Simon Chu, MD
RESIDENT PHYSICIAN
Surgery
School of Medicine
Simon N. Chu MD, MS is a General Surgery Resident in the UCSF Department of Surgery. He attended his undergraduate and graduate studies at the University of California, Berkeley in the fields of Public Health and Health and Medical Sciences.
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He completed his medical degree at UCSF in the UC Berkeley-UCSF Joint Medical Program and Program in Medicine for the Urban Underserved and was inducted into the Alpha Omega Alpha society. During his graduate and medical training, he conducted basic science research in virology and immunology, completing a Master's Degree and Howard Hughes Medical Institute Fellowship. He is currently a resident research fellow in the Mackenzie lab studying maternal-fetal tolerance in patients with alpha-thalassemia major who underwent an in-utero stem cell transplant. He is also participating in investigations of novel gene therapies to treat congenital diseases before birth using various genome editing strategies.
Specifically, his current work investigates whether the fetal immune system is responsive against maternal alloantigens after a maternal in utero stem cell transplant. Using an in vitro mixed lymphocyte reaction, proliferative responses in CD4+ and CD8+ fetal T cells are measured after exposure to maternal antigen-presenting cells. In addition to examining alloreactive responses, he is also pursuing high-throughput single cell sequencing to explore the T-cell receptor repertoire in the developing fetal immune system after IUSCT.
Education & Training
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- MS Health and Medical Sciences University of California, Berkeley
- BA Public Health, Infectious Diseases and Vaccinology University of California, Berkeley
- MD Medicine University of California, San Francisco
Interests
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- Solid Organ Transplantation in Persons with HIV
- Abdominal and Thoracic Transplantation
Publications (11)
Top publication keywords:
SemenPharmaceutical PreparationsCircadian ClocksOrgan TransplantationSpecialties, SurgicalSimian Immunodeficiency VirusSeminal Vesicle Secretory ProteinsTh17 CellsHIV-1AmyloidLactobacillusDendritic CellsVirus InternalizationImmunityIndoleamine-Pyrrole 2,3,-Dioxygenase
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Circadian clocks drive rhythmic antitumor immune responses mediated by migratory dendritic cells.
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 2023 Chu SN, Gardner JM -
Discordant Timing of Hypoglycemic Agent Screening Causing Delayed Diagnosis of Sulfonylurea-Induced Hypoglycemia.
AACE clinical case reports 2022 Folick A, Cheng C, Chu SN, Rick JW, Rushakoff RJ -
Everolimus, an mTORC1/2 inhibitor, in ART-suppressed individuals who received solid organ transplantation: A prospective study.
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 2020 Henrich TJ, Schreiner C, Cameron C, Hogan LE, Richardson B, Rutishauser RL, Deitchman AN, Chu S, Rogers R, Thanh C, Gibson EA, Zarinsefat A, Bakkour S, Aweeka F, Busch MP, Liegler T, Baker C, Milush J… -
Teaching in the robotic environment: Use of alternative approaches to guide operative instruction.
American journal of surgery 2019 Green CA, Chu SN, Huang E, Chern H, O'Sullivan P -
Improved Detection of Lung Fluid With Standardized Acoustic Stimulation of the Chest.
IEEE journal of translational engineering in health and medicine 2018 Rao A, Chu S, Batlivala N, Zetumer S, Roy S
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Gut-Resident Lactobacillus Abundance Associates with IDO1 Inhibition and Th17 Dynamics in SIV-Infected Macaques.
Cell reports 2015 Vujkovic-Cvijin I, Swainson LA, Chu SN, Ortiz AM, Santee CA, Petriello A, Dunham RM, Fadrosh DW, Lin DL, Faruqi AA, Huang Y, Apetrei C, Pandrea I, Hecht FM, Pilcher CD, Klatt NR, Brenchley JM, Lynch … -
Liquefaction of semen generates and later degrades a conserved semenogelin peptide that enhances HIV infection.
Journal of virology 2014 Roan NR, Liu H, Usmani SM, Neidleman J, Müller JA, Avila-Herrera A, Gawanbacht A, Zirafi O, Chu S, Dong M, Kumar ST, Smith JF, Pollard KS, Fändrich M, Kirchhoff F, Münch J, Witkowska HE, Greene WC -
Interaction of fibronectin with semen amyloids synergistically enhances HIV infection.
The Journal of infectious diseases 2014 Roan NR, Chu S, Liu H, Neidleman J, Witkowska HE, Greene WC -
Seminal plasma induces global transcriptomic changes associated with cell migration, proliferation and viability in endometrial epithelial cells and stromal fibroblasts.
Human reproduction (Oxford, England) 2014 Chen JC, Johnson BA, Erikson DW, Piltonen TT, Barragan F, Chu S, Kohgadai N, Irwin JC, Greene WC, Giudice LC, Roan NR -
Peptides released by physiological cleavage of semen coagulum proteins form amyloids that enhance HIV infection.
Cell host & microbe 2011 Roan NR, Müller JA, Liu H, Chu S, Arnold F, Stürzel CM, Walther P, Dong M, Witkowska HE, Kirchhoff F, Münch J, Greene WC -
DNA fingerprint analysis of three short tandem repeat (STR) loci for biochemistry and forensic science laboratory courses.
Biochemistry and molecular biology education : a bimonthly publication of the International Union of Biochemistry and Molecular Biology 2006 McNamara-Schroeder K, Olonan C, Chu S, Montoya MC, Alviri M, Ginty S, Love JJ