NJ, De Los Santos R, Cooperberg MR, Carroll PR, Nguyen HG, …
• Quantitative imaging biomarkers alliance (QIBA) recommendations for improved precision of DWI and DCE-MRI derived biomarkers in multicenter oncology trials.
  Journal of magnetic resonance imaging : JMRI 2018 Shukla-Dave A, Obuchowski NA, Chenevert TL, Jambawalikar S, Schwartz LH, Malyarenko D, Huang W, Noworolski SM, Young RJ, Shiroishi MS, Kim H, Coolens C, Laue H, Chung C, Rosen M, Boss M, Jackson EF
• Assessing high-intensity focused ultrasound treatment of prostate cancer with hyperpolarized 13 C dual-agent imaging of metabolism and perfusion.
  NMR in biomedicine 2018 Lee JE, Diederich CJ, Bok R, Sriram R, Santos RD, Noworolski SM, Salgaonkar VA, Adams MS, Vigneron DB, Kurhanewicz J
• Phase I study of dose escalation to dominant intraprostatic lesions using high-dose-rate brachytherapy.
  Journal of contemporary brachytherapy 2018 Chapman CH, Braunstein SE, Pouliot J, Noworolski SM, Weinberg V, Cunha A, Kurhanewicz J, Gottschalk AR, Roach MI, Hsu IC
• Characterization and stratification of prostate lesions based on comprehensive multiparametric MRI using detailed whole-mount histopathology as a reference standard.
  NMR in biomedicine 2017 Starobinets O, Simko JP, Kuchinsky K, Kornak J, Carroll PR, Greene KL, Kurhanewicz J, Noworolski SM
• Controlled attenuation parameter and magnetic resonance spectroscopy-measured liver steatosis are discordant in obese HIV-infected adults.
  AIDS (London, England) 2017 Price JC, Dodge JL, Ma Y, Scherzer R, Korn N, Tillinghast K, Peters MG, Noworolski S, Tien PC
• Effects of Dietary Fructose Restriction on Liver Fat, De Novo Lipogenesis, and Insulin Kinetics in Children With Obesity.
  Gastroenterology 2017 Schwarz JM, Noworolski SM, Erkin-Cakmak A, Korn NJ, Wen MJ, Tai VW, Jones GM, Palii SP, Velasco-Alin M, Pan K, Patterson BW, Gugliucci A, Lustig RH, Mulligan K
• Improved multiparametric MRI discrimination between low-risk prostate cancer and benign tissues in a small cohort of 5α-reductase inhibitor treated individuals as compared with an untreated cohort.
  NMR in biomedicine 2017 Starobinets O, Kurhanewicz J, Noworolski SM
• Human immunodeficiency virus-infected and uninfected adults with non-genotype 3 hepatitis C virus have less hepatic steatosis than adults with neither infection.
  Hepatology (Baltimore, Md.) 2017 Price JC, Ma Y, Scherzer R, Korn N, Tillinghast K, Peters MG, Noworolski SM, Tien PC
• Sex differences in the association of HIV infection with hepatic steatosis.
  AIDS (London, England) 2017 Kardashian A, Ma Y, Scherzer R, Price JC, Sarkar M, Korn N, Tillinghast K, Peters MG, Noworolski SM, Tien PC
• 18F Fluorocholine Dynamic Time-of-Flight PET/MR Imaging in Patients with Newly Diagnosed Intermediate- to High-Risk Prostate Cancer: Initial Clinical-Pathologic Comparisons.
  Radiology 2016 Choi JY, Yang J, Noworolski SM, Behr S, Chang AJ, Simko JP, Nguyen HG, Carroll PR, Kurhanewicz J, Seo Y
• Short-term isocaloric fructose restriction lowers apoC-III levels and yields less atherogenic lipoprotein profiles in children with obesity and metabolic syndrome.
  Atherosclerosis 2016 Gugliucci A, Lustig RH, Caccavello R, Erkin-Cakmak A, Noworolski SM, Tai VW, Wen MJ, Mulligan K, Schwarz JM
• Practical aspects of prostate MRI: hardware and software considerations, protocols, and patient preparation.
  Abdominal radiology (New York) 2016 Starobinets O, Korn N, Iqbal S, Noworolski SM, Zagoria R, Kurhanewicz J, Westphalen AC
• Isocaloric fructose restriction and metabolic improvement in children with obesity and metabolic syndrome.
  Obesity (Silver Spring, Md.) 2015 Lustig RH, Mulligan K, Noworolski SM, Tai VW, Wen MJ, Erkin-Cakmak A, Gugliucci A, Schwarz JM
• High-Resolution 3-T Endorectal Prostate MRI: A Multireader Study of Radiologist Preference and Perceived Interpretive Quality of 2D and 3D T2-Weighted Fast Spin-Echo MR Images.
  AJR. American journal of roentgenology 2015 Westphalen AC, Noworolski SM, Harisinghani M, Jhaveri KS, Raman SS, Rosenkrantz AB, Wang ZJ, Zagoria RJ, Kurhanewicz J
• Effect of a High-Fructose Weight-Maintaining Diet on Lipogenesis and Liver Fat.
  The Journal of clinical endocrinology and metabolism 2015 Schwarz JM, Noworolski SM, Wen MJ, Dyachenko A, Prior JL, Weinberg ME, Herraiz LA, Tai VW, Bergeron N, Bersot TP, Rao MN, Schambelan M, Mulligan K
• Abnormal findings on multiparametric prostate magnetic resonance imaging predict subsequent biopsy upgrade in patients with low risk prostate cancer managed with active surveillance.
  Abdominal imaging 2014 Flavell RR, Westphalen AC, Liang C, Sotto CC, Noworolski SM, Vigneron DB, Wang ZJ, Kurhanewicz J
• Reduced-FOV excitation decreases susceptibility artifact in diffusion-weighted MRI with endorectal coil for prostate cancer detection.
  Magnetic resonance imaging 2014 Korn N, Kurhanewicz J, Banerjee S, Starobinets O, Saritas E, Noworolski S
• Bone structure and perfusion quantification of bone marrow edema pattern in the wrist of patients with rheumatoid arthritis: a multimodality study.
  The Journal of rheumatology 2014 Teruel JR, Burghardt AJ, Rivoire J, Srikhum W, Noworolski SM, Link TM, Imboden JB, Li X
• A Randomized Controlled Trial of a Mindfulness-Based Intervention for Metabolic Health in Obese Adults.
  Journal of Alternative and Complementary Medicine 2014 Jennifer Daubenmier, Elissa Epel, Patricia Moran, Jean Kristeller, Michael Acree, Peter Bacchetti, Margaret Kemeny, Mary Dallman, Robert Lustig, Carl Grunfeld, Douglas Nixon, Jeffery Milush, Veronica …
• Role of endorectal MR imaging and MR spectroscopic imaging in defining treatable intraprostatic tumor foci in prostate cancer: quantitative analysis of imaging contour compared to whole-mount histopathology.
  Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology 2014 Anwar M, Westphalen AC, Jung AJ, Noworolski SM, Simko JP, Kurhanewicz J, Roach M, Carroll PR, Coakley FV
• Semiautomatic registration of digital histopathology images to in vivo MR images in molded and unmolded prostates.
  Journal of magnetic resonance imaging : JMRI 2013 Starobinets O, Guo R, Simko JP, Kuchinsky K, Kurhanewicz J, Carroll PR, Greene KL, Noworolski SM
• Role of Endorectal MRI and MRSI in Defining the Dominant Intraprostatic Lesion in Prostate Cancer: Quantitative Analysis of Imaging Contour Compared to Whole-Mount Histopathology.
  International Journal of Radiation Oncology • Biology • Physics 2012 M.M. Anwar, A.C. Westphalen, A. Jung, S. Noworolski, J. Kurhanewicz, J.P. Simko, P.R. Carroll, F.V. Coakley
• Liver steatosis: concordance of MR imaging and MR spectroscopic data with histologic grade.
  Radiology 2012 Noworolski SM, Lam MM, Merriman RB, Ferrell L, Qayyum A
• MRI steatosis grading: development and initial validation of a color mapping system.
  AJR. American journal of roentgenology 2012 Qayyum A, Nystrom M, Noworolski SM, Chu P, Mohanty A, Merriman R
• Liver diffusivity in healthy volunteers and patients with chronic liver disease: comparison of breathhold and free-breathing techniques.
  Journal of magnetic resonance imaging : JMRI 2011 Eatesam M, Noworolski SM, Tien PC, Nystrom M, Dodge JL, Merriman RB, Qayyum A
• Quantitative characterization of bone marrow edema pattern in rheumatoid arthritis using 3 Tesla MRI.
  Journal of magnetic resonance imaging : JMRI 2011 Li X, Yu A, Virayavanich W, Noworolski SM, Link TM, Imboden J
• Interactive, multi-modality image registrations for combined MRI/MRSI-planned HDR prostate brachytherapy.
  Journal of contemporary brachytherapy 2011 Reed G, Cunha JA, Noworolski S, Kurhanewicz J, Vigneron D, Hsu IC, Pouliot J
• A pilot study of endorectal magnetic resonance imaging and magnetic resonance spectroscopic imaging changes with dutasteride in patients with low risk prostate cancer.
  BJU international 2011 Chung HT, Noworolski SM, Kurhanewicz J, Weinberg V, Roach Iii M
• Adipose tissue and metabolic factors associated with steatosis in HIV/HCV coinfection: histology versus magnetic resonance spectroscopy.
  Journal of acquired immune deficiency syndromes (1999) 2010 Ghotb A, Noworolski SM, Madden E, Scherzer R, Qayyum A, Pannell J, Ferrell L, Peters M, Tien PC
• Post-processing correction of the endorectal coil reception effects in MR spectroscopic imaging of the prostate.
  Journal of magnetic resonance imaging : JMRI 2010 Noworolski SM, Reed GD, Kurhanewicz J, Vigneron DB
• Magnetic resonance imaging for secondary assessment of breast density in a high-risk cohort.
  Magnetic resonance imaging 2009 Klifa C, Carballido-Gamio J, Wilmes L, Laprie A, Shepherd J, Gibbs J, Fan B, Noworolski S, Hylton N
• Respiratory motion-corrected proton magnetic resonance spectroscopy of the liver.
  Magnetic resonance imaging 2008 Noworolski SM, Tien PC, Merriman R, Vigneron DB, Qayyum A
• Liver steatosis: investigation of opposed-phase T1-weighted liver MR signal intensity loss and visceral fat measurement as biomarkers.
  Radiology 2008 Bahl M, Qayyum A, Westphalen AC, Noworolski SM, Chu PW, Ferrell L, Tien PC, Bass NM, Merriman RB
• Dynamic contrast-enhanced MRI and MR diffusion imaging to distinguish between glandular and stromal prostatic tissues.
  Magnetic resonance imaging 2008 Noworolski SM, Vigneron DB, Chen AP, Kurhanewicz J
• A clinical comparison of rigid and inflatable endorectal-coil probes for MRI and 3D MR spectroscopic imaging (MRSI) of the prostate.
  Journal of magnetic resonance imaging : JMRI 2008 Noworolski SM, Crane JC, Vigneron DB, Kurhanewicz J
• Class solution in inverse planned HDR prostate brachytherapy for dose escalation of DIL defined by combined MRI/MRSI.
  Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology 2008 Kim Y, Hsu IC, Lessard E, Kurhanewicz J, Noworolski SM, Pouliot J
• Magnetic Resonance Spectroscopy and Spectroscopic Imaging of the Prostate, Breast, and Liver.
  Modern Magnetic Resonance 2008 Mark G. Swanson, Susan M. Noworolski, John Kurhanewicz
• Estimation of metabolite T1 relaxation times using tissue specific analysis, signal averaging and bootstrapping from magnetic resonance spectroscopic imaging data.
  Magma (New York, N.Y.) 2007 Ratiney H, Noworolski SM, Sdika M, Srinivasan R, Henry RG, Nelson SJ, Pelletier D
• Dynamic Contrast-Enhanced MRI in Normal and Abnormal Prostate Tissues as Defined by Biopsy, MRI, and 3D MRSI.
  The Journal of Urology 2006 S.M. Noworolski, R.G. Henry, D.B. Vigneron, J. Kurhanewicz
• Registration of MR prostate images with biomechanical modeling and nonlinear parameter estimation.
  Medical physics 2006 Alterovitz R, Goldberg K, Pouliot J, Hsu IC, Kim Y, Noworolski SM, Kurhanewicz J
• Expandable and rigid endorectal coils for prostate MRI: impact on prostate distortion and rigid image registration.
  Medical physics 2005 Kim Y, Hsu IC, Pouliot J, Noworolski SM, Vigneron DB, Kurhanewicz J
• Dynamic contrast-enhanced MRI in normal and abnormal prostate tissues as defined by biopsy, MRI, and 3D MRSI.
  Magnetic resonance in medicine 2005 Noworolski SM, Henry RG, Vigneron DB, Kurhanewicz J
• Challenges in dynamic contrast-enhanced MRI imaging of cervical lymph nodes to detect metastatic disease.
  Journal of magnetic resonance imaging : JMRI 2003 Noworolski SM, Fischbein NJ, Kaplan MJ, Lu Y, Nelson SJ, Carvajal L, Henry RG
• Assessment of metastatic cervical adenopathy using dynamic contrast-enhanced MR imaging.
  AJNR. American journal of neuroradiology 2003 Fischbein NJ, Noworolski SM, Henry RG, Kaplan MJ, Dillon WP, Nelson SJ
• Three-dimensional proton MR spectroscopic imaging of premature and term neonates.
  AJNR. American journal of neuroradiology 2001 Vigneron DB, Barkovich AJ, Noworolski SM, von dem Bussche M, Henry RG, Lu Y, Partridge JC, Gregory G, Ferriero DM
• Time-dependent effects of hormone-deprivation therapy on prostate metabolism as detected by combined magnetic resonance imaging and 3D magnetic resonance spectroscopic imaging.
  Magnetic resonance in medicine 2001 Mueller-Lisse UG, Swanson MG, Vigneron DB, Hricak H, Bessette A, Males RG, Wood PJ, Noworolski S, Nelson SJ, Barken I, Carroll PR, Kurhanewicz J
• Preoperative proton MR spectroscopic imaging of brain tumors: correlation with histopathologic analysis of resection specimens.
  AJNR. American journal of neuroradiology 2001 Dowling C, Bollen AW, Noworolski SM, McDermott MW, Barbaro NM, Day MR, Henry RG, Chang SM, Dillon WP, Nelson SJ, Vigneron DB
• An automated technique for the quantitative assessment of 3D-MRSI data from patients with glioma.
  Journal of magnetic resonance imaging : JMRI 2001 McKnight TR, Noworolski SM, Vigneron DB, Nelson SJ
• Three-dimensional magnetic resonance spectroscopic imaging of histologically confirmed brain tumors.
  Magnetic resonance imaging 2001 Vigneron D, Bollen A, McDermott M, Wald L, Day M, Moyher-Noworolski S, Henry R, Chang S, Berger M, Dillon W, Nelson S
• Comparison of relative cerebral blood volume and proton spectroscopy in patients with treated gliomas.
  AJNR. American journal of neuroradiology 2000 Henry RG, Vigneron DB, Fischbein NJ, Grant PE, Day MR, Noworolski SM, Star-Lack JM, Wald LL, Dillon WP, Chang SM, Nelson SJ
• High spatial resolution 1H-MRSI and segmented MRI of cortical gray matter and subcortical white matter in three regions of the human brain.
  Magnetic resonance in medicine 1999 Noworolski SM, Nelson SJ, Henry RG, Day MR, Wald LL, Star-Lack J, Vigneron DB
• Serial proton magnetic resonance spectroscopy imaging of glioblastoma multiforme after brachytherapy.
  Journal of neurosurgery 1997 Wald LL, Nelson SJ, Day MR, Noworolski SE, Henry RG, Huhn SL, Chang S, Prados MD, Sneed PK, Larson DA, Wara WM, McDermott M, Dillon WP, Gutin PH, Vigneron DB
• High resolution T2-weighted imaging of the human brain using surface coils and an analytical reception profile correction.
  Journal of magnetic resonance imaging : JMRI 1997 Moyher SE, Wald LL, Nelson SJ, Hallam D, Dillon WP, Norman D, Vigneron DB
• Phased array detectors and an automated intensity-correction algorithm for high-resolution MR imaging of the human brain.
  Magnetic resonance in medicine 1995 Wald LL, Carvajal L, Moyher SE, Nelson SJ, Grant PE, Barkovich AJ, Vigneron DB
• Proton spectroscopic imaging of the human brain using phased array detectors.
  Magnetic resonance in medicine 1995 Wald LL, Moyher SE, Day MR, Nelson SJ, Vigneron DB
• Surface coil MR imaging of the human brain with an analytic reception profile correction.
  Journal of magnetic resonance imaging : JMRI 1995 Moyher SE, Vigneron DB, Nelson SJ