Sonam Prakash, MD
Professor
Laboratory Medicine
School of Medicine

My clinical work involves signing out bone marrows, lymph nodes, peripheral smears, body fluids and coagulation cases. I have a special interest in myeloproliferative neoplasms, myelodysplastic/myeloproliferative neoplasms and lymphomas.

Education & Training

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• Diversity, Equity, and Inclusion Champion Training University of California 2019
• Fellowship Hematopathology National Cancer Institute 2006
• Fellowship Oncologic Pathology Memorial Sloan-Kettering Cancer Center 2004
• Residency Anatomic/Clinical Pathology Cedars-Sinai Medical Center 2003
• MBBS Lady Hardinge Medical College 1995

Interests

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• myeloproliferative neoplasms
• Lymphoma
• MDS/MPN

Publications (25)

Top publication keywords:
NeoplasmsPrimary MyelofibrosisBone MarrowLymphoma, B-CellMyeloproliferative DisordersPhiladelphia ChromosomeHistiocytesMyelodysplastic-Myeloproliferative DiseasesSpleenPolycythemia VeraLeukemia, Myeloid, AcuteImmunoglobulin DHematopoiesis, ExtramedullaryMyelodysplastic SyndromesSplenectomy

• DeepHeme, a high-performance, generalizable deep ensemble for bone marrow morphometry and hematologic diagnosis.
  Science translational medicine 2025 Sun S, Yin Z, Van Cleave JG, Wang L, Fried B, Bilal KH, Lucas F, S Isgor I, Webb DC, Singi S, Brown L, Shouval R, Lin J, Yan ES, Spector JD, Ardon O, Boiocchi L, Sardana R, Baik J, Zhu M, Syed A, Yabe…
• Diagnostic Approach to Myeloproliferative Neoplasms and Myelodysplastic/Myeloproliferative Neoplasms.
  Advances in anatomic pathology 2025 Prakash S, Orazi A
• Monoclonal Gammopathy of Anemic Significance? Resolution of Pure Red Cell Aplasia With Daratumumab-Based Therapy.
  The American journal of medicine 2024 Khan O, Prakash S, Chung A, Wong SW, Kennedy VE
• An interactive e-learning module on peripheral blood smear analysis is an effective option for teaching pathology trainees.
  American journal of clinical pathology 2023 Moore ME, Courville EL, Prakash S, Brown LE, Beck RC, Qualtieri JN, Siddon AJ, Wake LM
• DeepHeme: A generalizable, bone marrow classifier with hematopathologist-level performance.
  bioRxiv : the preprint server for biology 2023 Goldgof GM, Sun S, Van Cleave J, Wang L, Lucas F, Brown L, Spector JD, Boiocchi L, Baik J, Zhu M, Ardon O, Lu CM, Dogan A, Goldgof DB, Carmichael I, Prakash S, Butte AJ

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• Advances in myelodysplastic/myeloproliferative neoplasms.
  Virchows Archiv : an international journal of pathology 2022 Prakash S, Arber DA, Bueso-Ramos C, Hasserjian RP, Orazi A
• The surfaceome of multiple myeloma cells suggests potential immunotherapeutic strategies and protein markers of drug resistance.
  Nature communications 2022 Ferguson ID, Patiño-Escobar B, Tuomivaara ST, Lin YT, Nix MA, Leung KK, Kasap C, Ramos E, Nieves Vasquez W, Talbot A, Hale M, Naik A, Kishishita A, Choudhry P, Lopez-Girona A, Miao W, Wong SW, Wolf JL…
• Genomic Features of Interstitial Deletions of Chromosome 9q in Acute Myeloid Leukemia.
  Cytogenetic and genome research 2022 Qi Z, Wen KW, Ki A, Prakash S, Kogan S, Yu J
• A case of plasma cell neoplasm-associated chronic neutrophilic leukemia with ASXL1 and JAK2V617F mutations.
  Annals of hematology 2022 Lauw MIS, Hakim N, Arora S, Prakash S, Xie Y
• How I Diagnose Primary Myelofibrosis.
  American journal of clinical pathology 2022 Prakash S, Orazi A
• Distinct pathologic feature of myeloid neoplasm with t(v;11p15); NUP98 rearrangement.
  Human pathology 2022 Lauw MIS, Qi Z, Eversmeyer L, Prakash S, Wen KW, Yu J, Monaghan SA, Aggarwal N, Wang L
• Detection of cryptogenic malignancies from metagenomic whole genome sequencing of body fluids.
  Genome medicine 2021 Gu W, Talevich E, Hsu E, Qi Z, Urisman A, Federman S, Gopez A, Arevalo S, Gottschall M, Liao L, Tung J, Chen L, Lim H, Ho C, Kasowski M, Oak J, Holmes BJ, Yeh I, Yu J, Wang L, Miller S, DeRisi JL, …
• New developments in non-Hodgkin lymphoid malignancies.
  Pathology 2021 Ganapathi KA, Brown LE, Prakash S, Bhargava P
• Entrustable Professional Activities in Hematopathology Pathology Fellowship Training: Consensus Design and Proposal.
  Academic pathology 2021 White K, Qualtieri J, Courville EL, Beck RC, Alobeid B, Czuchlewski DR, Teruya-Feldstein J, Soma LA, Prakash S, Gratzinger D
• Genomic analysis in myeloid sarcoma and comparison with paired acute myeloid leukemia.
  Human pathology 2020 Greenland NY, Van Ziffle JA, Liu YC, Qi Z, Prakash S, Wang L
• B-cell neoplasms and Hodgkin lymphoma in the spleen.
  Seminars in diagnostic pathology 2020 Geyer JT, Prakash S, Orazi A
• Myeloid, mast cell, histiocytic and dendritic cell neoplasms and proliferations involving the spleen.
  Seminars in diagnostic pathology 2020 Prakash S, Padilla O, Tam W
• Molecular and Cytogenetic Education in Hematopathology Fellowship.
  American journal of clinical pathology 2019 Soma LA, Kovach AE, Siddon AJ, Beck R, Gibson SE, Swerdlow SH, Kim AS, Wu D, Jones D, Cook JR, Prakash S, Rosado F, Crane G, Bradley K, Weinberg OK, Sargent RL
• Venetoclax in Combination with Decitabine for Relapsed T-Cell Acute Lymphoblastic Leukemia after Allogeneic Hematopoietic Cell Transplant.
  Case reports in hematology 2018 Rahmat LT, Nguyen A, Abdulhaq H, Prakash S, Logan AC, Mannis GN
• Spleens of myelofibrosis patients contain malignant hematopoietic stem cells.
  The Journal of clinical investigation 2012 Wang X, Prakash S, Lu M, Tripodi J, Ye F, Najfeld V, Li Y, Schwartz M, Weinberg R, Roda P, Orazi A, Hoffman R
• Splenic extramedullary hematopoietic proliferation in Philadelphia chromosome-negative myeloproliferative neoplasms: heterogeneous morphology and cytological composition.
  Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc 2012 Prakash S, Hoffman R, Barouk S, Wang YL, Knowles DM, Orazi A
• The bone marrow stroma in hematological neoplasms--a guilty bystander.
  Nature reviews. Clinical oncology 2011 Tripodo C, Sangaletti S, Piccaluga PP, Prakash S, Franco G, Borrello I, Orazi A, Colombo MP, Pileri SA
• IgD positive L&H cells identify a unique subset of nodular lymphocyte predominant Hodgkin lymphoma.
  The American journal of surgical pathology 2006 Prakash S, Fountaine T, Raffeld M, Jaffe ES, Pittaluga S
• Deep-seated plexiform schwannoma: a pathologic study of 16 cases and comparative analysis with the superficial variety.
  The American journal of surgical pathology 2005 Agaram NP, Prakash S, Antonescu CR
• Comparative immunohistochemical profile of hepatocellular carcinoma, cholangiocarcinoma, and metastatic adenocarcinoma.
  Human pathology 2002 Lau SK, Prakash S, Geller SA, Alsabeh R