Sulggi Lee, MD, PhD
Associate Professor
Medicine
School of Medicine
Sulggi Lee, MD PhD, is an Associate Professor of Medicine at the University of California, San Francisco (UCSF) and a faculty member in the Division of HIV, Infectious Diseases, and Global Medicine at the Zuckerberg San Francisco General Hospital.
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She is the PI of the UCSF Treat Acute HIV study, Co-PI of the UCSF SCOPE HIV cohort, the PI of the COVID-19 Host Immune Response Pathogenesis (CHIRP) study, Co-PI of the UCSF AIDS Cancer Specimen Resource (ACSR), and Co-Director of the UCSF Center for AIDS Research (CFAR) Bioinformatics Core. She is one of the founding executive committee members of the UCSF Women's Physician Scientist Supergroup (WPSS) and a faculty mentor for the UCSF Medical Scientist Training Program (MSTP) Community of Underrepresented Physician Scientists (CUPS) program. Her research focuses on clinical translational studies aimed at determining how natural host responses to pathogens (e.g., HIV, SARS-CoV-2) can be leveraged as future therapeutic targets using discovery-based analytic approaches. Her collaborative, interdisciplinary team includes data scientists, immunologists, virologists, and clinicians. Her work involves the application of highly advanced laboratory assays to well-characterized patient samples from observational studies and clinical trials. The goal of her research is to identify underlying host mechanisms of pathogen control to enable the identification of potential novel therapeutic targets for reducing morbidity and mortality associated with HIV and COVID-19.
Awards
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- Excellence in Translational Science Award, UCSF Center for AIDS Research Program (CFAR), 2018
Education & Training
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- Fellowship Infectious Diseases University of California San Francisco 07/2013
- Residency Internal Medicine Stanford Hospital & Clinics 06/2010
- M.D., Ph.D. Medicine, Genetic Epidemiology University of Southern California 06/2007
- B.A. Human Biology Stanford University 06/1998
Websites
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- COVID-19 Host Immune Response Pathogenesis Study (hividgm.ucsf.edu)
- Lee Lab Website (sulggileelab.ucsf.edu)
Grants and Projects
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- Evaluation of Novel Clonal Hematopoiesis Of InDEterminate Potential, Mosaic Chromosomal Alterations and CardioVascular Disease in HIV Infection (ENCODE CVD in HIV), NIH/NHLBI, 2023-2028
- UCSF-Bay Area Center for AIDS Research, NIH/NIAID, 2022-2027
- The heterogeneous HIV-expressing reservoir: dynamics, persistence mechanisms, tissue distribution, and contribution to rebound., NIH/NIAID, 2022-2027
- MHC Variation in Host Response to SARS-CoV2 and COVID-19 Outcomes, NIH/NIAID, 2021-2026
- Evolutionary Dynamics of Viral Reservoir Cells, Bill & Melinda Gates Foundation, 2019-2024
- AIDS and Cancer Specimen Resource, NIH/NCI, 2019-2024
- COVID-19 Host Immune Response Pathogenesis (CHIRP) Study, Emergent Ventures at the Mercatus Center, George Mason University, 2020-2024
- Host genetic predictors of plasma IL-1b levels and pharmacogenomics of in vivo IL-1b blockade during treated HIV disease, NIH, 2019-2024
- Short-term and long-term effects of methamphetamine exposure on residual viral transcription during treated HIV disease, NIH, 2018-2022
- Immediate Initiation of Antiretroviral Therapy During Acute HIV Infection - Tissue-Based Studies, Gilead Sciences, 2018-2021
- amfAR Institute for HIV Cure Research, The Foundation for AIDS Research (amfAR), 2016-2020
- Immediate Initiation of Antiretroviral Therapy During Acute HIV Infection, VIiv Healthcare, 2017-2020
- A pharmacogenomics study of HIV latency: the role of PD-1 signaling, NIH, 2014-2019
Publications (50)
Top publication keywords:
Virus LatencyAntiretroviral Therapy, Highly ActiveTrench FeverCD57 AntigensHIV InfectionsHIV-1KynurenineBartonella quintanaDisulfiramTryptophanInterferon Type IViral LoadAnti-HIV AgentsCD8-Positive T-LymphocytesIndoleamine-Pyrrole 2,3,-Dioxygenase
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No detectable alloreactive transcriptional responses under standard sample preparation conditions during donor-multiplexed single-cell RNA sequencing of peripheral blood mononuclear cells.
BMC biology 2021 McGinnis CS, Siegel DA, Xie G, Hartoularos G, Stone M, Ye CJ, Gartner ZJ, Roan NR, Lee SA -
Tissue memory CD4+ T cells expressing IL-7 receptor-alpha (CD127) preferentially support latent HIV-1 infection.
PLoS pathogens 2020 Hsiao F, Frouard J, Gramatica A, Xie G, Telwatte S, Lee GQ, Roychoudhury P, Schwarzer R, Luo X, Yukl SA, Lee S, Hoh R, Deeks SG, Jones RB, Cavrois M, Greene WC, Roan NR -
Antiretroviral Therapy Concentrations Differ in Gut vs. Lymph Node Tissues and Are Associated With HIV Viral Transcription by a Novel RT-ddPCR Assay.
Journal of acquired immune deficiency syndromes (1999) 2020 Lee SA, Telwatte S, Hatano H, Kashuba ADM, Cottrell ML, Hoh R, Liegler TJ, Stephenson S, Somsouk M, Hunt PW, Deeks SG, Yukl S, Savic RM -
RAPID antiretroviral therapy: high virologic suppression rates with immediate antiretroviral therapy initiation in a vulnerable urban clinic population.
AIDS (London, England) 2019 Coffey S, Bacchetti P, Sachdev D, Bacon O, Jones D, Ospina-Norvell C, Torres S, Lynch E, Camp C, Mercer-Slomoff R, Lee S, Christopoulos K, Pilcher C, Hsu L, Jin C, Scheer S, Havlir D, Gandhi M -
Acquisition of tenofovir-susceptible, emtricitabine-resistant HIV despite high adherence to daily pre-exposure prophylaxis: a case report.
The lancet. HIV 2018 Cohen SE, Sachdev D, Lee SA, Scheer S, Bacon O, Chen MJ, Okochi H, Anderson PL, Kearney MF, Coffey S, Scott H, Grant RM, Havlir D, Gandhi M -
Gut and blood differ in constitutive blocks to HIV transcription, suggesting tissue-specific differences in the mechanisms that govern HIV latency.
PLoS pathogens 2018 Telwatte S, Lee S, Somsouk M, Hatano H, Baker C, Kaiser P, Kim P, Chen TH, Milush J, Hunt PW, Deeks SG, Wong JK, Yukl SA -
Population Pharmacokinetics and Pharmacodynamics of Disulfiram on Inducing Latent HIV-1 Transcription in a Phase IIb Trial.
Clinical pharmacology and therapeutics 2018 Lee SA, Elliott JH, McMahon J, Hartogenesis W, Bumpus NN, Lifson JD, Gorelick RJ, Bacchetti P, Deeks SG, Lewin SR, Savic RM -
CYP2B6 Genetic Polymorphisms, Depression, and Viral Suppression in Adults Living with HIV Initiating Efavirenz-Containing Antiretroviral Therapy Regimens in Uganda: Pooled Analysis of Two Prospective Studies.
AIDS research and human retroviruses 2018 Chang JL, Lee SA, Tsai AC, Musinguzi N, Muzoora C, Bwana B, Boum Y, Haberer JE, Hunt PW, Martin J, Bangsberg DR, Kroetz DL, Siedner MJ -
Recent stimulant use and leukocyte gene expression in methamphetamine users with treated HIV infection.
Brain, behavior, and immunity 2018 Carrico AW, Flentje A, Kober K, Lee S, Hunt P, Riley ED, Shoptaw S, Flowers E, Dilworth SE, Pahwa S, Aouizerat BE -
Immunologic Pathways That Predict Mortality in HIV-Infected Ugandans Initiating Antiretroviral Therapy.
The Journal of infectious diseases 2017 Lee S, Byakwaga H, Boum Y, Burdo TH, Williams KC, Lederman MM, Huang Y, Tracy RP, Cao H, Haberer JE, Kembabazi A, Bangsberg DR, Martin JN, Hunt PW -
Immunologic Biomarkers, Morbidity, and Mortality in Treated HIV Infection.
The Journal of infectious diseases 2016 Hunt PW, Lee SA, Siedner MJ -
The Benefits of Early Antiretroviral Therapy for HIV Infection: How Early is Early Enough?
EBioMedicine 2016 Lee SA, Deeks SG -
Anti-HIV Antibody Responses and the HIV Reservoir Size during Antiretroviral Therapy.
PloS one 2016 Lee SA, Bacchetti P, Chomont N, Fromentin R, Lewin SR, O'Doherty U, Palmer S, Richman DD, Siliciano JD, Yukl SA, Deeks SG, Burbelo PD -
Host genetic predictors of the kynurenine pathway of tryptophan catabolism among treated HIV-infected Ugandans.
AIDS (London, England) 2016 Lee SA, Mefford JA, Huang Y, Witte JS, Martin JN, Haas DW, Mclaren PJ, Mushiroda T, Kubo M, Byakwaga H, Hunt PW, Kroetz DL -
IL-15 promotes activation and expansion of CD8+ T cells in HIV-1 infection.
The Journal of clinical investigation 2016 Younes SA, Freeman ML, Mudd JC, Shive CL, Reynaldi A, Panigrahi S, Estes JD, Deleage C, Lucero C, Anderson J, Schacker TW, Davenport MP, McCune JM, Hunt PW, Lee SA, Serrano-Villar S, Debernardo RL, … -
Immunologic profiles distinguish aviremic HIV-infected adults.
AIDS (London, England) 2016 Ramirez CM, Sinclair E, Epling L, Lee SA, Jain V, Hsue PY, Hatano H, Conn D, Hecht FM, Martin JN, McCune JM, Deeks SG, Hunt PW -
Reply to Barrett, et al.
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 2016 Freeman ML, Mudd JC, Shive CL, Younes SA, Panigrahi S, Sieg SF, Lee SA, Hunt PW, Calabrese LH, Gianella S, Rodriguez B, Lederman MM -
Short-term administration of disulfiram for reversal of latent HIV infection: a phase 2 dose-escalation study.
The lancet. HIV 2015 Elliott JH, McMahon JH, Chang CC, Lee SA, Hartogensis W, Bumpus N, Savic R, Roney J, Hoh R, Solomon A, Piatak M, Gorelick RJ, Lifson J, Bacchetti P, Deeks SG, Lewin SR -
CD8 T-Cell Expansion and Inflammation Linked to CMV Coinfection in ART-treated HIV Infection.
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 2015 Freeman ML, Mudd JC, Shive CL, Younes SA, Panigrahi S, Sieg SF, Lee SA, Hunt PW, Calabrese LH, Gianella S, Rodriguez B, Lederman MM -
Highlights from the Keystone Symposium on HIV Persistence 2015: 26-30 April 2015, Boston, Massachusetts, USA.
Journal of virus eradication 2015 Lee SA -
Bartonella quintana Aortitis in a Man with AIDS, Diagnosed by Needle Biopsy and 16S rRNA Gene Amplification.
Journal of clinical microbiology 2015 Lee SA, Plett SK, Luetkemeyer AF, Borgo GM, Ohliger MA, Conrad MB, Cookson BT, Sengupta DJ, Koehler JE -
HIV-infected individuals with low CD4/CD8 ratio despite effective antiretroviral therapy exhibit altered T cell subsets, heightened CD8+ T cell activation, and increased risk of non-AIDS morbidity and mortality.
PLoS pathogens 2014 Serrano-Villar S, Sainz T, Lee SA, Hunt PW, Sinclair E, Shacklett BL, Ferre AL, Hayes TL, Somsouk M, Hsue PY, Van Natta ML, Meinert CL, Lederman MM, Hatano H, Jain V, Huang Y, Hecht FM, Martin JN, … -
Low proportions of CD28- CD8+ T cells expressing CD57 can be reversed by early ART initiation and predict mortality in treated HIV infection.
The Journal of infectious diseases 2014 Lee SA, Sinclair E, Jain V, Huang Y, Epling L, Van Natta M, Meinert CL, Martin JN, McCune JM, Deeks SG, Lederman MM, Hecht FM, Hunt PW -
Impact of HIV on CD8+ T cell CD57 expression is distinct from that of CMV and aging.
PloS one 2014 Lee SA, Sinclair E, Hatano H, Hsue PY, Epling L, Hecht FM, Bangsberg DR, Martin JN, McCune JM, Deeks SG, Hunt PW -
A comprehensive analysis of common genetic variation in prolactin (PRL) and PRL receptor (PRLR) genes in relation to plasma prolactin levels and breast cancer risk: the multiethnic cohort.
BMC medical genetics 2007 Lee SA, Haiman CA, Burtt NP, Pooler LC, Cheng I, Kolonel LN, Pike MC, Altshuler D, Hirschhorn JN, Henderson BE, Stram DO -
Complexity of Plasmodium falciparum infections and antimalarial drug efficacy at 7 sites in Uganda.
The Journal of infectious diseases 2006 Lee SA, Yeka A, Nsobya SL, Dokomajilar C, Rosenthal PJ, Talisuna A, Dorsey G -
Postmenopausal hormone therapy and breast cancer risk: the Multiethnic Cohort.
International journal of cancer 2006 Lee S, Kolonel L, Wilkens L, Wan P, Henderson B, Pike M -
An overview of menopausal oestrogen-progestin hormone therapy and breast cancer risk.
British journal of cancer 2005 Lee SA, Ross RK, Pike MC
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Long COVID manifests with T cell dysregulation, inflammation and an uncoordinated adaptive immune response to SARS-CoV-2.
Nature immunology 2024 Yin K, Peluso MJ, Luo X, Thomas R, Shin MG, Neidleman J, Andrew A, Young KC, Ma T, Hoh R, Anglin K, Huang B, Argueta U, Lopez M, Valdivieso D, Asare K, Deveau TM, Munter SE, Ibrahim R, Ständker L, Lu … -
A cohort-based study of host gene expression: tumor suppressor and innate immune/inflammatory pathways associated with the HIV reservoir size.
PLoS pathogens 2023 Dwivedi AK, Gornalusse GG, Siegel DA, Barbehenn A, Thanh C, Hoh R, Hobbs KS, Pan T, Gibson EA, Martin J, Hecht F, Pilcher C, Milush J, Busch MP, Stone M, Huang ML, Reppetti J, Vo PM, Levy CN, … -
Transient Anti-Interferon Auto Antibodies in the Airway Are Associated with Recovery in Mild COVID-19.
Blood 2023 Benjamin R Babcock, Astrid Kosters, Nadia R Roan, Sulggi Lee, Eliver E.B. Ghosn -
Assessing the associations between known genetic variants and substance use in people with HIV in the United States.
PloS one 2023 Haas CB, Jordahl KM, Nance RM, Whitney BM, Wang L, Delaney JAC, Ruderman S, Jia T, Mathews WC, Saag MS, Lee SA, Napravnik S, Jacobson JM, Chander G, McCall EM, Moore RD, Mayer KH, Mukherjee S, Lee WJ,… -
Long COVID manifests with T cell dysregulation, inflammation, and an uncoordinated adaptive immune response to SARS-CoV-2.
bioRxiv : the preprint server for biology 2023 Yin K, Peluso MJ, Luo X, Thomas R, Shin MG, Neidleman J, Andrew A, Young K, Ma T, Hoh R, Anglin K, Huang B, Argueta U, Lopez M, Valdivieso D, Asare K, Deveau TM, Munter SE, Ibrahim R, Ständker L, Lu S… -
Differences in expression of tumor suppressor, innate immune, inflammasome, and potassium/gap junction channel host genes significantly predict viral reservoir size during treated HIV infection.
bioRxiv : the preprint server for biology 2023 Dwivedi AK, Siegel DA, Thanh C, Hoh R, Hobbs KS, Pan T, Gibson EA, Martin J, Hecht F, Pilcher C, Milush J, Busch MP, Stone M, Huang ML, Levy CN, Roychoudhury P, Hladik F, Jerome KR, Henrich TJ, Deeks … -
Host variation in type I interferon signaling genes (MX1), C-C chemokine receptor type 5 gene, and major histocompatibility complex class I alleles in treated HIV+ noncontrollers predict viral reservoir size.
AIDS (London, England) 2022 Siegel DA, Thanh C, Wan E, Hoh R, Hobbs K, Pan T, Gibson EA, Kroetz DL, Martin J, Hecht F, Pilcher C, Martin M, Carrington M, Pillai S, Busch MP, Stone M, Levy CN, Huang ML, Roychoudhury P, Hladik F, … -
Common and Divergent Features of T Cells from Blood, Gut, and Genital Tract of Antiretroviral Therapy-Treated HIV+ Women.
Journal of immunology (Baltimore, Md. : 1950) 2022 Xie G, Moron-Lopez S, Siegel DA, Yin K, Polos A, Cohen J, Greenblatt RM, Tien PC, Lee SA, Yukl SA, Roan NR -
Deep Phenotypic Analysis of Blood and Lymphoid T and NK Cells From HIV+ Controllers and ART-Suppressed Individuals.
Frontiers in immunology 2022 George AF, Luo X, Neidleman J, Hoh R, Vohra P, Thomas R, Shin MG, Lee MJ, Blish CA, Deeks SG, Greene WC, Lee SA, Roan NR -
mRNA vaccine-induced T cells respond identically to SARS-CoV-2 variants of concern but differ in longevity and homing properties depending on prior infection status.
eLife 2021 Neidleman J, Luo X, McGregor M, Xie G, Murray V, Greene WC, Lee SA, Roan NR -
Protracted yet Coordinated Differentiation of Long-Lived SARS-CoV-2-Specific CD8+ T Cells during Convalescence.
Journal of immunology (Baltimore, Md. : 1950) 2021 Ma T, Ryu H, McGregor M, Babcock B, Neidleman J, Xie G, George AF, Frouard J, Murray V, Gill G, Ghosn E, Newell EW, Lee SA, Roan NR -
mRNA vaccine-induced T cells respond identically to SARS-CoV-2 variants of concern but differ in longevity and homing properties depending on prior infection status.
bioRxiv : the preprint server for biology 2021 Neidleman J, Luo X, McGregor M, Xie G, Murray V, Greene WC, Lee SA, Roan NR -
Distinctive features of SARS-CoV-2-specific T cells predict recovery from severe COVID-19.
Cell reports 2021 Neidleman J, Luo X, George AF, McGregor M, Yang J, Yun C, Murray V, Gill G, Greene WC, Vasquez J, Lee SA, Ghosn E, Lynch KL, Roan NR -
SARS-CoV-2-Specific T Cells Exhibit Phenotypic Features of Helper Function, Lack of Terminal Differentiation, and High Proliferation Potential.
Cell reports. Medicine 2020 Neidleman J, Luo X, Frouard J, Xie G, Gill G, Stein ES, McGregor M, Ma T, George AF, Kosters A, Greene WC, Vasquez J, Ghosn E, Lee S, Roan NR -
TCR+CD4-CD8- (double negative) T cells protect from cisplatin-induced renal epithelial cell apoptosis and acute kidney injury.
American journal of physiology. Renal physiology 2020 Gong J, Noel S, Hsu J, Bush EL, Arend LJ, Sadasivam M, Lee SA, Kurzhagen JT, Hamad ARA, Rabb H -
OP 4.2 Characterising ‘exceptional’ control among HIV elite controllers.
Journal of virus eradication 2019 M. Peluso, P. Burbelo, S. Kumar, S. Munter, R. Hoh, S. Lee, P. Hunt, R. Rutishauser, T. Henrich, S. Deeks -
20 Kansui, an ingenol-containing herbal supplement, safely induced CD8, NK, and monocyte activation in three ART-suppressed SIVmac251-infected rhesus macaques.
Journal of virus eradication 2019 S. Lee, K. Kesmy, P. Bacchetti, R. Hoh, J. Lifson, D. Cary, B. Peterlin, S. Deeks, D. Hartigan-O’Connor -
Activation and Proliferation of PD-1+ Kidney Double-Negative T Cells Is Dependent on Nonclassical MHC Proteins and IL-2.
Journal of the American Society of Nephrology : JASN 2019 Sadasivam M, Noel S, Lee SA, Gong J, Allaf ME, Pierorazio P, Rabb H, Hamad ARA -
PP4.10 HIV integrates in genes regulating cell cycle, DNA damage, and viral transport.
Journal of virus eradication 2017 S. Lee, K. Haworth, T. Henrich, S. Deeks, H.P. Kiem -
Efavirenz-metabolizing polymorphisms, viral suppression, and depression in HIV-infected individuals initiating antiretroviral therapy in southwestern Uganda.
Open Forum Infectious Diseases 2017 Jonathan Chang, Sulggi Lee, Peter Hunt, Deanna Kroetz, Mark Siedner -
IL-15 drives CD8 T cell cycling and differentiation in chronic HIV-1 infection (VIR6P.1162).
The Journal of Immunology 2015 souheil younes, carey shive, Arnold Reynaldi, Michael Freeman, Soumya Panigrahi, Jacob Estes, Jodi Anderson, Timothy Schacker, Miles Davenport, Joseph McCune, Peter Hunt, Sulggi Lee, Sergio Serrano-… -
Chapter 40 Body weight, menopausal hormone therapy, and risk of breast cancer.
Treatment of the Postmenopausal Woman 2007 Anna H. Wu, C. Leigh Pearce, Darcy V. Spicer, Sulggi Lee, Malalcolm C. Pike