Stephen Gluck, MD
Professor
Medicine
School of Medicine

Professor, Division of Nephrology Areas of expertise: acute and chronic kidney disease, electrolyte disorders, kidney stones, outpatient and home dialysis

Education & Training

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• M.D. School of Medicine University of California Los Angeles 1977

Websites

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• Clinical Profile at UCSF Medical Center (ucsfhealth.org)

Grants and Projects

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• Academic Training Program in Nephrology, NIH, 1976-2023
• Pre &Post-Doctoral Training in Nephrology &Hypertension, NIH, 1985-2013
• Regulation of Renal H+ATPase by Glycolysis, NIH, 2003-2008
• Pathophysiology of Renal Disease, NIH, 1974-2005
• Expression of the Renal H+ Atpase in Metanephrogenesis, NIH, 1998-2003
• Biology of Cell/cell Communication in Bone, NIH, 1983-2003
• Renal Genes, Growth Factors, Development and Disease, NIH, 1992-2003
• H+ Atpase in Urinary Acidification, NIH, 1986-2002
• Characterization of H+atpase in Urinary Acidification, NIH, 1984-1987
• Characterization of H+atpase in Urinary Acidification, NIH, 1984-1986

Publications (54)

Top publication keywords:
Kidney Tubules, DistalVacuolar Proton-Translocating ATPasesProton PumpsFructose-Bisphosphate AldolaseVacuolesAcidosis, Renal TubularKidney Tubules, ProximalKidneyProton-Translocating ATPasesAnion Exchange Protein 1, ErythrocyteMatrix Metalloproteinase 1OsteoclastsAdenosine TriphosphatasesProtein SubunitsBone Resorption

• A Case Report of Kidney-Only Transplantation in Primary Hyperoxaluria Type 1: A Novel Approach with the Use of Nedosiran.
  Case reports in nephrology and dialysis 2023 Breeggemann MC, Gluck SL, Stoller ML, Lee MM
• Transient Hyperkalemia Following Treatment of Chronic Hypokalemia: A Case Report and Review of Distal Tubule Physiology.
  Case reports in nephrology and dialysis 2022 Breeggemann MC, Gluck SL
• IFN-gamma regulation of vacuolar pH, cathepsin D processing and autophagy in mammary epithelial cells.
  Journal of cellular biochemistry 2008 Khalkhali-Ellis Z, Abbott DE, Bailey CM, Goossens W, Margaryan NV, Gluck SL, Reuveni M, Hendrix MJ
• Physical interaction between aldolase and vacuolar H+-ATPase is essential for the assembly and activity of the proton pump.
  The Journal of biological chemistry 2007 Lu M, Ammar D, Ives H, Albrecht F, Gluck SL
• Distribution of Rab GTPases in mouse kidney and comparison with vacuolar H+-ATPase.
  Nephron. Physiology 2005 Curtis LM, Gluck S

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• Phosphatidylinositol 3-kinase-mediated effects of glucose on vacuolar H+-ATPase assembly, translocation, and acidification of intracellular compartments in renal epithelial cells.
  Molecular and cellular biology 2005 Sautin YY, Lu M, Gaugler A, Zhang L, Gluck SL
• Acid sensing in renal epithelial cells.
  The Journal of clinical investigation 2004 Gluck SL
• The glycolytic enzyme aldolase mediates assembly, expression, and activity of vacuolar H+-ATPase.
  The Journal of biological chemistry 2003 Lu M, Sautin YY, Holliday LS, Gluck SL
• Vacuolar H+-ATPase binding to microfilaments: regulation in response to phosphatidylinositol 3-kinase activity and detailed characterization of the actin-binding site in subunit B.
  The Journal of biological chemistry 2003 Chen SH, Bubb MR, Yarmola EG, Zuo J, Jiang J, Lee BS, Lu M, Gluck SL, Hurst IR, Holliday LS
• Interstitial collagenase activity stimulates the formation of actin rings and ruffled membranes in mouse marrow osteoclasts.
  Calcified tissue international 2003 Holliday LS, Welgus HG, Hanna J, Lee BS, Lu M, Jeffrey JJ, Gluck SL
• The amino-terminal domain of the E subunit of vacuolar H(+)-ATPase (V-ATPase) interacts with the H subunit and is required for V-ATPase function.
  The Journal of biological chemistry 2002 Lu M, Vergara S, Zhang L, Holliday LS, Aris J, Gluck SL
• The amino-terminal domain of the B subunit of vacuolar H+-ATPase contains a filamentous actin binding site.
  The Journal of biological chemistry 2000 Holliday LS, Lu M, Lee BS, Nelson RD, Solivan S, Zhang L, Gluck SL
• 1,25-Dihydroxy-19-nor-vitamin D(2), a vitamin D analog with reduced bone resorbing activity in vitro.
  Journal of the American Society of Nephrology : JASN 2000 Holliday LS, Gluck SL, Slatopolsky E, Brown AJ
• Vacuolar H+-ATPase activity and expression in mouse bone marrow cultures.
  Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 1999 Lee BS, Holliday LS, Krits I, Gluck SL
• Interaction between vacuolar H(+)-ATPase and microfilaments during osteoclast activation.
  The Journal of biological chemistry 1999 Lee BS, Gluck SL, Holliday LS
• Plasma membrane V-ATPases in proton-transporting cells of the mammalian kidney and osteoclast.
  Acta physiologica Scandinavica. Supplementum 1998 Gluck SL, Lee BS, Wang SP, Underhill D, Nemoto J, Holliday LS
• Granulocyte colony-stimulating factor upregulates the vacuolar proton ATPase in human neutrophils.
  Blood 1997 Niessen H, Meisenholder GW, Li HL, Gluck SL, Lee BS, Bowman B, Engler RL, Babior BM, Gottlieb RA
• Initiation of osteoclast bone resorption by interstitial collagenase.
  The Journal of biological chemistry 1997 Holliday LS, Welgus HG, Fliszar CJ, Veith GM, Jeffrey JJ, Gluck SL
• Preservation of intercalated cell H(+)-ATPase in two patients with lupus nephritis and hyperkalemic distal renal tubular acidosis.
  Journal of the American Society of Nephrology : JASN 1997 Bastani B, Underhill D, Chu N, Nelson RD, Haragsim L, Gluck S
• Vacuolar H+-ATPase in ocular ciliary epithelium.
  Proceedings of the National Academy of Sciences of the United States of America 1997 Wax MB, Saito I, Tenkova T, Krupin T, Becker B, Nelson N, Brown D, Gluck SL
• Adaptational changes in renal vacuolar H(+)-ATPase in the rat remnant kidney.
  Journal of the American Society of Nephrology : JASN 1997 Bastani B, Gluck S
• Low NO concentrations inhibit osteoclast formation in mouse marrow cultures by cGMP-dependent mechanism.
  The American journal of physiology 1997 Holliday LS, Dean AD, Lin RH, Greenwald JE, Gluck SL
• A novel transcription factor regulates expression of the vacuolar H+-ATPase B2 subunit through AP-2 sites during monocytic differentiation.
  The Journal of biological chemistry 1997 Lee BS, Krits I, Crane-Zelkovic MK, Gluck SL
• Regulation of AE1 anion exchanger and H(+)-ATPase in rat cortex by acute metabolic acidosis and alkalosis.
  Kidney international 1997 Sabolic I, Brown D, Gluck SL, Alper SL
• Distal urinary acidification from Homer Smith to the present.
  Kidney international 1996 Gluck SL, Iyori M, Holliday LS, Kostrominova T, Lee BS
• Immunocytochemical localization of vacuolar H+-ATPase and Cl--HCO3- anion exchanger (erythrocyte band-3 protein) in avian osteoclasts: effect of calcium-deficient diet on polar expression of the H+-ATPase pump.
  Calcified tissue international 1996 Bastani B, Ross FP, Kopito RR, Gluck SL
• Osteoclasts express the B2 isoform of vacuolar H(+)-ATPase intracellularly and on their plasma membranes.
  The American journal of physiology 1996 Lee BS, Holliday LS, Ojikutu B, Krits I, Gluck SL
• Physiology and biochemistry of the kidney vacuolar H+-ATPase.
  Annual review of physiology 1996 Gluck SL, Underhill DM, Iyori M, Holliday LS, Kostrominova TY, Lee BS
• Complete degradation of type X collagen requires the combined action of interstitial collagenase and osteoclast-derived cathepsin-B.
  The Journal of clinical investigation 1995 Sires UI, Schmid TM, Fliszar CJ, Wang ZQ, Gluck SL, Welgus HG
• Transcriptional regulation of the vacuolar H(+)-ATPase B2 subunit gene in differentiating THP-1 cells.
  The Journal of biological chemistry 1995 Lee BS, Underhill DM, Crane MK, Gluck SL
• Properties and regulation of the renal vacuolar H(+)-ATPase and H(+)-K(+)-ATPase.
  Current opinion in nephrology and hypertension 1993 Gluck SL, Nelson RD, Lee BS
• The vacuolar H(+)-ATPases: versatile proton pumps participating in constitutive and specialized functions of eukaryotic cells.
  International review of cytology 1993 Gluck SL
• Biochemistry of the renal V-ATPase.
  The Journal of experimental biology 1992 Gluck SL, Nelson RD, Lee BS, Wang ZQ, Guo XL, Fu JY, Zhang K
• Introduction to the principles and methods of recombinant DNA technology.
  Seminars in nephrology 1992 Gluck SL, Nelson RD, Lee BS
• The role of the V-ATPase in renal epithelial H+ transport.
  The Journal of experimental biology 1992 Gluck S, Nelson R
• Absence of H(+)-ATPase in cortical collecting tubules of a patient with Sjogren's syndrome and distal renal tubular acidosis.
  Journal of the American Society of Nephrology : JASN 1992 Cohen EP, Bastani B, Cohen MR, Kolner S, Hemken P, Gluck SL
• Expression of vacuolar H(+)-ATPase in mouse osteoclasts during in vitro differentiation.
  The American journal of physiology 1992 Wang ZQ, Hemken P, Menton D, Gluck S
• The structure and biochemistry of the vacuolar H+ ATPase in proximal and distal urinary acidification.
  Journal of bioenergetics and biomembranes 1992 Gluck SL
• cDNA sequence and tissue expression of bovine vacuolar H(+)-ATPase M(r) 70,000 subunit.
  The American journal of physiology 1992 Marushack MM, Lee BS, Masood K, Gluck S
• Immunologic evidence that vacuolar H+ ATPases with heterogeneous forms of Mr = 31,000 subunit have different membrane distributions in mammalian kidney.
  The Journal of biological chemistry 1992 Hemken P, Guo XL, Wang ZQ, Zhang K, Gluck S
• Selectively amplified expression of an isoform of the vacuolar H(+)-ATPase 56-kilodalton subunit in renal intercalated cells.
  Proceedings of the National Academy of Sciences of the United States of America 1992 Nelson RD, Guo XL, Masood K, Brown D, Kalkbrenner M, Gluck S
• Expression and distribution of renal vacuolar proton-translocating adenosine triphosphatase in response to chronic acid and alkali loads in the rat.
  The Journal of clinical investigation 1991 Bastani B, Purcell H, Hemken P, Trigg D, Gluck S
• Colocalization of H(+)-ATPase and band 3 anion exchanger in rabbit collecting duct intercalated cells.
  The American journal of physiology 1991 Schuster VL, Fejes-Tóth G, Naray-Fejes-Tóth A, Gluck S
• Distribution and structure of the vacuolar H+ ATPase in endosomes and lysosomes from LLC-PK1 cells.
  Experimental cell research 1991 Rodman JS, Stahl PD, Gluck S
• Isolation and properties of bovine kidney brush border vacuolar H(+)-ATPase. A proton pump with enzymatic and structural differences from kidney microsomal H(+)-ATPase.
  The Journal of biological chemistry 1990 Wang ZQ, Gluck S
• Osteoclastic bone resorption by a polarized vacuolar proton pump.
  Science (New York, N.Y.) 1989 Blair HC, Teitelbaum SL, Ghiselli R, Gluck S
• Subtypes of intercalated cells in rat kidney collecting duct defined by antibodies against erythroid band 3 and renal vacuolar H+-ATPase.
  Proceedings of the National Academy of Sciences of the United States of America 1989 Alper SL, Natale J, Gluck S, Lodish HF, Brown D
• Localization of a proton-pumping ATPase in rat kidney.
  The Journal of clinical investigation 1988 Brown D, Hirsch S, Gluck S
• Kinetics of a novel cytosolic protein during the onset of renal epithelial cell growth.
  The American journal of physiology 1988 Aithal HN, Walsh-Reitz MM, Kartha S, Gluck SL, Franklin WA, Knigge KM, Toback FG
• Isolation and sequence of a cDNA clone encoding the 31-kDa subunit of bovine kidney vacuolar H+-ATPase.
  Proceedings of the National Academy of Sciences of the United States of America 1988 Hirsch S, Strauss A, Masood K, Lee S, Sukhatme V, Gluck S
• Immunoaffinity purification and characterization of vacuolar H+ATPase from bovine kidney.
  The Journal of biological chemistry 1987 Gluck S, Caldwell J
• Production and characterization of a monoclonal antibody to vacuolar H+ATPase of renal epithelia.
  The Journal of biological chemistry 1987 Yurko MA, Gluck S
• Structure of the novel membrane-coating material in proton-secreting epithelial cells and identification as an H+ATPase.
  The Journal of cell biology 1987 Brown D, Gluck S, Hartwig J
• An electrogenic proton-translocating adenosine triphosphatase from bovine kidney medulla.
  The Journal of clinical investigation 1984 Gluck S, Al-Awqati Q