Susan Fisher, PhD
Professor
Ob/Gyn, Reproductive Sciences
School of Medicine
Our group works in three areas. In the first, we are studying the mechanisms used by the trophoblast cells of the human placenta to invade the uterus during normal pregnancy. Human fetal development depends on the embryo's ability to rapidly gain access to the maternal circulation.
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The cytotrophoblasts that form the fetal portion of the human placenta have solved this problem by transiently exhibiting certain invasive, tumor-like properties. Our studies show that, in normal pregnancy, cytotrophoblast invasion, both in vivo and in vitro, is accompanied by a dramatic switch in the cells' expression of matrix-degrading metalloproteinases and adhesion molecules. Function-perturbation experiments suggest that cytotrophoblasts carefully regulate their invasive potential by simultaneously expressing a number of molecules that either promote or inhibit invasion. Additionally, we found that cytotrophoblasts that replace the endothelial lining of uterine blood vessels also have the amazing ability to mimic the adhesion phenotype of vascular cells. This phenomenon is likely to be a critical component of normal placentation. What controls this highly unusual differentiation process? Since cytotrophoblasts target large-bore arterioles for invasion, we reasoned that oxygen tension could play a role. Recently, we showed that oxygen controls whether cells proliferate or exit the cell cycle and differentiate; Eph/ephrin family members, transmembrane ligands and receptors, pattern invasion in terms of arterial bias. Finally, we use information about molecular aspects of cytotrophoblast function in normal pregnancy to search for defects that are associated with pregnancy complications such as preeclampsia (e.g., dangerously high blood pressure). For example, our work shows that this pregnancy complication is characterized by specific aberrations in trophoblast secretion of vasculogenic/angiogenic substances.
In parallel, our lab has begun studying the earliest stages of human development using human embryonic stem cells as a model system. Our work to date has focused on deriving additional lines using feeders formed from human placental cells. We recently made the surprising discovery that the cells exhibit apical-basal type polarization. Currently we are investigating how this highly specialized phenomenon is related to pluripotency. Our recently funded CIRM comprehensive grant is focused on constructing a fate map of the human embryo.
Finally, we are using mass spectrometry-based approaches for proteome analyses. Three projects are under way. The first is compilation of an initial draft of the salivary proteome of healthy individuals as a first step in using this body fluid for diagnosis of common diseases. The second is an analysis of the primary proteome and protein complexes of the soil organism Desulfovibrio vulgaris. The goal of the third and newest project is to formulate novel methods that enable robust mass spectrometry-based platforms for the discovery of biomarkers in body fluid for the early detection of tumors.
Websites
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- Profile at UCSF Cancer Center (cancer.ucsf.edu)
Grants and Projects
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- Dissecting gene dysregulation at the maternal-fetal interface in preeclampsia, NIH, 2013-2023
- Cancer Center Support Grant, NIH, 1999-2023
- Center for Research, Innovation and Training in Reproduction and Infertility, NIH, 2007-2023
- THC effects on human implantation: role of trophoblast CB1, NIH, 2017-2019
- The UCSF Pregnancy Exposures to Environmental Chemicals (PEEC) Children's Center, NIH, 2013-2019
- Dissecting gene dysregulation at the maternal-fetal interface in preeclampsia, NIH/NICHD, 2013-2018
- Mass Spectrometry Tools in Pursuit of Salivary Biomarkers of Sjogren's Syndrome, NIH, 2012-2018
- Functional Glycomics of Human Saliva, NIH, 2011-2017
- Origins and Biological Consequences of Human Infertility, NIH, 2007-2017
- A Novel Model for Assessing the Effects of BPA Exposures on Human Placentation, NIH, 2012-2015
- Bio-Organic Biomedical Mass Spectrometry Resource, NIH, 1982-2015
- Mechanisms of Preeclampsia: Impact of Obesity, NIH, 1993-2014
- Targeted and global proteomic strategies for early breast cancer detection, NIH, 2006-2013
- Fetal Programming and Environmental Exposures: Implications for Prenatal Care and, NIH, 2012-2013
- Molecular Mechanisms of Plasmodium Falciparum Adherence to the Human Placenta, NIH, 2009-2012
- The Immune Paradox of Human Pregnancy: Fetal Trophoblasts and Maternal Leukocytes, NIH, 2008-2011
- Neuronal Guidance Mechanisms in Placental Development, NIH, 2004-2010
- Cataloguing the Human Salivary Proteome, NIH, 2004-2010
- Molecular Mechanisms--Bacterial Adherence to Cementum, NIH, 1985-2009
- Trophoblast Selectins and Their Uterine Mucin Ligands, NIH, 2002-2008
- New Strategies for Enhancing Tissue Integrity and Repair, NIH, 1999-2006
- A Novel Vasculogenesis Program in Cytotrophoblasts, NIH, 2000-2005
- Molecular Mechanisms--Bacterial Adherence to Cementum, NIH, 1985-2004
- Developmental Biology of the Implanting Mammalian Embryo, NIH, 1991-2002
- Gordon Research Conference on Reproductive Tract Biology, NIH, 2000-2001
- CANDIDA ADHERENCE, NIH, 1994-1997
- Prenatal Diagnosis Using Fetal Cells from Maternal Blood, NIH/NICHD, 1987-1992
- Mechanisms of Trophoblast Invasion During Placentation, NIH, 1988-1991
Publications (234)
Top publication keywords:
PregnancyDeciduaChorionic VilliTrophoblastsProteomeUterusEmbryo ImplantationSalivary Proteins and PeptidesChorionPlacentationPre-EclampsiaMaternal-Fetal ExchangePlacentaEmbryonic Stem CellsGlycoproteins
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Urine, peritoneal fluid and omental fat proteomes of reproductive age women: Endometriosis-related changes and associations with endocrine disrupting chemicals.
Journal of proteomics 2014 Williams KE, Miroshnychenko O, Johansen EB, Niles RK, Sundaram R, Kannan K, Albertolle M, Zhou Y, Prasad N, Drake PM, Giudice LC, Hall SC, Witkowska HE, Buck Louis GM, Fisher SJ -
Preterm labor: one syndrome, many causes.
Science (New York, N.Y.) 2014 Romero R, Dey SK, Fisher SJ -
Reversal of gene dysregulation in cultured cytotrophoblasts reveals possible causes of preeclampsia.
The Journal of clinical investigation 2013 Zhou Y, Gormley MJ, Hunkapiller NM, Kapidzic M, Stolyarov Y, Feng V, Nishida M, Drake PM, Bianco K, Wang F, McMaster MT, Fisher SJ -
Lectin chromatography/mass spectrometry discovery workflow identifies putative biomarkers of aggressive breast cancers.
Journal of proteome research 2012 Drake PM, Schilling B, Niles RK, Prakobphol A, Li B, Jung K, Cho W, Braten M, Inerowicz HD, Williams K, Albertolle M, Held JM, Iacovides D, Sorensen DJ, Griffith OL, Johansen E, Zawadzka AM, Cusack MP… -
Establishment of human trophoblast progenitor cell lines from the chorion.
Stem cells (Dayton, Ohio) 2011 Genbacev O, Donne M, Kapidzic M, Gormley M, Lamb J, Gilmore J, Larocque N, Goldfien G, Zdravkovic T, McMaster MT, Fisher SJ
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Fluoride-related changes in the fetal cord blood proteome; a pilot study.
Research square 2024 Tuomivaara ST, Goin DE, Fisher SJ, Hall SC, Mattis AN, Den Besten PK -
Perfluorooctanoic acid induces transcriptomic alterations in second trimester human cytotrophoblasts.
Toxicological sciences : an official journal of the Society of Toxicology 2023 Chen H, Kapidzic M, Gantar D, Aksel S, Levan J, Abrahamsson DP, Jigmeddagva U, Basrai S, San A, Gaw SL, Woodruff TJ, Fisher SJ, Robinson JF -
Distinct transcriptional profiles of maternal and fetal placental macrophages at term are associated with gravidity.
bioRxiv : the preprint server for biology 2023 Ozarslan N, Robinson JF, Buarpung S, Kim MY, Ansbro MR, Akram J, Montoya DJ, Kamya MR, Kakuru A, Dorsey G, Rosenthal PJ, Cheng G, Feeney ME, Fisher SJ, Gaw SL -
Proteomic analyses of primary human villous trophoblasts exposed to flame retardant BDE-47 using SWATH-MS.
Toxicology 2023 Chen H, Williams KE, Kwan EY, Kapidzic M, Puckett KA, San A, Fisher SJ, Robinson JF -
Lipidomics Reveals Elevated Plasmalogens in Women with Obesity Who Develop Preeclampsia.
Journal of clinical medicine 2023 Williams IM, Albertolle ME, Layden AJ, Tao SY, Fisher SJ, Gandley RE, Roberts JM -
Vedolizumab Antagonizes MAdCAM-1-Dependent Human Placental Cytotrophoblast Adhesion and Invasion In Vitro.
Inflammatory bowel diseases 2022 Blaisdell A, Zhou Y, Kattah MG, Fisher SJ, Mahadevan U -
Regionally distinct trophoblast regulate barrier function and invasion in the human placenta.
eLife 2022 Marsh B, Zhou Y, Kapidzic M, Fisher S, Blelloch R -
Bisphenol A replacement chemicals, BPF and BPS, induce protumorigenic changes in human mammary gland organoid morphology and proteome.
Proceedings of the National Academy of Sciences of the United States of America 2022 Winkler J, Liu P, Phong K, Hinrichs JH, Ataii N, Williams K, Hadler-Olsen E, Samson S, Gartner ZJ, Fisher S, Werb Z -
Establishment of fetomaternal tolerance through glycan-mediated B cell suppression.
Nature 2022 Rizzuto G, Brooks JF, Tuomivaara ST, McIntyre TI, Ma S, Rideaux D, Zikherman J, Fisher SJ, Erlebacher A -
RNA profiling of laser microdissected human trophoblast subtypes at mid-gestation reveals a role for cannabinoid signaling in invasion.
Development (Cambridge, England) 2021 Gormley M, Oliverio O, Kapidzic M, Ona K, Hall S, Fisher SJ -
Global proteomic analyses of human cytotrophoblast differentiation/invasion.
Development (Cambridge, England) 2021 Chen H, Williams KE, Kwan EY, Kapidzic M, Puckett KA, Aburajab RK, Robinson JF, Fisher SJ -
The Placenta - Fast, Loose, and in Control.
The New England journal of medicine 2021 Costello JF, Fisher SJ -
Organophosphate Flame Retardants, Highly Fluorinated Chemicals, and Biomarkers of Placental Development and Disease During Mid-Gestation.
Toxicological sciences : an official journal of the Society of Toxicology 2021 Varshavsky JR, Robinson JF, Zhou Y, Puckett KA, Kwan E, Buarpung S, Aburajab R, Gaw SL, Sen S, Gao S, Smith SC, Park JS, Zakharevich I, Gerona RR, Fisher SJ, Woodruff TJ -
Human placental cytotrophoblast epigenome dynamics over gestation and alterations in placental disease.
Developmental cell 2021 Zhang B, Kim MY, Elliot G, Zhou Y, Zhao G, Li D, Lowdon RF, Gormley M, Kapidzic M, Robinson JF, McMaster MT, Hong C, Mazor T, Hamilton E, Sears RL, Pehrsson EC, Marra MA, Jones SJM, Bilenky M, Hirst M… -
Cytotrophoblast extracellular vesicles enhance decidual cell secretion of immune modulators via TNFα.
Development (Cambridge, England) 2020 Taylor SK, Houshdaran S, Robinson JF, Gormley MJ, Kwan EY, Kapidzic M, Schilling B, Giudice LC, Fisher SJ -
Gravidity-dependent associations between interferon response and birth weight in placental malaria.
Malaria journal 2020 Quanquin NM, Barres LG, Aliyari SR, Day NT, Gerami H, Fisher SJ, Kakuru A, Kamya MR, Havlir DV, Feeney M, Dorsey G, Cheng G, Gaw SL -
Racial/ethnic and geographic differences in polybrominated diphenyl ether (PBDE) levels across maternal, placental, and fetal tissues during mid-gestation.
Scientific reports 2020 Varshavsky JR, Sen S, Robinson JF, Smith SC, Frankenfield J, Wang Y, Yeh G, Park JS, Fisher SJ, Woodruff TJ -
Up-regulated cytotrophoblast DOCK4 contributes to over-invasion in placenta accreta spectrum.
Proceedings of the National Academy of Sciences of the United States of America 2020 McNally L, Zhou Y, Robinson JF, Zhao G, Chen LM, Chen H, Kim MY, Kapidzic M, Gormley M, Hannibal R, Fisher SJ -
Association of polybrominated diphenyl ether (PBDE) levels with biomarkers of placental development and disease during mid-gestation.
Environmental health : a global access science source 2020 Varshavsky JR, Robinson JF, Zhou Y, Puckett KA, Kwan E, Buarpung S, Aburajab R, Gaw SL, Sen S, Smith SC, Frankenfield J, Park JS, Fisher SJ, Woodruff TJ -
Discordant Zika Virus Findings in Twin Pregnancies Complicated by Antenatal Zika Virus Exposure: A Prospective Cohort.
The Journal of infectious diseases 2020 Sobhani NC, Avvad-Portari E, Nascimento ACM, Machado HN, Lobato DSS, Pereira JP, Esquivel MS, Vasconcelos ZC, Zin AA, Tsui I, Adachi K, Brickley EB, Fisher SJ, Nielsen-Saines K, Brasil P, Moreira ME, … -
Trisomy 21 is Associated with Caspase-2 Upregulation in Cytotrophoblasts at the Maternal-Fetal Interface.
Reproductive sciences (Thousand Oaks, Calif.) 2020 Leon-Martinez D, Robinson JF, Zdravkovic T, Genbacev O, Gormley M, Mcmaster M, Fisher SJ, Bianco K -
Reply.
Gastroenterology 2019 Mahadevan U, Fisher S, Riley L, Chambers C, Jain R, Robinson C, co-authors of the AGA Inflammatory Bowel Disease in Pregnancy Clinical Care Pathway -
Hormone receptor expression of colorectal cancer diagnosed during the peri-partum period.
Endocrine connections 2019 Silverstein J, Kidder W, Fisher S, Hope TA, Maisel S, Ng D, Van Ziffle J, Atreya CE, Van Loon K -
Menstrual cycle-dependent alterations in glycosylation: a roadmap for defining biomarkers of favorable and unfavorable mucus.
Journal of assisted reproduction and genetics 2019 Reynoso-Prieto M, Takeda M, Prakobphol A, Seidman D, Averbach S, Fisher S, Smith-McCune K -
Differential Activation of Fetal Hofbauer Cells in Primigravidas Is Associated with Decreased Birth Weight in Symptomatic Placental Malaria.
Malaria research and treatment 2019 Gaw SL, Hromatka BS, Ngeleza S, Buarpung S, Ozarslan N, Tshefu A, Fisher SJ -
Genomic Profiling of BDE-47 Effects on Human Placental Cytotrophoblasts.
Toxicological sciences : an official journal of the Society of Toxicology 2019 Robinson JF, Kapidzic M, Hamilton EG, Chen H, Puckett KW, Zhou Y, Ona K, Parry E, Wang Y, Park JS, Costello JF, Fisher SJ -
Placental Structure in Preterm Birth Among HIV-Positive Versus HIV-Negative Women in Kenya.
Journal of acquired immune deficiency syndromes (1999) 2019 Obimbo MM, Zhou Y, McMaster MT, Cohen CR, Qureshi Z, Ong'ech J, Ogeng'o JA, Fisher SJ -
Large Differences in Small RNA Composition Between Human Biofluids.
Cell reports 2018 Godoy PM, Bhakta NR, Barczak AJ, Cakmak H, Fisher S, MacKenzie TC, Patel T, Price RW, Smith JF, Woodruff PG, Erle DJ -
Reply to Liu et al.: Decidualization defect in severe preeclampsia.
Proceedings of the National Academy of Sciences of the United States of America 2018 Garrido-Gomez T, Fisher SJ, Simón C -
Altered downstream target gene expression of the placental Vitamin D receptor in human idiopathic fetal growth restriction.
Cell cycle (Georgetown, Tex.) 2018 Nguyen TPH, Yong HEJ, Chollangi T, Brennecke SP, Fisher SJ, Wallace EM, Ebeling PR, Murthi P -
Baby's First Organ.
Scientific American 2017 Erlebacher A, Fisher SJ -
Defective decidualization during and after severe preeclampsia reveals a possible maternal contribution to the etiology.
Proceedings of the National Academy of Sciences of the United States of America 2017 Garrido-Gomez T, Dominguez F, Quiñonero A, Diaz-Gimeno P, Kapidzic M, Gormley M, Ona K, Padilla-Iserte P, McMaster M, Genbacev O, Perales A, Fisher SJ, Simón C -
Reductive dissolution of supergrowth carbon nanotubes for tougher nanocomposites by reactive coagulation spinning.
Nanoscale 2017 Clancy AJ, Anthony DB, Fisher SJ, Leese HS, Roberts CS, Shaffer MSP -
Transcriptional Dynamics of Cultured Human Villous Cytotrophoblasts.
Endocrinology 2017 Robinson JF, Kapidzic M, Gormley M, Ona K, Dent T, Seifikar H, Hamilton EG, Fisher SJ -
Alterations in the Salivary Proteome and N-Glycome of Sjögren's Syndrome Patients.
Journal of proteome research 2017 Hall SC, Hassis ME, Williams KE, Albertolle ME, Prakobphol A, Dykstra AB, Laurance M, Ona K, Niles RK, Prasad N, Gormley M, Shiboski C, Criswell LA, Witkowska HE, Fisher SJ -
Preeclampsia: novel insights from global RNA profiling of trophoblast subpopulations.
American journal of obstetrics and gynecology 2017 Gormley M, Ona K, Kapidzic M, Garrido-Gomez T, Zdravkovic T, Fisher SJ -
The human chorion contains definitive hematopoietic stem cells from the fifteenth week of gestation.
Development (Cambridge, England) 2017 Muench MO, Kapidzic M, Gormley M, Gutierrez AG, Ponder KL, Fomin ME, Beyer AI, Stolp H, Qi Z, Fisher SJ, Bárcena A -
Severe pre-eclampsia is associated with alterations in cytotrophoblasts of the smooth chorion.
Development (Cambridge, England) 2017 Garrido-Gomez T, Ona K, Kapidzic M, Gormley M, Simón C, Genbacev O, Fisher SJ -
The Macronuclear Genome of Stentor coeruleus Reveals Tiny Introns in a Giant Cell.
Current biology : CB 2017 Slabodnick MM, Ruby JG, Reiff SB, Swart EC, Gosai S, Prabakaran S, Witkowska E, Larue GE, Fisher S, Freeman RM, Gunawardena J, Chu W, Stover NA, Gregory BD, Nowacki M, Derisi J, Roy SW, Marshall WF, … -
Placental transcriptomes in the common aneuploidies reveal critical regions on the trisomic chromosomes and genome-wide effects.
Prenatal diagnosis 2016 Bianco K, Gormley M, Farrell J, Zhou Y, Oliverio O, Tilden H, McMaster M, Fisher SJ -
Stromal Cell-Derived Factor 2: A Novel Protein that Interferes in Endoplasmic Reticulum Stress Pathway in Human Placental Cells.
Biology of reproduction 2016 Lorenzon-Ojea AR, Guzzo CR, Kapidzic M, Fisher SJ, Bevilacqua E -
Integrin α4-positive human trophoblast progenitors: functional characterization and transcriptional regulation.
Human reproduction (Oxford, England) 2016 Genbacev O, Larocque N, Ona K, Prakobphol A, Garrido-Gomez T, Kapidzic M, Bárcena A, Gormley M, Fisher SJ -
Novel aspects of sialoglycan recognition by the Siglec-like domains of streptococcal SRR glycoproteins.
Glycobiology 2016 Bensing BA, Khedri Z, Deng L, Yu H, Prakobphol A, Fisher SJ, Chen X, Iverson TM, Varki A, Sullam PM -
Preeclampsia and Inflammatory Preterm Labor Alter the Human Placental Hematopoietic Niche.
Reproductive sciences (Thousand Oaks, Calif.) 2016 Ponder KL, Bárcena A, Bos FL, Gormley M, Zhou Y, Ona K, Kapidzic M, Zovein AC, Fisher SJ -
Quantitative proteomic analyses of mammary organoids reveals distinct signatures after exposure to environmental chemicals.
Proceedings of the National Academy of Sciences of the United States of America 2016 Williams KE, Lemieux GA, Hassis ME, Olshen AB, Fisher SJ, Werb Z -
Bacterial Interactomes: Interacting Protein Partners Share Similar Function and Are Validated in Independent Assays More Frequently Than Previously Reported.
Molecular & cellular proteomics : MCP 2016 Shatsky M, Allen S, Gold BL, Liu NL, Juba TR, Reveco SA, Elias DA, Prathapam R, He J, Yang W, Szakal ED, Liu H, Singer ME, Geller JT, Lam BR, Saini A, Trotter VV, Hall SC, Fisher SJ, Brenner SE, … -
A genomics-based framework for identifying biomarkers of human neurodevelopmental toxicity.
Reproductive toxicology (Elmsford, N.Y.) 2016 Robinson JF, Gormley MJ, Fisher SJ -
Mass spectrometry-based analyses showing the effects of secretor and blood group status on salivary N-glycosylation.
Clinical proteomics 2015 Albertolle ME, Hassis ME, Ng CJ, Cuison S, Williams K, Prakobphol A, Dykstra AB, Hall SC, Niles RK, Ewa Witkowska H, Fisher SJ -
Human stem cells from single blastomeres reveal pathways of embryonic or trophoblast fate specification.
Development (Cambridge, England) 2015 Zdravkovic T, Nazor KL, Larocque N, Gormley M, Donne M, Hunkapillar N, Giritharan G, Bernstein HS, Wei G, Hebrok M, Zeng X, Genbacev O, Mattis A, McMaster MT, Krtolica A, Valbuena D, Simón C, Laurent … -
Placenta: the forgotten organ.
Annual review of cell and developmental biology 2015 Maltepe E, Fisher SJ -
Why is placentation abnormal in preeclampsia?
American journal of obstetrics and gynecology 2015 Fisher SJ -
Human Stem Cells from Single Blastomeres Reveal Pathways of Embryonic or Trophoblast Fate Specification (in Press)
Development 2015 Zdravkovic T, Nazor KL, Larocque N, Gormley M, Donne M, Hunkapiller N, Gnanaratnam G, Bernstein HS, Wei G, Hebrok M, Zeng X, Genbacev O, Mattis A, McMaster MT, Krtolica A, Valbuena D, Simón C, Laurent… -
Evaluating the effects of preanalytical variables on the stability of the human plasma proteome.
Analytical biochemistry 2015 Hassis ME, Niles RK, Braten MN, Albertolle ME, Ewa Witkowska H, Hubel CA, Fisher SJ, Williams KE -
Integrative analysis of 111 reference human epigenomes.
Nature 2015 Roadmap Epigenomics Consortium, Kundaje A, Meuleman W, Ernst J, Bilenky M, Yen A, Heravi-Moussavi A, Kheradpour P, Zhang Z, Wang J, Ziller MJ, Amin V, Whitaker JW, Schultz MD, Ward LD, Sarkar A, Quon … -
Large-Scale Interlaboratory Study to Develop, Analytically Validate and Apply Highly Multiplexed, Quantitative Peptide Assays to Measure Cancer-Relevant Proteins in Plasma.
Molecular & cellular proteomics : MCP 2015 Abbatiello SE, Schilling B, Mani DR, Zimmerman LJ, Hall SC, MacLean B, Albertolle M, Allen S, Burgess M, Cusack MP, Gosh M, Hedrick V, Held JM, Inerowicz HD, Jackson A, Keshishian H, Kinsinger CR, … -
Roadmay Epigenomics Consortium: Integrative Analysis of 111 Reference Human Epigenomes
Nature 2015 Kundaje A, Meuleman W, Ernst J, Bilenky M, Yen A, Heravi-Moussavi A, Kheradpour P, Zhang Z, Wang J, Ziller MJ, Amin V, Whitaker JW, Schultz MD, Ward LD, Sarkar A, Quon G, Sandstrom RS, Eaton ML, Wu YC… -
Perdeuteration: improved visualization of solvent structure in neutron macromolecular crystallography.
Acta crystallographica. Section D, Biological crystallography 2014 Fisher SJ, Blakeley MP, Howard EI, Petit-Haertlein I, Haertlein M, Mitschler A, Cousido-Siah A, Salvay AG, Popov A, Muller-Dieckmann C, Petrova T, Podjarny A -
Rbpj links uterine transformation and embryo orientation.
Cell research 2014 Robinson JF, Fisher SJ -
Variation and quantification among a target set of phosphopeptides in human plasma by multiple reaction monitoring and SWATH-MS2 data-independent acquisition.
Electrophoresis 2014 Zawadzka AM, Schilling B, Held JM, Sahu AK, Cusack MP, Drake PM, Fisher SJ, Gibson BW -
Stromal cell derived factor-2 (Sdf2): a novel protein expressed in mouse.
The international journal of biochemistry & cell biology 2014 Lorenzon-Ojea AR, Caldeira W, Ribeiro AF, Fisher SJ, Guzzo CR, Bevilacqua E -
Phosphoprotein secretome of tumor cells as a source of candidates for breast cancer biomarkers in plasma.
Molecular & cellular proteomics : MCP 2014 Zawadzka AM, Schilling B, Cusack MP, Sahu AK, Drake P, Fisher SJ, Benz CC, Gibson BW -
Histopathologies, immunolocalization, and a glycan binding screen provide insights into Plasmodium falciparum interactions with the human placenta.
Biology of reproduction 2013 Hromatka BS, Ngeleza S, Adibi JJ, Niles RK, Tshefu AK, Fisher SJ -
Maternal decidual macrophages inhibit NK cell killing of invasive cytotrophoblasts during human pregnancy.
Biology of reproduction 2013 Co EC, Gormley M, Kapidzic M, Rosen DB, Scott MA, Stolp HA, McMaster M, Lanier LL, Bárcena A, Fisher SJ -
Protein composition of bronchoalveolar lavage fluid and airway surface liquid from newborn pigs.
American journal of physiology. Lung cellular and molecular physiology 2013 Bartlett JA, Albertolle ME, Wohlford-Lenane C, Pezzulo AA, Zabner J, Niles RK, Fisher SJ, McCray PB, Williams KE -
Design, implementation and multisite evaluation of a system suitability protocol for the quantitative assessment of instrument performance in liquid chromatography-multiple reaction monitoring-MS (LC-MRM-MS).
Molecular & cellular proteomics : MCP 2013 Abbatiello SE, Mani DR, Schilling B, Maclean B, Zimmerman LJ, Feng X, Cusack MP, Sedransk N, Hall SC, Addona T, Allen S, Dodder NG, Ghosh M, Held JM, Hedrick V, Inerowicz HD, Jackson A, Keshishian H, … -
Retrospective. Robert G. Edwards (1925-2013).
Science (New York, N.Y.) 2013 Fisher SJ, Giudice LC -
Human trophoblast progenitors: where do they reside?
Seminars in reproductive medicine 2013 Genbacev O, Lamb JD, Prakobphol A, Donne M, McMaster MT, Fisher SJ -
Elucidation of N-glycosites within human plasma glycoproteins for cancer biomarker discovery.
Methods in molecular biology (Clifton, N.J.) 2013 Drake P, Schilling B, Gibson B, Fisher S -
Polysialic acid enhances the migration and invasion of human cytotrophoblasts.
Glycobiology 2012 Hromatka BS, Drake PM, Kapidzic M, Stolp H, Goldfien GA, Shih IeM, Fisher SJ -
High-throughput isolation and characterization of untagged membrane protein complexes: outer membrane complexes of Desulfovibrio vulgaris.
Journal of proteome research 2012 Walian PJ, Allen S, Shatsky M, Zeng L, Szakal ED, Liu H, Hall SC, Fisher SJ, Lam BR, Singer ME, Geller JT, Brenner SE, Chandonia JM, Hazen TC, Witkowska HE, Biggin MD, Jap BK -
Comparative transcriptome analysis of human trophectoderm and embryonic stem cell-derived trophoblasts reveal key participants in early implantation.
Biology of reproduction 2012 Aghajanova L, Shen S, Rojas AM, Fisher SJ, Irwin JC, Giudice LC -
Breaking the bottleneck in the protein biomarker pipeline.
Clinical chemistry 2011 Witkowska HE, Hall SC, Fisher SJ -
SGK1: a fine balancing act for human pregnancy.
Nature medicine 2011 Fisher SJ, Giudice LC -
Human placenta and chorion: potential additional sources of hematopoietic stem cells for transplantation.
Transfusion 2011 Bárcena A, Muench MO, Kapidzic M, Gormley M, Goldfien GA, Fisher SJ -
Automated iterative MS/MS acquisition: a tool for improving efficiency of protein identification using a LC-MALDI MS workflow.
Analytical chemistry 2011 Liu H, Yang L, Khainovski N, Dong M, Hall SC, Fisher SJ, Biggin MD, Jin J, Witkowska HE -
A role for Notch signaling in trophoblast endovascular invasion and in the pathogenesis of pre-eclampsia.
Development (Cambridge, England) 2011 Hunkapiller NM, Gasperowicz M, Kapidzic M, Plaks V, Maltepe E, Kitajewski J, Cross JC, Fisher SJ -
Pre-eclampsia is associated with elevated CXCL12 levels in placental syncytiotrophoblasts and maternal blood.
European journal of obstetrics, gynecology, and reproductive biology 2011 Schanz A, Winn VD, Fisher SJ, Blumenstein M, Heiss C, Hess AP, Kruessel JS, Mcmaster M, North RA -
GROα regulates human embryonic stem cell self-renewal or adoption of a neuronal fate.
Differentiation; research in biological diversity 2011 Krtolica A, Larocque N, Genbacev O, Ilic D, Coppe JP, Patil CK, Zdravkovic T, McMaster M, Campisi J, Fisher SJ -
Transcriptomic signature of trophoblast differentiation in a human embryonic stem cell model.
Biology of reproduction 2011 Marchand M, Horcajadas JA, Esteban FJ, McElroy SL, Fisher SJ, Giudice LC -
The Impact of Preeclampsia on Gene Expression at the Maternal-Fetal Interface.
Pregnancy hypertension 2011 Winn VD, Gormley M, Fisher SJ -
Trophoblast stem cells.
Biology of reproduction 2010 Roberts RM, Fisher SJ -
A lectin affinity workflow targeting glycosite-specific, cancer-related carbohydrate structures in trypsin-digested human plasma.
Analytical biochemistry 2010 Drake PM, Schilling B, Niles RK, Braten M, Johansen E, Liu H, Lerch M, Sorensen DJ, Li B, Allen S, Hall SC, Witkowska HE, Regnier FE, Gibson BW, Fisher SJ -
The placenta: transcriptional, epigenetic, and physiological integration during development.
The Journal of clinical investigation 2010 Maltepe E, Bakardjiev AI, Fisher SJ -
Research ethics. NIH guidelines for stem cell research and gamete donors.
Science (New York, N.Y.) 2010 Lo B, Parham L, Cedars M, Fisher S, Gates E, Giudice L, Halme DG, Hershon W, Kriegstein A, Rao R, Roberts C, Wagner R -
Repeatability and reproducibility in proteomic identifications by liquid chromatography-tandem mass spectrometry.
Journal of proteome research 2010 Tabb DL, Vega-Montoto L, Rudnick PA, Variyath AM, Ham AJ, Bunk DM, Kilpatrick LE, Billheimer DD, Blackman RK, Cardasis HL, Carr SA, Clauser KR, Jaffe JD, Kowalski KA, Neubert TA, Regnier FE, Schilling… -
Cloning mice and men: prohibiting the use of iPS cells for human reproductive cloning.
Cell stem cell 2010 Lo B, Parham L, Alvarez-Buylla A, Cedars M, Conklin B, Fisher S, Gates E, Giudice L, Halme DG, Hershon W, Kriegstein A, Kwok PY, Wagner R -
Analytical validation of protein-based multiplex assays: a workshop report by the NCI-FDA interagency oncology task force on molecular diagnostics.
Clinical chemistry 2009 Rodriguez H, Tezak Z, Mesri M, Carr SA, Liebler DC, Fisher SJ, Tempst P, Hiltke T, Kessler LG, Kinsinger CR, Philip R, Ransohoff DF, Skates SJ, Regnier FE, Anderson NL, Mansfield E, Workshop … -
Protein-based multiplex assays: mock presubmissions to the US Food and Drug Administration.
Clinical chemistry 2009 Regnier FE, Skates SJ, Mesri M, Rodriguez H, Tezak Z, Kondratovich MV, Alterman MA, Levin JD, Roscoe D, Reilly E, Callaghan J, Kelm K, Brown D, Philip R, Carr SA, Liebler DC, Fisher SJ, Tempst P, … -
Sweetening the pot: adding glycosylation to the biomarker discovery equation.
Clinical chemistry 2009 Drake PM, Cho W, Li B, Prakobphol A, Johansen E, Anderson NL, Regnier FE, Gibson BW, Fisher SJ -
Derivation of human embryonic stem cell lines from biopsied blastomeres on human feeders with minimal exposure to xenomaterials.
Stem cells and development 2009 Ilic D, Giritharan G, Zdravkovic T, Caceres E, Genbacev O, Fisher SJ, Krtolica A -
Interlaboratory study characterizing a yeast performance standard for benchmarking LC-MS platform performance.
Molecular & cellular proteomics : MCP 2009 Paulovich AG, Billheimer D, Ham AJ, Vega-Montoto L, Rudnick PA, Tabb DL, Wang P, Blackman RK, Bunk DM, Cardasis HL, Clauser KR, Kinsinger CR, Schilling B, Tegeler TJ, Variyath AM, Wang M, Whiteaker JR… -
Performance metrics for liquid chromatography-tandem mass spectrometry systems in proteomics analyses.
Molecular & cellular proteomics : MCP 2009 Rudnick PA, Clauser KR, Kilpatrick LE, Tchekhovskoi DV, Neta P, Blonder N, Billheimer DD, Blackman RK, Bunk DM, Cardasis HL, Ham AJ, Jaffe JD, Kinsinger CR, Mesri M, Neubert TA, Schilling B, Tabb DL, … -
A lectin HPLC method to enrich selectively-glycosylated peptides from complex biological samples.
Journal of visualized experiments : JoVE 2009 Johansen E, Schilling B, Lerch M, Niles RK, Liu H, Li B, Allen S, Hall SC, Witkowska HE, Regnier FE, Gibson BW, Fisher SJ, Drake PM -
Multi-site assessment of the precision and reproducibility of multiple reaction monitoring-based measurements of proteins in plasma.
Nature biotechnology 2009 Addona TA, Abbatiello SE, Schilling B, Skates SJ, Mani DR, Bunk DM, Spiegelman CH, Zimmerman LJ, Ham AJ, Keshishian H, Hall SC, Allen S, Blackman RK, Borchers CH, Buck C, Cardasis HL, Cusack MP, … -
mTOR supports long-term self-renewal and suppresses mesoderm and endoderm activities of human embryonic stem cells.
Proceedings of the National Academy of Sciences of the United States of America 2009 Zhou J, Su P, Wang L, Chen J, Zimmermann M, Genbacev O, Afonja O, Horne MC, Tanaka T, Duan E, Fisher SJ, Liao J, Chen J, Wang F -
Acid-catalyzed oxygen-18 labeling of peptides.
Analytical chemistry 2009 Niles R, Witkowska HE, Allen S, Hall SC, Fisher SJ, Hardt M -
A new role for the human placenta as a hematopoietic site throughout gestation.
Reproductive sciences (Thousand Oaks, Calif.) 2009 Bárcena A, Muench MO, Kapidzic M, Fisher SJ -
The human placenta is a hematopoietic organ during the embryonic and fetal periods of development.
Developmental biology 2008 Bárcena A, Kapidzic M, Muench MO, Gormley M, Scott MA, Weier JF, Ferlatte C, Fisher SJ -
Severe preeclampsia-related changes in gene expression at the maternal-fetal interface include sialic acid-binding immunoglobulin-like lectin-6 and pappalysin-2.
Endocrinology 2008 Winn VD, Gormley M, Paquet AC, Kjaer-Sorensen K, Kramer A, Rumer KK, Haimov-Kochman R, Yeh RF, Overgaard MT, Varki A, Oxvig C, Fisher SJ -
Human embryonic stem cells as a model system for studying the effects of smoke exposure on the embryo.
Reproductive toxicology (Elmsford, N.Y.) 2008 Zdravkovic T, Genbacev O, LaRocque N, McMaster M, Fisher S -
The proteomes of human parotid and submandibular/sublingual gland salivas collected as the ductal secretions.
Journal of proteome research 2008 Denny P, Hagen FK, Hardt M, Liao L, Yan W, Arellanno M, Bassilian S, Bedi GS, Boontheung P, Cociorva D, Delahunty CM, Denny T, Dunsmore J, Faull KF, Gilligan J, Gonzalez-Begne M, Halgand F, Hall SC, … -
A "tagless" strategy for identification of stable protein complexes genome-wide by multidimensional orthogonal chromatographic separation and iTRAQ reagent tracking.
Journal of proteome research 2008 Dong M, Yang LL, Williams K, Fisher SJ, Hall SC, Biggin MD, Jin J, Witkowska HE -
A mass spectrometry-based strategy for detecting and characterizing endogenous proteinase activities in complex biological samples.
Proteomics 2008 Robinson S, Niles RK, Witkowska HE, Rittenbach KJ, Nichols RJ, Sargent JA, Dixon SE, Prakobphol A, Hall SC, Fisher SJ, Hardt M -
Nuclear FAK promotes cell proliferation and survival through FERM-enhanced p53 degradation.
Molecular cell 2008 Lim ST, Chen XL, Lim Y, Hanson DA, Vo TT, Howerton K, Larocque N, Fisher SJ, Schlaepfer DD, Ilic D -
Human embryonic stem cell lines generated without embryo destruction.
Cell stem cell 2008 Chung Y, Klimanskaya I, Becker S, Li T, Maserati M, Lu SJ, Zdravkovic T, Ilic D, Genbacev O, Fisher S, Krtolica A, Lanza R -
Chapter 12. Placental remodeling of the uterine vasculature.
Methods in enzymology 2008 Hunkapiller NM, Fisher SJ -
Disruption of apical-basal polarity of human embryonic stem cells enhances hematoendothelial differentiation.
Stem cells (Dayton, Ohio) 2007 Krtolica A, Genbacev O, Escobedo C, Zdravkovic T, Nordstrom A, Vabuena D, Nath A, Simon C, Mostov K, Fisher SJ -
Comparative analysis of maternal-fetal interface in preeclampsia and preterm labor.
Cell and tissue research 2007 Zhou Y, Bianco K, Huang L, Nien JK, McMaster M, Romero R, Fisher SJ -
Focal adhesion kinase controls pH-dependent epidermal barrier homeostasis by regulating actin-directed Na+/H+ exchanger 1 plasma membrane localization.
The American journal of pathology 2007 Ilic D, Mao-Qiang M, Crumrine D, Dolganov G, Larocque N, Xu P, Demerjian M, Brown BE, Lim ST, Ossovskaya V, Schlaepfer DD, Fisher SJ, Feingold KR, Elias PM, Mauro TM -
Gene expression profiling of the human maternal-fetal interface reveals dramatic changes between midgestation and term.
Endocrinology 2006 Winn VD, Haimov-Kochman R, Paquet AC, Yang YJ, Madhusudhan MS, Gormley M, Feng KT, Bernlohr DA, McDonagh S, Pereira L, Sali A, Fisher SJ -
Decidual stromal cell response to paracrine signals from the trophoblast: amplification of immune and angiogenic modulators.
Biology of reproduction 2006 Hess AP, Hamilton AE, Talbi S, Dosiou C, Nyegaard M, Nayak N, Genbecev-Krtolica O, Mavrogianis P, Ferrer K, Kruessel J, Fazleabas AT, Fisher SJ, Giudice LC -
Cytotrophoblast induction of arterial apoptosis and lymphangiogenesis in an in vivo model of human placentation.
The Journal of clinical investigation 2006 Red-Horse K, Rivera J, Schanz A, Zhou Y, Winn V, Kapidzic M, Maltepe E, Okazaki K, Kochman R, Vo KC, Giudice L, Erlebacher A, McCune JM, Stoddart CA, Fisher SJ -
MUC1 is a scaffold for selectin ligands in the human uterus.
Frontiers in bioscience : a journal and virtual library 2006 Carson DD, Julian J, Lessey BA, Prakobphol A, Fisher SJ -
Nicotine downregulates the l-selectin system that mediates cytotrophoblast emigration from cell columns and attachment to the uterine wall.
Reproductive toxicology (Elmsford, N.Y.) 2006 Zdravkovic T, Genbacev O, Prakobphol A, Cvetkovic M, Schanz A, McMaster M, Fisher SJ -
A role for the L-selectin adhesion system in mediating cytotrophoblast emigration from the placenta.
Developmental biology 2006 Prakobphol A, Genbacev O, Gormley M, Kapidzic M, Fisher SJ -
Binding of the streptococcal surface glycoproteins GspB and Hsa to human salivary proteins.
Infection and immunity 2006 Takamatsu D, Bensing BA, Prakobphol A, Fisher SJ, Sullam PM -
Hair cycle and wound healing in mice with a keratinocyte-restricted deletion of FAK.
Oncogene 2006 Essayem S, Kovacic-Milivojevic B, Baumbusch C, McDonagh S, Dolganov G, Howerton K, Larocque N, Mauro T, Ramirez A, Ramos DM, Fisher SJ, Jorcano JL, Beggs HE, Reichardt LF, Ilic D -
Literature watch. Cytotrophoblast induction of arterial apoptosis and lymphangiogenesis in an in vivo model of human placentation.
Lymphatic research and biology 2006 Red-Horse K, Rivera J, Schanz A, Zhou Y, Winn V, Kapidzic M, Maltepe E, Okazaki K, Kochman R, Vo KC, Giudice L, Erlebacher A, McCune JM, Stoddart CA, Fisher SJ -
Modification of the standard Trizol-based technique improves the integrity of RNA isolated from RNase-rich placental tissue.
Clinical chemistry 2006 Haimov-Kochman R, Fisher SJ, Winn VD -
Molecular cytogenetic studies towards the full karyotype analysis of human blastocysts and cytotrophoblasts.
Cytogenetic and genome research 2006 Weier JF, Ferlatte C, Baumgartner A, Jung CJ, Nguyen HN, Chu LW, Pedersen RA, Fisher SJ, Weier HU -
EPHB4 regulates chemokine-evoked trophoblast responses: a mechanism for incorporating the human placenta into the maternal circulation.
Development (Cambridge, England) 2005 Red-Horse K, Kapidzic M, Zhou Y, Feng KT, Singh H, Fisher SJ -
Assessing the effects of diurnal variation on the composition of human parotid saliva: quantitative analysis of native peptides using iTRAQ reagents.
Analytical chemistry 2005 Hardt M, Witkowska HE, Webb S, Thomas LR, Dixon SE, Hall SC, Fisher SJ -
Highlight for phenols, quinolines, indoles, benzene and 2-cyclopenten-1-ones are oviduct toxicants in cigarette smoke, by Prue Talbot, Karen Riveles, and Ryan Rosa: list of tobacco-smoke constituents that are harmful for reproduction grows--passive smokers may be at risk.
Toxicological sciences : an official journal of the Society of Toxicology 2005 Genbacev-Krtolica O -
Hypoxia-inducible factor-dependent histone deacetylase activity determines stem cell fate in the placenta.
Development (Cambridge, England) 2005 Maltepe E, Krampitz GW, Okazaki KM, Red-Horse K, Mak W, Simon MC, Fisher SJ -
Serum-free derivation of human embryonic stem cell lines on human placental fibroblast feeders.
Fertility and sterility 2005 Genbacev O, Krtolica A, Zdravkovic T, Brunette E, Powell S, Nath A, Caceres E, McMaster M, McDonagh S, Li Y, Mandalam R, Lebkowski J, Fisher SJ -
The adverse effects of maternal smoking on the human placenta: a review.
Placenta 2005 Zdravkovic T, Genbacev O, McMaster MT, Fisher SJ -
Human cytotrophoblasts acquire aneuploidies as they differentiate to an invasive phenotype.
Developmental biology 2005 Weier JF, Weier HU, Jung CJ, Gormley M, Zhou Y, Chu LW, Genbacev O, Wright AA, Fisher SJ -
Toward defining the human parotid gland salivary proteome and peptidome: identification and characterization using 2D SDS-PAGE, ultrafiltration, HPLC, and mass spectrometry.
Biochemistry 2005 Hardt M, Thomas LR, Dixon SE, Newport G, Agabian N, Prakobphol A, Hall SC, Witkowska HE, Fisher SJ -
Highly glycosylated human salivary molecules present oligosaccharides that mediate adhesion of leukocytes and Helicobacter pylori.
Biochemistry 2005 Prakobphol A, Borén T, Ma W, Zhixiang P, Fisher SJ -
First derivation in Spain of human embryonic stem cell lines: use of long-term cryopreserved embryos and animal-free conditions.
Fertility and sterility 2005 Simón C, Escobedo C, Valbuena D, Genbacev O, Galan A, Krtolica A, Asensi A, Sánchez E, Esplugues J, Fisher S, Pellicer A -
Abnormal placentation and the syndrome of preeclampsia.
Seminars in nephrology 2004 McMaster MT, Zhou Y, Fisher SJ -
Trisomy 21 is associated with variable defects in cytotrophoblast differentiation along the invasive pathway.
American journal of medical genetics. Part A 2004 Wright A, Zhou Y, Weier JF, Caceres E, Kapidzic M, Tabata T, Kahn M, Nash C, Fisher SJ -
Functional and placental expression analysis of the human NRF3 transcription factor.
Molecular endocrinology (Baltimore, Md.) 2004 Chénais B, Derjuga A, Massrieh W, Red-Horse K, Bellingard V, Fisher SJ, Blank V -
Trophoblast differentiation during embryo implantation and formation of the maternal-fetal interface.
The Journal of clinical investigation 2004 Red-Horse K, Zhou Y, Genbacev O, Prakobphol A, Foulk R, McMaster M, Fisher SJ -
Viral and bacterial pathogens at the maternal-fetal interface.
The Journal of infectious diseases 2004 McDonagh S, Maidji E, Ma W, Chang HT, Fisher S, Pereira L -
The placental problem: linking abnormal cytotrophoblast differentiation to the maternal symptoms of preeclampsia.
Reproductive biology and endocrinology : RB&E 2004 Fisher SJ -
Human pregnancy: the role of chemokine networks at the fetal-maternal interface.
Expert reviews in molecular medicine 2004 Red-Horse K, Drake PM, Fisher SJ -
Reciprocal chemokine receptor and ligand expression in the human placenta: implications for cytotrophoblast differentiation.
Developmental dynamics : an official publication of the American Association of Anatomists 2004 Drake PM, Red-Horse K, Fisher SJ -
Human cytomegalovirus interleukin-10 downregulates metalloproteinase activity and impairs endothelial cell migration and placental cytotrophoblast invasiveness in vitro.
Journal of virology 2004 Yamamoto-Tabata T, McDonagh S, Chang HT, Fisher S, Pereira L -
Listeriosis in the pregnant guinea pig: a model of vertical transmission.
Infection and immunity 2004 Bakardjiev AI, Stacy BA, Fisher SJ, Portnoy DA -
Human cytomegalovirus transmission from the uterus to the placenta correlates with the presence of pathogenic bacteria and maternal immunity.
Journal of virology 2003 Pereira L, Maidji E, McDonagh S, Genbacev O, Fisher S -
Human cytotrophoblasts promote endothelial survival and vascular remodeling through secretion of Ang2, PlGF, and VEGF-C.
Developmental biology 2003 Zhou Y, Bellingard V, Feng KT, McMaster M, Fisher SJ -
Disruption of oxygen-regulated responses underlies pathological changes in the placentas of women who smoke or who are passively exposed to smoke during pregnancy.
Reproductive toxicology (Elmsford, N.Y.) 2003 Genbacev O, McMaster MT, Zdravkovic T, Fisher SJ -
The human placenta remodels the uterus by using a combination of molecules that govern vasculogenesis or leukocyte extravasation.
Annals of the New York Academy of Sciences 2003 Zhou Y, Genbacev O, Fisher SJ -
Trophoblast L-selectin-mediated adhesion at the maternal-fetal interface.
Science (New York, N.Y.) 2003 Genbacev OD, Prakobphol A, Foulk RA, Krtolica AR, Ilic D, Singer MS, Yang ZQ, Kiessling LL, Rosen SD, Fisher SJ -
Longitudinal serum concentrations of placental growth factor: evidence for abnormal placental angiogenesis in pathologic pregnancies.
American journal of obstetrics and gynecology 2003 Taylor RN, Grimwood J, Taylor RS, McMaster MT, Fisher SJ, North RA -
Transmission of human cytomegalovirus from infected uterine microvascular endothelial cells to differentiating/invasive placental cytotrophoblasts.
Virology 2002 Maidji E, Percivalle E, Gerna G, Fisher S, Pereira L -
Chemokine expression and function at the human maternal-fetal interface.
Reviews in endocrine & metabolic disorders 2002 Drake PM, Red-Horse K, Fisher SJ -
Vascular endothelial growth factor ligands and receptors that regulate human cytotrophoblast survival are dysregulated in severe preeclampsia and hemolysis, elevated liver enzymes, and low platelets syndrome.
The American journal of pathology 2002 Zhou Y, McMaster M, Woo K, Janatpour M, Perry J, Karpanen T, Alitalo K, Damsky C, Fisher SJ -
Chemokine ligand and receptor expression in the pregnant uterus: reciprocal patterns in complementary cell subsets suggest functional roles.
The American journal of pathology 2001 Red-Horse K, Drake PM, Gunn MD, Fisher SJ -
Implantation and the survival of early pregnancy.
The New England journal of medicine 2001 Norwitz ER, Schust DJ, Fisher SJ -
Plasma membrane-associated pY397FAK is a marker of cytotrophoblast invasion in vivo and in vitro.
The American journal of pathology 2001 Ilic D, Genbacev O, Jin F, Caceres E, Almeida EA, Bellingard-Dubouchaud V, Schaefer EM, Damsky CH, Fisher SJ -
Human placental cytotrophoblasts attract monocytes and CD56(bright) natural killer cells via the actions of monocyte inflammatory protein 1alpha.
The Journal of experimental medicine 2001 Drake PM, Gunn MD, Charo IF, Tsou CL, Zhou Y, Huang L, Fisher SJ -
Human cytotrophoblast expression of the von Hippel-Lindau protein is downregulated during uterine invasion in situ and upregulated by hypoxia in vitro.
Developmental biology 2001 Genbacev O, Krtolica A, Kaelin W, Fisher SJ -
Functional proteomics: examining the effects of hypoxia on the cytotrophoblast protein repertoire.
Biochemistry 2001 Hoang VM, Foulk R, Clauser K, Burlingame A, Gibson BW, Fisher SJ -
Conditioned medium from hypoxic cytotrophoblasts alters arterial function.
American journal of obstetrics and gynecology 2001 Gratton RJ, Gandley RE, Genbacev O, McCarthy JF, Fisher SJ, McLaughlin MK -
Salivary agglutinin, which binds Streptococcus mutans and Helicobacter pylori, is the lung scavenger receptor cysteine-rich protein gp-340.
The Journal of biological chemistry 2000 Prakobphol A, Xu F, Hoang VM, Larsson T, Bergstrom J, Johansson I, Frängsmyr L, Holmskov U, Leffler H, Nilsson C, Borén T, Wright JR, Strömberg N, Fisher SJ -
Concordant in situ and in vitro data show that maternal cigarette smoking negatively regulates placental cytotrophoblast passage through the cell cycle.
Reproductive toxicology (Elmsford, N.Y.) 2000 Genbacev O, McMaster MT, Lazic J, Nedeljkovic S, Cvetkovic M, Joslin R, Fisher SJ -
HLA-G, -E, -F preworkshop: tools and protocols for analysis of non-classical class I genes transcription and protein expression.
Human immunology 2000 Paul P, Rouas-Freiss N, Moreau P, Cabestre FA, Menier C, Khalil-Daher I, Pangault C, Onno M, Fauchet R, Martinez-Laso J, Morales P, Villena AA, Giacomini P, Natali PG, Frumento G, Ferrara GB, McMaster… -
A repertoire of cell cycle regulators whose expression is coordinated with human cytotrophoblast differentiation.
The American journal of pathology 2000 Genbacev O, McMaster MT, Fisher SJ -
The glial cells missing-1 protein is essential for branching morphogenesis in the chorioallantoic placenta.
Nature genetics 2000 Anson-Cartwright L, Dawson K, Holmyard D, Fisher SJ, Lazzarini RA, Cross JC -
Posttranscriptional regulation of human leukocyte antigen G during human extravillous cytotrophoblast differentiation.
Biology of reproduction 2000 Copeman J, Han RN, Caniggia I, McMaster M, Fisher SJ, Cross JC -
Id-2 regulates critical aspects of human cytotrophoblast differentiation, invasion and migration.
Development (Cambridge, England) 2000 Janatpour MJ, McMaster MT, Genbacev O, Zhou Y, Dong J, Cross JC, Israel MA, Fisher SJ -
Invasive cytotrophoblasts manifest evidence of oxidative stress in preeclampsia.
The American journal of pathology 2000 Many A, Hubel CA, Fisher SJ, Roberts JM, Zhou Y -
Lack of human leukocyte antigen-G expression in extravillous trophoblasts is associated with pre-eclampsia.
Molecular human reproduction 2000 Goldman-Wohl DS, Ariel I, Greenfield C, Hochner-Celnikier D, Cross J, Fisher S, Yagel S -
The placenta dilemma.
Seminars in reproductive medicine 2000 Fisher SJ -
Upregulation of human cytotrophoblast invasion by hepatocyte growth factor.
Journal of reproduction and fertility. Supplement 2000 Nasu K, Zhou Y, McMaster MT, Fisher SJ -
Invasive cytotrophoblast apoptosis in pre-eclampsia.
Human reproduction (Oxford, England) 1999 Genbacev O, DiFederico E, McMaster M, Fisher SJ -
Preeclampsia is associated with widespread apoptosis of placental cytotrophoblasts within the uterine wall.
The American journal of pathology 1999 DiFederico E, Genbacev O, Fisher SJ -
The placenta and the prolactin family of hormones: regulation of the physiology of pregnancy.
Molecular endocrinology (Baltimore, Md.) 1999 Linzer DI, Fisher SJ -
Separate oligosaccharide determinants mediate interactions of the low-molecular-weight salivary mucin with neutrophils and bacteria.
Biochemistry 1999 Prakobphol A, Tangemann K, Rosen SD, Hoover CI, Leffler H, Fisher SJ -
A repertoire of differentially expressed transcription factors that offers insight into mechanisms of human cytotrophoblast differentiation.
Developmental genetics 1999 Janatpour MJ, Utset MF, Cross JC, Rossant J, Dong J, Israel MA, Fisher SJ -
IL-10 is an autocrine inhibitor of human placental cytotrophoblast MMP-9 production and invasion.
Developmental biology 1999 Roth I, Fisher SJ -
Cloning and regulated expression of the Candida albicans phospholipase B (PLB1) gene.
FEMS microbiology letters 1998 Hoover CI, Jantapour MJ, Newport G, Agabian N, Fisher SJ -
Trophoblast pseudo-vasculogenesis: faking it with endothelial adhesion receptors.
Current opinion in cell biology 1998 Damsky CH, Fisher SJ -
Oxygen regulates human cytotrophoblast differentiation and invasion: implications for endovascular invasion in normal pregnancy and in pre-eclampsia.
Journal of reproductive immunology 1998 Zhou Y, Genbacev O, Damsky CH, Fisher SJ -
Human low-molecular-weight salivary mucin expresses the sialyl lewisx determinant and has L-selectin ligand activity.
Biochemistry 1998 Prakobphol A, Thomsson KA, Hansson GC, Rosen SD, Singer MS, Phillips NJ, Medzihradszky KF, Burlingame AL, Leffler H, Fisher SJ -
Complementary expression of HIP, a cell-surface heparan sulfate binding protein, and perlecan at the human fetal-maternal interface.
Biology of reproduction 1998 Rohde LH, Janatpore MJ, McMaster MT, Fisher S, Zhou Y, Lim KH, French M, Hoke D, Julian J, Carson DD -
Human cytotrophoblast differentiation/invasion is abnormal in pre-eclampsia.
The American journal of pathology 1997 Lim KH, Zhou Y, Janatpour M, McMaster M, Bass K, Chun SH, Fisher SJ -
Elevated nonesterified fatty acid concentrations in severe preeclampsia shift the isoelectric characteristics of plasma albumin.
The Journal of clinical endocrinology and metabolism 1997 Vigne JL, Murai JT, Arbogast BW, Jia W, Fisher SJ, Taylor RN -
Regulation of human placental development by oxygen tension.
Science (New York, N.Y.) 1997 Genbacev O, Zhou Y, Ludlow JW, Fisher SJ -
Identification of a thymic epithelial cell subset sharing expression of the class Ib HLA-G molecule with fetal trophoblasts.
The Journal of experimental medicine 1997 Crisa L, McMaster MT, Ishii JK, Fisher SJ, Salomon DR -
Palmitoyl carnitine, a lysophospholipase-transacylase inhibitor, prevents Candida adherence in vitro.
FEMS microbiology letters 1997 Prakobphol A, Leffler H, Hoover CI, Fisher SJ -
Human cytotrophoblasts adopt a vascular phenotype as they differentiate. A strategy for successful endovascular invasion?
The Journal of clinical investigation 1997 Zhou Y, Fisher SJ, Janatpour M, Genbacev O, Dejana E, Wheelock M, Damsky CH -
Preeclampsia is associated with failure of human cytotrophoblasts to mimic a vascular adhesion phenotype. One cause of defective endovascular invasion in this syndrome?
The Journal of clinical investigation 1997 Zhou Y, Damsky CH, Fisher SJ -
The solid state environment orchestrates embryonic development and tissue remodeling.
Kidney international 1997 Damsky CH, Moursi A, Zhou Y, Fisher SJ, Globus RK -
Tissue inhibitor of metalloproteinase-3 expression is upregulated during human cytotrophoblast invasion in vitro.
Developmental genetics 1997 Bass KE, Li H, Hawkes SP, Howard E, Bullen E, Vu TK, McMaster M, Janatpour M, Fisher SJ -
Human placental cytotrophoblasts produce the immunosuppressive cytokine interleukin 10.
The Journal of experimental medicine 1996 Roth I, Corry DB, Locksley RM, Abrams JS, Litton MJ, Fisher SJ -
Hypoxia alters early gestation human cytotrophoblast differentiation/invasion in vitro and models the placental defects that occur in preeclampsia.
The Journal of clinical investigation 1996 Genbacev O, Joslin R, Damsky CH, Polliotti BM, Fisher SJ -
PRB1, PRB2, and PRB4 coded polymorphisms among human salivary concanavalin-A binding, II-1, and Po proline-rich proteins.
American journal of human genetics 1996 Azen EA, Amberger E, Fisher S, Prakobphol A, Niece RL -
Conference report: placental growth and function.
Placenta 1995 Challis JR, Andres SF, Catz CS, Fisher SJ, Hay WW, Hunt JS, Illsley NP, Thornburg KL -
Maternal smoking inhibits early human cytotrophoblast differentiation.
Reproductive toxicology (Elmsford, N.Y.) 1995 Genbacev O, Bass KE, Joslin RJ, Fisher SJ -
Quantifying the strength of bacterial adhesive interactions with salivary glycoproteins.
Journal of dental research 1995 Prakobphol A, Burdsal CA, Fisher SJ -
Human placental HLA-G expression is restricted to differentiated cytotrophoblasts.
Journal of immunology (Baltimore, Md. : 1950) 1995 McMaster MT, Librach CL, Zhou Y, Lim KH, Janatpour MJ, DeMars R, Kovats S, Damsky C, Fisher SJ -
Identifying bacterial receptor proteins and quantifying strength of interactions they mediate.
Methods in enzymology 1995 Prakobphol A, Leffler H, Fisher SJ -
Implantation and the placenta: key pieces of the development puzzle.
Science (New York, N.Y.) 1994 Cross JC, Werb Z, Fisher SJ -
Integrin switching regulates normal trophoblast invasion.
Development (Cambridge, England) 1994 Damsky CH, Librach C, Lim KH, Fitzgerald ML, McMaster MT, Janatpour M, Zhou Y, Logan SK, Fisher SJ -
Glycosylation of human trophoblast integrins is stage and cell-type specific.
Glycobiology 1994 Moss L, Prakobphol A, Wiedmann TW, Fisher SJ, Damsky CH -
Human trophoblast invasion. Autocrine control and paracrine modulation.
Annals of the New York Academy of Sciences 1994 McMaster MT, Bass KE, Fisher SJ -
Specific adherence of Candida tropicalis to lysophospholipids.
Biochemistry 1994 Prakobphol A, Leffler H, Fisher SJ -
Human cytotrophoblast invasion is up-regulated by epidermal growth factor: evidence that paracrine factors modify this process.
Developmental biology 1994 Bass KE, Morrish D, Roth I, Bhardwaj D, Taylor R, Zhou Y, Fisher SJ -
Interleukin-1 beta regulates human cytotrophoblast metalloproteinase activity and invasion in vitro.
The Journal of biological chemistry 1994 Librach CL, Feigenbaum SL, Bass KE, Cui TY, Verastas N, Sadovsky Y, Quigley JP, French DL, Fisher SJ -
PRB3 null mutations result in absence of the proline-rich glycoprotein Gl and abolish Fusobacterium nucleatum interactions with saliva in vitro.
Infection and immunity 1993 Azen E, Prakobphol A, Fisher SJ -
Increased depth of trophoblast invasion after chronic constriction of the lower aorta in rhesus monkeys.
American journal of obstetrics and gynecology 1993 Zhou Y, Chiu K, Brescia RJ, Combs CA, Katz MA, Kitzmiller JL, Heilbron DC, Fisher SJ -
Human cytotrophoblast invasion.
Seminars in cell biology 1993 Fisher SJ, Damsky CH -
Preeclampsia is associated with abnormal expression of adhesion molecules by invasive cytotrophoblasts.
The Journal of clinical investigation 1993 Zhou Y, Damsky CH, Chiu K, Roberts JM, Fisher SJ -
The high-molecular-weight human mucin is the primary salivary carrier of ABH, Le(a), and Le(b) blood group antigens.
Critical reviews in oral biology and medicine : an official publication of the American Association of Oral Biologists 1993 Prakobphol A, Leffler H, Fisher SJ -
Human placental cells transformed with temperature-sensitive simian virus 40 are immortalized and mimic the phenotype of invasive cytotrophoblasts at both permissive and nonpermissive temperatures.
Cancer research 1992 Logan SK, Fisher SJ, Damsky CH -
Adherence of oral streptococci to salivary glycoproteins.
Infection and immunity 1992 Murray PA, Prakobphol A, Lee T, Hoover CI, Fisher SJ -
Distribution patterns of extracellular matrix components and adhesion receptors are intricately modulated during first trimester cytotrophoblast differentiation along the invasive pathway, in vivo.
The Journal of clinical investigation 1992 Damsky CH, Fitzgerald ML, Fisher SJ -
An inhibitor of the matrix metalloproteinase synthesized by rabbit corneal epithelium.
Investigative ophthalmology & visual science 1991 Fini ME, Cui TY, Mouldovan A, Grobelny D, Galardy RE, Fisher SJ -
Structure and bacterial receptor activity of a human salivary proline-rich glycoprotein.
The Journal of biological chemistry 1991 Gillece-Castro BL, Prakobphol A, Burlingame AL, Leffler H, Fisher SJ -
92-kD type IV collagenase mediates invasion of human cytotrophoblasts.
The Journal of cell biology 1991 Librach CL, Werb Z, Fitzgerald ML, Chiu K, Corwin NM, Esteves RA, Grobelny D, Galardy R, Damsky CH, Fisher SJ -
Effect of plasma on composition of human enamel and cementum pellicle.
Scandinavian journal of dental research 1990 Kajisa L, Prakobphol A, Schiödt M, Fisher SJ -
A class I antigen, HLA-G, expressed in human trophoblasts.
Science (New York, N.Y.) 1990 Kovats S, Main EK, Librach C, Stubblebine M, Fisher SJ, DeMars R -
Adhesive and degradative properties of human placental cytotrophoblast cells in vitro.
The Journal of cell biology 1989 Fisher SJ, Cui TY, Zhang L, Hartman L, Grahl K, Zhang GY, Tarpey J, Damsky CH -
Structure and heterogeneity of the oligosaccharides from the lipopolysaccharides of a pyocin-resistant Neisseria gonorrhoeae.
Proceedings of the National Academy of Sciences of the United States of America 1989 Gibson BW, Webb JW, Yamasaki R, Fisher SJ, Burlingame AL, Mandrell RE, Schneider H, Griffiss JM -
Structural characterization of intact, branched oligosaccharides by high performance liquid chromatography and liquid secondary ion mass spectrometry.
Analytical biochemistry 1988 Webb JW, Jiang K, Gillece-Castro BL, Tarentino AL, Plummer TH, Byrd JC, Fisher SJ, Burlingame AL -
Bacterial adherence on replicas of sodium dodecyl sulfate-polyacrylamide gels.
Analytical biochemistry 1987 Prakobphol A, Murray PA, Fisher SJ -
Structure of the oligosaccharide portion of human hepatitis B surface antigen.
Archives of biochemistry and biophysics 1987 Gillece-Castro BL, Fisher SJ, Tarentino AL, Peterson DL, Burlingame AL -
External radiolabelling of components of pellicle on human enamel and cementum.
Archives of oral biology 1987 Fisher SJ, Prakobphol A, Kajisa L, Murray PA -
Preparation of placental (fetal tissue) fibronectin and its carbohydrates.
Methods in enzymology 1987 Laine RA, Fisher SJ, Zhu BC -
Degradation of extracellular matrix by the trophoblastic cells of first-trimester human placentas.
Journal of cellular biochemistry 1985 Fisher SJ, Leitch MS, Kantor MS, Basbaum CB, Kramer RH -
Characterization of oral streptococci that activate the dietary glycoside rutin to a mutagen.
Journal of the National Cancer Institute 1984 Shillitoe EJ, Hoover CI, Fisher SJ, Abdel-Salam M, Greenspan JS -
External labelling of glycoproteins from first-trimester human placental microvilli.
The Biochemical journal 1984 Fisher SJ, Leitch MS, Laine RA -
Human placental (fetal) fibronectin: increased glycosylation and higher protease resistance than plasma fibronectin. Presence of polylactosamine glycopeptides and properties of a 44-kilodalton chymotryptic collagen-binding domain: difference from human plasma fibronectin.
The Journal of biological chemistry 1984 Zhu BC, Fisher SF, Pande H, Calaycay J, Shively JE, Laine RA -
High alpha-amylase activity in the syncytiotrophoblastic cells of first-trimester human placentas.
Journal of cellular biochemistry 1983 Fisher SJ, Laine RA -
Accumulation of malto-oligosaccharides in the syncytiotrophoblastic cells of first-trimester human placentas.
The Biochemical journal 1981 Fisher SJ, Laine RA -
Carbohydrate structure of the major glycopeptide from human cold-insoluble globulin.
Journal of supramolecular structure 1979 Fisher SJ, Laine RA