Suneil Koliwad, MD, PhD
Professor
Medicine
School of Medicine

His group strives to link basic mechanisms of metabolic regulation to causality in important clinical contexts, and has developed a highly innovative and deeply curated multiethnic obesity cohort at UCSF to assist in achieving this goal.

• The Diabetes Technology Society Error Grid and Trend Accuracy Matrix for Glucose Monitors.
  Journal of diabetes science and technology 2024 Klonoff DC, Freckmann G, Pleus S, Kovatchev BP, Kerr D, Tse CC, Li C, Agus MSD, Dungan K, Voglová Hagerf B, Krouwer JS, Lee WA, Misra S, Rhee SY, Sabharwal A, Seley JJ, Shah VN, Tran NK, Waki K, Worth…
• 8154 The Pro-Fibrotic Transcriptional Profile of Adipose Tissue in Insulin Resistant Individuals.
  Journal of the Endocrine Society 2024 M Choi, A Abdellatif, D L Alba, S K Koliwad
• Microglia mediate the early-life programming of adult glucose control.
  bioRxiv : the preprint server for biology 2024 Valdearcos M, McGrath ER, Brown Mayfield SM, Folick A, Cheang RT, Li L, Bachor TP, Lippert RN, Xu AW, Koliwad SK
• 1879-LB: Automated Self-Adjusting Subcutaneous Insulin Algorithm (SQIA) Improves Glycemic Control in Hospitalized Patients—Three-Year Experience.
  Diabetes 2024 GWENDOLYN LEE, MICHAEL A. KOHN, ESTHER ROV-IKPAH, PARAS MEHTA, CRAIG SAN LUIS, CRAIG JOHNSON, SUNEIL K. KOLIWAD, ROBERT J. RUSHAKOFF
• Novel Automated Self-adjusting Subcutaneous Insulin Algorithm Improves Glycemic Control and Physician Efficiency in Hospitalized Patients.
  Journal of diabetes science and technology 2024 Mehta PB, Kohn MA, Rov-Ikpah E, San Luis C, Johnson C, Lee G, Koliwad S, Rushakoff RJ
• PTP1B mediates the inhibitory effect of MFGE8 on insulin signaling through the β5 integrin.
  The Journal of biological chemistry 2024 Datta R, Mukherjee D, Podolsky MJ, Yang CD, Alba DL, Singh S, Arnold TD, Koliwad S, Lizama CO, Atabai K
• Second-Line Pharmaceutical Treatments for Patients with Type 2 Diabetes.
  JAMA network open 2023 Vashisht R, Patel A, Dahm L, Han C, Medders KE, Mowers R, Byington CL, Koliwad SK, Butte AJ
• Obesity-associated microglial inflammatory activation paradoxically improves glucose tolerance.
  Cell metabolism 2023 Douglass JD, Ness KM, Valdearcos M, Wyse-Jackson A, Dorfman MD, Frey JM, Fasnacht RD, Santiago OD, Niraula A, Banerjee J, Robblee M, Koliwad SK, Thaler JP
• Twenty-first century management of diabetes with shared telemedicine appointments.
  Journal of telemedicine and telecare 2023 Klonoff DC, Yeung AM, Huang J, Espinoza JC, Raymond JK, Lee WA, Koliwad SK, Kerr D
• MFGE8 inhibits insulin signaling through PTP1B.
  bioRxiv : the preprint server for biology 2023 Datta R, Podolsky MJ, Yang CD, Alba DL, Singh S, Koliwad S, Lizama CO, Atabai K
• Obesogens and Obesity: State-of-the-Science and Future Directions Summary from a Healthy Environment and Endocrine Disruptors Strategies Workshop.
  The American journal of clinical nutrition 2023 Heindel JJ, Alvarez JA, Atlas E, Cave MC, Chatzi VL, Collier D, Corkey B, Fischer D, Goran MI, Howard S, Kahan S, Kayhoe M, Koliwad S, Kotz CM, La Merrill M, Lobstein T, Lumeng C, Ludwig DS, Lustig RH…
• 407 Moving from observational studies to a clinical trial: the impact of obesity and surgical weight loss on breast imaging, tissue, and cancer screening experience: the B-BRITE study.
  Journal of Clinical and Translational Science 2023 Elle N Clelland, Judy Gonzalez-Vargas, Sarah G Palilla, Suneil K Koliwad, Heather I Greenwood, Christopher J Schwartz, Chris C. Benz, Diana L Alba, Rita A Mukhtar
• The Impact of Insulin Resistance on Loss of Lung Function and Response to Treatment in Asthma.
  American journal of respiratory and critical care medicine 2022 Peters MC, Schiebler ML, Cardet JC, Johansson MW, Sorkness R, DeBoer MD, Bleecker ER, Meyers DA, Castro M, Sumino K, Erzurum SC, Tattersall MC, Zein JG, Hastie AT, Moore W, Levy BD, Israel E, Phillips…
• Excess natural-cause deaths in California by cause and setting: March 2020 through February 2021.
  PNAS nexus 2022 Chen YH, Stokes AC, Aschmann HE, Chen R, DeVost S, Kiang MV, Koliwad S, Riley AR, Glymour MM, Bibbins-Domingo K
• ASB4 modulates central melanocortinergic neurons and calcitonin signaling to control satiety and glucose homeostasis.
  Science signaling 2022 Vagena E, Crneta J, Engström P, He L, Yulyaningsih E, Korpel NL, Cheang RT, Bachor TP, Huang A, Michel G, Attal K, Berrios DI, Valdearcos M, Koliwad SK, Olson DP, Yi CX, Xu AW
• Metabolic factors in the regulation of hypothalamic innate immune responses in obesity.
  Experimental & molecular medicine 2022 Folick A, Cheang RT, Valdearcos M, Koliwad SK
• A Glycemia Risk Index (GRI) of Hypoglycemia and Hyperglycemia for Continuous Glucose Monitoring Validated by Clinician Ratings.
  Journal of diabetes science and technology 2022 Klonoff DC, Wang J, Rodbard D, Kohn MA, Li C, Liepmann D, Kerr D, Ahn D, Peters AL, Umpierrez GE, Seley JJ, Xu NY, Nguyen KT, Simonson G, Agus MSD, Al-Sofiani ME, Armaiz-Pena G, Bailey TS, Basu A, …
• A gene-diet interaction controlling relative intake of dietary carbohydrates and fats.
  Molecular metabolism 2022 Nelson NG, Wu L, Maier MT, Lam D, Cheang R, Alba D, Huang A, Neumann DA, Hill T, Vagena E, Barsh GS, Medina MW, Krauss RM, Koliwad SK, Xu AW
• Reducing Methylglyoxal Rescues Obesity Related Phenotypes and Lifespan in a Leptin Receptor Deficient Mouse Model.
  Innovation in Aging 2021 Lauren Wimer, Martin Valdearcos Contreras, Muniesh Muthaiyan Shanmugam, Jessica Ramirez, Jennifer Beck, Suneil Koliwad, Pankaj Kapahi
• Reducing Methylglyoxal Rescues Obesity Related Phenotypes and Lifespan in a Leptin Receptor Deficient Mouse Model.
  Innovation in Aging 2021 Lauren Wimer, Martin Valdearcos Contreras, Muniesh Muthaiyan Shanmugam, Jessica Ramirez, Jennifer Beck, Suneil Koliwad, Pankaj Kapahi
• The relationship between physical activity intensity and volume on prospective falls in older adults.
  Innovation in Aging 2021 Lauren Wimer, Martin Valdearcos Contreras, Muniesh Muthaiyan Shanmugam, Jessica Ramirez, Jennifer Beck, Suneil Koliwad, Pankaj Kapahi
• Probing Insulin Sensitivity with Metabolically Competent Human Stem Cell-Derived White Adipose Tissue Microphysiological Systems.
  Small (Weinheim an der Bergstrasse, Germany) 2021 Qi L, Zushin PH, Chang CF, Lee YT, Alba DL, Koliwad SK, Stahl A
• The East Asian gut microbiome is distinct from colocalized White subjects and connected to metabolic health.
  eLife 2021 Ang QY, Alba DL, Upadhyay V, Bisanz JE, Cai J, Lee HL, Barajas E, Wei G, Noecker C, Patterson AD, Koliwad SK, Turnbaugh PJ
• Continuous Ketone Monitoring Consensus Report 2021.
  Journal of diabetes science and technology 2021 Nguyen KT, Xu NY, Zhang JY, Shang T, Basu A, Bergenstal RM, Castorino K, Chen KY, Kerr D, Koliwad SK, Laffel LM, Mathioudakis N, Midyett LK, Miller JD, Nichols JH, Pasquel FJ, Prahalad P, Prausnitz MR…
• Microglial Lipid Biology in the Hypothalamic Regulation of Metabolic Homeostasis.
  Frontiers in endocrinology 2021 Folick A, Koliwad SK, Valdearcos M
• Invariant Natural Killer T cells coordinate removal of senescent cells.
  Med (New York, N.Y.) 2021 Arora S, Thompson PJ, Wang Y, Bhattacharyya A, Apostolopoulou H, Hatano R, Naikawadi RP, Shah A, Wolters PJ, Koliwad S, Bhattacharya M, Bhushan A
• Autoregulation of insulin receptor signaling through MFGE8 and the αvβ5 integrin.
  Proceedings of the National Academy of Sciences of the United States of America 2021 Datta R, Lizama CO, Soltani AK, Mckleroy W, Podolsky MJ, Yang CD, Huynh TL, Cautivo KM, Wang B, Koliwad SK, Abumrad NA, Atabai K
• Lack of association between either outpatient or inpatient glycemic control and COVID-19 illness severity or mortality in patients with diabetes.
  BMJ open diabetes research & care 2021 Mehta PB, Kohn MA, Koliwad SK, Rushakoff RJ
• Continuous Ketone Monitoring: A New Paradigm for Physiologic Monitoring.
  Journal of diabetes science and technology 2021 Zhang JY, Shang T, Koliwad SK, Klonoff DC
• Quantifying Variation in Treatment Utilization for Type 2 Diabetes Across Five Major University of California Health Systems.
  Diabetes care 2021 Peterson TA, Fontil V, Koliwad SK, Patel A, Butte AJ
• Blocking Kv1.3 potassium channels prevents postoperative neuroinflammation and cognitive decline without impairing wound healing in mice.
  British journal of anaesthesia 2020 Lai IK, Valdearcos M, Morioka K, Saxena S, Feng X, Li R, Uchida Y, Lijun A, Li W, Pan J, Koliwad S, Marcucio R, Wulff H, Maze M
• CD81 Controls Beige Fat Progenitor Cell Growth and Energy Balance via FAK Signaling.
  Cell 2020 Oguri Y, Shinoda K, Kim H, Alba DL, Bolus WR, Wang Q, Brown Z, Pradhan RN, Tajima K, Yoneshiro T, Ikeda K, Chen Y, Cheang RT, Tsujino K, Kim CR, Greiner VJ, Datta R, Yang CD, Atabai K, McManus MT, …
• 1769-P: Microglial Activation and Inactivation via Designer Receptors Exclusively Activated by Designer Drugs (DREADDs) Alters Peripheral Glucose Homeostasis.
  Diabetes 2020 KELLY M. NESS, JOHN DOUGLASS, MARTIN VALDEARCOS-CONTRERAS, MAURICIO D. DORFMAN, ANZELA NIRAULA, SUNEIL K. KOLIWAD, JOSHUA THALER
• Neuronal modulation of hepatic lipid accumulation induced by bingelike drinking.
  American journal of physiology. Endocrinology and metabolism 2020 Ibars M, Maier MT, Yulyaningsih E, Perez L, Cheang R, Vilhelmsson A, Louie SM, Wegner SA, Yuan X, Eltzschig HK, Hopf FW, Nomura DK, Koliwad SK, Xu AW
• Genetic basis for the cooperative bioactivation of plant lignans by Eggerthella lenta and other human gut bacteria.
  Nature microbiology 2019 Bess EN, Bisanz JE, Yarza F, Bustion A, Rich BE, Li X, Kitamura S, Waligurski E, Ang QY, Alba DL, Spanogiannopoulos P, Nayfach S, Koliwad SK, Wolan DW, Franke AA, Turnbaugh PJ
• Obesity and Fat Metabolism in Human Immunodeficiency Virus-Infected Individuals: Immunopathogenic Mechanisms and Clinical Implications.
  The Journal of infectious diseases 2019 Godfrey C, Bremer A, Alba D, Apovian C, Koethe JR, Koliwad S, Lewis D, Lo J, McComsey GA, Eckard A, Srinivasa S, Trevillyan J, Palmer C, Grinspoon S
• mTORC1 to AMPK switching underlies β-cell metabolic plasticity during maturation and diabetes.
  The Journal of clinical investigation 2019 Jaafar R, Tran S, Shah AN, Sun G, Valdearcos M, Marchetti P, Masini M, Swisa A, Giacometti S, Bernal-Mizrachi E, Matveyenko A, Hebrok M, Dor Y, Rutter GA, Koliwad SK, Bhushan A
• Sweet cognition: The differential effects of glucose consumption on attentional food bias in individuals of lean and obese status.
  Physiology & behavior 2019 Mason AE, Jhaveri K, Schleicher S, Almeida C, Hartman A, Wackerly A, Alba D, Koliwad SK, Epel ES, Aschbacher K
• Hypothalamic microglia as potential regulators of metabolic physiology.
  Nature metabolism 2019 Valdearcos M, Myers MG, Koliwad SK
• Progranulin in the hematopoietic compartment protects mice from atherosclerosis.
  Atherosclerosis 2018 Nguyen AD, Nguyen TA, Singh RK, Eberlé D, Zhang J, Abate JP, Robles A, Koliwad S, Huang EJ, Maxfield FR, Walther TC, Farese RV
• Microglial Inflammatory Signaling Orchestrates the Hypothalamic Immune Response to Dietary Excess and Mediates Obesity Susceptibility.
  Cell metabolism 2018 Valdearcos M, Douglass JD, Robblee MM, Dorfman MD, Stifler DR, Bennett ML, Gerritse I, Fasnacht R, Barres BA, Thaler JP, Koliwad SK
• Regulation of Hepatic Lipid Accumulation and Distribution by Agouti-Related Protein in Male Mice.
  Endocrinology 2018 Maier MT, Vilhelmsson A, Louie SM, Vagena E, Nomura DK, Koliwad SK, Xu AW
• Microglia Activation Regulates Systemic Glucose Tolerance.
  Diabetes 2018 JOHN DOUGLASS, MARTIN VALDEARCOS, SUNEIL K. KOLIWAD, JOSH THALER
• Interleukin-6 is both necessary and sufficient to produce perioperative neurocognitive disorder in mice.
  British journal of anaesthesia 2018 Hu J, Feng X, Valdearcos M, Lutrin D, Uchida Y, Koliwad SK, Maze M
• Angiopoietin-like 4 (Angptl4) protein is a physiological mediator of intracellular lipolysis in murine adipocytes.
  The Journal of biological chemistry 2017 Gray NE, Lam LN, Yang K, Zhou AY, Koliwad S, Wang JC
• The C-terminal fibrinogen-like domain of angiopoietin-like 4 stimulates adipose tissue lipolysis and promotes energy expenditure.
  The Journal of biological chemistry 2017 McQueen AE, Kanamaluru D, Yan K, Gray NE, Wu L, Li ML, Chang A, Hasan A, Stifler D, Koliwad SK, Wang JC
• Digital Diabetes Congress 2017.
  Journal of diabetes science and technology 2017 Klonoff DC, Kerr D, Wong JC, Pavlovic Y, Koliwad S, Hu J, Salber P, Aguilera A, Long W, Hamilton G, Chen KY, Adi S
• Triglyceride Synthesis by DGAT1 Protects Adipocytes from Lipid-Induced ER Stress during Lipolysis.
  Cell metabolism 2017 Chitraju C, Mejhert N, Haas JT, Diaz-Ramirez LG, Grueter CA, Imbriglio JE, Pinto S, Koliwad SK, Walther TC, Farese RV
• Acute Lesioning and Rapid Repair of Hypothalamic Neurons outside the Blood-Brain Barrier.
  Cell reports 2017 Yulyaningsih E, Rudenko IA, Valdearcos M, Dahlén E, Vagena E, Chan A, Alvarez-Buylla A, Vaisse C, Koliwad SK, Xu AW
• Microglia mediate postoperative hippocampal inflammation and cognitive decline in mice.
  JCI insight 2017 Feng X, Valdearcos M, Uchida Y, Lutrin D, Maze M, Koliwad SK
• GLUT3 upregulation promotes metabolic reprogramming associated with antiangiogenic therapy resistance.
  JCI insight 2017 Kuang R, Jahangiri A, Mascharak S, Nguyen A, Chandra A, Flanigan PM, Yagnik G, Wagner JR, De Lay M, Carrera D, Castro BA, Hayes J, Sidorov M, Garcia JLI, Eriksson P, Ronen S, Phillips J, Molinaro A, …
• The Electronic CardioMetabolic Program (eCMP) for Patients With Cardiometabolic Risk: A Randomized Controlled Trial.
  Journal of medical Internet research 2016 Azar KM, Koliwad S, Poon T, Xiao L, Lv N, Griggs R, Ma J
• Acyl-CoA:Diacylglycerol Acyltransferase 1 Expression Level in the Hematopoietic Compartment Impacts Inflammation in the Vascular Plaques of Atherosclerotic Mice.
  PloS one 2016 Vujic N, Porter Abate J, Schlager S, David T, Kratky D, Koliwad SK
• Saturated Fatty Acids Engage an IRE1α-Dependent Pathway to Activate the NLRP3 Inflammasome in Myeloid Cells.
  Cell reports 2016 Robblee MM, Kim CC, Porter Abate J, Valdearcos M, Sandlund KL, Shenoy MK, Volmer R, Iwawaki T, Koliwad SK
• Leptin potentiates astrogenesis in the developing hypothalamus.
  Molecular metabolism 2015 Rottkamp DM, Rudenko IA, Maier MT, Roshanbin S, Yulyaningsih E, Perez L, Valdearcos M, Chua S, Koliwad SK, Xu AW
• Hypothalamic inflammation in the control of metabolic function.
  Annual review of physiology 2015 Valdearcos M, Xu AW, Koliwad SK
• Microglia dictate the impact of saturated fat consumption on hypothalamic inflammation and neuronal function.
  Cell reports 2014 Valdearcos M, Robblee MM, Benjamin DI, Nomura DK, Xu AW, Koliwad SK
• A screen in mice uncovers repression of lipoprotein lipase by microRNA-29a as a mechanism for lipid distribution away from the liver.
  Hepatology (Baltimore, Md.) 2014 Mattis AN, Song G, Hitchner K, Kim RY, Lee AY, Sharma AD, Malato Y, McManus MT, Esau CC, Koller E, Koliwad S, Lim LP, Maher JJ, Raffai RL, Willenbring H
• Coordinated regulation of hepatic energy stores by leptin and hypothalamic agouti-related protein.
  The Journal of neuroscience : the official journal of the Society for Neuroscience 2013 Warne JP, Varonin JM, Nielsen SS, Olofsson LE, Kaelin CB, Chua S, Barsh GS, Koliwad SK, Xu AW
• Angiopoietin-like 4 (Angptl4): A glucocorticoid-dependent gatekeeper of fatty acid flux during fasting.
  Adipocyte 2012 Koliwad SK, Gray NE, Wang JC
• Angiopoietin-like 4 (ANGPTL4, fasting-induced adipose factor) is a direct glucocorticoid receptor target and participates in glucocorticoid-regulated triglyceride metabolism.
  Journal of Biological Chemistry 2012 Suneil K. Koliwad, Taiyi Kuo, Lauren E. Shipp, Nora E. Gray, Fredrik Backhed, Alex Yick-Lun So, Robert V. Farese, Jen-Chywan Wang
• Angiopoietin-like 4 (Angptl4) protein is a physiological mediator of intracellular lipolysis in murine adipocytes.
  The Journal of biological chemistry 2012 Gray NE, Lam LN, Yang K, Zhou AY, Koliwad S, Wang JC
• Deficiency of the lipid synthesis enzyme, DGAT1, extends longevity in mice.
  Aging 2012 Streeper RS, Grueter CA, Salomonis N, Cases S, Levin MC, Koliwad SK, Zhou P, Hirschey MD, Verdin E, Farese RV
• DGAT1-dependent triacylglycerol storage by macrophages protects mice from diet-induced insulin resistance and inflammation.
  Journal of Clinical Investigation 2011 Suneil K. Koliwad, Ryan S. Streeper, Mara Monetti, Ivo Cornelissen, Liana Chan, Koji Terayama, Stephen Naylor, Meghana Rao, Brian Hubbard, Robert V. Farese
• DGAT1-dependent triacylglycerol storage by macrophages protects mice from diet-induced insulin resistance and inflammation.
  The Journal of clinical investigation 2010 Koliwad SK, Streeper RS, Monetti M, Cornelissen I, Chan L, Terayama K, Naylor S, Rao M, Hubbard B, Farese RV
• Angiopoietin-like 4 (ANGPTL4, fasting-induced adipose factor) is a direct glucocorticoid receptor target and participates in glucocorticoid-regulated triglyceride metabolism.
  The Journal of biological chemistry 2009 Koliwad SK, Kuo T, Shipp LE, Gray NE, Backhed F, So AY, Farese RV, Wang JC
• Thematic review series: glycerolipids. DGAT enzymes and triacylglycerol biosynthesis.
  Journal of lipid research 2008 Yen CL, Stone SJ, Koliwad S, Harris C, Farese RV
• Effects of DGAT1 deficiency on energy and glucose metabolism are independent of adiponectin.
  American journal of physiology. Endocrinology and metabolism 2006 Streeper RS, Koliwad SK, Villanueva CJ, Farese RV
• Increased longevity in mice lacking DGAT1.
  The FASEB Journal 2006 Ryan S Streeper, Sylvaine Cases, Suneil K Koliwad, Robert V Farese
• 4 Redox Regulation of Ion Channels.
  Antioxidant and Redox Regulation of Genes 2000 Suneil K. Koliwad, Anna K. Brezinska, Stephen J. Elliott
• Analysis of a Ca2+-activated K+ channel that mediates hyperpolarization via the thrombin receptor pathway.
  The American journal of physiology 1998 Sullivan R, Koliwad SK, Kunze DL
• Redox control of ion channel activity in vascular endothelial cells by glutathione.
  Microcirculation (New York, N.Y. : 1994) 1997 Elliott SJ, Koliwad SK
• Oxidized glutathione mediates cation channel activation in calf vascular endothelial cells during oxidant stress.
  The Journal of physiology 1996 Koliwad SK, Elliott SJ, Kunze DL
• Oxidant stress activates a non-selective cation channel responsible for membrane depolarization in calf vascular endothelial cells.
  The Journal of physiology 1996 Koliwad SK, Kunze DL, Elliott SJ
• Oxidant stress and endothelial membrane transport.
  Free radical biology & medicine 1995 Elliott SJ, Koliwad SK