Sonja Schrepfer, MD, PhD
Professor
Surgery
School of Medicine

Grants and Projects

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• Hypo-immunogenic cardiomyocytes for myocardial repair, NIH, 2018-2022
• Microgravity as model for immunological senescence and its impact on tissue stem cells and regeneration, NIH, 2017-2022
• Microgravity as model for immunological senescence and its impact on tissue stem cells and regeneration, NIH, 2017-2020

Publications (98)

Top publication keywords:
Heart TransplantationCD47 AntigenGraft SurvivalBronchiolitis ObliteransIslets of Langerhans TransplantationTransplantation, HeterologousInduced Pluripotent Stem CellsAorta, AbdominalGraft RejectionEmbryonic Stem CellsGraft Occlusion, VascularTracheaTunica IntimaIsoxazolesJanus Kinase 3

• Hypoimmune islets achieve insulin independence after allogeneic transplantation in a fully immunocompetent non-human primate.
  Cell stem cell 2024 Hu X, White K, Young C, Olroyd AG, Kievit P, Connolly AJ, Deuse T, Schrepfer S
• Synthetic immune checkpoint engagers protect HLA-deficient iPSCs and derivatives from innate immune cell cytotoxicity.
  Cell stem cell 2023 Gravina A, Tediashvili G, Zheng Y, Iwabuchi KA, Peyrot SM, Roodsari SZ, Gargiulo L, Kaneko S, Osawa M, Schrepfer S, Deuse T
• Hypoimmune induced pluripotent stem cells survive long term in fully immunocompetent, allogeneic rhesus macaques.
  Nature biotechnology 2023 Hu X, White K, Olroyd AG, DeJesus R, Dominguez AA, Dowdle WE, Friera AM, Young C, Wells F, Chu EY, Ito CE, Krishnapura H, Jain S, Ankala R, McGill TJ, Lin A, Egenberger K, Gagnon A, Michael Rukstalis …
• Human hypoimmune primary pancreatic islets avoid rejection and autoimmunity and alleviate diabetes in allogeneic humanized mice.
  Science translational medicine 2023 Hu X, Gattis C, Olroyd AG, Friera AM, White K, Young C, Basco R, Lamba M, Wells F, Ankala R, Dowdle WE, Lin A, Egenberger K, Rukstalis JM, Millman JR, Connolly AJ, Deuse T, Schrepfer S
• Hypoimmune anti-CD19 chimeric antigen receptor T cells provide lasting tumor control in fully immunocompetent allogeneic humanized mice.
  Nature communications 2023 Hu X, Manner K, DeJesus R, White K, Gattis C, Ngo P, Bandoro C, Tham E, Chu EY, Young C, Wells F, Basco R, Friera A, Kangeyan D, Beauchesne P, Dowdle WE, Deuse T, Fry TJ, Foster AE, Schrepfer S

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• Protection of cell therapeutics from antibody-mediated killing by CD64 overexpression.
  Nature biotechnology 2023 Gravina A, Tediashvili G, Rajalingam R, Quandt Z, Deisenroth C, Schrepfer S, Deuse T
• Author Correction: Hypoimmunogenic derivatives of induced pluripotent stem cells evade immune rejection in fully immunocompetent allogeneic recipients.
  Nature biotechnology 2022 Deuse T, Hu X, Gravina A, Wang D, Tediashvili G, De C, Thayer WO, Wahl A, Garcia JV, Reichenspurner H, Davis MM, Lanier LL, Schrepfer S
• Hypoimmune induced pluripotent stem cell-derived cell therapeutics treat cardiovascular and pulmonary diseases in immunocompetent allogeneic mice.
  Proceedings of the National Academy of Sciences of the United States of America 2021 Deuse T, Tediashvili G, Hu X, Gravina A, Tamenang A, Wang D, Connolly A, Mueller C, Mallavia B, Looney MR, Alawi M, Lanier LL, Schrepfer S
• Immunomodulation Therapy Using Tolerogenic Macrophages in a Rodent Model of Pulmonary Hypertension.
  Stem cells and development 2021 Guihaire J, Deuse T, Wang D, Spin JM, Blankenberg FG, Fadel E, Reichenspurner H, Schrepfer S
• The SIRPα-CD47 immune checkpoint in NK cells.
  The Journal of experimental medicine 2021 Deuse T, Hu X, Agbor-Enoh S, Jang MK, Alawi M, Saygi C, Gravina A, Tediashvili G, Nguyen VQ, Liu Y, Valantine H, Lanier LL, Schrepfer S
• Comprehensive Multi-omics Analysis Reveals Mitochondrial Stress as a Central Biological Hub for Spaceflight Impact.
  Cell 2020 da Silveira WA, Fazelinia H, Rosenthal SB, Laiakis EC, Kim MS, Meydan C, Kidane Y, Rathi KS, Smith SM, Stear B, Ying Y, Zhang Y, Foox J, Zanello S, Crucian B, Wang D, Nugent A, Costa HA, Zwart SR, …
• The H-Y Antigen in Embryonic Stem Cells Causes Rejection in Syngeneic Female Recipients.
  Stem cells and development 2020 Hu X, Kueppers ST, Kooreman NG, Gravina A, Wang D, Tediashvili G, Schlickeiser S, Frentsch M, Nikolaou C, Thiel A, Marcus S, Fuchs S, Velden J, Reichenspurner H, Volk HD, Deuse T, Schrepfer S
• A Cryoinjury Model to Study Myocardial Infarction in the Mouse.
  Journal of visualized experiments : JoVE 2019 Wang D, Tediashvili G, Hu X, Gravina A, Marcus SG, Zhang H, Olgin JE, Deuse T, Schrepfer S
• De novo mutations in mitochondrial DNA of iPSCs produce immunogenic neoepitopes in mice and humans.
  Nature biotechnology 2019 Deuse T, Hu X, Agbor-Enoh S, Koch M, Spitzer MH, Gravina A, Alawi M, Marishta A, Peters B, Kosaloglu-Yalcin Z, Yang Y, Rajalingam R, Wang D, Nashan B, Kiefmann R, Reichenspurner H, Valantine H, …
• Hypoimmunogenic derivatives of induced pluripotent stem cells evade immune rejection in fully immunocompetent allogeneic recipients.
  Nature biotechnology 2019 Deuse T, Hu X, Gravina A, Wang D, Tediashvili G, De C, Thayer WO, Wahl A, Garcia JV, Reichenspurner H, Davis MM, Lanier LL, Schrepfer S
• Dead space ventilation promotes alveolar hypocapnia reducing surfactant secretion by altering mitochondrial function.
  Thorax 2019 Kiefmann M, Tank S, Tritt MO, Keller P, Heckel K, Schulte-Uentrop L, Olotu C, Schrepfer S, Goetz AE, Kiefmann R
• Exosomal profiling in cardiac allograft rejection: Best basic science article in 2018.
  The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation 2018 Kulkarni HS, Diamond JM, Schrepfer S, Cantu E
• No effect of thymosin beta-4 on the expression of the transcription factor Islet-1 in the adult murine heart.
  Pharmacology research & perspectives 2018 Weinberger F, Nicol P, Starbatty J, Stubbendorff M, Becher PM, Schrepfer S, Eschenhagen T
• Sphingosine-1-phosphate receptor 1 regulates neointimal growth in a humanized model for restenosis.
  Journal of vascular surgery 2018 Braetz J, Becker A, Geissen M, Larena-Avellaneda A, Schrepfer S, Daum G
• Optimization of oxygenation during ex vivo lung perfusion-Best basic science article in 2017.
  The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation 2018 Shaver CM, Diamond JM, Schrepfer S, Cantu E
• Balloon-based Injury to Induce Myointimal Hyperplasia in the Mouse Abdominal Aorta.
  Journal of visualized experiments : JoVE 2018 Tediashvili G, Wang D, Reichenspurner H, Deuse T, Schrepfer S
• Opportunities for Lung Repair and Regeneration: An Overview.
  Annals of the American Thoracic Society 2017 Schrepfer S
• Thalidomide treatment prevents chronic graft rejection after aortic transplantation in rats - an experimental study.
  Transplant international : official journal of the European Society for Organ Transplantation 2017 Miller KK, Wang D, Hu X, Hua X, Deuse T, Neofytou E, Renne T, Velden J, Reichenspurner H, Schrepfer S, Bernstein D
• Differences in Vascular Response between Balloon Overstretch and Stent Overexpansion in Nonatherosclerotic Porcine Coronary Arteries.
  Comparative medicine 2017 Mitsutake Y, Reifart J, Pyun WB, Lyons JK, Deuse T, Schrepfer S, Ikeno F
• The ubiquitin-proteasome system: A potential therapeutic target for heart failure.
  The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation 2017 Barac YD, Emrich F, Krutzwakd-Josefson E, Schrepfer S, Sampaio LC, Willerson JT, Robbins RC, Ciechanover A, Mohr FW, Aravot D, Taylor DA
• Vein Interposition Model: A Suitable Model to Study Bypass Graft Patency.
  Journal of visualized experiments : JoVE 2017 Wang D, Tediashvili G, Pecha S, Reichenspurner H, Deuse T, Schrepfer S
• Orthotopic tracheal transplantation using human bronchus: an original xenotransplant model of obliterative airway disorder.
  Transplant international : official journal of the European Society for Organ Transplantation 2016 Guihaire J, Itagaki R, Stubbendorff M, Hua X, Deuse T, Ullrich S, Fadel E, Dorfmüller P, Robbins RC, Reichenspurner H, Schumacher U, Schrepfer S
• miR-126: a potential new key player in hypoxia and reperfusion?
  Annals of translational medicine 2016 Guenther SP, Schrepfer S
• The Selective JAK1/3-Inhibitor R507 Mitigates Obliterative Airway Disease Both With Systemic Administration and Aerosol Inhalation.
  Transplantation 2016 Deuse T, Hua X, Stubbendorff M, Spin JM, Neofytou E, Taylor V, Chen Y, Park G, Fink JB, Renne T, Kiefmann M, Kiefmann R, Reichenspurner H, Robbins RC, Schrepfer S
• "Bioengineered lungs" Best science paper in JHLT 2014-2015.
  The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation 2016 Schrepfer S, Cantu E, Gandy K, Baan CC, West LJ
• miR-21 promotes fibrosis in an acute cardiac allograft transplantation model.
  Cardiovascular research 2016 Gupta SK, Itagaki R, Zheng X, Batkai S, Thum S, Ahmad F, Van Aelst LN, Sharma A, Piccoli MT, Weinberger F, Fiedler J, Heuser M, Heymans S, Falk CS, Förster R, Schrepfer S, Thum T
• Sex Differences in Immunology: More Severe Development of Experimental Pulmonary Hypertension in Male Rats Exposed to Vascular Endothelial Growth Factor Receptor Blockade.
  BioMed research international 2015 Guihaire J, Deuse T, Wang D, Fadel E, Reichenspurner H, Schrepfer S
• Alagebrium inhibits neointimal hyperplasia and restores distributions of wall shear stress by reducing downstream vascular resistance in obese and diabetic rats.
  American journal of physiology. Heart and circulatory physiology 2015 Wang H, Weihrauch D, Kersten JR, Toth JM, Passerini AG, Rajamani A, Schrepfer S, LaDisa JF
• Distal Airway Stem Cells are Essential for Lung Regeneration.
  Transplantation 2015 Deuse T, Schrepfer S
• Local MicroRNA Modulation Using a Novel Anti-miR-21-Eluting Stent Effectively Prevents Experimental In-Stent Restenosis.
  Arteriosclerosis, thrombosis, and vascular biology 2015 Wang D, Deuse T, Stubbendorff M, Chernogubova E, Erben RG, Eken SM, Jin H, Li Y, Busch A, Heeger CH, Behnisch B, Reichenspurner H, Robbins RC, Spin JM, Tsao PS, Schrepfer S, Maegdefessel L
• Advancing knowledge of right ventricular pathophysiology in chronic pressure overload: Insights from experimental studies.
  Archives of cardiovascular diseases 2015 Guihaire J, Noly PE, Schrepfer S, Mercier O
• Effective Apical Infection of Differentiated Human Bronchial Epithelial Cells and Induction of Proinflammatory Chemokines by the Highly Pneumotropic Human Adenovirus Type 14p1.
  PloS one 2015 Lam E, Ramke M, Warnecke G, Schrepfer S, Kopfnagel V, Dobner T, Heim A
• Mesenchymal stromal cell therapy: different sources exhibit different immunobiological properties.
  Transplantation 2015 Neofytou E, Deuse T, Beygui RE, Schrepfer S
• Immunobiology of fibrin-based engineered heart tissue.
  Stem cells translational medicine 2015 Conradi L, Schmidt S, Neofytou E, Deuse T, Peters L, Eder A, Hua X, Hansen A, Robbins RC, Beygui RE, Reichenspurner H, Eschenhagen T, Schrepfer S
• Impaired Endothelial Regeneration Through Human Parvovirus B19-Infected Circulating Angiogenic Cells in Patients With Cardiomyopathy.
  The Journal of infectious diseases 2015 Schmidt-Lucke C, Zobel T, Schrepfer S, Kuhl U, Wang D, Klingel K, Becher PM, Fechner H, Pozzuto T, Van Linthout S, Lassner D, Spillmann F, Escher F, Holinski S, Volk HD, Schultheiss HP, Tschope C
• Erratum: miR-24 limits aortic vascular inflammation and murine abdominal aneurysm development.
  Nature communications 2015 Maegdefessel L, Spin JM, Raaz U, Eken SM, Toh R, Azuma J, Adam M, Nakagami F, Heymann HM, Chernogubova E, Jin H, Roy J, Hultgren R, Caidahl K, Schrepfer S, Hamsten A, Eriksson P, McConnell MV, Dalman …
• SCNT-derived ESCs with mismatched mitochondria trigger an immune response in allogeneic hosts.
  Cell stem cell 2014 Deuse T, Wang D, Stubbendorff M, Itagaki R, Grabosch A, Greaves LC, Alawi M, Grünewald A, Hu X, Hua X, Velden J, Reichenspurner H, Robbins RC, Jaenisch R, Weissman IL, Schrepfer S
• miR-24 limits aortic vascular inflammation and murine abdominal aneurysm development.
  Nature communications 2014 Maegdefessel L, Spin JM, Raaz U, Eken SM, Toh R, Azuma J, Adam M, Nakagami F, Nagakami F, Heymann HM, Chernogubova E, Chernugobova E, Jin H, Roy J, Hultgren R, Caidahl K, Schrepfer S, Hamsten A, …
• Inducing myointimal hyperplasia versus atherosclerosis in mice: an introduction of two valid models.
  Journal of visualized experiments : JoVE 2014 Stubbendorff M, Hua X, Deuse T, Ali Z, Reichenspurner H, Maegdefessel L, Robbins RC, Schrepfer S
• Dichloroacetate prevents restenosis in preclinical animal models of vessel injury.
  Nature 2014 Deuse T, Hua X, Wang D, Maegdefessel L, Heeren J, Scheja L, Bolaños JP, Rakovic A, Spin JM, Stubbendorff M, Ikeno F, Länger F, Zeller T, Schulte-Uentrop L, Stoehr A, Itagaki R, Haddad F, Eschenhagen T…
• The Ca²⁺-activated K⁺ channel KCa3.1 as a potential new target for the prevention of allograft vasculopathy.
  PloS one 2013 Chen YJ, Lam J, Gregory CR, Schrepfer S, Wulff H
• Immunological properties of extraembryonic human mesenchymal stromal cells derived from gestational tissue.
  Stem cells and development 2013 Stubbendorff M, Deuse T, Hua X, Phan TT, Bieback K, Atkinson K, Eiermann TH, Velden J, Schröder C, Reichenspurner H, Robbins RC, Volk HD, Schrepfer S
• Small animal models of experimental obliterative bronchiolitis.
  American journal of respiratory cell and molecular biology 2013 Jungraithmayr W, Jang JH, Schrepfer S, Inci I, Weder W
• The potassium channel KCa3.1 as new therapeutic target for the prevention of obliterative airway disease.
  Transplantation 2013 Hua X, Deuse T, Chen YJ, Wulff H, Stubbendorff M, Köhler R, Miura H, Länger F, Reichenspurner H, Robbins RC, Schrepfer S
• Significant reduction of acute cardiac allograft rejection by selective janus kinase-1/3 inhibition using R507 and R545.
  Transplantation 2012 Deuse T, Hua X, Taylor V, Stubbendorff M, Baluom M, Chen Y, Park G, Velden J, Streichert T, Reichenspurner H, Robbins RC, Schrepfer S
• Effects of intracoronary CD34+ stem cell transplantation in nonischemic dilated cardiomyopathy patients: 5-year follow-up.
  Circulation research 2012 Vrtovec B, Poglajen G, Lezaic L, Sever M, Domanovic D, Cernelc P, Socan A, Schrepfer S, Torre-Amione G, Haddad F, Wu JC
• Human internal mammary artery (IMA) transplantation and stenting: a human model to study the development of in-stent restenosis.
  Journal of visualized experiments : JoVE 2012 Hua X, Deuse T, Michelakis ED, Haromy A, Tsao PS, Maegdefessel L, Erben RG, Bergow C, Behnisch BB, Reichenspurner H, Robbins RC, Schrepfer S
• Localization of Islet-1-positive cells in the healthy and infarcted adult murine heart.
  Circulation research 2012 Weinberger F, Mehrkens D, Friedrich FW, Stubbendorff M, Hua X, Müller JC, Schrepfer S, Evans SM, Carrier L, Eschenhagen T
• Human leukocyte antigen I knockdown human embryonic stem cells induce host ignorance and achieve prolonged xenogeneic survival.
  Circulation 2011 Deuse T, Seifert M, Phillips N, Fire A, Tyan D, Kay M, Tsao PS, Hua X, Velden J, Eiermann T, Volk HD, Reichenspurner H, Robbins RC, Schrepfer S
• Immunobiology of naïve and genetically modified HLA-class-I-knockdown human embryonic stem cells.
  Journal of cell science 2011 Deuse T, Seifert M, Phillips N, Fire A, Tyan D, Kay M, Tsao PS, Hua X, Velden J, Eiermann T, Volk HD, Reichenspurner H, Robbins RC, Schrepfer S
• Assessment of physiologic natural killer cell cytotoxicity in vitro.
  Human immunology 2011 Duske H, Sputtek A, Binder T, Kröger N, Schrepfer S, Eiermann T
• Peptide ligands incorporated into the threefold spike capsid domain to re-direct gene transduction of AAV8 and AAV9 in vivo.
  PloS one 2011 Michelfelder S, Varadi K, Raupp C, Hunger A, Körbelin J, Pahrmann C, Schrepfer S, Müller OJ, Kleinschmidt JA, Trepel M
• Bioluminescence imaging for assessment of immune responses following implantation of engineered heart tissue (EHT).
  Journal of visualized experiments : JoVE 2011 Conradi L, Pahrmann C, Schmidt S, Deuse T, Hansen A, Eder A, Reichenspurner H, Robbins RC, Eschenhagen T, Schrepfer S
• Prevention of transplant coronary artery disease by prenylation inhibitors.
  The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation 2011 Stein W, Schrepfer S, Itoh S, Kimura N, Velotta J, Palmer O, Bartos J, Wang X, Robbins RC, Fischbein MP
• Orthotopic aortic transplantation: a rat model to study the development of chronic vasculopathy.
  Journal of visualized experiments : JoVE 2010 Stubbendorff M, Deuse T, Hammel A, Robbins RC, Reichenspurner H, Schrepfer S
• Immunogenicity and immunomodulatory properties of umbilical cord lining mesenchymal stem cells.
  Cell transplantation 2010 Deuse T, Stubbendorff M, Tang-Quan K, Phillips N, Kay MA, Eiermann T, Phan TT, Volk HD, Reichenspurner H, Robbins RC, Schrepfer S
• Sustained inhibition of epsilon protein kinase C inhibits vascular restenosis after balloon injury and stenting.
  Circulation 2010 Deuse T, Koyanagi T, Erben RG, Hua X, Velden J, Ikeno F, Reichenspurner H, Robbins RC, Mochly-Rosen D, Schrepfer S
• Non-volume-loaded heart provides a more relevant heterotopic transplantation model.
  Transplant immunology 2010 Tang-Quan KR, Bartos J, Deuse T, Churchill E, Schäfer H, Reichenspurner H, Mochly-Rosen D, Robbins RC, Schrepfer S
• Heterotopic and orthotopic tracheal transplantation in mice used as models to study the development of obliterative airway disease.
  Journal of visualized experiments : JoVE 2010 Hua X, Deuse T, Tang-Quan KR, Robbins RC, Reichenspurner H, Schrepfer S
• Mechanisms behind local immunosuppression using inhaled tacrolimus in preclinical models of lung transplantation.
  American journal of respiratory cell and molecular biology 2009 Deuse T, Blankenberg F, Haddad M, Reichenspurner H, Phillips N, Robbins RC, Schrepfer S
• LAD-ligation: a murine model of myocardial infarction.
  Journal of visualized experiments : JoVE 2009 Kolk MV, Meyberg D, Deuse T, Tang-Quan KR, Robbins RC, Reichenspurner H, Schrepfer S
• Poor functional recovery after transplantation of diabetic bone marrow stem cells in ischemic myocardium.
  The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation 2009 Govaert JA, Swijnenburg RJ, Schrepfer S, Xie X, van der Bogt KE, Hoyt G, Stein W, Ransohoff KJ, Robbins RC, Wu JC
• Hepatocyte growth factor or vascular endothelial growth factor gene transfer maximizes mesenchymal stem cell-based myocardial salvage after acute myocardial infarction.
  Circulation 2009 Deuse T, Peter C, Fedak PW, Doyle T, Reichenspurner H, Zimmermann WH, Eschenhagen T, Stein W, Wu JC, Robbins RC, Schrepfer S
• Imaging in-stent restenosis: an inexpensive, reliable, and rapid preclinical model.
  Journal of visualized experiments : JoVE 2009 Deuse T, Ikeno F, Robbins RC, Schrepfer S
• A novel JAK3 inhibitor, R348, attenuates chronic airway allograft rejection.
  Transplantation 2009 Velotta JB, Deuse T, Haddad M, Masuda E, Park G, Carroll D, Taylor V, Robbins RC, Schrepfer S
• Comparison of transplantation of adipose tissue- and bone marrow-derived mesenchymal stem cells in the infarcted heart.
  Transplantation 2009 van der Bogt KE, Schrepfer S, Yu J, Sheikh AY, Hoyt G, Govaert JA, Velotta JB, Contag CH, Robbins RC, Wu JC
• In vivo imaging of embryonic stem cells reveals patterns of survival and immune rejection following transplantation.
  Stem cells and development 2008 Swijnenburg RJ, Schrepfer S, Cao F, Pearl JI, Xie X, Connolly AJ, Robbins RC, Wu JC
• Comparison of different adult stem cell types for treatment of myocardial ischemia.
  Circulation 2008 van der Bogt KE, Sheikh AY, Schrepfer S, Hoyt G, Cao F, Ransohoff KJ, Swijnenburg RJ, Pearl J, Lee A, Fischbein M, Contag CH, Robbins RC, Wu JC
• Immunosuppressive therapy mitigates immunological rejection of human embryonic stem cell xenografts.
  Proceedings of the National Academy of Sciences of the United States of America 2008 Swijnenburg RJ, Schrepfer S, Govaert JA, Cao F, Ransohoff K, Sheikh AY, Haddad M, Connolly AJ, Davis MM, Robbins RC, Wu JC
• Novel immunosuppression: R348, a JAK3- and Syk-inhibitor attenuates acute cardiac allograft rejection.
  Transplantation 2008 Deuse T, Velotta JB, Hoyt G, Govaert JA, Taylor V, Masuda E, Herlaar E, Park G, Carroll D, Pelletier MP, Robbins RC, Schrepfer S
• Prevention and inhibition but not reversion of chronic allograft vasculopathy by FK778.
  Transplantation 2008 Deuse T, Hoyt G, Koyanagi T, Robbins RC, Schrepfer S
• Introducing the first polymer-free leflunomide eluting stent.
  Atherosclerosis 2008 Deuse T, Erben RG, Ikeno F, Behnisch B, Boeger R, Connolly AJ, Reichenspurner H, Bergow C, Pelletier MP, Robbins RC, Schrepfer S
• Inhibition of aldehyde dehydrogenase type 2 attenuates vasodilatory action of nitroglycerin in human veins.
  FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2008 Huellner MW, Schrepfer S, Weyand M, Weiner H, Wimplinger I, Eschenhagen T, Rau T
• Failed induction of heme oxygenase 1 in endothelial cells exposed to the hemoglobin based oxygen carrier Oxyglobin.
  Artificial cells, blood substitutes, and immobilization biotechnology 2008 Rempf C, Ritter A, Schrepfer S, Freitag M, Standl T, Gottschalk A
• Right atrial mass after primary repair of an atrial septal defect: thrombus masquerading as a myxoma.
  The Annals of thoracic surgery 2007 Sheikh AY, Schrepfer S, Stein W, West J, Lombard J, Burdon T, Pinsker B, Pelletier MP
• Techniques for experimental heterotopic and orthotopic tracheal transplantations - When to use which model?
  Transplant immunology 2007 Deuse T, Schrepfer S, Reichenspurner H, Hoyt G, Fischbein MP, Robbins RC, Pelletier MP
• Coincidence of aortic valve stenosis and regurgitation and multiple cardiac papillary fibroelastomas in a young male adult.
  The Journal of thoracic and cardiovascular surgery 2007 Sydow K, Schrepfer S, Franzen O, Detter C, Willems S, Meinertz T, Reichenspurner H
• Simplified protocol to isolate, purify, and culture expand mesenchymal stem cells.
  Stem cells and development 2007 Schrepfer S, Deuse T, Lange C, Katzenberg R, Reichenspurner H, Robbins RC, Pelletier MP
• Experimental orthotopic tracheal transplantation: The Stanford technique.
  Microsurgery 2007 Schrepfer S, Deuse T, Hoyt G, Sheikh AY, Hoffmann J, Reichenspurner H, Robbins RC, Pelletier MP
• FK778 in experimental xenotransplantation: a detailed analysis of drug efficacy.
  The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation 2007 Schrepfer S, Deuse T, Koch-Nolte F, Krieger T, Haddad M, Schäfer H, Pelletier MP, Robbins RC, Reichenspurner H
• Inhibition of restenosis development after mechanical injury: a new field of application for malononitrilamides?
  Cardiology 2006 Schrepfer S, Deuse T, Sultan KR, Haddad M, Böger R, Münzel T, Schäfer H, Pelletier MP, Robbins RC, Reichenspurner H
• The selective estrogen receptor-beta agonist biochanin A shows vasculoprotective effects without uterotrophic activity.
  Menopause (New York, N.Y.) 2006 Schrepfer S, Deuse T, Münzel T, Schäfer H, Braendle W, Reichenspurner H
• Heparins increase endothelial nitric oxide bioavailability by liberating vessel-immobilized myeloperoxidase.
  Circulation 2006 Baldus S, Rudolph V, Roiss M, Ito WD, Rudolph TK, Eiserich JP, Sydow K, Lau D, Szöcs K, Klinke A, Kubala L, Berglund L, Schrepfer S, Deuse T, Haddad M, Risius T, Klemm H, Reichenspurner HC, Meinertz T…
• Sirolimus and FK778: a comparison of two anti-proliferative immunosuppressants for prevention of experimental obliterative airway disease.
  Transplant international : official journal of the European Society for Organ Transplantation 2006 Deuse T, Schrepfer S, Koch-Nolte F, Haddad M, Schäfer H, Detter C, Reichenspurner H
• The phytoestrogen biochaninA weakens acute cardiac allograft rejection without affecting the reproductive system.
  Transplant immunology 2005 Schrepfer S, Deuse T, Schäfer H, Koch-Nolte F, Braendle W, Reichenspurner H
• FK778 and tacrolimus prevent the development of obliterative airway disease after heterotopic rat tracheal transplantation.
  The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation 2005 Deuse T, Schrepfer S, Koch-Nolte F, Haddad M, Schwedhelm E, Böger R, Schäfer H, Detter C, Reichenspurner H
• FK778, a novel immunosuppressive agent, reduces early adhesion molecule up-regulation and prolongs cardiac allograft survival.
  Transplant international : official journal of the European Society for Organ Transplantation 2005 Schrepfer S, Deuse T, Schäfer H, Reichenspurner H
• FK778 attenuates lymphocyte-endothelium interaction after cardiac transplantation: in vivo and in vitro studies.
  Transplantation 2004 Deuse T, Schrepfer S, Schäfer H, Koch-Nolte F, Schwedhelm E, Böger RH, Reichenspurner H
• The interaction between FK778 and tacrolimus in the prevention of rat cardiac allograft rejection is dose dependent.
  Transplantation 2004 Deuse T, Schrepfer S, Reichenspurner H
• Immunosuppression with FK778 and mycophenolate mofetil in a rat cardiac transplantation model.
  Transplantation 2003 Deuse T, Schrepfer S, Reichenspurner H
• Successful resection of a symptomatic right ventricular lipoma.
  The Annals of thoracic surgery 2003 Schrepfer S, Deuse T, Detter C, Treede H, Koops A, Boehm DH, Willems S, Lacour-Gayet F, Reichenspurner H
• New technique for chest opening in mice: U-sternotomy.
  Microsurgery 2003 Schrepfer S, Deuse T, Reichenspurner H
• Myoblasts survive intracardiac transfer and divide further after transplantation.
  The heart surgery forum 2002 Gulbins H, Schrepfer S, Uhlig A, Goldemund A, Oberhoffer M, Reichenspurner H, Meiser B, Reichart B