Sophie Dumont, PhD
Professor
Bioengineering
School of Pharmacy
Awards
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- UCSF Byers Award in Basic Science, 2021
- Chan Zuckerberg Biohub Investigator, 2020
- UCSF Outstanding Faculty Mentorship Award, 2018
- Women in Cell Biology Junior Award for Excellence in Research (ASCB), 2018
- Margaret Oakley Dayhoff Award of the Biophysical Society, 2016
- NSF CAREER Award, 2016
- NIH New Innovator Award, 2015
- Kimmel Cancer Foundation Scholar, 2013
- Rita Allen Foundation and Milton E. Cassel Scholar, 2013
- Searle Scholar, 2013
- Sloan Research Fellow, 2013
- NIH K99/R00 Award, 2010
- Alan Bearden Outstanding Graduate Research Award, UC Berkeley, 2006
- Junior Fellow, Harvard Society of Fellows, 2006
- Weintraub Graduate Student Award, 2006
- Allen G. Shenstone Prize in Physics, Princeton University, 1999
- Rhodes Scholarship, 1999
Websites
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- @@DumontLab on Twitter (twitter.com)
- Dumont Lab Website (dumontlab.ucsf.edu)
Grants and Projects
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- Emergent mechanics of mammalian chromosome segregation, NIH, 2020-2025
- , CZ Biohub Investigator, 2020-2025
- , UCSF Program in Breakthrough Biomedical Research, 2021-2023
- Center for Cellular Construction, NSF, 2016-2022
- Mechanics of the dynamic mammalian kinetochore-microtubule interface, NIH, 2019-2021
- CAREER: Slip-Clutch of Biological Machines: The Kinetochore-Microtubule Interface, NSF, 2016-2021
- , Rita Allen Foundation Scholars Program, 2013-2020
- Rewiring cellular architecture to probe mechanical signal processing at kinetochores, NIH, 2015-2020
- , Sloan Research Fellowships, 2013-2017
- , Searle Scholars Program, 2013-2017
- Spindle forces for chromosome movement, NIH, 2010-2016
- , Sidney Kimmel Foundation for Cancer Research, 2013-2016
- , UCSF Program for Breakthrough Biomedical Research, 2012-2014
- Dynamics in the tissue state: from normal to tumor and back, NIH/NCI, 2012-2014
- Force generation and detection in the spindle: the case of the kinetochore, NIH, 2010-2012
Publications (54)
Top publication keywords:
Spindle ApparatusMicrotubulesChromosome SegregationMetaphaseKinetochoresCell Cycle ProteinsChromosomesMammalsPotoroidaeMechanotransduction, CellularCyclin D1CentrosomeDyneinsMitosisCell Division
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The oncogene cyclin D1 promotes bipolar spindle integrity under compressive force.
PloS one 2024 Sutanto R, Neahring L, Serra Marques A, Jacobo Jacobo M, Kilinc S, Goga A, Dumont S -
NuMA mechanically reinforces mammalian spindle poles independent of its partner dynein.
Biophysical Journal 2024 Nathan Cho, Sophie Dumont -
Torques within and outside the human spindle balance twist at anaphase.
bioRxiv : the preprint server for biology 2023 Neahring L, He Y, Cho NH, Liu G, Fernandes J, Rux CJ, Nakos K, Subramanian R, Upadhyayula S, Yildiz A, Dumont S -
Chromosome size-dependent polar ejection force impairs mammalian mitotic error correction.
bioRxiv : the preprint server for biology 2023 Chong MK, Rosas-Salvans M, Tran V, Dumont S -
Cytoplasmic division cycles without the nucleus and mitotic CDK/cyclin complexes.
Cell 2023 Bakshi A, Iturra FE, Alamban A, Rosas-Salvans M, Dumont S, Aydogan MG
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Kinetochore-fiber lengths are maintained locally but coordinated globally by poles in the mammalian spindle.
eLife 2023 Richter M, Neahring L, Tao J, Sutanto R, Cho NH, Dumont S -
The oncogene cyclin D1 promotes bipolar spindle integrity under compressive force.
bioRxiv : the preprint server for biology 2023 Sutanto R, Neahring L, Marques AS, Kilinc S, Goga A, Dumont S -
Mechanisms underlying spindle assembly and robustness.
Nature reviews. Molecular cell biology 2023 Valdez VA, Neahring L, Petry S, Dumont S -
Modeling and mechanical perturbations reveal how spatially regulated anchorage gives rise to spatially distinct mechanics across the mammalian spindle.
eLife 2022 Suresh P, Galstyan V, Phillips R, Dumont S -
ECM dimensionality tunes actin tension to modulate endoplasmic reticulum function and spheroid phenotypes of mammary epithelial cells.
The EMBO journal 2022 Kai F, Ou G, Tourdot RW, Stashko C, Gaietta G, Swift MF, Volkmann N, Long AF, Han Y, Huang HH, Northey JJ, Leidal AM, Viasnoff V, Bryant DM, Guo W, Wiita AP, Guo M, Dumont S, Hanein D, Radhakrishnan R… -
The Astrin-SKAP complex reduces friction at the kinetochore-microtubule interface.
Current biology : CB 2022 Rosas-Salvans M, Sutanto R, Suresh P, Dumont S -
Connections distributed within 3 µm of chromosomes are necessary and sufficient for the kinetochore-fiber’s robust anchorage in the mammalian spindle.
Biophysical Journal 2022 Pooja Suresh, Vahe Galstyan, Rob Phillips, Sophie Dumont -
The Astrin-SKAP complex lubricates the kinetochore-microtubule interface.
Biophysical Journal 2022 Miquel R. Salvans, Renaldo Sutanto, Sophie Dumont -
Opposing motors provide mechanical and functional robustness in the human spindle.
Developmental cell 2021 Neahring L, Cho NH, Dumont S -
Opposing Motors Provide Mechanical and Functional Robustness in the Mammalian Spindle.
Biophysical Journal 2021 Lila Neahring, Sophie Dumont -
Understanding the Mechanisms that Give Rise to the Mammalian Spindle's Response to Force using Theory and Microneedle Manipulation.
Biophysical Journal 2021 Vahe Galstyan, Pooja Suresh, Sophie Dumont, Rob Phillips -
The mitotic protein NuMA plays a spindle-independent role in nuclear formation and mechanics.
The Journal of cell biology 2020 Serra-Marques A, Houtekamer R, Hintzen D, Canty JT, Yildiz A, Dumont S -
Individual kinetochore-fibers locally dissipate force to maintain robust mammalian spindle structure.
The Journal of cell biology 2020 Long AF, Suresh P, Dumont S -
Microneedle manipulation of the mammalian spindle reveals specialized, short-lived reinforcement near chromosomes.
eLife 2020 Suresh P, Long AF, Dumont S -
MYC Dysregulates Mitosis, Revealing Cancer Vulnerabilities.
Cell reports 2020 Rohrberg J, Van de Mark D, Amouzgar M, Lee JV, Taileb M, Corella A, Kilinc S, Williams J, Jokisch ML, Camarda R, Balakrishnan S, Shankar R, Zhou A, Chang AN, Chen B, Rugo HS, Dumont S, Goga A -
Mammalian kinetochores count attached microtubules in a sensitive and switch-like manner.
The Journal of cell biology 2019 Kuhn J, Dumont S -
Abstract 1028: Extracellular matrix dimensionality reduces cellular cortical tension to stimulate pro-survival signaling in mammary epithelial cells.
Cancer Research 2019 FuiBoon Kai, Guanqing Ou, Alexandra Long, Wei Guo, Richard Tourdot, Ravi Radhakrishnan, Christopher Chen, Sophie Dumont, Valerie M. Weaver -
Abstract 2902: Non-genetic TPX2/AURKA signaling facilitates tumor evolution in EGFR-TKI resistance in NSCLC.
Tumor Biology 2019 Khyati N. Shah, Roma Bhatt, Julia Rotow, Julia Rohrberg, Victor Olivas, Victoria E. Wang, Jonathan Kuhn, Sophie Dumont, Frank Mccormick, Andrei Goga, Collin M. Blakely, Trever G. Bivona, Sourav … -
The mammalian kinetochore-microtubule interface: robust mechanics and computation with many microtubules.
Current opinion in cell biology 2019 Long AF, Kuhn J, Dumont S -
Microtubule End-Clustering Maintains a Steady-State Spindle Shape.
Current biology : CB 2019 Hueschen CL, Galstyan V, Amouzgar M, Phillips R, Dumont S -
Chromosome Segregation Fidelity Integrates Information across Scales.
Developmental cell 2018 Neahring L, Dumont S -
Aurora kinase A drives the evolution of resistance to third-generation EGFR inhibitors in lung cancer.
Nature medicine 2018 Shah KN, Bhatt R, Rotow J, Rohrberg J, Olivas V, Wang VE, Hemmati G, Martins MM, Maynard A, Kuhn J, Galeas J, Donnella HJ, Kaushik S, Ku A, Dumont S, Krings G, Haringsma HJ, Robillard L, Simmons AD, … -
The Spindle: Integrating Architecture and Mechanics across Scales.
Trends in cell biology 2018 Elting MW, Suresh P, Dumont S -
Shining light on spindle positioning.
eLife 2018 Serra-Marques A, Dumont S -
NuMA recruits dynein activity to microtubule minus-ends at mitosis.
eLife 2017 Hueschen CL, Kenny SJ, Xu K, Dumont S -
Mapping Load-Bearing in the Mammalian Spindle Reveals Local Kinetochore Fiber Anchorage that Provides Mechanical Isolation and Redundancy.
Current biology : CB 2017 Elting MW, Prakash M, Udy DB, Dumont S -
Hec1 Tail Phosphorylation Differentially Regulates Mammalian Kinetochore Coupling to Polymerizing and Depolymerizing Microtubules.
Current biology : CB 2017 Long AF, Udy DB, Dumont S -
Spindle assembly checkpoint satisfaction occurs via end-on but not lateral attachments under tension.
The Journal of cell biology 2017 Kuhn J, Dumont S -
The chromokinesin Klp3a and microtubules facilitate acentric chromosome segregation.
The Journal of cell biology 2017 Karg T, Elting MW, Vicars H, Dumont S, Sullivan W -
Increased lateral microtubule contact at the cell cortex is sufficient to drive mammalian spindle elongation.
Molecular biology of the cell 2017 Guild J, Ginzberg MB, Hueschen CL, Mitchison TJ, Dumont S -
Embryonic Stem Cells Cultured in Microfluidic Chambers Take Control of Their Fate by Producing Endogenous Signals Including LIF.
Stem cells (Dayton, Ohio) 2016 Guild J, Haque A, Gheibi P, Gao Y, Son KJ, Foster E, Dumont S, Revzin A -
Kinesin-5: A Team Is Just the Sum of Its Parts.
Developmental cell 2015 Hueschen CL, Long AF, Dumont S -
Draft De Novo Transcriptome of the Rat Kangaroo Potorous tridactylus as a Tool for Cell Biology.
PloS one 2015 Udy DB, Voorhies M, Chan PP, Lowe TM, Dumont S -
Emergent mechanics of biological structures.
Molecular biology of the cell 2014 Dumont S, Prakash M -
Force on spindle microtubule minus ends moves chromosomes.
The Journal of cell biology 2014 Elting MW, Hueschen CL, Udy DB, Dumont S -
Spindle size: small droplets and a big step forward.
Current biology : CB 2014 Dumont S -
Imaging and physically probing kinetochores in live dividing cells.
Methods in cell biology 2014 Kuhn J, Dumont S -
Deformations within moving kinetochores reveal different sites of active and passive force generation.
Science (New York, N.Y.) 2012 Dumont S, Salmon ED, Mitchison TJ -
4.16 Mechanical Forces in Mitosis.
Comprehensive Biophysics 2012 S. Dumont, T.J. Mitchison -
Comprehensive Biophysics
Mechanical Forces in Mitosis 2012 Dumont S, Mitchison TJ -
Chromosome segregation: spindle mechanics come to life.
Current biology : CB 2011 Dumont S -
Force and length in the mitotic spindle.
Current biology : CB 2009 Dumont S, Mitchison TJ -
Compression regulates mitotic spindle length by a mechanochemical switch at the poles.
Current biology : CB 2009 Dumont S, Mitchison TJ -
How does a millimeter-sized cell find its center?
Cell cycle (Georgetown, Tex.) 2009 Wühr M, Dumont S, Groen AC, Needleman DJ, Mitchison TJ -
Evidence for an upper limit to mitotic spindle length.
Current biology : CB 2008 Wühr M, Chen Y, Dumont S, Groen AC, Needleman DJ, Salic A, Mitchison TJ -
NS3 helicase actively separates RNA strands and senses sequence barriers ahead of the opening fork.
Proceedings of the National Academy of Sciences of the United States of America 2007 Cheng W, Dumont S, Tinoco I, Bustamante C -
RNA translocation and unwinding mechanism of HCV NS3 helicase and its coordination by ATP.
Nature 2006 Dumont S, Cheng W, Serebrov V, Beran RK, Tinoco I, Pyle AM, Bustamante C -
Identifying kinetic barriers to mechanical unfolding of the T. thermophila ribozyme.
Science (New York, N.Y.) 2003 Onoa B, Dumont S, Liphardt J, Smith SB, Tinoco I, Bustamante C -
Equilibrium information from nonequilibrium measurements in an experimental test of Jarzynski's equality.
Science (New York, N.Y.) 2002 Liphardt J, Dumont S, Smith SB, Tinoco I, Bustamante C