Srilaxmi Nerella, MS
Specialist
Medicine
School of Medicine
I am a Bioinformatics Specialist with 15+ years of experience in genomic data analysis, next-generation sequencing (NGS), and computational biology. My work focuses on developing and applying reproducible bioinformatics workflows for high-throughput sequencing data, including bulk RNA-seq, single-cell RNA-seq, immune profiling, genome annotation, biomarker discovery, and functional genomics analysis.
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I have experience working with large-scale transcriptomic and genomic datasets across pulmonary disease and cancer research. My recent work includes single-cell RNA-seq analysis, Cell Ranger-based processing, sample demultiplexing, quality control, data integration, cell-type annotation, differential expression analysis, pathway/signature analysis, and interpretation of immune cell populations such as T cells, NK cells, myeloid cells, and other disease-relevant cell states.
In addition to bioinformatics, I have experience with Drupal-based web development for scientific website design and research content management. I am also interested in expanding my work in machine learning, statistical modeling, and high-performance computing approaches to support genomics research and translational biomedical discovery.
Education & Training
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- Postgraduate program Artificial Intelligence and Machine Learning: Business Applications The University of Texas at Austin 01/2026
- Master of Science Bioinformatics The University of Texas at El Paso (UTEP), USA 2010
- Master of Science Biotechnology Osmania University College for Women (OUCW), India 2007
- Bachelor of Science Genetics Osmania University College for Women (OUCW), India 2005
Interests
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- R
- High-throughput sequencing
- Data visualization
- Asthma
- Bioinformatics
- Genomics
- Statistical analysis
- Computational biology
- Python
- single-cell RNAseq
- Next-generation sequencing analysis
Websites
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- Srilaxmi Nerella | Single-cell Genomics and Translational Bioinformatics (nsrilaxmi.github.io)
Publications (18)
Top publication keywords:
BronchiContactinsCpG IslandsGenome-Wide Association StudyHigh-Throughput Nucleotide SequencingSequence Analysis, DNAExtracellular MatrixEpigenomicsGenetic Association StudiesHepatic Stellate CellsInterferon Regulatory Factor-3DNA MethylationMyeloid CellsLymphocytesRespiratory Mucosa
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Resolving fibrosis by stimulating HSC-dependent extracellular matrix degradation.
Science translational medicine 2025 Sharma S, Prathigudupu V, Cable C, Serrano LR, Nerella S, Chen A, Hassan G, Lakins J, Valenzuela CL, Tsukui T, Ramamoorthi R, Kim JJ, Willenbring H, Mattis AN, Volk RF, Zaro BW, Coon JJ, Beresis R, … -
Genetic and non-genetic factors affecting the expression of COVID-19-relevant genes in the large airway epithelium.
Genome medicine 2021 Kasela S, Ortega VE, Martorella M, Garudadri S, Nguyen J, Ampleford E, Pasanen A, Nerella S, Buschur KL, Barjaktarevic IZ, Barr RG, Bleecker ER, Bowler RP, Comellas AP, Cooper CB, Couper DJ, Criner GJ… -
Single-Cell Mapping of Progressive Fetal-to-Adult Transition in Human Naive T Cells.
Cell reports 2021 Bunis DG, Bronevetsky Y, Krow-Lucal E, Bhakta NR, Kim CC, Nerella S, Jones N, Mendoza VF, Bryson YJ, Gern JE, Rutishauser RL, Ye CJ, Sirota M, McCune JM, Burt TD -
IFN-stimulated Gene Expression, Type 2 Inflammation, and Endoplasmic Reticulum Stress in Asthma.
American journal of respiratory and critical care medicine 2018 Bhakta NR, Christenson SA, Nerella S, Solberg OD, Nguyen CP, Choy DF, Jung KL, Garudadri S, Bonser LR, Pollack JL, Zlock LT, Erle DJ, Langelier C, Derisi JL, Arron JR, Fahy JV, Woodruff PG -
HuR Regulates GATA3-Driven Type 2 Inflammation in CD4? T cells and ILC2 in Airway Inflammation.
bioRxiv : the preprint server for biology 2026 Atasoy U, Fattahi F, Yaekle L, Holden J, Tepper B, Hussein K, Meier J, Xu L, Nerella S, Lei J, Bentley K, Hershenson M, Huang SK
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Deep Sequencing of 71 Candidate Genes to Characterize Variation Associated with Alcohol Dependence.
Alcoholism, clinical and experimental research 2017 Clark SL, McClay JL, Adkins DE, Kumar G, Aberg KA, Nerella S, Xie L, Collins AL, Crowley JJ, Quackenbush CR, Hilliard CE, Shabalin AA, Vrieze SI, Peterson RE, Copeland WE, Silberg JL, McGue M, Maes H,… -
High density methylation QTL analysis in human blood via next-generation sequencing of the methylated genomic DNA fraction.
Genome biology 2015 McClay JL, Shabalin AA, Dozmorov MG, Adkins DE, Kumar G, Nerella S, Clark SL, Bergen SE, Swedish Schizophrenia Consortium, Hultman CM, Magnusson PK, Sullivan PF, Aberg KA, van den Oord EJ -
Deep Sequencing of Three Loci Implicated in Large-Scale Genome-Wide Association Study Smoking Meta-Analyses.
Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco 2015 Clark SL, McClay JL, Adkins DE, Aberg KA, Kumar G, Nerella S, Xie L, Collins AL, Crowley JJ, Quakenbush CR, Hillard CE, Gao G, Shabalin AA, Peterson RE, Copeland WE, Silberg JL, Maes H, Sullivan PF, … -
Combined Whole Methylome and Genomewide Association Study Implicates CNTN4 in Alcohol Use.
Alcoholism, clinical and experimental research 2015 Clark SL, Aberg KA, Nerella S, Kumar G, McClay JL, Chen W, Xie LY, Harada A, Shabalin AA, Gao G, Bergen SE, Hultman CM, Magnusson PK, Sullivan PF, van den Oord EJ -
Refinement of schizophrenia GWAS loci using methylome-wide association data.
Human genetics 2014 Kumar G, Clark SL, McClay JL, Shabalin AA, Adkins DE, Xie L, Chan R, Nerella S, Kim Y, Sullivan PF, Hultman CM, Magnusson PK, Aberg KA, van den Oord EJ -
Methylome-wide association study of schizophrenia: identifying blood biomarker signatures of environmental insults.
JAMA psychiatry 2014 Aberg KA, McClay JL, Nerella S, Clark S, Kumar G, Chen W, Khachane AN, Xie L, Hudson A, Gao G, Harada A, Hultman CM, Sullivan PF, Magnusson PK, van den Oord EJ -
A methylome-wide study of aging using massively parallel sequencing of the methyl-CpG-enriched genomic fraction from blood in over 700 subjects.
Human molecular genetics 2013 McClay JL, Aberg KA, Clark SL, Nerella S, Kumar G, Xie LY, Hudson AD, Harada A, Hultman CM, Magnusson PK, Sullivan PF, Van Den Oord EJ -
Testing two models describing how methylome-wide studies in blood are informative for psychiatric conditions.
Epigenomics 2013 Aberg KA, Xie LY, McClay JL, Nerella S, Vunck S, Snider S, Beardsley PM, van den Oord EJ -
High quality methylome-wide investigations through next-generation sequencing of DNA from a single archived dry blood spot.
Epigenetics 2013 Aberg KA, Xie LY, Nerella S, Copeland WE, Costello EJ, van den Oord EJ -
MethylPCA: a toolkit to control for confounders in methylome-wide association studies.
BMC bioinformatics 2013 Chen W, Gao G, Nerella S, Hultman CM, Magnusson PK, Sullivan PF, Aberg KA, van den Oord EJ -
Estimation of CpG coverage in whole methylome next-generation sequencing studies.
BMC bioinformatics 2013 van den Oord EJ, Bukszar J, Rudolf G, Nerella S, McClay JL, Xie LY, Aberg KA -
MBD-seq as a cost-effective approach for methylome-wide association studies: demonstration in 1500 case--control samples.
Epigenomics 2012 Aberg KA, McClay JL, Nerella S, Xie LY, Clark SL, Hudson AD, Bukszár J, Adkins D, Swedish Schizophrenia Consortium, Hultman CM, Sullivan PF, Magnusson PK, van den Oord EJ -
Methylome-wide comparison of human genomic DNA extracted from whole blood and from EBV-transformed lymphocyte cell lines.
European journal of human genetics : EJHG 2012 Åberg K, Khachane AN, Rudolf G, Nerella S, Fugman DA, Tischfield JA, van den Oord EJ