Sugandh Kumar, PhD
Postdoctoral Scholar
Dermatology
School of Medicine

My current research focus at UCSF involves the in-depth analysis, integration, and exploration of T-cell regulatory mechanisms, utilizing Spatial and single-cell transcriptomics, BulkSeq, GWAS, and machine learning techniques. Also, I actively contribute to the design of innovative therapeutic compounds through computational drug design approaches, with a keen dedication to advancing our understanding of complex diseases and discovering novel treatments using various computational methodologies. I have collaboration with clinical fellows involves leveraging my biostatistics and machine-learning skills to establish meaningful associations between patient outcomes.

Beyond the laboratory, I find joy in traveling, exploring new destinations, meeting diverse people, and engaging in outdoor activities such as hiking and biking. Additionally, I have a penchant for experimenting with various culinary delights.

• A partitioned 88-loci psoriasis genetic risk score reveals HLA and non-HLA contributions to clinical phenotypes in a Newfoundland psoriasis cohort.
  Frontiers in genetics 2023 Bui A, Kumar S, Liu J, Orcales F, Gulliver S, Tsoi LC, Gulliver W, Liao W
• Human sperm proteome reveals the effect of environmental borne seminal polyaromatic hydrocarbons exposome in etiology of idiopathic male factor infertility.
  Frontiers in cell and developmental biology 2023 Nayak J, Jena SR, Kumar S, Kar S, Dixit A, Samanta L
• JEADV Clinical Practice
  The association of hidradenitis suppurativa with obstructive sleep apnea: A cross-sectional study using the All of Us database 2023 Samuel Yeroushalmi, Jared Liu, Mimi Chung, Kareem G. Elhage, Erin Bartholomew, Marwa Hakimi, Sugandh Kumar, Alexander Ildardashty, Haley B. Naik, Tina Bhutani, Wilson Liao
• Biologic insights from single-cell studies of psoriasis and psoriatic arthritis.
  Expert opinion on biological therapy 2022 Jin JQ, Wu D, Spencer R, Elhage KG, Liu J, Davis M, Hakimi M, Kumar S, Huang ZM, Bhutani T, Liao W
• Factors Associated with Multi-Biologic Use in Psoriasis Patients at an Academic Medical Center and Review of Biologic Survival
  Journal of Psoriasis and Psoriatic Arthritis 2022 Edward Hadeler, Sugandh Kumar, Samuel Yeroushalmi, Julie Hong, Elizabeth Wallace, George Han, Megan Mosca, Erin Bartholomew, Mimi Chung, Marwa Hakimi, Soumya Reddy, Jose Scher, Tina Bhutani, George …
• TRPV1 channel in spermatozoa is a molecular target for ROS-mediated sperm dysfunction and differentially expressed in both natural and ART pregnancy failure.
  Frontiers in cell and developmental biology 2022 Swain N, Samanta L, Goswami C, Kar S, Majhi RK, Kumar S, Dixit A
• Identification of therapeutically potential targets and their ligands for the treatment of OSCC.
  Frontiers in oncology 2022 Kumari P, Kumar S, Sethy M, Bhue S, Mohanta BK, Dixit A
• Comparative proteome profiling of seminal components reveal impaired immune cell signalling as paternal contributors in recurrent pregnancy loss patients.
  American journal of reproductive immunology (New York, N.Y. : 1989) 2022 Jena SR, Nayak J, Kumar S, Kar S, Samanta L
• Hypoxia-responsive and HIF1α-regulated AAA+ ATPase ATAD2 shows high oncogenic potential in stomach cancer
  Cancer Research 2022 A Roychowdhury, A Nayak, Sugandh Kumar, A Dixit, A Bhattacharyya
• Single Cell Transcriptome and Surface Epitope Analysis of Ankylosing Spondylitis Facilitates Disease Classification by Machine Learning.
  Frontiers in immunology 2022 Alber S, Kumar S, Liu J, Huang ZM, Paez D, Hong J, Chang HW, Bhutani T, Gensler LS, Liao W
• Association of seminal polyaromatic hydrocarbons exposome with idiopathic male factor infertility: A proteomic insight into sperm function
  BioRxiv 2022 Jasmine Nayak, Soumya Ranjan Jena, Sugandh Kumar, Anshuman Dixit, Luna Samanta
• Combined Single Cell Transcriptome and Surface Epitope Profiling Identifies Potential Biomarkers of Psoriatic Arthritis and Facilitates Diagnosis via Machine Learning.
  Frontiers in immunology 2022 Liu J, Kumar S, Hong J, Huang ZM, Paez D, Castillo M, Calvo M, Chang HW, Cummins DD, Chung M, Yeroushalmi S, Bartholomew E, Hakimi M, Ye CJ, Bhutani T, Matloubian M, Gensler LS, Liao W
• Nimbolide-encapsulated PLGA nanoparticles induces Mesenchymal-to-Epithelial Transition by dual inhibition of AKT and mTOR in pancreatic cancer stem cells.
  Toxicology in vitro : an international journal published in association with BIBRA 2021 Singh D, Mohapatra P, Kumar S, Behera S, Dixit A, Sahoo SK
• Correction: RRBP1 rewires cisplatin resistance in oral squamous cell carcinoma by regulating Hippo pathway.
  British journal of cancer 2021 Shriwas O, Arya R, Mohanty S, Mohapatra P, Kumar S, Rath R, Kaushik SR, Pahwa F, Murmu KC, Das Majumdar SK, Muduly DK, Dixit A, Prasad P, Nanda RK, Dash R
• RRBP1 rewires cisplatin resistance in oral squamous cell carcinoma by regulating Hippo pathway.
  British journal of cancer 2021 Shriwas O, Arya R, Mohanty S, Mohapatra P, Kumar S, Rath R, Kaushik SR, Pahwa F, Murmu KC, Majumdar SKD, Muduly DK, Dixit A, Prasad P, Nanda RK, Dash R
• Oncogenic potential of ATAD2 in stomach cancer and insights into the protein-protein interactions at its AAA + ATPase domain and bromodomain.
  Journal of biomolecular structure & dynamics 2021 Nayak A, Kumar S, Singh SP, Bhattacharyya A, Dixit A, Roychowdhury A
• Paternal contributors in recurrent pregnancy loss: Cues from comparative proteome profiling of seminal extracellular vesicles.
  Molecular reproduction and development 2020 Jena SR, Nayak J, Kumar S, Kar S, Dixit A, Samanta L
• Analysis of Indian SARS-CoV-2 Genomes Reveals Prevalence of D614G Mutation in Spike Protein Predicting an Increase in Interaction With TMPRSS2 and Virus Infectivity.
  Frontiers in microbiology 2020 Raghav S, Ghosh A, Turuk J, Kumar S, Jha A, Madhulika S, Priyadarshini M, Biswas VK, Shyamli PS, Singh B, Singh N, Singh D, Datey A, Avula K, Smita S, Sabat J, Bhattacharya D, Kshatri JS, Vasudevan D,…
• Identification of stage-wise miRNAs signature as a potential biomarker in head and neck squamous cell carcinoma
  Clinical Cancer Research 2020 Sugandh Kumar, Anshuman Dixit
• Aberrant Upregulation of Compensatory Redox Molecular Machines May Contribute to Sperm Dysfunction in Infertile Men with Unilateral Varicocele: A Proteomic Insight.
  Antioxidants & redox signaling 2019 Swain N, Samanta L, Agarwal A, Kumar S, Dixit A, Gopalan B, Durairajanayagam D, Sharma R, Pushparaj PN, Baskaran S