Simone Sacco, MD
Assistant Researcher
Neurology
School of Medicine

Education & Training

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• DIagnostic Neuroradiology Fellowship University of Toronto 07/2021
• Residency in Diagnostic Radiology University of Pavia 12/2019
• MD Medical school University of Pavia 07/2013

Publications (24)

Top publication keywords:
Imaging, Three-DimensionalDemyelinating DiseasesEncephalitisProton TherapyReflex, Vestibulo-OcularDiffusion Magnetic Resonance ImagingNeuritesMultiple Sclerosis, Relapsing-RemittingMeningeal NeoplasmsMultiple SclerosisMeningiomaCreutzfeldt-Jakob SyndromeMyelin-Oligodendrocyte GlycoproteinOptic ChiasmNeuroimaging

• Synaptic injury in the inner plexiform layer of the retina is associated with progression in multiple sclerosis.
  Cell reports. Medicine 2024 Cordano C, Werneburg S, Abdelhak A, Bennett DJ, Beaudry-Richard A, Duncan GJ, Oertel FC, Boscardin WJ, Yiu HH, Jabassini N, Merritt L, Nocera S, Sin JH, Samana IP, Condor Montes SY, Ananth K, Bischof …
• Susceptibility-based imaging aids accurate distinction of pediatric-onset MS from myelin oligodendrocyte glycoprotein antibody-associated disease.
  Multiple sclerosis (Houndmills, Basingstoke, England) 2023 Sacco S, Virupakshaiah A, Papinutto N, Schoeps VA, Akula A, Zhao H, Arona J, Stern WA, Chong J, Hart J, Zamvil SS, Sati P, Henry RG, Waubant E
• PRNP expression predicts imaging findings in sporadic Creutzfeldt-Jakob disease.
  Annals of clinical and translational neurology 2023 Broce IJ, Caverzasi E, Sacco S, Nillo RM, Paoletti M, Desikan RS, Geschwind M, Sugrue LP
• Differences in Age-related Retinal and Cortical Atrophy Rates in Multiple Sclerosis.
  Neurology 2022 Cordano C, Nourbakhsh B, Yiu HH, Papinutto N, Caverzasi E, Abdelhak A, Oertel FC, Beaudry-Richard A, Santaniello A, Sacco S, Bennett DJ, Gomez A, Sigurdson CJ, Hauser SL, Magliozzi R, Cree BAC, Henry …
• Reply to "Spinal Cord Atrophy Is a Preclinical Marker of Progressive MS".
  Annals of neurology 2022 Bischof A, Papinutto N, Keshavan A, Rajesh A, Kirkish G, Zhang X, Mallott JM, Asteggiano C, Sacco S, Gundel TJ, Zhao C, Stern WA, Caverzasi E, Zhou Y, Gomez R, Ragan NR, Santaniello A, Zhu AH, Juwono …

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• Spinal Cord Atrophy Predicts Progressive Disease in Relapsing Multiple Sclerosis.
  Annals of neurology 2022 Bischof A, Papinutto N, Keshavan A, Rajesh A, Kirkish G, Zhang X, Mallott JM, Asteggiano C, Sacco S, Gundel TJ, Zhao C, Stern WA, Caverzasi E, Zhou Y, Gomez R, Ragan NR, Santaniello A, Zhu AH, Juwono …
• Tractography dissection variability: What happens when 42 groups dissect 14 white matter bundles on the same dataset?
  NeuroImage 2021 Schilling KG, Rheault F, Petit L, Hansen CB, Nath V, Yeh FC, Girard G, Barakovic M, Rafael-Patino J, Yu T, Fischi-Gomez E, Pizzolato M, Ocampo-Pineda M, Schiavi S, Canales-Rodríguez EJ, Daducci A, …
• Junctional Scotoma and Patterns of Visual Field Defects Produced by Lesions Involving the Optic Chiasm.
  Journal of neuro-ophthalmology : the official journal of the North American Neuro-Ophthalmology Society 2021 Donaldson LC, Eshtiaghi A, Sacco S, Micieli JA, Margolin EA
• Cortically constrained shape recognition: Automated white matter tract segmentation validated in the pediatric brain.
  Journal of neuroimaging : official journal of the American Society of Neuroimaging 2021 Jordan KM, Lauricella M, Licata AE, Sacco S, Asteggiano C, Wang C, Sudarsan SP, Watson C, Scheffler AW, Battistella G, Miller ZA, Gorno-Tempini ML, Caverzasi E, Mandelli ML
• Improving the characterization of meningioma microstructure in proton therapy from conventional apparent diffusion coefficient measurements using Monte Carlo simulations of diffusion MRI.
  Medical physics 2021 Buizza G, Paganelli C, Ballati F, Sacco S, Preda L, Iannalfi A, Alexander DC, Baroni G, Palombo M
• Correction: Application of an Adaptive, Digital, Game-Based Approach for Cognitive Assessment in Multiple Sclerosis: Observational Study.
  Journal of medical Internet research 2021 Hsu WY, Rowles W, Anguera JA, Zhao C, Anderson A, Alexander A, Sacco S, Henry R, Gazzaley A, Bove R
• Application of an Adaptive, Digital, Game-Based Approach for Cognitive Assessment in Multiple Sclerosis: Observational Study.
  Journal of medical Internet research 2021 Hsu WY, Rowles W, Anguera JA, Zhao C, Anderson A, Alexander A, Sacco S, Henry R, Gazzaley A, Bove R
• Intravoxel incoherent motion as a tool to detect early microstructural changes in meningiomas treated with proton therapy.
  Neuroradiology 2021 Franconeri A, Sacco S, Raciti MV, Maggi A, Muzic SI, Imparato S, Farina L, Bacila A, Paganelli C, Buizza G, Fontana G, Baroni G, Riva G, Iannalfi A, Orlandi E, Preda L
• Multimodal MRI staging for tracking progression and clinical-imaging correlation in sporadic Creutzfeldt-Jakob disease.
  NeuroImage. Clinical 2020 Sacco S, Paoletti M, Staffaroni AM, Kang H, Rojas J, Marx G, Goh SY, Luisa Mandelli M, Allen IE, Kramer JH, Bastianello S, Henry RG, Rosen HJ, Caverzasi E, Geschwind MD
• Fulminant inflammatory demyelination presenting as stroke-in-evolution in an elderly subject.
  Brain and behavior 2020 Sacco S, Callegari I, Canavero I, Coloberti E, Farina LM, Ravaglia S, Simoncelli A, Pichiecchio A, Micieli G
• Neurite Orientation Dispersion and Density Imaging for Assessing Acute Inflammation and Lesion Evolution in MS.
  AJNR. American journal of neuroradiology 2020 Sacco S, Caverzasi E, Papinutto N, Cordano C, Bischof A, Gundel T, Cheng S, Asteggiano C, Kirkish G, Mallott J, Stern WA, Bastianello S, Bove RM, Gelfand JM, Goodin DS, Green AJ, Waubant E, Wilson MR,…
• A novel in-home digital treatment to improve processing speed in people with multiple sclerosis: A pilot study.
  Multiple sclerosis (Houndmills, Basingstoke, England) 2020 Bove R, Rowles W, Zhao C, Anderson A, Friedman S, Langdon D, Alexander A, Sacco S, Henry R, Gazzaley A, Feinstein A, Anguera JA
• Multi-parametric qualitative and quantitative MRI assessment as predictor of histological grading in previously treated meningiomas.
  Neuroradiology 2020 Sacco S, Ballati F, Gaetani C, Lomoro P, Farina LM, Bacila A, Imparato S, Paganelli C, Buizza G, Iannalfi A, Baroni G, Valvo F, Bastianello S, Preda L
• Silent progression in disease activity-free relapsing multiple sclerosis.
  Annals of neurology 2019 University of California, San Francisco MS-EPIC Team, Cree BAC, Hollenbach JA, Bove R, Kirkish G, Sacco S, Caverzasi E, Bischof A, Gundel T, Zhu AH, Papinutto N, Stern WA, Bevan C, Romeo A, Goodin DS,…
• Neuroimaging in Dementia.
  Seminars in neurology 2017 Staffaroni AM, Elahi FM, McDermott D, Marton K, Karageorgiou E, Sacco S, Paoletti M, Caverzasi E, Hess CP, Rosen HJ, Geschwind MD
• Late-onset Pompe disease: a genetic-radiological correlation on cerebral vascular anomalies.
  Journal of neurology 2017 Pichiecchio A, Sacco S, De Filippi P, Caverzasi E, Ravaglia S, Bastianello S, Danesino C
• Ocular vestibular evoked myogenic potentials in response to air-conducted 500 Hz short tones: Effect of stimulation procedure (monaural or binaural), age and gender.
  Journal of vestibular research : equilibrium & orientation 2015 Versino M, Colnaghi S, Ranzani M, Alloni R, Bolis C, Sacco S, Moglia A, Callieco R
• Reading while moving: the functional assessment of VOR.
  Journal of vestibular research : equilibrium & orientation 2014 Versino M, Colagiorgio P, Sacco S, Colnaghi S, Quaglieri S, Manfrin M, Benazzo M, Moglia A, Ramat S
• Artifact avoidance for head impulse testing.
  Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology 2013 Versino M, Colagiorgio P, Sacco S, Colnaghi S, Ramat S