Stephen Nishimura, MD
Professor
Pathology
School of Medicine

Education & Training

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• Residency School of Medicine University of California, San Francisco

Websites

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• Clinical Profile at UCSF Medical Center (ucsfhealth.org)

Grants and Projects

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• Structural mechanism of integrin-mediated TGF-b activation, NIH, 2016-2024
• Role of genetic variation in TGF-beta overactivation in COPD, NIH, 2012-2017
• Integrative Study of Brain Vascular Malformations, NIH/NINDS, 2002-2014
• Integrin alphavbeta8 Inhibits Airway Epithelial Cell Growth, NIH, 1999-2013
• Role of Squamous Metaplasia in Small Airways Disease in COPD, NIH, 2009-2011
• Integrin Regulation of Airway Epithelial Proliferation, NIH, 2002-2007
• Distribution and Function of the Integrin Andyb8, NIH, 1995-2001
• Integrins and Blastocyst-endometrial Interaction, NIH, 1993-1900

Publications (70)

Top publication keywords:
Pulmonary FibrosisTracheitisTransforming Growth Factor beta1Interleukin-1betaTransforming Growth Factor betaIntegrinsDendritic CellsChemokine CCL20Epithelial CellsLatent TGF-beta Binding ProteinsCryoelectron MicroscopyT-Lymphocytes, RegulatoryIntegrin beta ChainsPulmonary Disease, Chronic ObstructiveTumor Escape

• Dynamic allostery drives autocrine and paracrine TGF-ß signaling.
  Cell 2024 Jin M, Seed RI, Cai G, Shing T, Wang L, Ito S, Cormier A, Wankowicz SA, Jespersen JM, Baron JL, Carey ND, Campbell MG, Yu Z, Tang PK, Cossio P, Wen W, Lou J, Marks J, Nishimura SL, Cheng Y
• Macrophage Cx43 Is Necessary for Fibroblast Cytosolic Calcium and Lung Fibrosis After Injury.
  Frontiers in immunology 2022 Bhattacharyya A, Torre P, Yadav P, Boostanpour K, Chen TY, Tsukui T, Sheppard D, Muramatsu R, Seed RI, Nishimura SL, Jung JB, Tang XZ, Allen CDC, Bhattacharya M
• Measurement of Cell Intrinsic TGF-β Activation Mediated by the Integrin αvβ8.
  Bio-protocol 2022 Seed RI, Nishimura SL
• Acquisition of cellular properties during alveolar formation requires differential activity and distribution of mitochondria.
  eLife 2022 Zhang K, Yao E, Chen B, Chuang E, Wong J, Seed RI, Nishimura SL, Wolters PJ, Chuang PT
• Diagnosis of acute mesenteric ischemia assisted by dual-energy CT: a case report.
  Emergency radiology 2022 Chen JV, Ohliger MA, Chung M, Sugi MD, Ye J, Nishimura SL, Choi HH

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• TGFβ activating integrins β6 and β8 are dysregulated in inflammatory skin disease and cutaneous melanoma.
  Journal of dermatological science 2022 Nguyen BA, Ho J, De La Cruz Diaz JS, Nishimura S, Kaplan DH
• Role of the transcriptional regulator SP140 in resistance to bacterial infections via repression of type I interferons.
  eLife 2021 Ji DX, Witt KC, Kotov DI, Margolis SR, Louie A, Chevée V, Chen KJ, Gaidt MM, Dhaliwal HS, Lee AY, Nishimura SL, Zamboni DS, Kramnik I, Portnoy DA, Darwin KH, Vance RE
• A tumor-specific mechanism of Treg enrichment mediated by the integrin αvβ8.
  Science immunology 2021 Seed RI, Kobayashi K, Ito S, Takasaka N, Cormier A, Jespersen JM, Publicover J, Trilok S, Combes AJ, Chew NW, Chapman J, Krummel MF, Lou J, Marks J, Cheng Y, Baron JL, Nishimura SL
• Mapping the Endothelial Cell S-Sulfhydrome Highlights the Crucial Role of Integrin Sulfhydration in Vascular Function.
  Circulation 2020 Bibli SI, Hu J, Looso M, Weigert A, Ratiu C, Wittig J, Drekolia MK, Tombor L, Randriamboavonjy V, Leisegang MS, Goymann P, Delgado Lagos F, Fisslthaler B, Zukunft S, Kyselova A, Justo AFO, Heidler J, …
• Age-dependent regulation of cell-mediated collagen turnover.
  JCI insight 2020 Podolsky MJ, Yang CD, Valenzuela CL, Datta R, Huang SK, Nishimura SL, Dallas SL, Wolters PJ, Le Saux CJ, Atabai K
• Cryo-EM Reveals Integrin-Mediated TGF-β Activation without Release from Latent TGF-β.
  Cell 2020 Campbell MG, Cormier A, Ito S, Seed RI, Bondesson AJ, Lou J, Marks JD, Baron JL, Cheng Y, Nishimura SL
• Integrin αvβ8-expressing tumor cells evade host immunity by regulating TGF-β activation in immune cells.
  JCI insight 2018 Takasaka N, Seed RI, Cormier A, Bondesson AJ, Lou J, Elattma A, Ito S, Yanagisawa H, Hashimoto M, Ma R, Levine MD, Publicover J, Potts R, Jespersen JM, Campbell MG, Conrad F, Marks JD, Cheng Y, Baron …
• PRKN-regulated mitophagy and cellular senescence during COPD pathogenesis.
  Autophagy 2018 Araya J, Tsubouchi K, Sato N, Ito S, Minagawa S, Hara H, Hosaka Y, Ichikawa A, Saito N, Kadota T, Yoshida M, Fujita Y, Utsumi H, Kobayashi K, Yanagisawa H, Hashimoto M, Wakui H, Ishikawa T, Numata T, …
• Cryo-EM structure of the αvβ8 integrin reveals a mechanism for stabilizing integrin extension.
  Nature structural & molecular biology 2018 Cormier A, Campbell MG, Ito S, Wu S, Lou J, Marks J, Baron JL, Nishimura SL, Cheng Y
• An OX40/OX40L interaction directs successful immunity to hepatitis B virus.
  Science translational medicine 2018 Publicover J, Gaggar A, Jespersen JM, Halac U, Johnson AJ, Goodsell A, Avanesyan L, Nishimura SL, Holdorf M, Mansfield KG, Judge JB, Koshti A, Croft M, Wakil AE, Rosenthal P, Pai E, Cooper S, Baron JL
• Cigarette smoke exposure worsens acute lung injury in antibiotic-treated bacterial pneumonia in mice.
  American journal of physiology. Lung cellular and molecular physiology 2018 Gotts JE, Chun L, Abbott J, Fang X, Takasaka N, Nishimura SL, Springer ML, Schick SF, Calfee CS, Matthay MA
• Blocking immunosuppression by human Tregs in vivo with antibodies targeting integrin αVβ8.
  Proceedings of the National Academy of Sciences of the United States of America 2017 Stockis J, Liénart S, Colau D, Collignon A, Nishimura SL, Sheppard D, Coulie PG, Lucas S
• Cigarette Smoke Exposure Worsens Endotoxin-Induced Lung Injury and Pulmonary Edema in Mice.
  Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco 2017 Gotts JE, Abbott J, Fang X, Yanagisawa H, Takasaka N, Nishimura SL, Calfee CS, Matthay MA
• Role of IL-17A in murine models of COPD airway disease.
  American journal of physiology. Lung cellular and molecular physiology 2016 Yanagisawa H, Hashimoto M, Minagawa S, Takasaka N, Ma R, Moermans C, Ito S, Araya J, Budelsky A, Goodsell A, Baron JL, Nishimura SL
• Integrin β8 Deletion Enhances Vascular Dysplasia and Hemorrhage in the Brain of Adult Alk1 Heterozygous Mice.
  Translational stroke research 2016 Ma L, Shen F, Jun K, Bao C, Kuo R, Young WL, Nishimura SL, Su H
• Liver capsule: Age-influenced hepatic immune priming determines HBV infection fate: Implications from mouse to man.
  Hepatology (Baltimore, Md.) 2015 Publicover J, Jespersen JM, Johnson AJ, Nishimura SL, Goodsell A, Wakil AE, Rosenthal P, Pai E, Avanesyan L, Cooper S, Baron JL
• TGF-β-Dependent Dendritic Cell Chemokinesis in Murine Models of Airway Disease.
  Journal of immunology (Baltimore, Md. : 1950) 2015 Hashimoto M, Yanagisawa H, Minagawa S, Sen D, Ma R, Murray LA, Tsui P, Lou J, Marks JD, Baron JL, Krummel MF, Nishimura SL
• Transforming Growth Factor-β and Interleukin-1β Signaling Pathways Converge on the Chemokine CCL20 Promoter.
  The Journal of biological chemistry 2015 Brand OJ, Somanath S, Moermans C, Yanagisawa H, Hashimoto M, Cambier S, Markovics J, Bondesson AJ, Hill A, Jablons D, Wolters P, Lou J, Marks JD, Baron JL, Nishimura SL
• A critical role for dendritic cells in the evolution of IL-1β-mediated murine airway disease.
  Journal of immunology (Baltimore, Md. : 1950) 2015 Hashimoto M, Yanagisawa H, Minagawa S, Sen D, Goodsell A, Ma R, Moermans C, McKnelly KJ, Baron JL, Krummel MF, Nishimura SL
• PARK2-mediated mitophagy is involved in regulation of HBEC senescence in COPD pathogenesis.
  Autophagy 2015 Ito S, Araya J, Kurita Y, Kobayashi K, Takasaka N, Yoshida M, Hara H, Minagawa S, Wakui H, Fujii S, Kojima J, Shimizu K, Numata T, Kawaishi M, Odaka M, Morikawa T, Harada T, Nishimura SL, Kaneko Y, …
• Selective targeting of TGF-β activation to treat fibroinflammatory airway disease.
  Science translational medicine 2014 Minagawa S, Lou J, Seed RI, Cormier A, Wu S, Cheng Y, Murray L, Tsui P, Connor J, Herbst R, Govaerts C, Barker T, Cambier S, Yanagisawa H, Goodsell A, Hashimoto M, Brand OJ, Cheng R, Ma R, McKnelly KJ…
• Reprogramming tumor-infiltrating dendritic cells for CD103+ CD8+ mucosal T-cell differentiation and breast cancer rejection.
  Cancer immunology research 2014 Wu TC, Xu K, Banchereau R, Marches F, Yu CI, Martinek J, Anguiano E, Pedroza-Gonzalez A, Snipes GJ, O'Shaughnessy J, Nishimura S, Liu YJ, Pascual V, Banchereau J, Oh S, Palucka K
• Functional genomic screen identifies novel mediators of collagen uptake.
  Molecular biology of the cell 2014 Lee TH, McKleroy W, Khalifeh-Soltani A, Sakuma S, Lazarev S, Riento K, Nishimura SL, Nichols BJ, Atabai K
• Autophagy induction by SIRT6 through attenuation of insulin-like growth factor signaling is involved in the regulation of human bronchial epithelial cell senescence.
  Journal of immunology (Baltimore, Md. : 1950) 2013 Takasaka N, Araya J, Hara H, Ito S, Kobayashi K, Kurita Y, Wakui H, Yoshii Y, Yumino Y, Fujii S, Minagawa S, Tsurushige C, Kojima J, Numata T, Shimizu K, Kawaishi M, Kaneko Y, Kamiya N, Hirano J, …
• Age-dependent hepatic lymphoid organization directs successful immunity to hepatitis B.
  The Journal of clinical investigation 2013 Publicover J, Gaggar A, Nishimura S, Van Horn CM, Goodsell A, Muench MO, Reinhardt RL, van Rooijen N, Wakil AE, Peters M, Cyster JG, Erle DJ, Rosenthal P, Cooper S, Baron JL
• Insufficient autophagy in idiopathic pulmonary fibrosis.
  American journal of physiology. Lung cellular and molecular physiology 2012 Araya J, Kojima J, Takasaka N, Ito S, Fujii S, Hara H, Yanagisawa H, Kobayashi K, Tsurushige C, Kawaishi M, Kamiya N, Hirano J, Odaka M, Morikawa T, Nishimura SL, Kawabata Y, Hano H, Nakayama K, …
• Insufficient autophagy promotes bronchial epithelial cell senescence in chronic obstructive pulmonary disease.
  Oncoimmunology 2012 Fujii S, Hara H, Araya J, Takasaka N, Kojima J, Ito S, Minagawa S, Yumino Y, Ishikawa T, Numata T, Kawaishi M, Hirano J, Odaka M, Morikawa T, Nishimura S, Nakayama K, Kuwano K
• Interleukin-1beta induces increased transcriptional activation of the transforming growth factor-beta-activating integrin subunit beta8 through altering chromatin architecture.
  The Journal of biological chemistry 2011 Markovics JA, Araya J, Cambier S, Somanath S, Gline S, Jablons D, Hill A, Wolters PJ, Nishimura SL
• Insulin-dependent phosphatidylinositol 3-kinase/Akt and ERK signaling pathways inhibit TLR3-mediated human bronchial epithelial cell apoptosis.
  Journal of immunology (Baltimore, Md. : 1950) 2011 Numata T, Araya J, Fujii S, Hara H, Takasaka N, Kojima J, Minagawa S, Yumino Y, Kawaishi M, Hirano J, Odaka M, Morikawa T, Nishimura SL, Nakayama K, Kuwano K
• Mouse and human lung fibroblasts regulate dendritic cell trafficking, airway inflammation, and fibrosis through integrin αvβ8-mediated activation of TGF-β.
  The Journal of clinical investigation 2011 Kitamura H, Cambier S, Somanath S, Barker T, Minagawa S, Markovics J, Goodsell A, Publicover J, Reichardt L, Jablons D, Wolters P, Hill A, Marks JD, Lou J, Pittet JF, Gauldie J, Baron JL, Nishimura SL
• IL-21 is pivotal in determining age-dependent effectiveness of immune responses in a mouse model of human hepatitis B.
  The Journal of clinical investigation 2011 Publicover J, Goodsell A, Nishimura S, Vilarinho S, Wang ZE, Avanesyan L, Spolski R, Leonard WJ, Cooper S, Baron JL
• Accelerated epithelial cell senescence in IPF and the inhibitory role of SIRT6 in TGF-β-induced senescence of human bronchial epithelial cells.
  American journal of physiology. Lung cellular and molecular physiology 2010 Minagawa S, Araya J, Numata T, Nojiri S, Hara H, Yumino Y, Kawaishi M, Odaka M, Morikawa T, Nishimura SL, Nakayama K, Kuwano K
• Transcription of the transforming growth factor beta activating integrin beta8 subunit is regulated by SP3, AP-1, and the p38 pathway.
  The Journal of biological chemistry 2010 Markovics JA, Araya J, Cambier S, Jablons D, Hill A, Wolters PJ, Nishimura SL
• Low prevalence of chronic beryllium disease among workers at a nuclear weapons research and development facility.
  Journal of occupational and environmental medicine 2010 Arjomandi M, Seward J, Gotway MB, Nishimura S, Fulton GP, Thundiyil J, King TE, Harber P, Balmes JR
• Fibrogenic reactions in lung disease.
  Annual review of pathology 2010 Araya J, Nishimura SL
• Reduced expression of integrin alphavbeta8 is associated with brain arteriovenous malformation pathogenesis.
  The American journal of pathology 2009 Su H, Kim H, Pawlikowska L, Kitamura H, Shen F, Cambier S, Markovics J, Lawton MT, Sidney S, Bollen AW, Kwok PY, Reichardt L, Young WL, Yang GY, Nishimura SL
• Fusion of epithelial cells by Epstein-Barr virus proteins is triggered by binding of viral glycoproteins gHgL to integrins alphavbeta6 or alphavbeta8.
  Proceedings of the National Academy of Sciences of the United States of America 2009 Chesnokova LS, Nishimura SL, Hutt-Fletcher LM
• Integrin-mediated transforming growth factor-beta activation, a potential therapeutic target in fibrogenic disorders.
  The American journal of pathology 2009 Nishimura SL
• Restoring transcription factor HoxA5 expression inhibits the growth of experimental hemangiomas in the brain.
  Journal of neuropathology and experimental neurology 2009 Zhu Y, Cuevas IC, Gabriel RA, Su H, Nishimura S, Gao P, Fields A, Hao Q, Young WL, Yang GY, Boudreau NJ
• mTOR mediates survival signals in malignant mesothelioma grown as tumor fragment spheroids.
  American journal of respiratory cell and molecular biology 2008 Wilson SM, Barbone D, Yang TM, Jablons DM, Bueno R, Sugarbaker DJ, Nishimura SL, Gordon GJ, Broaddus VC
• Targeted drug delivery to mesothelioma cells using functionally selected internalizing human single-chain antibodies.
  Molecular cancer therapeutics 2008 An F, Drummond DC, Wilson S, Kirpotin DB, Nishimura SL, Broaddus VC, Liu B
• Blockade of NKG2D on NKT cells prevents hepatitis and the acute immune response to hepatitis B virus.
  Proceedings of the National Academy of Sciences of the United States of America 2007 Vilarinho S, Ogasawara K, Nishimura S, Lanier LL, Baron JL
• Squamous metaplasia amplifies pathologic epithelial-mesenchymal interactions in COPD patients.
  The Journal of clinical investigation 2007 Araya J, Cambier S, Markovics JA, Wolters P, Jablons D, Hill A, Finkbeiner W, Jones K, Broaddus VC, Sheppard D, Barzcak A, Xiao Y, Erle DJ, Nishimura SL
• Integrin-mediated transforming growth factor-beta activation regulates homeostasis of the pulmonary epithelial-mesenchymal trophic unit.
  The American journal of pathology 2006 Araya J, Cambier S, Morris A, Finkbeiner W, Nishimura SL
• Case report: a case of wood-smoke-related pulmonary disease.
  Environmental health perspectives 2006 Diaz JV, Koff J, Gotway MB, Nishimura S, Balmes JR
• Activation of transforming growth factor-beta by the integrin alphavbeta8 delays epithelial wound closure.
  American journal of respiratory cell and molecular biology 2006 Neurohr C, Nishimura SL, Sheppard D
• A novel in vitro model of human mesothelioma for studying tumor biology and apoptotic resistance.
  American journal of respiratory cell and molecular biology 2005 Kim KU, Wilson SM, Abayasiriwardana KS, Collins R, Fjellbirkeland L, Xu Z, Jablons DM, Nishimura SL, Broaddus VC
• Integrin alpha(v)beta8-mediated activation of transforming growth factor-beta by perivascular astrocytes: an angiogenic control switch.
  The American journal of pathology 2005 Cambier S, Gline S, Mu D, Collins R, Araya J, Dolganov G, Einheber S, Boudreau N, Nishimura SL
• A 50-A separation of the integrin alpha v beta 3 extracellular domain C termini reveals an intermediate activation state.
  The Journal of biological chemistry 2004 Gline SE, Cambier S, Govaerts C, Nishimura SL
• Integrin alphavbeta8 functions as a receptor for foot-and-mouth disease virus: role of the beta-chain cytodomain in integrin-mediated infection.
  Journal of virology 2004 Jackson T, Clark S, Berryman S, Burman A, Cambier S, Mu D, Nishimura S, King AM
• Sarcoidosis following HIV infection: evidence for CD4+ lymphocyte dependence.
  Chest 2003 Morris DG, Jasmer RM, Huang L, Gotway MB, Nishimura S, King TE
• Integrin alphavbeta8-mediated activation of transforming growth factor-beta inhibits human airway epithelial proliferation in intact bronchial tissue.
  The American journal of pathology 2003 Fjellbirkeland L, Cambier S, Broaddus VC, Hill A, Brunetta P, Dolganov G, Jablons D, Nishimura SL
• Fas activation induces renal tubular epithelial cell beta 8 integrin expression and function in the absence of apoptosis.
  The Journal of biological chemistry 2002 Jarad G, Wang B, Khan S, DeVore J, Miao H, Wu K, Nishimura SL, Wible BA, Konieczkowski M, Sedor JR, Schelling JR
• The integrin alpha(v)beta8 mediates epithelial homeostasis through MT1-MMP-dependent activation of TGF-beta1.
  The Journal of cell biology 2002 Mu D, Cambier S, Fjellbirkeland L, Baron JL, Munger JS, Kawakatsu H, Sheppard D, Broaddus VC, Nishimura SL
• Activation of a nonclassical NKT cell subset in a transgenic mouse model of hepatitis B virus infection.
  Immunity 2002 Baron JL, Gardiner L, Nishimura S, Shinkai K, Locksley R, Ganem D
• A role for the integrin alphavbeta8 in the negative regulation of epithelial cell growth.
  Cancer research 2000 Cambier S, Mu DZ, O'Connell D, Boylen K, Travis W, Liu WH, Broaddus VC, Nishimura SL
• Subacute hypersensitivity pneumonitis in an HIV infected patient receiving antiretroviral therapy.
  Thorax 2000 Morris AM, Nishimura S, Huang L
• Asbestos-induced pleural disease.
  Clinics in chest medicine 1998 Nishimura SL, Broaddus VC
• Synaptic and glial localization of the integrin alphavbeta8 in mouse and rat brain.
  Brain research 1998 Nishimura SL, Boylen KP, Einheber S, Milner TA, Ramos DM, Pytela R
• Stromal fibroblasts influence oral squamous-cell carcinoma cell interactions with tenascin-C.
  International journal of cancer 1997 Ramos DM, Chen BL, Boylen K, Stern M, Kramer RH, Sheppard D, Nishimura SL, Greenspan D, Zardi L, Pytela R
• Expression of the beta 6 integrin subunit in development, neoplasia and tissue repair suggests a role in epithelial remodeling.
  Journal of cell science 1995 Breuss JM, Gallo J, DeLisser HM, Klimanskaya IV, Folkesson HG, Pittet JF, Nishimura SL, Aldape K, Landers DV, Carpenter W
• Integrin alpha v beta 8. Interaction with vitronectin and functional divergence of the beta 8 cytoplasmic domain.
  The Journal of biological chemistry 1994 Nishimura SL, Sheppard D, Pytela R
• Role of the integrin alpha v beta 6 in cell attachment to fibronectin. Heterologous expression of intact and secreted forms of the receptor.
  The Journal of biological chemistry 1994 Weinacker A, Chen A, Agrez M, Cone RI, Nishimura S, Wayner E, Pytela R, Sheppard D
• Evaluation of an enzyme immunoassay for detection of cryptococcal capsular polysaccharide antigen in serum and cerebrospinal fluid.
  Journal of clinical microbiology 1993 Frank UK, Nishimura SL, Li NC, Sugai K, Yajko DM, Hadley WK, Ng VL
• Clinical and pathological features of bacillary peliosis hepatis in association with human immunodeficiency virus infection.
  The New England journal of medicine 1990 Perkocha LA, Geaghan SM, Yen TS, Nishimura SL, Chan SP, Garcia-Kennedy R, Honda G, Stoloff AC, Klein HZ, Goldman RL