Smita Patel, PhD
Staff Research Associate IV
Institute for Neurodegenerative Diseases
School of Medicine

Education & Training

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• PhD

Publications (32)

Top publication keywords:
Bacteriophage T7DNA PrimaseViral ProteinsTranscription Elongation, GeneticMutant ProteinsRad51 RecombinaseDNA-Directed RNA PolymerasesPromoter Regions, GeneticDNA, Single-StrandedDNAPrionsHomologous RecombinationViral Nonstructural ProteinsDNA HelicasesRotation

• Expression and Purification of Recombinant Human Mitochondrial RNA Polymerase (POLRMT) and the Initiation Factors TFAM and TFB2M.
  Bio-protocol 2023 Hsieh AH, Reardon SD, Munozvilla-Cabellon JH, Shen J, Patel SS, Mishanina TV
• Kinetics of α-synuclein prions preceding neuropathological inclusions in multiple system atrophy.
  PLoS pathogens 2020 Woerman AL, Patel S, Kazmi SA, Oehler A, Lee J, Mordes DA, Olson SH, Prusiner SB
• Familial Parkinson's point mutation abolishes multiple system atrophy prion replication.
  Proceedings of the National Academy of Sciences of the United States of America 2017 Woerman AL, Kazmi SA, Patel S, Aoyagi A, Oehler A, Widjaja K, Mordes DA, Olson SH, Prusiner SB
• Kinetics of Human Mutant Tau Prion Formation in the Brains of 2 Transgenic Mouse Lines.
  JAMA neurology 2017 Woerman AL, Patel S, Kazmi SA, Oehler A, Freyman Y, Espiritu L, Cotter R, Castaneda JA, Olson SH, Prusiner SB
• Tau prions from Alzheimer's disease and chronic traumatic encephalopathy patients propagate in cultured cells.
  Proceedings of the National Academy of Sciences of the United States of America 2016 Woerman AL, Aoyagi A, Patel S, Kazmi SA, Lobach I, Grinberg LT, McKee AC, Seeley WW, Olson SH, Prusiner SB

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• Guinea Pig Prion Protein Supports Rapid Propagation of Bovine Spongiform Encephalopathy and Variant Creutzfeldt-Jakob Disease Prions.
  Journal of virology 2016 Watts JC, Giles K, Saltzberg DJ, Dugger BN, Patel S, Oehler A, Bhardwaj S, Sali A, Prusiner SB
• Towards authentic transgenic mouse models of heritable PrP prion diseases.
  Acta neuropathologica 2016 Watts JC, Giles K, Bourkas ME, Patel S, Oehler A, Gavidia M, Bhardwaj S, Lee J, Prusiner SB
• Evidence for α-synuclein prions causing multiple system atrophy in humans with parkinsonism.
  Proceedings of the National Academy of Sciences of the United States of America 2015 Prusiner SB, Woerman AL, Mordes DA, Watts JC, Rampersaud R, Berry DB, Patel S, Oehler A, Lowe JK, Kravitz SN, Geschwind DH, Glidden DV, Halliday GM, Middleton LT, Gentleman SM, Grinberg LT, Giles K
• Propagation of prions causing synucleinopathies in cultured cells.
  Proceedings of the National Academy of Sciences of the United States of America 2015 Woerman AL, Stöhr J, Aoyagi A, Rampersaud R, Krejciova Z, Watts JC, Ohyama T, Patel S, Widjaja K, Oehler A, Sanders DW, Diamond MI, Seeley WW, Middleton LT, Gentleman SM, Mordes DA, Südhof TC, Giles K…
• Different 2-Aminothiazole Therapeutics Produce Distinct Patterns of Scrapie Prion Neuropathology in Mouse Brains.
  The Journal of pharmacology and experimental therapeutics 2015 Giles K, Berry DB, Condello C, Hawley RC, Gallardo-Godoy A, Bryant C, Oehler A, Elepano M, Bhardwaj S, Patel S, Silber BM, Guan S, DeArmond SJ, Renslo AR, Prusiner SB
• Finding the right match fast.
  Cell 2015 Nandakumar D, Patel SS
• Evidence that bank vole PrP is a universal acceptor for prions.
  PLoS pathogens 2014 Watts JC, Giles K, Patel S, Oehler A, DeArmond SJ, Prusiner SB
• Relaxed rotational and scrunching changes in P266L mutant of T7 RNA polymerase reduce short abortive RNAs while delaying transition into elongation.
  PloS one 2014 Tang GQ, Nandakumar D, Bandwar RP, Lee KS, Roy R, Ha T, Patel SS
• Switching from single-stranded to double-stranded DNA limits the unwinding processivity of ring-shaped T7 DNA helicase.
  Nucleic acids research 2013 Jeong YJ, Rajagopal V, Patel SS
• Identification of I137M and other mutations that modulate incubation periods for two human prion strains.
  Journal of virology 2012 Giles K, De Nicola GF, Patel S, Glidden DV, Korth C, Oehler A, DeArmond SJ, Prusiner SB
• Spontaneous generation of rapidly transmissible prions in transgenic mice expressing wild-type bank vole prion protein.
  Proceedings of the National Academy of Sciences of the United States of America 2012 Watts JC, Giles K, Stöhr J, Oehler A, Bhardwaj S, Grillo SK, Patel S, DeArmond SJ, Prusiner SB
• Conserved properties of human and bovine prion strains on transmission to guinea pigs.
  Laboratory investigation; a journal of technical methods and pathology 2011 Safar JG, Giles K, Lessard P, Letessier F, Patel S, Serban A, Dearmond SJ, Prusiner SB
• Human prion strain selection in transgenic mice.
  Annals of neurology 2010 Giles K, Glidden DV, Patel S, Korth C, Groth D, Lemus A, DeArmond SJ, Prusiner SB
• Mitochondrial transcription factor Mtf1 traps the unwound non-template strand to facilitate open complex formation.
  The Journal of biological chemistry 2009 Paratkar S, Patel SS
• Single strand binding proteins increase the processivity of DNA unwinding by the hepatitis C virus helicase.
  Journal of molecular biology 2007 Rajagopal V, Patel SS
• Mechanisms of a ring shaped helicase.
  Nucleic acids research 2006 Donmez I, Patel SS
• Sequential release of promoter contacts during transcription initiation to elongation transition.
  Journal of molecular biology 2006 Bandwar RP, Tang GQ, Patel SS
• Rapid binding of T7 RNA polymerase is followed by simultaneous bending and opening of the promoter DNA.
  Biochemistry 2006 Tang GQ, Patel SS
• T7 RNA polymerase-induced bending of promoter DNA is coupled to DNA opening.
  Biochemistry 2006 Tang GQ, Patel SS
• Human but not yeast CHD1 binds directly and selectively to histone H3 methylated at lysine 4 via its tandem chromodomains.
  The Journal of biological chemistry 2005 Sims RJ, Chen CF, Santos-Rosa H, Kouzarides T, Patel SS, Reinberg D
• DNA synthesis provides the driving force to accelerate DNA unwinding by a helicase.
  Nature 2005 Stano NM, Jeong YJ, Donmez I, Tummalapalli P, Levin MK, Patel SS
• A Brownian motor mechanism of translocation and strand separation by hepatitis C virus helicase.
  Nature structural & molecular biology 2005 Levin MK, Gurjar M, Patel SS
• The DNA-unwinding mechanism of the ring helicase of bacteriophage T7.
  Proceedings of the National Academy of Sciences of the United States of America 2004 Jeong YJ, Levin MK, Patel SS
• Fluorescence methods for studying the kinetics and thermodynamics of transcription initiation.
  Methods in enzymology 2003 Patel SS, Bandwar RP
• The energetics of consensus promoter opening by T7 RNA polymerase.
  Journal of molecular biology 2002 Bandwar RP, Patel SS
• T7 DNA helicase: a molecular motor that processively and unidirectionally translocates along single-stranded DNA.
  Journal of molecular biology 2002 Kim DE, Narayan M, Patel SS
• The intercalating beta-hairpin of T7 RNA polymerase plays a role in promoter DNA melting and in stabilizing the melted DNA for efficient RNA synthesis.
  Journal of molecular biology 2002 Stano NM, Patel SS