Sook Wah Yee, PhD
Associate Professor
Bioengineering
School of Pharmacy

I am actively involved in Pharmacogenomics Research Network (PGRN)-Hub (www.pgrn.org) to enhance scientific exchange and to expand the boundaries of understanding drug response within the context of precision medicine, both within the PGRN and between the PGRN and the scientific community at large. I work together with the team to create a robust PGRN website with multiple features and facilitating opportunities to access large resources that will enable collaborative research.

• TICBase: Integrated Resource for Data on Drug and Environmental Chemical Interactions with Mammalian Drug Transporters.
  Clinical pharmacology and therapeutics 2023 Michel ME, Wen CC, Yee SW, Giacomini KM, Hamdoun A, Nicklisch SCT
• Illuminating the Function of the Orphan Transporter, SLC22A10 in Humans and Other Primates.
  bioRxiv : the preprint server for biology 2023 Yee SW, Ferrández-Peral L, Alentorn P, Fontsere C, Ceylan M, Koleske ML, Handin N, Artegoitia VM, Lara G, Chien HC, Zhou X, Dainat J, Zalevsky A, Sali A, Brand CM, Capra JA, Artursson P, Newman JW, …
• Identification of Genetic Variation Influencing Metformin Response in a Multiancestry Genome-Wide Association Study in the Diabetes Prevention Program (DPP).
  Diabetes 2023 Li JH, Perry JA, Jablonski KA, Srinivasan S, Chen L, Todd JN, Harden M, Mercader JM, Pan Q, Dawed AY, Yee SW, Pearson ER, Giacomini KM, Giri A, Hung AM, Xiao S, Williams LK, Franks PW, Hanson RL, Kahn…
• The Impacts of Slc19a3 Deletion and Intestinal SLC19A3 Insertion on Thiamine Distribution and Brain Metabolism in the Mouse.
  Metabolites 2023 Wen A, Zhu Y, Yee SW, Park BI, Giacomini KM, Greenberg AS, Newman JW
• Cardiac contraction and relaxation are regulated by distinct subcellular cAMP pools.
  Nature chemical biology 2023 Lin TY, Mai QN, Zhang H, Wilson E, Chien HC, Yee SW, Giacomini KM, Olgin JE, Irannejad R
• OR18-06-23 The Impacts of slc19a3 Deletion and Intestinal SLC19A3 Insertion on Thiamine Distribution and Brain Metabolism in the Mouse.
  Current Developments in Nutrition 2023 Anita Wen, Andrew Greenberg, Kathleen Giacomini, John Newman, Brian Park, Sook Wah Yee, Ying Zhu
• The full spectrum of OCT1 (SLC22A1) mutations bridges transporter biophysics to drug pharmacogenomics.
  bioRxiv : the preprint server for biology 2023 Yee SW, Macdonald C, Mitrovic D, Zhou X, Koleske ML, Yang J, Silva DB, Grimes PR, Trinidad D, More SS, Kachuri L, Witte JS, Delemotte L, Giacomini KM, Coyote-Maestas W
• The Effect of Trimethoprim on Thiamine Absorption: A Transporter-Mediated Drug-Nutrient Interaction.
  Clinical pharmacology and therapeutics 2023 Vora B, Wen A, Yee SW, Trinh K, Azimi M, Green EAE, Sirota M, Greenberg AS, Newman JW, Giacomini KM
• Initial Insights into the Genetic Variation Associated with Metformin Treatment Failure in Youth with Type 2 Diabetes.
  Pediatric diabetes 2023 Srinivasan S, Chen L, Udler M, Todd J, Kelsey MM, Haymond MW, Arslanian S, Zeitler P, Gubitosi-Klug R, Nadeau KJ, Kutney K, White NH, Li JH, Perry JA, Kaur V, Brenner L, Mercader JM, Dawed A, Pearson …
• Characterization of P-glycoprotein orthologs from human, sheep, pig, dog, and cat.
  Journal of veterinary pharmacology and therapeutics 2023 Azimi M, Yee SW, Riselli A, Silva DB, Giacomini CP, Giacomini KM, Brett CM
• New and Emerging Research on Solute Carrier and ATP Binding Cassette Transporters in Drug Discovery and Development: Outlook From the International Transporter Consortium.
  Clinical pharmacology and therapeutics 2022 Giacomini KM, Yee SW, Koleske ML, Zou L, Matsson P, Chen EC, Kroetz DL, Miller MA, Gozalpour E, Chu X
• Response to Comment on Dawed et al. Genome-Wide Meta-analysis Identifies Genetic Variants Associated With Glycemic Response to Sulfonylureas. Diabetes Care 2021;44:2673-2682.
  Diabetes care 2022 Dawed AY, Yee SW, Zhou K, van Leeuwen N, Zhang Y, Siddiqui MK, Etheridge A, Innocenti F, Xu F, Li JH, Beulens JW, van der Heijden AA, Slieker RC, Chang YC, Mercader JM, Kaur V, Witte JS, Lee MTM, …
• The Clinical Pharmacogenetics Implementation Consortium Guideline for SLCO1B1, ABCG2, and CYP2C9 genotypes and Statin-Associated Musculoskeletal Symptoms.
  Clinical pharmacology and therapeutics 2022 Cooper-DeHoff RM, Niemi M, Ramsey LB, Luzum JA, Tarkiainen EK, Straka RJ, Gong L, Tuteja S, Wilke RA, Wadelius M, Larson EA, Roden DM, Klein TE, Yee SW, Krauss RM, Turner RM, Palaniappan L, Gaedigk A,…
• High Throughput Screening of a Prescription Drug Library for Inhibitors of Organic Cation Transporter 3, OCT3.
  Pharmaceutical research 2022 Chen EC, Matsson P, Azimi M, Zhou X, Handin N, Yee SW, Artursson P, Giacomini KM
• Chapter 13 Mechanisms and genetics of drug transport.
  2022 Lei Zhang, Osatohanmwen J. Enogieru, Sook Wah Yee, Shiew-Mei Huang, Kathleen M. Giacomini
• Emerging Roles of the Human Solute Carrier 22 Family.
  Drug metabolism and disposition: the biological fate of chemicals 2021 Yee SW, Giacomini KM
• Genome-Wide Meta-analysis Identifies Genetic Variants Associated With Glycemic Response to Sulfonylureas.
  Diabetes care 2021 Dawed AY, Yee SW, Zhou K, van Leeuwen N, Zhang Y, Siddiqui MK, Etheridge A, Innocenti F, Xu F, Li JH, Beulens JW, van der Heijden AA, Slieker RC, Chang YC, Mercader JM, Kaur V, Witte JS, Lee MTM, …
• Genomewide Association Studies in Pharmacogenomics.
  Clinical pharmacology and therapeutics 2021 McInnes G, Yee SW, Pershad Y, Altman RB
• Drugs in COVID-19 Clinical Trials: Predicting Transporter-Mediated Drug-Drug Interactions Using In Vitro Assays and Real-World Data.
  Clinical pharmacology and therapeutics 2021 Yee SW, Vora B, Oskotsky T, Zou L, Jakobsen S, Enogieru OJ, Koleske ML, Kosti I, Rödin M, Sirota M, Giacomini KM
• The Effects of Genetic Mutations and Drugs on the Activity of the Thiamine Transporter, SLC19A2.
  The AAPS journal 2021 Enogieru OJ, Koleske ML, Vora B, Ngo H, Yee SW, Chatad D, Sirota M, Giacomini KM
• Deorphaning a solute carrier 22 family member, SLC22A15, through functional genomic studies.
  FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2020 Yee SW, Buitrago D, Stecula A, Ngo HX, Chien HC, Zou L, Koleske ML, Giacomini KM
• Synthesis, Optimization, Antifungal Activity, Selectivity, and CYP51 Binding of New 2-Aryl-3-azolyl-1-indolyl-propan-2-ols.
  Pharmaceuticals (Basel, Switzerland) 2020 Lebouvier N, Pagniez F, Na YM, Shi D, Pinson P, Marchivie M, Guillon J, Hakki T, Bernhardt R, Yee SW, Simons C, Lézé MP, Hartmann RW, Mularoni A, Le Baut G, Krimm I, Abagyan R, Le Pape P, Le Borgne M
• GenEpi: gene-based epistasis discovery using machine learning.
  BMC bioinformatics 2020 Chang YC, Wu JT, Hong MY, Tung YA, Hsieh PH, Yee SW, Giacomini KM, Oyang YJ, Chen CY, Alzheimer’s Disease Neuroimaging Initiative
• SC1.3 - Influence of transporter polymorphisms on drug disposition and response: A Perspective from the international transporter consortium.
  Drug Metabolism and Pharmacokinetics 2020 Sook Wah Yee
• Expanding Precompetitive Multisector Collaborations to Advance Drug Development and Pharmacogenomics.
  Clinical pharmacology and therapeutics 2019 Yee SW, Do TP, Huang SM, Krauss RM, Kusuhara H, Sugiyama Y, Unadkat JD, Giacomini KM
• Unraveling the functional role of the orphan solute carrier, SLC22A24 in the transport of steroid conjugates through metabolomic and genome-wide association studies.
  PLoS genetics 2019 Yee SW, Stecula A, Chien HC, Zou L, Feofanova EV, van Borselen M, Cheung KWK, Yousri NA, Suhre K, Kinchen JM, Boerwinkle E, Irannejad R, Yu B, Giacomini KM
• Genome-Wide Association and Functional Studies Reveal Novel Pharmacological Mechanisms for Allopurinol.
  Clinical pharmacology and therapeutics 2019 Brackman DJ, Yee SW, Enogieru OJ, Shaffer C, Ranatunga D, Denny JC, Wei WQ, Kamatani Y, Kubo M, Roden DM, Jorgenson E, Giacomini KM
• Functional and structural analysis of rare SLC2A2 variants associated with Fanconi-Bickel syndrome and metabolic traits.
  Human mutation 2019 Enogieru OJ, Ung PMU, Yee SW, Schlessinger A, Giacomini KM
• Organic Anion Transporter Polypeptide 1B1 Polymorphism Modulates the Extent of Drug-Drug Interaction and Associated Biomarker Levels in Healthy Volunteers.
  Clinical and translational science 2019 Yee SW, Giacomini MM, Shen H, Humphreys WG, Horng H, Brian W, Lai Y, Kroetz DL, Giacomini KM
• Organic cation transporter 3 (Oct3) is a distinct catecholamines clearance route in adipocytes mediating the beiging of white adipose tissue.
  PLoS biology 2019 Song W, Luo Q, Zhang Y, Zhou L, Liu Y, Ma Z, Guo J, Huang Y, Cheng L, Meng Z, Li Z, Zhang B, Li S, Yee SW, Fan H, Li P, Giacomini KM, Chen L
• Unveiling the Genetic Architecture of Human Disease for Precision Medicine.
  Clinical and translational science 2018 Ramamoorthy A, Yee SW, Karnes J
• GenEpi: Gene-based Epistasis Discovery Using Machine Learning.
  bioRxiv 2018 Yu-Chuan Chang, June-Tai Wu, Ming-Yi Hong, Yi-An Tung, Ping-Han Hsieh, Sook Wah Yee, Kathleen M. Giacomini, Yen-Jen Oyang, Chien-Yu Chen, for the Alzheimer’s Disease Neuroimaging Initiative
• Transporters in Drug Development: 2018 ITC Recommendations for Transporters of Emerging Clinical Importance.
  Clinical pharmacology and therapeutics 2018 Zamek-Gliszczynski MJ, Taub ME, Chothe PP, Chu X, Giacomini KM, Kim RB, Ray AS, Stocker SL, Unadkat JD, Wittwer MB, Xia C, Yee SW, Zhang L, Zhang Y, International Transporter Consortium
• Influence of Transporter Polymorphisms on Drug Disposition and Response: A Perspective From the International Transporter Consortium.
  Clinical pharmacology and therapeutics 2018 Yee SW, Brackman DJ, Ennis EA, Sugiyama Y, Kamdem LK, Blanchard R, Galetin A, Zhang L, Giacomini KM
• Pharmacogenetics of Antidiabetic Drugs.
  Advances in pharmacology (San Diego, Calif.) 2018 Srinivasan S, Yee SW, Giacomini KM
• Molecular Mechanisms for Species Differences in Organic Anion Transporter 1, OAT1: Implications for Renal Drug Toxicity.
  Molecular pharmacology 2018 Zou L, Stecula A, Gupta A, Prasad B, Chien HC, Yee SW, Wang L, Unadkat JD, Stahl SH, Fenner KS, Giacomini KM
• Organic cation transporter 1 (OCT1) modulates multiple cardiometabolic traits through effects on hepatic thiamine content.
  PLoS biology 2018 Liang X, Yee SW, Chien HC, Chen EC, Luo Q, Zou L, Piao M, Mifune A, Chen L, Calvert ME, King S, Norheim F, Abad J, Krauss RM, Giacomini KM
• Genetic Variants in CPA6 and PRPF31 Are Associated With Variation in Response to Metformin in Individuals With Type 2 Diabetes.
  Diabetes 2018 Rotroff DM, Yee SW, Zhou K, Marvel SW, Shah HS, Jack JR, Havener TM, Hedderson MM, Kubo M, Herman MA, Gao H, Mychaleckyi JC, McLeod HL, Doria A, Giacomini KM, Pearson ER, Wagner MJ, Buse JB, Motsinger…
• New Pharmacogenomics Research Network: An Open Community Catalyzing Research and Translation in Precision Medicine.
  Clinical pharmacology and therapeutics 2017 Relling MV, Krauss RM, Roden DM, Klein TE, Fowler DM, Terada N, Lin L, Riel-Mehan M, Do TP, Kubo M, Yee SW, Johnson GT, Giacomini KM
• Computational Discovery and Experimental Validation of Inhibitors of the Human Intestinal Transporter OATP2B1.
  Journal of chemical information and modeling 2017 Khuri N, Zur AA, Wittwer MB, Lin L, Yee SW, Sali A, Giacomini KM
• Discovery of Competitive and Noncompetitive Ligands of the Organic Cation Transporter 1 (OCT1; SLC22A1).
  Journal of medicinal chemistry 2017 Chen EC, Khuri N, Liang X, Stecula A, Chien HC, Yee SW, Huang Y, Sali A, Giacomini KM
• Genomic Characterization of Metformin Hepatic Response.
  PLoS genetics 2016 Luizon MR, Eckalbar WL, Wang Y, Jones SL, Smith RP, Laurance M, Lin L, Gallins PJ, Etheridge AS, Wright F, Zhou Y, Molony C, Innocenti F, Yee SW, Giacomini KM, Ahituv N
• Genome-wide association studies of drug response and toxicity: an opportunity for genome medicine.
  Nature reviews. Drug discovery 2016 Giacomini KM, Yee SW, Mushiroda T, Weinshilboum RM, Ratain MJ, Kubo M
• A Longitudinal HbA1c Model Elucidates Genes Linked to Disease Progression on Metformin.
  Clinical pharmacology and therapeutics 2016 Goswami S, Yee SW, Xu F, Sridhar SB, Mosley JD, Takahashi A, Kubo M, Maeda S, Davis RL, Roden DM, Hedderson MM, Giacomini KM, Savic RM
• Metabolomic and Genome-wide Association Studies Reveal Potential Endogenous Biomarkers for OATP1B1.
  Clinical pharmacology and therapeutics 2016 Yee SW, Giacomini MM, Hsueh CH, Weitz D, Liang X, Goswami S, Kinchen JM, Coelho A, Zur AA, Mertsch K, Brian W, Kroetz DL, Giacomini KM
• Variation in the glucose transporter gene SLC2A2 is associated with glycemic response to metformin.
  Nature genetics 2016 Zhou K, Yee SW, Seiser EL, van Leeuwen N, Tavendale R, Bennett AJ, Groves CJ, Coleman RL, van der Heijden AA, Beulens JW, de Keyser CE, Zaharenko L, Rotroff DM, Out M, Jablonski KA, Chen L, Javorský M…
• Genomewide Association Studies in Pharmacogenomics: Meeting Report of the NIH Pharmacogenomics Research Network-RIKEN (PGRN-RIKEN) Collaboration.
  Clinical pharmacology and therapeutics 2016 Yee SW, Momozawa Y, Kamatani Y, Tyndale RF, Weinshilboum RM, Ratain MJ, Giacomini KM, Kubo M
• Pharmacometabolomic Assessment of Metformin in Non-diabetic, African Americans.
  Frontiers in pharmacology 2016 Rotroff DM, Oki NO, Liang X, Yee SW, Stocker SL, Corum DG, Meisner M, Fiehn O, Motsinger-Reif AA, Giacomini KM, Kaddurah-Daouk R
• The Effect of Famotidine, a MATE1-Selective Inhibitor, on the Pharmacokinetics and Pharmacodynamics of Metformin.
  Clinical pharmacokinetics 2016 Hibma JE, Zur AA, Castro RA, Wittwer MB, Keizer RJ, Yee SW, Goswami S, Stocker SL, Zhang X, Huang Y, Brett CM, Savic RM, Giacomini KM
• Transcriptomic variation of pharmacogenes in multiple human tissues and lymphoblastoid cell lines.
  The pharmacogenomics journal 2016 Chhibber A, French CE, Yee SW, Gamazon ER, Theusch E, Qin X, Webb A, Papp AC, Wang A, Simmons CQ, Konkashbaev A, Chaudhry AS, Mitchel K, Stryke D, Ferrin TE, Weiss ST, Kroetz DL, Sadee W, Nickerson DA…
• Pharmacogenetics of Metformin.
  The Genetics of Type 2 Diabetes and Related Traits 2016 Sook Wah Yee, Kaixin Zhou, Kathleen M. Giacomini
• Rapid Method To Determine Intracellular Drug Concentrations in Cellular Uptake Assays: Application to Metformin in Organic Cation Transporter 1-Transfected Human Embryonic Kidney 293 Cells.
  Drug metabolism and disposition: the biological fate of chemicals 2015 Chien HC, Zur AA, Maurer TS, Yee SW, Tolsma J, Jasper P, Scott DO, Giacomini KM
• Metformin Is a Substrate and Inhibitor of the Human Thiamine Transporter, THTR-2 (SLC19A3).
  Molecular pharmaceutics 2015 Liang X, Chien HC, Yee SW, Giacomini MM, Chen EC, Piao M, Hao J, Twelves J, Lepist EI, Ray AS, Giacomini KM
• Prediction and validation of enzyme and transporter off-targets for metformin.
  Journal of pharmacokinetics and pharmacodynamics 2015 Yee SW, Lin L, Merski M, Keiser MJ, Gupta A, Zhang Y, Chien HC, Shoichet BK, Giacomini KM
• SLC transporters as therapeutic targets: emerging opportunities.
  Nature reviews. Drug discovery 2015 Lin L, Yee SW, Kim RB, Giacomini KM
• Targeted disruption of organic cation transporter 3 attenuates the pharmacologic response to metformin.
  Molecular pharmacology 2015 Chen EC, Liang X, Yee SW, Geier EG, Stocker SL, Chen L, Giacomini KM
• Genome-wide association study identifies ABCG2 (BCRP) as an allopurinol transporter and a determinant of drug response.
  Clinical pharmacology and therapeutics 2015 Wen CC, Yee SW, Liang X, Hoffmann TJ, Kvale MN, Banda Y, Jorgenson E, Schaefer C, Risch N, Giacomini KM
• OCT1 in hepatic steatosis and thiamine disposition.
  Cell cycle (Georgetown, Tex.) 2015 Chen L, Yee SW, Giacomini KM
• OCT1 is a high-capacity thiamine transporter that regulates hepatic steatosis and is a target of metformin.
  Proceedings of the National Academy of Sciences of the United States of America 2014 Chen L, Shu Y, Liang X, Chen EC, Yee SW, Zur AA, Li S, Xu L, Keshari KR, Lin MJ, Chien HC, Zhang Y, Morrissey KM, Liu J, Ostrem J, Younger NS, Kurhanewicz J, Shokat KM, Ashrafi K, Giacomini KM
• Genetic variants in transcription factors are associated with the pharmacokinetics and pharmacodynamics of metformin.
  Clinical pharmacology and therapeutics 2014 Goswami S, Yee SW, Stocker S, Mosley JD, Kubo M, Castro R, Mefford JA, Wen C, Liang X, Witte J, Brett C, Maeda S, Simpson MD, Hedderson MM, Davis RL, Roden DM, Giacomini KM, Savic RM
• Clinical Pharmacogenetics Implementation Consortium (CPIC) guidelines for ivacaftor therapy in the context of CFTR genotype.
  Clinical pharmacology and therapeutics 2014 Clancy JP, Johnson SG, Yee SW, McDonagh EM, Caudle KE, Klein TE, Cannavo M, Giacomini KM, Clinical Pharmacogenetics Implementation Consortium
• Profiling solute carrier transporters in the human blood-brain barrier.
  Clinical pharmacology and therapeutics 2013 Geier EG, Chen EC, Webb A, Papp AC, Yee SW, Sadee W, Giacomini KM
• A genome-wide association study of bronchodilator response in Latinos implicates rare variants.
  The Journal of allergy and clinical immunology 2013 Drake KA, Torgerson DG, Gignoux CR, Galanter JM, Roth LA, Huntsman S, Eng C, Oh SS, Yee SW, Lin L, Bustamante CD, Moreno-Estrada A, Sandoval K, Davis A, Borrell LN, Farber HJ, Kumar R, Avila PC, …
• International Transporter Consortium commentary on clinically important transporter polymorphisms.
  Clinical pharmacology and therapeutics 2013 Giacomini KM, Balimane PV, Cho SK, Eadon M, Edeki T, Hillgren KM, Huang SM, Sugiyama Y, Weitz D, Wen Y, Xia CQ, Yee SW, Zimdahl H, Niemi M, International Transporter Consortium
• SLC classification: an update.
  Clinical pharmacology and therapeutics 2013 Schlessinger A, Yee SW, Sali A, Giacomini KM
• Impact of polymorphisms in drug pathway genes on disease-free survival in adults with acute myeloid leukemia.
  Journal of human genetics 2013 Yee SW, Mefford JA, Singh N, Percival ME, Stecula A, Yang K, Witte JS, Takahashi A, Kubo M, Matsuda K, Giacomini KM, Andreadis C
• Reduced renal clearance of cefotaxime in asians with a low-frequency polymorphism of OAT3 (SLC22A8).
  Journal of pharmaceutical sciences 2013 Yee SW, Nguyen AN, Brown C, Savic RM, Zhang Y, Castro RA, Cropp CD, Choi JH, Singh D, Tahara H, Stocker SL, Huang Y, Brett CM, Giacomini KM
• The Pharmacogenomics of Membrane Transporters Project.
  Pharmacogenomics of Human Drug Transporters 2013 Sook Wah Yee, Deanna L. Kroetz, Kathleen M. Giacomini
• Clinical pharmacogenetics implementation consortium guidelines for thiopurine methyltransferase genotype and thiopurine dosing: 2013 update.
  Clinical pharmacology and therapeutics 2013 Relling MV, Gardner EE, Sandborn WJ, Schmiegelow K, Pui CH, Yee SW, Stein CM, Carrillo M, Evans WE, Hicks JK, Schwab M, Klein TE, Clinical Pharmacogenetics Implementation Consortium
• Germline Genetic Polymorphisms Are Associated with Disease-Free Survival in Adults with Acute Myeloid Leukemia (AML): A Genomewide Association Study From the Pgrn-Riken Global Alliance.
  Blood 2012 Sook Wah Yee, Joel Mefford, John Witte, Michiaki Kubo, Koichi Matsuda, Kathleen Giacomini, Charalambos Andreadis
• Pharmacogenomics and patient care: one size does not fit all.
  Science translational medicine 2012 Giacomini KM, Yee SW, Ratain MJ, Weinshilboum RM, Kamatani N, Nakamura Y
• Evaluation of Norepinephrine Transporter Expression and Metaiodobenzylguanidine Avidity in Neuroblastoma: A Report from the Children's Oncology Group.
  International journal of molecular imaging 2012 Dubois SG, Geier E, Batra V, Yee SW, Neuhaus J, Segal M, Martinez D, Pawel B, Yanik G, Naranjo A, London WB, Kreissman S, Baker D, Attiyeh E, Hogarty MD, Maris JM, Giacomini K, Matthay KK
• Pharmacogene regulatory elements: from discovery to applications.
  Genome medicine 2012 Smith RP, Lam ET, Markova S, Yee SW, Ahituv N
• The role of ATM in response to metformin treatment and activation of AMPK.
  Nature genetics 2012 Yee SW, Chen L, Giacomini KM
• A common 5'-UTR variant in MATE2-K is associated with poor response to metformin.
  Clinical pharmacology and therapeutics 2011 Choi JH, Yee SW, Ramirez AH, Morrissey KM, Jang GH, Joski PJ, Mefford JA, Hesselson SE, Schlessinger A, Jenkins G, Castro RA, Johns SJ, Stryke D, Sali A, Ferrin TE, Witte JS, Kwok PY, Roden DM, Wilke …
• Interaction of sirolimus and everolimus with hepatic and intestinal organic anion-transporting polypeptide transporters.
  Xenobiotica; the fate of foreign compounds in biological systems 2011 Picard N, Levoir L, Lamoureux F, Yee SW, Giacomini KM, Marquet P
• Discovery of regulatory elements in human ATP-binding cassette transporters through expression quantitative trait mapping.
  The pharmacogenomics journal 2011 Matsson P, Yee SW, Markova S, Morrissey K, Jenkins G, Xuan J, Jorgenson E, Kroetz DL, Giacomini KM
• Functional characterization of liver enhancers that regulate drug-associated transporters.
  Clinical pharmacology and therapeutics 2011 Kim MJ, Skewes-Cox P, Fukushima H, Hesselson S, Yee SW, Ramsey LB, Nguyen L, Eshragh JL, Castro RA, Wen CC, Stryke D, Johns SJ, Ferrin TE, Kwok PY, Relling MV, Giacomini KM, Kroetz DL, Ahituv N
• Clinical Pharmacogenetics Implementation Consortium guidelines for thiopurine methyltransferase genotype and thiopurine dosing.
  Clinical pharmacology and therapeutics 2011 Relling MV, Gardner EE, Sandborn WJ, Schmiegelow K, Pui CH, Yee SW, Stein CM, Carrillo M, Evans WE, Klein TE, Clinical Pharmacogenetics Implementation Consortium
• SLC19A1 pharmacogenomics summary.
  Pharmacogenetics and genomics 2010 Yee SW, Gong L, Badagnani I, Giacomini KM, Klein TE, Altman RB
• Synthesis and CYP24A1 inhibitory activity of N-(2-(1H-imidazol-1-yl)-2-phenylethyl)arylamides.
  Bioorganic & medicinal chemistry 2010 Aboraia AS, Yee SW, Gomaa MS, Shah N, Robotham AC, Makowski B, Prosser D, Brancale A, Jones G, Simons C
• Organic cation transporters modulate the uptake and cytotoxicity of picoplatin, a third-generation platinum analogue.
  Molecular cancer therapeutics 2010 More SS, Li S, Yee SW, Chen L, Xu Z, Jablons DM, Giacomini KM
• Pharmacogenomics of membrane transporters: past, present and future.
  Pharmacogenomics 2010 Yee SW, Chen L, Giacomini KM
• Comparison of human solute carriers.
  Protein science : a publication of the Protein Society 2010 Schlessinger A, Matsson P, Shima JE, Pieper U, Yee SW, Kelly L, Apeltsin L, Stroud RM, Ferrin TE, Giacomini KM, Sali A
• Membrane transporters in drug development.
  Nature reviews. Drug discovery 2010 International Transporter Consortium, Giacomini KM, Huang SM, Tweedie DJ, Benet LZ, Brouwer KL, Chu X, Dahlin A, Evers R, Fischer V, Hillgren KM, Hoffmaster KA, Ishikawa T, Keppler D, Kim RB, Lee CA, …
• The pharmacogenomics of membrane transporters project: research at the interface of genomics and transporter pharmacology.
  Clinical pharmacology and therapeutics 2009 Kroetz DL, Yee SW, Giacomini KM
• The role of organic anion-transporting polypeptides and their common genetic variants in mycophenolic acid pharmacokinetics.
  Clinical pharmacology and therapeutics 2009 Picard N, Yee SW, Woillard JB, Lebranchu Y, Le Meur Y, Giacomini KM, Marquet P
• Identification and characterization of novel polymorphisms in the basal promoter of the human transporter, MATE1.
  Pharmacogenetics and genomics 2009 Ha Choi J, Wah Yee S, Kim MJ, Nguyen L, Ho Lee J, Kang JO, Hesselson S, Castro RA, Stryke D, Johns SJ, Kwok PY, Ferrin TE, Goo Lee M, Black BL, Ahituv N, Giacomini KM
• Genetic variation in the proximal promoter of ABC and SLC superfamilies: liver and kidney specific expression and promoter activity predict variation.
  PloS one 2009 Hesselson SE, Matsson P, Shima JE, Fukushima H, Yee SW, Kobayashi Y, Gow JM, Ha C, Ma B, Poon A, Johns SJ, Stryke D, Castro RA, Tahara H, Choi JH, Chen L, Picard N, Sjödin E, Roelofs MJ, Ferrin TE, …
• Effect of genetic variation in the organic cation transporter 2 on the renal elimination of metformin.
  Pharmacogenetics and genomics 2009 Chen Y, Li S, Brown C, Cheatham S, Castro RA, Leabman MK, Urban TJ, Chen L, Yee SW, Choi JH, Huang Y, Brett CM, Burchard EG, Giacomini KM
• Genetic variants in multidrug and toxic compound extrusion-1, hMATE1, alter transport function.
  The pharmacogenomics journal 2009 Chen Y, Teranishi K, Li S, Yee SW, Hesselson S, Stryke D, Johns SJ, Ferrin TE, Kwok P, Giacomini KM
• Functional genetic variation in the basal promoter of the organic cation/carnitine transporters OCTN1 (SLC22A4) and OCTN2 (SLC22A5).
  The Journal of pharmacology and experimental therapeutics 2009 Tahara H, Yee SW, Urban TJ, Hesselson S, Castro RA, Kawamoto M, Stryke D, Johns SJ, Ferrin TE, Kwok PY, Giacomini KM
• Identification and characterization of proximal promoter polymorphisms in the human concentrative nucleoside transporter 2 (SLC28A2).
  The Journal of pharmacology and experimental therapeutics 2008 Yee SW, Shima JE, Hesselson S, Nguyen L, De Val S, Lafond RJ, Kawamoto M, Johns SJ, Stryke D, Kwok PY, Ferrin TE, Black BL, Gurwitz D, Ahituv N, Giacomini KM
• Genetic variation in drug transporters in ethnic populations.
  Clinical pharmacology and therapeutics 2008 Cropp CD, Yee SW, Giacomini KM
• Organic anion transporter 2 (SLC22A7) is a facilitative transporter of cGMP.
  Molecular pharmacology 2008 Cropp CD, Komori T, Shima JE, Urban TJ, Yee SW, More SS, Giacomini KM
• Homology model of human retinoic acid metabolising enzyme cytochrome P450 26A1 (CYP26A1): active site architecture and ligand binding.
  Journal of enzyme inhibition and medicinal chemistry 2006 Gomaa MS, Yee SW, Milbourne CE, Barbera MC, Simons C, Brancale A
• Inhibition of Vitamin D3 metabolism enhances VDR signalling in androgen-independent prostate cancer cells.
  The Journal of steroid biochemistry and molecular biology 2006 Yee SW, Campbell MJ, Simons C
• Potent CYP19 (aromatase) 1-[(benzofuran-2-yl)(phenylmethyl)pyridine, -imidazole, and -triazole inhibitors: synthesis and biological evaluation.
  Journal of medicinal chemistry 2006 Saberi MR, Vinh TK, Yee SW, Griffiths BJ, Evans PJ, Simons C
• Synthesis and CYP26A1 inhibitory activity of 1-[benzofuran-2-yl-(4-alkyl/aryl-phenyl)-methyl]-1H-triazoles.
  Bioorganic & medicinal chemistry 2006 Pautus S, Yee SW, Jayne M, Coogan MP, Simons C
• Novel tetralone-derived retinoic acid metabolism blocking agents: synthesis and in vitro evaluation with liver microsomal and MCF-7 CYP26A1 cell assays.
  Journal of medicinal chemistry 2005 Yee SW, Jarno L, Gomaa MS, Elford C, Ooi LL, Coogan MP, McClelland R, Nicholson RI, Evans BA, Brancale A, Simons C
• Synthesis and CYP24 Inhibitory Activity of 2-Substituted-3,4-dihydro-2H-naphthalen-1-one (Tetralone) Derivatives.
  ChemInform 2005 Sook Wah Yee, Claire Simons
• Synthesis and antimycobacterial activity of 7-O-substituted-4-methyl-2H-2-chromenone derivatives vs Mycobacterium tuberculosis.
  Journal of enzyme inhibition and medicinal chemistry 2005 Yee SW, Shah B, Simons C
• Synthesis and CYP24 inhibitory activity of 2-substituted-3,4-dihydro-2H-naphthalen-1-one (tetralone) derivatives.
  Bioorganic & medicinal chemistry letters 2004 Yee SW, Simons C