Spencer Yost, MD
Professor
Anesthesia
School of Medicine

Education & Training

Show all (2) Hide

• Diversity, Equity, and Inclusion Champion Training University of California 2018
• M.D. Medicine University of California, San Francisco 1983

Websites

Show all (1) Hide

• Clinical Profile at UCSF Medical Center (ucsfhealth.org)

Publications (46)

Top publication keywords:
Neuromuscular Nondepolarizing AgentsNicotinic AntagonistsPulmonary AlveoliHalothaneXenopus laevisPotassium Channels, Tandem Pore DomainMembrane PotentialsReceptors, NicotinicShaker Superfamily of Potassium ChannelsPotassium ChannelsRespiratory System AgentsVecuronium BromideOocytesDoxapramAnesthetics, Inhalation

• Successful implementation of an Enhanced Recovery After Surgery program shortens length of stay and improves postoperative pain, and bowel and bladder function after colorectal surgery.
  BMC anesthesiology 2016 Sarin A, Litonius ES, Naidu R, Yost CS, Varma MG, Chen LL
• Anaphylaxis complicating graft reperfusion during orthotopic liver transplantation: a case report.
  Transplantation proceedings 2010 Anderson A, Eilers H, Yost CS
• Regional expression of the anesthetic-activated potassium channel TRESK in the rat nervous system.
  Neuroscience letters 2009 Yoo S, Liu J, Sabbadini M, Au P, Xie GX, Yost CS
• Molecular biology of background K channels: insights from K(2P) knockout mice.
  Journal of molecular biology 2008 Sabbadini M, Yost CS
• Knockout of the gene encoding the K(2P) channel KCNK7 does not alter volatile anesthetic sensitivity.
  Behavioural brain research 2008 Yost CS, Oh I, Eger EI, Sonner JM

Show all (41 more) Hide

• A new look at the respiratory stimulant doxapram.
  CNS drug reviews 2006 Yost CS
• The ventilatory stimulant doxapram inhibits TASK tandem pore (K2P) potassium channel function but does not affect minimum alveolar anesthetic concentration.
  Anesthesia and analgesia 2006 Cotten JF, Keshavaprasad B, Laster MJ, Eger EI, Yost CS
• Species-specific differences in response to anesthetics and other modulators by the K2P channel TRESK.
  Anesthesia and analgesia 2005 Keshavaprasad B, Liu C, Au JD, Kindler CH, Cotten JF, Yost CS
• Antiemetics of the 5-hydroxytryptamine 3A antagonist class inhibit muscle nicotinic acetylcholine receptors.
  Anesthesia and analgesia 2005 Paul M, Callahan R, Au J, Kindler CH, Yost CS
• Protective effects of TASK-3 (KCNK9) and related 2P K channels during cellular stress.
  Brain research 2005 Liu C, Cotten JF, Schuyler JA, Fahlman CS, Au JD, Bickler PE, Yost CS
• Potent activation of the human tandem pore domain K channel TRESK with clinical concentrations of volatile anesthetics.
  Anesthesia and analgesia 2004 Liu C, Au JD, Zou HL, Cotten JF, Yost CS
• Identification of native rat cerebellar granule cell currents due to background K channel KCNK5 (TASK-2).
  Brain research. Molecular brain research 2004 Cotten JF, Zou HL, Liu C, Au JD, Yost CS
• Immunolocalization of TASK-3 (KCNK9) to a subset of cortical neurons in the rat CNS.
  Biochemical and biophysical research communications 2004 Callahan R, Labunskiy DA, Logvinova A, Abdallah M, Liu C, Cotten JF, Yost CS
• Functional inhibition by methadone of N-methyl-D-aspartate receptors expressed in Xenopus oocytes: stereospecific and subunit effects.
  Anesthesia and analgesia 2004 Callahan RJ, Au JD, Paul M, Liu C, Yost CS
• Genomic structure, cochlear expression, and mutation screening of KCNK6, a candidate gene for DFNA4.
  Journal of neuroscience research 2004 Mhatre AN, Li J, Chen AF, Yost CS, Smith RJ, Kindler CH, Lalwani AK
• Update on tandem pore (2P) domain K+ channels.
  Current drug targets 2003 Yost CS
• Intraoperative hemodynamics and liver function in adult-to-adult living liver donors.
  Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society 2002 Niemann CU, Roberts JP, Ascher NL, Yost CS
• Characterization of the interactions between volatile anesthetics and neuromuscular blockers at the muscle nicotinic acetylcholine receptor.
  Anesthesia and analgesia 2002 Paul M, Fokt RM, Kindler CH, Dipp NC, Yost CS
• Evaluation of the splanchnic circulation with indocyanine green pharmacokinetics in liver transplant patients.
  Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society 2002 Niemann CU, Yost CS, Mandell S, Henthorn TK
• Isobolographic analysis of non-depolarising muscle relaxant interactions at their receptor site.
  European journal of pharmacology 2002 Paul M, Kindler CH, Fokt RM, Dipp NC, Yost CS
• The potency of new muscle relaxants on recombinant muscle-type acetylcholine receptors.
  Anesthesia and analgesia 2002 Paul M, Kindler CH, Fokt RM, Dresser MJ, Dipp NC, Yost CS
• Etiology of acute pulmonary edema during liver transplantation : a series of cases with analysis of the edema fluid.
  Chest 2001 Yost CS, Matthay MA, Gropper MA
• Tandem pore domain K channels: an important site of volatile anesthetic action?
  Current drug targets 2000 Yost CS
• Volatile anesthetics activate the human tandem pore domain baseline K+ channel KCNK5.
  Anesthesiology 2000 Gray AT, Zhao BB, Kindler CH, Winegar BD, Mazurek MJ, Xu J, Chavez RA, Forsayeth JR, Yost CS
• Additive inhibition of nicotinic acetylcholine receptors by corticosteroids and the neuromuscular blocking drug vecuronium.
  Anesthesiology 2000 Kindler CH, Verotta D, Gray AT, Gropper MA, Yost CS
• Local anesthetic inhibition of baseline potassium channels with two pore domains in tandem.
  Anesthesiology 1999 Kindler CH, Yost CS, Gray AT
• Potassium channels: basic aspects, functional roles, and medical significance.
  Anesthesiology 1999 Yost CS
• Assignment of KCNK6 encoding the human weak inward rectifier potassium channel TWIK-2 to chromosome band 19q13.1 by radiation hybrid mapping.
  Cytogenetics and cell genetics 1999 Gray AT, Kindler CH, Sampson ER, Yost CS
• Activation of single potassium channels in rat cerebellar granule cells by volatile anesthetics.
  Toxicology letters 1998 Winegar BD, Yost CS
• Baseline K+ channels as targets of general anesthetics: studies of the action of volatile anesthetics on TOK1.
  Toxicology letters 1998 Yost CS, Gray AT, Winegar BD, Leonoudakis D
• Volatile anesthetics directly activate baseline S K+ channels in aplysia neurons.
  Brain research 1998 Winegar BD, Yost CS
• Oleamide potentiates benzodiazepine-sensitive gamma-aminobutyric acid receptor activity but does not alter minimum alveolar anesthetic concentration.
  Anesthesia and analgesia 1998 Yost CS, Hampson AJ, Leonoudakis D, Koblin DD, Bornheim LM, Gray AT
• TOK1 is a volatile anesthetic stimulated K+ channel.
  Anesthesiology 1998 Gray AT, Winegar BD, Leonoudakis DJ, Forsayeth JR, Yost CS
• An open rectifier potassium channel with two pore domains in tandem cloned from rat cerebellum.
  The Journal of neuroscience : the official journal of the Society for Neuroscience 1998 Leonoudakis D, Gray AT, Winegar BD, Kindler CH, Harada M, Taylor DM, Chavez RA, Forsayeth JR, Yost CS
• Dual effects of anandamide on NMDA receptor-mediated responses and neurotransmission.
  Journal of neurochemistry 1998 Hampson AJ, Bornheim LM, Scanziani M, Yost CS, Gray AT, Hansen BM, Leonoudakis DJ, Bickler PE
• An active-site histidine of NR1/2C mediates voltage-independent inhibition by zinc.
  Brain research. Molecular brain research 1997 Gray AT, Leonoudakis DJ, Yost CS
• A recombinant adenovirus that directs secretion of biologically active kappa-bungarotoxin from mammalian cells.
  Brain research. Molecular brain research 1997 Gorman S, Viseshakul N, Cohen B, Hardy S, Grant GA, Yost CS, Forsayeth JR
• Potency of agonists and competitive antagonists on adult- and fetal-type nicotinic acetylcholine receptors.
  Cellular and molecular neurobiology 1997 Yost CS, Winegar BD
• Volatile general anesthetics produce hyperpolarization of Aplysia neurons by activation of a discrete population of baseline potassium channels.
  Anesthesiology 1996 Winegar BD, Owen DF, Yost CS, Forsayeth JR, Mayeri E
• Determinants of carboxyl-terminal domain translocation during prion protein biogenesis.
  The Journal of biological chemistry 1994 De Fea KA, Nakahara DH, Calayag MC, Yost CS, Mirels LF, Prusiner SB, Lingappa VR
• Clinical concentrations of edrophonium enhance desensitization of the nicotinic acetylcholine receptor.
  Anesthesia and analgesia 1994 Yost CS, Maestrone E
• G proteins: basic characteristics and clinical potential for the practice of anesthesia.
  Anesthesia and analgesia 1993 Yost CS
• Inhibition of the nicotinic acetylcholine receptor by barbiturates and by procaine: do they act at different sites?
  Cellular and molecular neurobiology 1993 Yost CS, Dodson BA
• Pneumothorax complicating the use of a Univent endotracheal tube.
  Anesthesia and analgesia 1993 Schwartz DE, Yost CS, Larson MD
• Unusual topogenic sequence directs prion protein biogenesis.
  Science (New York, N.Y.) 1990 Lopez CD, Yost CS, Prusiner SB, Myers RM, Lingappa VR
• Non-hydrophobic extracytoplasmic determinant of stop transfer in the prion protein.
  Nature 1990 Yost CS, Lopez CD, Prusiner SB, Myers RM, Lingappa VR