Sophia Levan, MD, PhD
Clinical Fellow
Medicine
School of Medicine

Awards

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• Clinical Fellowship Award - Research, Cystic Fibrosis Foundation, 2024-2026
• Diversity in Basic Science Award, UCSF, 2022-2028
• Commendation for Exceptional Volunteerism and University Service, UCSF, 2020
• Chancellor's Award for Diversity, UCSF, 2018

Education & Training

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• Residency Internal Medicine UCSF 7/2022
• MD/PhD Medicine, Biomedical Sciences UCSF 05/2020
• BA Chemistry, Molecular Biology Wesleyan University 05/2012
• Fellowship Pulmonary and Critical Care Medicine UCSF

Interests

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• Metabolism
• Host-Microbe
• Microbiome

Publications (14)

Top publication keywords:
PerforinPolysaccharidesGastrointestinal MicrobiomeClioquinolLongevityEpoxide HydrolasesLinoleic AcidsClinical Laboratory ServicesBacteriaNAD(P)H Dehydrogenase (Quinone)Caloric RestrictionFecesVibrio choleraeOligosaccharidesAsthma

• Elevated faecal 12,13-diHOME concentration in neonates at high risk for asthma is produced by gut bacteria and impedes immune tolerance.
  Nature microbiology 2019 Levan SR, Stamnes KA, Lin DL, Panzer AR, Fukui E, McCauley K, Fujimura KE, McKean M, Ownby DR, Zoratti EM, Boushey HA, Cabana MD, Johnson CC, Lynch SV
• 12,13-diHOME Promotes Inflammatory Macrophages and Epigenetically Modifies Their Capacity to Respond to Microbes and Allergens.
  Journal of immunology research 2024 Lin DL, Magnaye KM, Porsche CE, Levan SR, Rackaityte E, Özçam M, Lynch SV
• Broad susceptibility of Candida auris strains to 8-hydroxyquinolines and mechanisms of resistance.
  mBio 2023 Lohse MB, Laurie MT, Levan S, Ziv N, Ennis CL, Nobile CJ, DeRisi J, Johnson AD
• Broad sensitivity of Candida auris strains to quinolones and mechanisms of resistance.
  bioRxiv : the preprint server for biology 2023 Lohse MB, Laurie MT, Levan S, Ziv N, Ennis CL, Nobile CJ, DeRisi J, Johnson AD
• Impact of a Multidisciplinary Post-COVID-19 Clinic on Hospital Admissions and ED Visits.
  Chest 2023 Levan S, Mourad M, Block B, Shah R, Santhosh L

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• Impaired immune signaling and changes in the lung microbiome precede secondary bacterial pneumonia in COVID-19.
  medRxiv : the preprint server for health sciences 2021 Tsitsiklis A, Zha BS, Byrne A, DeVoe C, Rackaityte E, Levan S, Sunshine S, Mick E, Ghale R, Love C, Tarashansky AJ, Pisco A, Albright J, Jauregui A, Sarma A, Neff N, Serpa PH, Deiss TJ, Kistler A, …
• Impaired immune signaling and changes in the lung microbiome precede secondary bacterial pneumonia in COVID-19.
  Research square 2021 Tsitsiklis A, Zha BS, Byrne A, Devoe C, Levan S, Rackaityte E, Sunshine S, Mick E, Ghale R, Jauregui A, Sarma A, Neff N, Serpa PH, Deiss TJ, Kistler A, Carrillo S, Ansel KM, Leligdowicz A, Christenson…
• NQO1 protects obese mice through improvements in glucose and lipid metabolism.
  NPJ aging and mechanisms of disease 2020 Di Francesco A, Choi Y, Bernier M, Zhang Y, Diaz-Ruiz A, Aon MA, Kalafut K, Ehrlich MR, Murt K, Ali A, Pearson KJ, Levan S, Preston JD, Martin-Montalvo A, Martindale JL, Abdelmohsen K, Michel CR, …
• Rapid deployment of SARS-CoV-2 testing: The CLIAHUB.
  PLoS pathogens 2020 Crawford ED, Acosta I, Ahyong V, Anderson EC, Arevalo S, Asarnow D, Axelrod S, Ayscue P, Azimi CS, Azumaya CM, Bachl S, Bachmutsky I, Bhaduri A, Brown JB, Batson J, Behnert A, Boileau RM, Bollam SR, …
• Deletion of Nrf2 shortens lifespan in C57BL6/J male mice but does not alter the health and survival benefits of caloric restriction.
  Free radical biology & medicine 2020 Pomatto LCD, Dill T, Carboneau B, Levan S, Kato J, Mercken EM, Pearson KJ, Bernier M, de Cabo R
• Benefits of Caloric Restriction in Longevity and Chemical-Induced Tumorigenesis Are Transmitted Independent of NQO1.
  The journals of gerontology. Series A, Biological sciences and medical sciences 2019 Diaz-Ruiz A, Di Francesco A, Carboneau BA, Levan SR, Pearson KJ, Price NL, Ward TM, Bernier M, de Cabo R, Mercken EM
• Neonatal gut microbiota associates with childhood multisensitized atopy and T cell differentiation.
  Nature medicine 2016 Fujimura KE, Sitarik AR, Havstad S, Lin DL, Levan S, Fadrosh D, Panzer AR, LaMere B, Rackaityte E, Lukacs NW, Wegienka G, Boushey HA, Ownby DR, Zoratti EM, Levin AM, Johnson CC, Lynch SV
• Disease Severity and Immune Activity Relate to Distinct Interkingdom Gut Microbiome States in Ethnically Distinct Ulcerative Colitis Patients.
  mBio 2016 Mar JS, LaMere BJ, Lin DL, Levan S, Nazareth M, Mahadevan U, Lynch SV
• Vibrio cholerae cytolysin recognizes the heptasaccharide core of complex N-glycans with nanomolar affinity.
  Journal of molecular biology 2012 Levan S, De S, Olson R