Smriti Sangwan, PhD
Specialist
Biochemistry and Biophysics
School of Medicine

Education & Training

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• Ph.D. Molecular Biology University of California, Los Angeles 2017
• M.S. Biomedical Engineering University of California, Los Angeles 2012

Publications (13)

Top publication keywords:
Superoxide Dismutase-1Legionnaires' DiseaseEukaryotic Initiation Factor-2BLegionellaalpha-SynucleinProtein Aggregation, PathologicalSevere Acute Respiratory SyndromeLegionella pneumophilaAmyotrophic Lateral SclerosisGuanine Nucleotide Exchange FactorsCrystallography, X-RayProtein Conformation, beta-StrandMutationProtein AggregatesParkinson Disease

• A helical fulcrum in eIF2B coordinates allosteric regulation of stress signaling.
  Nature chemical biology 2023 Lawrence RE, Shoemaker SR, Deal A, Sangwan S, Anand AA, Wang L, Marqusee S, Walter P
• A Legionella toxin exhibits tRNA mimicry and glycosyl transferase activity to target the translation machinery and trigger a ribotoxic stress response.
  Nature cell biology 2023 Subramanian A, Wang L, Moss T, Voorhies M, Sangwan S, Stevenson E, Pulido EH, Kwok S, Chalkley RJ, Li KH, Krogan NJ, Swaney DL, Burlingame AL, Floor SN, Sil A, Walter P, Mukherjee S
• An ultrapotent synthetic nanobody neutralizes SARS-CoV-2 by stabilizing inactive Spike.
  Science (New York, N.Y.) 2020 Schoof M, Faust B, Saunders RA, Sangwan S, Rezelj V, Hoppe N, Boone M, Billesbølle CB, Puchades C, Azumaya CM, Kratochvil HT, Zimanyi M, Deshpande I, Liang J, Dickinson S, Nguyen HC, Chio CM, Merz GE,…
• Comparative host-coronavirus protein interaction networks reveal pan-viral disease mechanisms.
  Science (New York, N.Y.) 2020 Gordon DE, Hiatt J, Bouhaddou M, Rezelj VV, Ulferts S, Braberg H, Jureka AS, Obernier K, Guo JZ, Batra J, Kaake RM, Weckstein AR, Owens TW, Gupta M, Pourmal S, Titus EW, Cakir M, Soucheray M, McGregor…
• An ultra-potent synthetic nanobody neutralizes SARS-CoV-2 by locking Spike into an inactive conformation.
  bioRxiv : the preprint server for biology 2020 Schoof M, Faust B, Saunders RA, Sangwan S, Rezelj V, Hoppe N, Boone M, Billesbølle CB, Puchades C, Azumaya CM, Kratochvil HT, Zimanyi M, Deshpande I, Liang J, Dickinson S, Nguyen HC, Chio CM, Merz GE,…

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• Inhibition of synucleinopathic seeding by rationally designed inhibitors.
  eLife 2020 Sangwan S, Sahay S, Murray KA, Morgan S, Guenther EL, Jiang L, Williams CK, Vinters HV, Goedert M, Eisenberg DS
• Atomic structures of corkscrew-forming segments of SOD1 reveal varied oligomer conformations.
  Protein science : a publication of the Protein Society 2018 Sangwan S, Sawaya MR, Murray KA, Hughes MP, Eisenberg DS
• Distal amyloid β-protein fragments template amyloid assembly.
  Protein science : a publication of the Protein Society 2018 Do TD, Sangwan S, de Almeida NEC, Ilitchev AI, Giammona M, Sawaya MR, Buratto SK, Eisenberg DS, Bowers MT
• Atomic structure of a toxic, oligomeric segment of SOD1 linked to amyotrophic lateral sclerosis (ALS).
  Proceedings of the National Academy of Sciences of the United States of America 2017 Sangwan S, Zhao A, Adams KL, Jayson CK, Sawaya MR, Guenther EL, Pan AC, Ngo J, Moore DM, Soriaga AB, Do TD, Goldschmidt L, Nelson R, Bowers MT, Koehler CM, Shaw DE, Novitch BG, Eisenberg DS
• Crystal Structures of IAPP Amyloidogenic Segments Reveal a Novel Packing Motif of Out-of-Register Beta Sheets.
  The journal of physical chemistry. B 2016 Soriaga AB, Sangwan S, Macdonald R, Sawaya MR, Eisenberg D
• Perspective on SOD1 mediated toxicity in Amyotrophic Lateral Sclerosis.
  Postepy biochemii 2016 Sangwan S, Eisenberg DS
• Structure of the toxic core of α-synuclein from invisible crystals.
  Nature 2015 Rodriguez JA, Ivanova MI, Sawaya MR, Cascio D, Reyes FE, Shi D, Sangwan S, Guenther EL, Johnson LM, Zhang M, Jiang L, Arbing MA, Nannenga BL, Hattne J, Whitelegge J, Brewster AS, Messerschmidt M, …
• Factors that drive peptide assembly from native to amyloid structures: experimental and theoretical analysis of [leu-5]-enkephalin mutants.
  The journal of physical chemistry. B 2014 Do TD, LaPointe NE, Sangwan S, Teplow DB, Feinstein SC, Sawaya MR, Eisenberg DS, Bowers MT