Srinath Sanda, MD
Professor
Pediatrics
School of Medicine

In addition, I am a Director of Clinical and Translational Medicine in the Immune Tolerance Network, a large NIH-sponsored clinical trials consortium that conductsl immune modulating trials in type 1 diabetes, allergy, transplantation, and autoimmune diseases (https://www.immunetolerance.org). I design international, multi-center phase 1 and 2 clinical trials in type 1 diabetes and allergic disease utilizing cutting-edge immune modulation therapy. We combine data from the clinical trials data with cutting edge immunophenotyping data to better understand mechanisms of immune tolerance in humans.

• Nasal and blood transcriptomic pathways underpinning the clinical response to grass pollen immunotherapy.
  The Journal of allergy and clinical immunology 2023 Altman MC, Segnitz RM, Larson D, Jayavelu ND, Smith MT, Patel S, Scadding GW, Qin T, Sanda S, Steveling E, Eifan AO, Penagos M, Jacobson MR, Parkin RV, Shamji MH, Togias A, Durham SR
• Distinct trajectories distinguish antigen-specific T cells in peanut-allergic individuals undergoing oral immunotherapy.
  The Journal of allergy and clinical immunology 2023 Calise J, DeBerg H, Garabatos N, Khosa S, Bajzik V, Calderon LB, Aldridge K, Rosasco M, Ferslew BC, Zhu T, Smulders R, Wheatley LM, Laidlaw TM, Qin T, Chichili GR, Adelman DC, Farrington M, Robinson D…
• Gut Microbiome Membrane Lipids and Bile Acids Relate to Peanut Oral Immunotherapy Outcomes.
  Journal of Allergy and Clinical Immunology 2023 Mustafa Ozcam, Kathryn McCauley, Lisa Wheatley, Carolyn Baloh, Srinath Sanda, Stacie Jones, Susan Lynch
• HLA-associated outcomes in peanut oral immunotherapy trials identify mechanistic and clinical determinants of therapeutic success.
  Frontiers in immunology 2022 Kanchan K, Shankar G, Huffaker MF, Bahnson HT, Chinthrajah RS, Sanda S, Manohar M, Ling H, Paschall JE, Toit GD, Ruczinski I, Togias A, Lack G, Nadeau KC, Jones SM, Nepom GT, Mathias RA
• Effects of combination treatment with tezepelumab and allergen immunotherapy on nasal responses to allergen: A randomized controlled trial.
  The Journal of allergy and clinical immunology 2022 Corren J, Larson D, Altman MC, Segnitz RM, Avila PC, Greenberger PA, Baroody F, Moss MH, Nelson H, Burbank AJ, Hernandez ML, Peden D, Saini S, Tilles S, Hussain I, Whitehouse D, Qin T, Villarreal M, …
• IL-6-Driven pSTAT1 Response Is Linked to T Cell Features Implicated in Early Immune Dysregulation.
  Frontiers in immunology 2022 Lambert K, Diggins KE, Jones BE, Hundhausen C, Maerz MD, Hocking AM, Sanda S, Greenbaum CJ, Linsley PS, Cerosaletti K, Buckner JH
• Interpretation of Bone Mineral Density Z-Scores by Dual-Energy X-Ray Absorptiometry in Transgender and Gender Diverse Youth Prior to Gender-Affirming Medical Therapy.
  Journal of clinical densitometry : the official journal of the International Society for Clinical Densitometry 2022 Lee JY, Fan B, Montenegro G, Long RK, Sanda S, Capodanno G, Schafer AL, Burghardt AJ, Rosenthal SM, Fung EB
• Translating lessons learned on the role of HLA in immunological responses in LEAP to peanut OIT Trials: IMPACT and POISED.
  Journal of Allergy and Clinical Immunology 2022 Kanika Kanchan, Gautam Shankar, Michelle Huffaker, Henry Bahnson, R Sharon Chinthrajah, Srinath Sanda, Monali Manohar, George Du Toit, Ingo Ruczinski, Gideon Lack, Kari Nadeau, Stacie Jones, Gerald …
• Efficacy and safety of oral immunotherapy in children aged 1-3 years with peanut allergy (the Immune Tolerance Network IMPACT trial): a randomised placebo-controlled study.
  Lancet (London, England) 2022 Jones SM, Kim EH, Nadeau KC, Nowak-Wegrzyn A, Wood RA, Sampson HA, Scurlock AM, Chinthrajah S, Wang J, Pesek RD, Sindher SB, Kulis M, Johnson J, Spain K, Babineau DC, Chin H, Laurienzo-Panza J, Yan R,…
• IL-6 receptor blockade does not slow β cell loss in new-onset type 1 diabetes.
  JCI insight 2021 Greenbaum CJ, Serti E, Lambert K, Weiner LJ, Kanaparthi S, Lord S, Gitelman SE, Wilson DM, Gaglia JL, Griffin KJ, Russell WE, Raskin P, Moran A, Willi SM, Tsalikian E, DiMeglio LA, Herold KC, Moore WV…
• Diabetic ketoacidosis drives COVID-19 related hospitalizations in children with type 1 diabetes.
  Journal of diabetes 2021 Alonso GT, Ebekozien O, Gallagher MP, Rompicherla S, Lyons SK, Choudhary A, Majidi S, Pinnaro CT, Balachandar S, Gangat M, Curda Roberts AJ, Marks BE, Creo A, Sanchez J, Seeherunvong T, Jimenez-Vega J…
• Differential induction of allergen-specific IgA responses following timothy grass subcutaneous and sublingual immunotherapy.
  The Journal of allergy and clinical immunology 2021 Shamji MH, Larson D, Eifan A, Scadding GW, Qin T, Lawson K, Sever ML, Macfarlane E, Layhadi JA, Würtzen PA, Parkin RV, Sanda S, Harris KM, Nepom GT, Togias A, Durham SR
• Inequities in Diabetic Ketoacidosis Among Patients With Type 1 Diabetes and COVID-19: Data From 52 US Clinical Centers.
  The Journal of clinical endocrinology and metabolism 2021 Ebekozien O, Agarwal S, Noor N, Albanese-O'Neill A, Wong JC, Seeherunvong T, Sanchez J, DeSalvo D, Lyons SK, Majidi S, Wood JR, Acharya R, Aleppo G, Sumpter KM, Cymbaluk A, Shah NA, Van Name M, Cruz-…
• Sensitive detection of multiple islet autoantibodies in type 1 diabetes using small sample volumes by agglutination-PCR.
  PloS one 2020 Cortez FJ, Gebhart D, Robinson PV, Seftel D, Pourmandi N, Owyoung J, Bertozzi CR, Wilson DM, Maahs DM, Buckingham BA, Mills JR, Roforth MM, Pittock SJ, McKeon A, Page K, Wolf WA, Sanda S, Speake C, …
• Nasal allergen challenge and environmental exposure chamber challenge: A randomized trial comparing clinical and biological responses to cat allergen.
  The Journal of allergy and clinical immunology 2020 Larson D, Patel P, Salapatek AM, Couroux P, Whitehouse D, Pina A, Johnson JL, Sever ML, Sanda S, Poyser J, Allio T, Scadding GW, Qin T, Shamji MH, Kwok WW, James EA, French D, Lelic A, Larché M, …
• Effects of Combined Treatment with Cat Allergen Immunotherapy and Tezepelumab on Nasal Allergen Challenge.
  Journal of Allergy and Clinical Immunology 2020 Jonathan Corren, Lisa Wheatley, Srinath Sanda, David Larson, Tielin Qin, Pedro Avila, Fuad Baroody, Paul Greenberger, Iftikhar Hussain, Mark Moss, Harold Nelson, Sarbjit Saini, Stephen Tilles, Joy …
• Tolerance Development Following Oral Immunotherapy (OIT) in 1-3 Year Old Children with Peanut Allergy: Findings from the Immune Tolerance Network (ITN) IMPACT TRIAL.
  Journal of Allergy and Clinical Immunology 2020 Stacie Jones, Edwin Kim, Kari Nadeau, Anna Nowak-Wegrzyn, Robert Wood, Hugh Sampson, Amy Scurlock, Sharon Chinthrajan, Jacqueline Johnson, Katharine Spain, Joy Laurienzo, David Larson, Marshall Plaut,…
• Hyaluronan levels are increased systemically in human type 2 but not type 1 diabetes independently of glycemic control.
  Matrix biology : journal of the International Society for Matrix Biology 2018 Nagy N, Sunkari VG, Kaber G, Hasbun S, Lam DN, Speake C, Sanda S, McLaughlin TL, Wight TN, Long SR, Bollyky PL
• Islet Interleukin-1β Immunoreactivity Is an Early Feature of Cystic Fibrosis That May Contribute to β-Cell Failure.
  Diabetes care 2018 Hull RL, Gibson RL, McNamara S, Deutsch GH, Fligner CL, Frevert CW, Ramsey BW, Sanda S
• Remodeling T cell compartments during anti-CD3 immunotherapy of type 1 diabetes.
  Cellular immunology 2017 Long SA, Thorpe J, Herold KC, Ehlers M, Sanda S, Lim N, Linsley PS, Nepom GT, Harris KM
• Avidity-dependent programming of autoreactive T cells in T1D.
  PloS one 2014 Durinovic-Belló I, Gersuk VH, Ni C, Wu R, Thorpe J, Jospe N, Sanda S, Greenbaum CJ, Nepom GT
• Use of a "fuzzy logic" controller in a closed-loop artificial pancreas.
  Diabetes technology & therapeutics 2013 Mauseth R, Hirsch IB, Bollyky J, Kircher R, Matheson D, Sanda S, Greenbaum C
• Interleukin-1 antagonism in type 1 diabetes of recent onset: two multicentre, randomised, double-blind, placebo-controlled trials.
  Lancet (London, England) 2013 Moran A, Bundy B, Becker DJ, DiMeglio LA, Gitelman SE, Goland R, Greenbaum CJ, Herold KC, Marks JB, Raskin P, Sanda S, Schatz D, Wherrett DK, Wilson DM, Krischer JP, Skyler JS, Type 1 Diabetes …
• CD4+ T cells recognize diverse epitopes within GAD65: implications for repertoire development and diabetes monitoring.
  Immunology 2013 Yang J, James EA, Sanda S, Greenbaum C, Kwok WW
• Correlation of TSH with the risk of paediatric thyroid carcinoma.
  Clinical endocrinology 2012 Chiu HK, Sanda S, Fechner PY, Pihoker C
• Rapamycin/IL-2 combination therapy in patients with type 1 diabetes augments Tregs yet transiently impairs β-cell function.
  Diabetes 2012 Long SA, Rieck M, Sanda S, Bollyky JB, Samuels PL, Goland R, Ahmann A, Rabinovitch A, Aggarwal S, Phippard D, Turka LA, Ehlers MR, Bianchine PJ, Boyle KD, Adah SA, Bluestone JA, Buckner JH, Greenbaum …
• Through the fog: recent clinical trials to preserve β-cell function in type 1 diabetes.
  Diabetes 2012 Greenbaum CJ, Schatz DA, Haller MJ, Sanda S
• A SNP in G6PC2 predicts insulin secretion in type 1 diabetes.
  Acta diabetologica 2012 Sanda S, Wei S, Rue T, Shilling H, Greenbaum C
• Diabetes promotes an inflammatory macrophage phenotype and atherosclerosis through acyl-CoA synthetase 1.
  Proceedings of the National Academy of Sciences of the United States of America 2012 Kanter JE, Kramer F, Barnhart S, Averill MM, Vivekanandan-Giri A, Vickery T, Li LO, Becker L, Yuan W, Chait A, Braun KR, Potter-Perigo S, Sanda S, Wight TN, Pennathur S, Serhan CN, Heinecke JW, …
• Discovery of T cell antigens by high-throughput screening of synthetic minigene libraries.
  PloS one 2012 Hondowicz BD, Schwedhelm KV, Kas A, Tasch MA, Rawlings C, Ramchurren N, McIntosh M, D'Amico LA, Sanda S, Standifer NE, Shendure J, Stone B
• Altered B cell homeostasis is associated with type I diabetes and carriers of the PTPN22 allelic variant.
  Journal of immunology (Baltimore, Md. : 1950) 2011 Habib T, Funk A, Rieck M, Brahmandam A, Dai X, Panigrahi AK, Luning Prak ET, Meyer-Bahlburg A, Sanda S, Greenbaum C, Rawlings DJ, Buckner JH
• Comment on: Atkinson. It's time to consider changing the rules: the rationale for rethinking control groups in clinical trials aimed at reversing type 1 diabetes. Diabetes 2011;60:361-363.
  Diabetes 2011 Sanda S, Greenbaum CJ
• Short-term IL-1beta blockade reduces monocyte CD11b integrin expression in an IL-8 dependent fashion in patients with type 1 diabetes.
  Clinical immunology (Orlando, Fla.) 2010 Sanda S, Bollyky J, Standifer N, Nepom G, Hamerman JA, Greenbaum C
• A T1D-associated Variant of PTPN2 Correlates with Decreased IL-2/IL-15 Responsiveness, Reduced FOXP3 Expression and Altered CD8 T Cell Differentiation.
  Clinical Immunology 2010 S. Alice Long, Karen Cerosaletti, Heather Shilling, Paul Bollyky, David Rawlings, Srinath Sanda, Jane Buckner
• High-throughput Screening for CD8+ T Cell Epitopes Targeted in Type 1 Diabetes.
  Clinical Immunology 2010 Brian Hondowicz, Katharine Schwedhelm, Arnold Kas, Michael Tasch, Nirasha Ramchurren, Nathan Standifer, Srinath Sanda, Crystal Rawlings, Jay Shendure, Brad Stone
• Reduced CD11b Integrin Expression with Short-term Administration of an IL-1R Antagonist in Type 1 Diabetes Patients.
  Clinical Immunology 2010 Srinath Sanda, Jenna Bollyky, Gerald Nepom, Jessica Hamerman, Carla Greenbaum
• Defects in IL-2R signaling contribute to diminished maintenance of FOXP3 expression in CD4(+)CD25(+) regulatory T-cells of type 1 diabetic subjects.
  Diabetes 2009 Long SA, Cerosaletti K, Bollyky PL, Tatum M, Shilling H, Zhang S, Zhang ZY, Pihoker C, Sanda S, Greenbaum C, Buckner JH
• Diminished IL-2 responsiveness and FOXP3 expression in T1D subjects is revealed by a disease-associated variant of PTPN2 (49.1).
  The Journal of Immunology 2009 Sarah Alice Long, Paul Bollyky, Karen Cerosaletti, Heather Shilling, Catherine Pihoker, Srinath Sanda, Carla Greenbaum, Jane Buckner
• Functional islet-specific Treg can be generated from CD4+CD25- T cells of healthy and type 1 diabetic subjects.
  European journal of immunology 2009 Long SA, Walker MR, Rieck M, James E, Kwok WW, Sanda S, Pihoker C, Greenbaum C, Nepom GT, Buckner JH
• F.69. Selection of Antigen Specific Autoreactive T Cells is Influenced by INS-VNTR Genotype.
  Clinical Immunology 2009 Ivana Durinovic-Bello, Rebecca Wu, Srinath Sanda, Gerald Nepom
• OR.62. Impaired IL-2 Responsiveness and Treg Persistence in T1D is Revealed by Disease-Associated Variants in PTPN2.
  Clinical Immunology 2009 S. Alice Long, Paul Bollyky, Karen Cerosaletti, Heather Shilling, Catherine Pihoker, Srinath Sanda, Carla Greenbaum, Jane Buckner
• T.128. Short-term Administration of Anakinra does not Appear to Affect Stimulated C-peptide Responses Acutely in Patients with Type 1 Diabetes.
  Clinical Immunology 2009 Srinath Sanda, Jennifer Bollyky, Emily Burwell, Nathan Standifer, Gerald Nepom, Carla Greenbaum
• The effector T cells of diabetic subjects are resistant to regulation via CD4+ FOXP3+ regulatory T cells.
  Journal of immunology (Baltimore, Md. : 1950) 2008 Schneider A, Rieck M, Sanda S, Pihoker C, Greenbaum C, Buckner JH
• Type 1 diabetes mellitus: primary, secondary, and tertiary prevention.
  The Mount Sinai journal of medicine, New York 2008 Bollyky J, Sanda S, Greenbaum CJ
• Autosomal dominant hypoparathyroidism with severe hypomagnesemia and hypocalcemia, successfully treated with recombinant PTH and continuous subcutaneous magnesium infusion.
  Journal of pediatric endocrinology & metabolism : JPEM 2008 Sanda S, Schlingmann KP, Newfield RS
• A child with pericardial effusion and cardiac tamponade due to previously unrecognized hypothyroidism.
  Journal of the National Medical Association 2007 Sanda S, Newfield RS
• Type 1 diabetes as a relapsing-remitting disease?
  Nature reviews. Immunology 2007 von Herrath M, Sanda S, Herold K
• Reduced Foxp3 and Interleukin 10 Expression During the Partial Remission Phase of Type 1 Diabetes in Children.
  Clinical Immunology 2007 Srinath Sanda, Bart Roep, Matthias von Herrath