Stephen Massa, MD, PhD
Professor
Neurology
School of Medicine

Education & Training

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• Residency School of Medicine University of California, San Francisco

Grants and Projects

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• p75NTR ligands for ALS therapy, NIH, 2019-2021
• Trk Ligands for Treatment of Traumatic Brain Injury, NIH, 2009-2018
• ShEEP request for Real-Time Quantitative PCR machine, NIH, 2016
• Stress Genes in Brain Ischemia, NIH, 1993-1998
• Characterization of an 18K Brain Lectin, NIH, 1989-1900

Publications (75)

Top publication keywords:
Nerve DegenerationLigandsReceptor, trkBBrain-Derived Neurotrophic FactorNeuroprotective AgentsSignal TransductionAlzheimer DiseaseHuntington DiseaseNerve Growth FactorsReceptor, Nerve Growth FactorReceptors, Nerve Growth FactorMorpholinesIsoleucineClioquinolAmyloid beta-Peptides

• Senolytic therapy for Alzheimer's disease.
  Nature medicine 2023 Longo FM, Massa SM
• Use of Botulinum Toxin for Limb Immobilization for Rehabilitation in Rats with Experimental Stroke.
  Biomolecules 2023 Zhang H, Liu J, Bingham D, Orr A, Kawabori M, Kim JY, Zheng Z, Lam TI, Massa SM, Swanson RA, Yenari MA
• Targeting Endogenous Mechanisms of Brain Resilience for the Treatment and Prevention of Alzheimer's Disease.
  The journal of prevention of Alzheimer's disease 2023 Shanks HRC, Onuska KM, Massa SM, Schmitz TW, Longo FM
• Small molecule modulation of TrkB and TrkC neurotrophin receptors prevents cholinergic neuron atrophy in an Alzheimer's disease mouse model at an advanced pathological stage.
  Neurobiology of disease 2021 Gonzalez S, McHugh TLM, Yang T, Syriani W, Massa SM, Longo FM, Simmons DA
• Small molecule modulation of the p75 neurotrophin receptor inhibits multiple amyloid beta-induced tau pathologies.
  Scientific reports 2020 Yang T, Tran KC, Zeng AY, Massa SM, Longo FM

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• Small-molecule modulation of the p75 neurotrophin receptor inhibits a wide range of tau molecular pathologies and their sequelae in P301S tauopathy mice.
  Acta neuropathologica communications 2020 Yang T, Liu H, Tran KC, Leng A, Massa SM, Longo FM
• Editorial: Next-Generation Alzheimer's Therapeutics: Leveraging Deep Biology.
  The journal of prevention of Alzheimer's disease 2020 Longo FM, Massa SM
• Nerve Growth Factor Pathobiology During the Progression of Alzheimer's Disease.
  Frontiers in neuroscience 2019 Mufson EJ, Counts SE, Ginsberg SD, Mahady L, Perez SE, Massa SM, Longo FM, Ikonomovic MD
• Modulation of the p75 neurotrophin receptor suppresses age-related basal forebrain cholinergic neuron degeneration.
  Scientific reports 2019 Xie Y, Meeker RB, Massa SM, Longo FM
• Bioenergetic state regulates innate inflammatory responses through the transcriptional co-repressor CtBP.
  Nature communications 2017 Shen Y, Kapfhamer D, Minnella AM, Kim JE, Won SJ, Chen Y, Huang Y, Low LH, Massa SM, Swanson RA
• A data-driven approach for evaluating multi-modal therapy in traumatic brain injury.
  Scientific reports 2017 Haefeli J, Ferguson AR, Bingham D, Orr A, Won SJ, Lam TI, Shi J, Hawley S, Liu J, Swanson RA, Massa SM
• Neurotrophin Receptor Signaling as a Therapeutic Target for Huntington's Disease.
  CNS & neurological disorders drug targets 2017 Simmons DA, Longo FM, Massa SM
• A small molecule p75NTR ligand normalizes signalling and reduces Huntington's disease phenotypes in R6/2 and BACHD mice.
  Human molecular genetics 2016 Simmons DA, Belichenko NP, Ford EC, Semaan S, Monbureau M, Aiyaswamy S, Holman CM, Condon C, Shamloo M, Massa SM, Longo FM
• The Neurotrophic Factor Receptor p75 in the Rat Dorsolateral Striatum Drives Excessive Alcohol Drinking.
  The Journal of neuroscience : the official journal of the Society for Neuroscience 2016 Darcq E, Morisot N, Phamluong K, Warnault V, Jeanblanc J, Longo FM, Massa SM, Ron D
• A small molecule TrkB/TrkC neurotrophin receptor co-activator with distinctive effects on neuronal survival and process outgrowth.
  Neuropharmacology 2016 Yang T, Massa SM, Tran KC, Simmons DA, Rajadas J, Zeng AY, Jang T, Carsanaro S, Longo FM
• The BDNF Valine 68 to Methionine Polymorphism Increases Compulsive Alcohol Drinking in Mice That Is Reversed by Tropomyosin Receptor Kinase B Activation.
  Biological psychiatry 2015 Warnault V, Darcq E, Morisot N, Phamluong K, Wilbrecht L, Massa SM, Longo FM, Ron D
• Amelioration of cisplatin-induced experimental peripheral neuropathy by a small molecule targeting p75 NTR.
  Neurotoxicology 2014 Friesland A, Weng Z, Duenas M, Massa SM, Longo FM, Lu Q
• A small molecule p75NTR ligand, LM11A-31, reverses cholinergic neurite dystrophy in Alzheimer's disease mouse models with mid- to late-stage disease progression.
  PloS one 2014 Simmons DA, Knowles JK, Belichenko NP, Banerjee G, Finkle C, Massa SM, Longo FM
• Small molecule p75NTR ligands reduce pathological phosphorylation and misfolding of tau, inflammatory changes, cholinergic degeneration, and cognitive deficits in AβPP(L/S) transgenic mice.
  Journal of Alzheimer's disease : JAD 2014 Nguyen TV, Shen L, Vander Griend L, Quach LN, Belichenko NP, Saw N, Yang T, Shamloo M, Wyss-Coray T, Massa SM, Longo FM
• A small molecule TrkB ligand reduces motor impairment and neuropathology in R6/2 and BACHD mouse models of Huntington's disease.
  The Journal of neuroscience : the official journal of the Society for Neuroscience 2013 Simmons DA, Belichenko NP, Yang T, Condon C, Monbureau M, Shamloo M, Jing D, Massa SM, Longo FM
• A small molecule p75(NTR) ligand protects neurogenesis after traumatic brain injury.
  Stem cells (Dayton, Ohio) 2013 Shi J, Longo FM, Massa SM
• Small-molecule modulation of neurotrophin receptors: a strategy for the treatment of neurological disease.
  Nature reviews. Drug discovery 2013 Longo FM, Massa SM
• Beneficial effects of minocycline and botulinum toxin-induced constraint physical therapy following experimental traumatic brain injury.
  Neurorehabilitation and neural repair 2013 Lam TI, Bingham D, Chang TJ, Lee CC, Shi J, Wang D, Massa S, Swanson RA, Liu J
• Small molecule p75NTR ligand prevents cognitive deficits and neurite degeneration in an Alzheimer's mouse model.
  Neurobiology of aging 2013 Knowles JK, Simmons DA, Nguyen TV, Vander Griend L, Xie Y, Zhang H, Yang T, Pollak J, Chang T, Arancio O, Buckwalter MS, Wyss-Coray T, Massa SM, Longo FM
• Oral administration of a small molecule targeted to block proNGF binding to p75 promotes myelin sparing and functional recovery after spinal cord injury.
  The Journal of neuroscience : the official journal of the Society for Neuroscience 2013 Tep C, Lim TH, Ko PO, Getahun S, Ryu JC, Goettl VM, Massa SM, Basso M, Longo FM, Yoon SO
• Delayed administration of a small molecule tropomyosin-related kinase B ligand promotes recovery after hypoxic-ischemic stroke.
  Stroke 2012 Han J, Pollak J, Yang T, Siddiqui MR, Doyle KP, Taravosh-Lahn K, Cekanaviciute E, Han A, Goodman JZ, Jones B, Jing D, Massa SM, Longo FM, Buckwalter MS
• Microglial activation induced by brain trauma is suppressed by post-injury treatment with a PARP inhibitor.
  Journal of neuroinflammation 2012 d'Avila JC, Lam TI, Bingham D, Shi J, Won SJ, Kauppinen TM, Massa S, Liu J, Swanson RA
• A TrkB small molecule partial agonist rescues TrkB phosphorylation deficits and improves respiratory function in a mouse model of Rett syndrome.
  The Journal of neuroscience : the official journal of the Society for Neuroscience 2012 Schmid DA, Yang T, Ogier M, Adams I, Mirakhur Y, Wang Q, Massa SM, Longo FM, Katz DM
• PBT2 Reduces Toxicity in a C. elegans Model of polyQ Aggregation and Extends Lifespan, Reduces Striatal Atrophy and Improves Motor Performance in the R6/2 Mouse Model of Huntington's Disease.
  Journal of Huntington's disease 2012 Cherny RA, Ayton S, Finkelstein DI, Bush AI, McColl G, Massa SM
• Small molecule BDNF mimetics activate TrkB signaling and prevent neuronal degeneration in rodents.
  The Journal of clinical investigation 2010 Massa SM, Yang T, Xie Y, Shi J, Bilgen M, Joyce JN, Nehama D, Rajadas J, Longo FM
• The p75 neurotrophin receptor promotes amyloid-beta(1-42)-induced neuritic dystrophy in vitro and in vivo.
  The Journal of neuroscience : the official journal of the Society for Neuroscience 2009 Knowles JK, Rajadas J, Nguyen TV, Yang T, LeMieux MC, Vander Griend L, Ishikawa C, Massa SM, Wyss-Coray T, Longo FM
• Signaling through Rho GTPase pathway as viable drug target.
  Current medicinal chemistry 2009 Lu Q, Longo FM, Zhou H, Massa SM, Chen YH
• Small molecule, non-peptide p75 ligands inhibit Abeta-induced neurodegeneration and synaptic impairment.
  PloS one 2008 Yang T, Knowles JK, Lu Q, Zhang H, Arancio O, Moore LA, Chang T, Wang Q, Andreasson K, Rajadas J, Fuller GG, Xie Y, Massa SM, Longo FM
• Anti-cancer drug induced neurotoxicity and identification of Rho pathway signaling modulators as potential neuroprotectants.
  Neurotoxicology 2008 James SE, Burden H, Burgess R, Xie Y, Yang T, Massa SM, Longo FM, Lu Q
• Small molecule modulation of p75 neurotrophin receptor functions.
  CNS & neurological disorders drug targets 2008 Longo FM, Massa SM
• Small molecule neurotrophin receptor ligands: novel strategies for targeting Alzheimer's disease mechanisms.
  Current Alzheimer research 2007 Longo FM, Yang T, Knowles JK, Xie Y, Moore LA, Massa SM
• Injury-induced neurogenesis in Bax-deficient mice: evidence for regulation by voltage-gated potassium channels.
  The European journal of neuroscience 2007 Shi J, Miles DK, Orr BA, Massa SM, Kernie SG
• LAR protein tyrosine phosphatase receptor associates with TrkB and modulates neurotrophic signaling pathways.
  Journal of neurobiology 2006 Yang T, Massa SM, Longo FM
• Modulation of p75-dependent motor neuron death by a small non-peptidyl mimetic of the neurotrophin loop 1 domain.
  The European journal of neuroscience 2006 Pehar M, Cassina P, Vargas MR, Xie Y, Beckman JS, Massa SM, Longo FM, Barbeito L
• Small, nonpeptide p75NTR ligands induce survival signaling and inhibit proNGF-induced death.
  The Journal of neuroscience : the official journal of the Society for Neuroscience 2006 Massa SM, Xie Y, Yang T, Harrington AW, Kim ML, Yoon SO, Kraemer R, Moore LA, Hempstead BL, Longo FM
• Protein-tyrosine phosphatase (PTP) wedge domain peptides: a novel approach for inhibition of PTP function and augmentation of protein-tyrosine kinase function.
  The Journal of biological chemistry 2006 Xie Y, Massa SM, Ensslen-Craig SE, Major DL, Yang T, Tisi MA, Derevyanny VD, Runge WO, Mehta BP, Moore LA, Brady-Kalnay SM, Longo FM
• Small molecule approaches for promoting neurogenesis.
  Current Alzheimer research 2006 Longo FM, Yang T, Xie Y, Massa SM
• Clioquinol down-regulates mutant huntingtin expression in vitro and mitigates pathology in a Huntington's disease mouse model.
  Proceedings of the National Academy of Sciences of the United States of America 2005 Nguyen T, Hamby A, Massa SM
• Neurotrophin receptor-based strategies for Alzheimer's disease.
  Current Alzheimer research 2005 Longo FM, Massa SM
• Cloning and characterization of the hsp 18.55 gene, a new member of the small heat shock gene family isolated from wine Lactobacillus plantarum.
  Research in microbiology 2004 Spano G, Beneduce L, Perrotta C, Massa S
• Neurotrophin-based strategies for neuroprotection.
  Journal of Alzheimer's disease : JAD 2004 Longo FM, Massa SM
• Neuroprotective strategies in Alzheimer's disease.
  NeuroRx : the journal of the American Society for Experimental NeuroTherapeutics 2004 Longo FM, Massa SM
• A candidate chimeric mammalian mRNA transcript is derived from distinct chromosomes and is associated with nonconsensus splice junction motifs.
  DNA and cell biology 2003 Zhang C, Xie Y, Martignetti JA, Yeo TT, Massa SM, Longo FM
• Leukocyte antigen-related protein tyrosine phosphatase receptor: a small ectodomain isoform functions as a homophilic ligand and promotes neurite outgrowth.
  The Journal of neuroscience : the official journal of the Society for Neuroscience 2003 Yang T, Bernabeu R, Xie Y, Zhang JS, Massa SM, Rempel HC, Longo FM
• Adaptable modification of adenoviral tropism using a bifunctional ligand protein.
  Virus research 2003 Li Y, Yao XM, Hong-Brown L, Massa SM
• Alzheimer's therapeutics: neurotrophin domain small molecule mimetics.
  Journal of molecular neuroscience : MN 2003 Massa SM, Xie Y, Longo FM
• Alzheimer's therapeutics: neurotrophin small molecule mimetics.
  Journal of molecular neuroscience : MN 2002 Massa SM, Xie Y, Longo FM
• The leukocyte common antigen-related protein tyrosine phosphatase receptor regulates regenerative neurite outgrowth in vivo.
  The Journal of neuroscience : the official journal of the Society for Neuroscience 2001 Xie Y, Yeo TT, Zhang C, Yang T, Tisi MA, Massa SM, Longo FM
• Effects of transient global ischemia and kainate on poly(ADP-ribose) polymerase (PARP) gene expression and proteolytic cleavage in gerbil and rat brains.
  Brain research. Molecular brain research 2000 Liu J, Ying W, Massa S, Duriez PJ, Swanson RA, Poirier GG, Sharp FR
• Leukocyte common-antigen-related tyrosine phosphatase receptor: altered expression of mRNA and protein in the New England Deaconess Hospital rat line exhibiting spontaneous pheochromocytoma.
  Carcinogenesis 2000 Yang T, Martignetti JA, Massa SM, Longo FM
• Leukocyte common antigen-related tyrosine phosphatase receptor: increased expression and neuronal-type splicing in breast cancer cells and tissue.
  Molecular carcinogenesis 1999 Yang T, Zhang JS, Massa SM, Han X, Longo FM
• Heat-shock protein protection.
  Trends in neurosciences 1999 Sharp FR, Massa SM, Swanson RA
• Effect of genetic modification of acute inflammatory responsiveness on tumorigenesis in the mouse.
  Carcinogenesis 1998 Biozzi G, Ribeiro OG, Saran A, Araujo ML, Maria DA, De Franco M, Cabrera WK, Sant'anna OA, Massa S, Covelli V, Mouton D, Neveu T, Siqueira M, Ibanez OM
• Deficient LAR expression decreases basal forebrain cholinergic neuronal size and hippocampal cholinergic innervation.
  Journal of neuroscience research 1997 Yeo TT, Yang T, Massa SM, Zhang JS, Honkaniemi J, Butcher LL, Longo FM
• Focal hyperexpression of hemeoxygenase-1 protein and messenger RNA in rat brain caused by cellular stress following subarachnoid injections of lysed blood.
  Journal of neurosurgery 1996 Matz PG, Massa SM, Weinstein PR, Turner C, Panter SS, Sharp FR
• Global ischemia induces apoptosis-associated genes in hippocampus.
  Brain research. Molecular brain research 1996 Honkaniemi J, Massa SM, Breckinridge M, Sharp FR
• Patterns of cognitive recovery in sudden cardiac arrest survivors: the pilot study.
  Heart & lung : the journal of critical care 1996 Sauvé MJ, Walker JA, Massa SM, Winkle RA, Scheinman MM
• Heme oxygenase-1 (HO-1) protein induction in rat brain following focal ischemia.
  Brain research. Molecular brain research 1996 Nimura T, Weinstein PR, Massa SM, Panter S, Sharp FR
• Heme-oxygenase-1 induction in glia throughout rat brain following experimental subarachnoid hemorrhage.
  Brain research 1996 Matz P, Turner C, Weinstein PR, Massa SM, Panter SS, Sharp FR
• Apoptosis associated genes are induced in gerbil hippocampus following global ischemia.
  Restorative neurology and neuroscience 1996 Honkaniemi J, Massa SM, Sharp FR
• The stress gene response in brain.
  Cerebrovascular and brain metabolism reviews 1996 Massa SM, Swanson RA, Sharp FR
• Cloning of rat grp75, an hsp70-family member, and its expression in normal and ischemic brain.
  Journal of neuroscience research 1995 Massa SM, Longo FM, Zuo J, Wang S, Chen J, Sharp FR
• Sequence and mapping of galectin-5, a beta-galactoside-binding lectin, found in rat erythrocytes.
  The Journal of biological chemistry 1995 Gitt MA, Wiser MF, Leffler H, Herrmann J, Xia YR, Massa SM, Cooper DN, Lusis AJ, Barondes SH
• Phencyclidine induction of the hsp 70 stress gene in injured pyramidal neurons is mediated via multiple receptors and voltage gated calcium channels.
  Neuroscience 1994 Sharp FR, Butman M, Koistinaho J, Aardalen K, Nakki R, Massa SM, Swanson RA, Sagar SM
• Neuronal injury produced by NMDA antagonists can be detected using heat shock proteins and can be blocked with antipsychotics.
  Psychopharmacology bulletin 1994 Sharp FR, Butman M, Aardalen K, Nickolenko J, Nakki R, Massa SM, Swanson RA, Sagar SM
• cDNA cloning and expression of stress-inducible rat hsp70 in normal and injured rat brain.
  Journal of neuroscience research 1993 Longo FM, Wang S, Narasimhan P, Zhang JS, Chen J, Massa SM, Sharp FR
• L-29, an endogenous lectin, binds to glycoconjugate ligands with positive cooperativity.
  Biochemistry 1993 Massa SM, Cooper DN, Leffler H, Barondes SH
• Isolation and expression of a gene encoding L-14-II, a new human soluble lactose-binding lectin.
  The Journal of biological chemistry 1992 Gitt MA, Massa SM, Leffler H, Barondes SH
• Endogenous muscle lectin inhibits myoblast adhesion to laminin.
  The Journal of cell biology 1991 Cooper DN, Massa SM, Barondes SH
• Acute neurologic and psychiatric complications associated with cocaine abuse.
  The American journal of medicine 1987 Lowenstein DH, Massa SM, Rowbotham MC, Collins SD, McKinney HE, Simon RP