Shylaja Srinivasan, MD, MAS
Assistant Professor
Pediatrics
School of Medicine

I lead the type 2 diabetes program at the UCSF Madison Clinic for Pediatric Diabetes. I am also an Associate Program Director for the fellowship training program.

• Increased Genetic Risk for β-Cell Failure Is Associated With β-Cell Function Decline in People With Prediabetes.
  Diabetes 2024 Billings LK, Jablonski KA, Pan Q, Florez JC, Franks PW, Goldberg RB, Hivert MF, Kahn SE, Knowler WC, Lee CG, Merino J, Huerta-Chagoya A, Mercader JM, Raghavan S, Shi Z, Srinivasan S, Xu J, Udler MS
• Predictors of weight and waist gain in US South Asians: Findings from the Mediators of Atherosclerosis in South Asians Living in America (MASALA) study.
  Obesity pillars 2024 Seetharaman S, Allen IE, Gadgil M, Srinivasan S, Topor LS, Kanaya AM
• 1304-P: MODY Calculator Overestimates MODY Probability in Multiethnic Cohort with Youth-Onset Type 2 Diabetes Phenotype.
  Diabetes 2024 RAYMOND J. KREIENKAMP, BEVERLEY SHIELDS, TONI I. POLLIN, MUSTAFA TOSUR, AMY S. SHAH, ANGELA D. LIESE, CATHERINE PIHOKER, SHYLAJA SRINIVASAN, ANDREW T. HATTERSLEY, MIRIAM UDLER, MARIA J. REDONDO
• 146-OR: Clustering Pediatric Type 2 Diabetes Patients Exposes Differential Responses to Therapeutic Interventions.
  Diabetes 2024 RAYMOND J. KREIENKAMP, KIRK SMITH, THINLEY Y. WANGDEN, ELIZABETH T. JENSEN, AMY S. SHAH, CATHERINE PIHOKER, LUKASZ SZCZERBINSKI, JOSE C. FLOREZ, MIRIAM UDLER, SHYLAJA SRINIVASAN
• Pubertal Timing Across Asian American, Native Hawaiian, and Pacific Islander Subgroups.
  JAMA network open 2024 Kubo A, Acker J, Aghaee S, Kushi LH, Quesenberry CP, Greenspan LC, Srinivasan S, Kanaya AM, Deardorff J
• Predictors of weight and waist gain in US South Asians: Findings from the Mediators of Atherosclerosis in South Asians Living in America (MASALA) Study.
  Research square 2024 Seetharaman S, Allen I, Gadgil M, Srinivasan S, Topor L, Kanaya A
• Genetic architecture and biology of youth-onset type 2 diabetes.
  Nature metabolism 2024 Kwak SH, Srinivasan S, Chen L, Todd J, Mercader JM, Jensen ET, Divers J, Mottl AK, Pihoker C, Gandica RG, Laffel LM, Isganaitis E, Haymond MW, Levitsky LL, Pollin TI, Florez JC, Flannick J, Progress …
• Re-analysis and meta-analysis of summary statistics from gene-environment interaction studies.
  Bioinformatics (Oxford, England) 2023 Pham DT, Westerman KE, Pan C, Chen L, Srinivasan S, Isganaitis E, Vajravelu ME, Bacha F, Chernausek S, Gubitosi-Klug R, Divers J, Pihoker C, Marcovina SM, Manning AK, Chen H
• A Type 1 Diabetes Polygenic Score Is Not Associated With Prevalent Type 2 Diabetes in Large Population Studies.
  Journal of the Endocrine Society 2023 Srinivasan S, Wu P, Mercader JM, Udler MS, Porneala BC, Bartz TM, Floyd JS, Sitlani C, Guo X, Haessler J, Kooperberg C, Liu J, Ahmad S, van Duijn C, Liu CT, Goodarzi MO, Florez JC, Meigs JB, Rotter JI…
• Current insights and emerging trends in early-onset type 2 diabetes.
  The lancet. Diabetes & endocrinology 2023 Misra S, Ke C, Srinivasan S, Goyal A, Nyriyenda MJ, Florez JC, Khunti K, Magliano DJ, Luk A
• Identification of Genetic Variation Influencing Metformin Response in a Multiancestry Genome-Wide Association Study in the Diabetes Prevention Program (DPP).
  Diabetes 2023 Li JH, Perry JA, Jablonski KA, Srinivasan S, Chen L, Todd JN, Harden M, Mercader JM, Pan Q, Dawed AY, Yee SW, Pearson ER, Giacomini KM, Giri A, Hung AM, Xiao S, Williams LK, Franks PW, Hanson RL, Kahn…
• Greater Improvement in Obesity Among Children With Prediabetes in a Clinical Weight Management Program.
  Childhood obesity (Print) 2023 Tester JM, Xiao L, Chau CA, Tinajero-Deck L, Srinivasan S, Rosas LG
• 1091-P: Genetic Ancestry Influences Metformin Treatment Response in Youth with Type 2 Diabetes.
  Diabetes 2023 SHYLAJA SRINIVASAN, LING CHEN, MEGAN M. KELSEY, JENNIFER TODD, SILVA A. ARSLANIAN, NANCY T. CHANG, LORI M. LAFFEL, LYNNE L. LEVITSKY, JENNIFER E. SPRAGUE, TONI I. POLLIN, ALISA MANNING, JOSE C. FLOREZ
• Initial Insights into the Genetic Variation Associated with Metformin Treatment Failure in Youth with Type 2 Diabetes.
  Pediatric diabetes 2023 Srinivasan S, Chen L, Udler M, Todd J, Kelsey MM, Haymond MW, Arslanian S, Zeitler P, Gubitosi-Klug R, Nadeau KJ, Kutney K, White NH, Li JH, Perry JA, Kaur V, Brenner L, Mercader JM, Dawed A, Pearson …
• Insights from rare variants into the genetic architecture and biology of youth-onset type 2 diabetes.
  Research square 2023 Kwak SH, Srinivasan S, Chen L, Todd J, Mercader J, Jensen E, Divers J, Mottl A, Pihoker C, Gandica R, Laffel L, Isganaitis E, Haymond M, Levitsky L, Pollin T, Florez J, Flannick J
• The power of TOPMed imputation for the discovery of Latino-enriched rare variants associated with type 2 diabetes.
  Diabetologia 2023 Huerta-Chagoya A, Schroeder P, Mandla R, Deutsch AJ, Zhu W, Petty L, Yi X, Cole JB, Udler MS, Dornbos P, Porneala B, DiCorpo D, Liu CT, Li JH, Szczerbinski L, Kaur V, Kim J, Lu Y, Martin A, Eizirik DL…
• Pancreatic autoantibodies in individuals with a clinical diagnosis of type 2 diabetes mellitus.
  Journal of Pediatric Endocrinology and Diabetes 2023 Jeffrey Ernest Ferrell, Michael A. Kohn, Shylaja Srinivasan
• Real-Time Continuous Glucose Monitoring in Adolescents and Young Adults With Type 2 Diabetes Can Improve Quality of Life.
  Journal of diabetes science and technology 2022 Chesser H, Srinivasan S, Puckett C, Gitelman SE, Wong JC
• The Coronavirus Disease 2019 Pandemic is Associated with a Substantial Rise in Frequency and Severity of Presentation of Youth-Onset Type 2 Diabetes.
  The Journal of pediatrics 2022 Magge SN, Wolf RM, Pyle L, Brown EA, Benavides VC, Bianco ME, Chao LC, Cymbaluk A, Balikcioglu PG, Halpin K, Hsia DS, Huerta-Saenz L, Kim JJ, Kumar S, Levitt Katz LE, Marks BE, Neyman A, O'Sullivan KL…
• Rickets in a child with prolonged acquired hypothyroidism secondary to Hashimoto's thyroiditis.
  Endocrinology, diabetes & metabolism case reports 2022 Schulmeister C, Lee J, Perwad F, Long R, Srinivasan S
• The Genetics of Type 2 Diabetes in Youth: Where We Are and the Road Ahead.
  The Journal of pediatrics 2022 Srinivasan S, Todd J
• Genome-wide Association Study of Lipid Traits in Youth With Type 2 Diabetes.
  Journal of the Endocrine Society 2021 Santoro N, Chen L, Todd J, Divers J, Shah AS, Gidding SS, Burke B, Haymond M, Lange L, Marcovina S, Flannick J, Caprio S, Florez JC, Srinivasan S
• Monogenic Diabetes in Youth With Presumed Type 2 Diabetes: Results From the Progress in Diabetes Genetics in Youth (ProDiGY) Collaboration.
  Diabetes care 2021 Todd JN, Kleinberger JW, Zhang H, Srinivasan S, Tollefsen SE, Levitsky LL, Levitt Katz LE, Tryggestad JB, Bacha F, Imperatore G, Lawrence JM, Pihoker C, Divers J, Flannick J, Dabelea D, Florez JC, …
• Adjunctive Therapies to Optimize Closed-loop Glucose Control.
  Journal of diabetes science and technology 2021 Srinivasan S, Ekhlaspour L, Cengiz E
• 23-OR: ADA Presidents’ Select Abstract: Genetic Architecture and Novel Genes Implicated in Youth-Onset Type 2 Diabetes.
  Diabetes 2021 SOO HEON KWAK, SHYLAJA SRINIVASAN, LING CHEN, JENNIFER TODD, ELIZABETH T. JENSEN, JASMIN DIVERS, AMY K. MOTTL, CATHERINE PIHOKER, RACHELLE GANDICA, LORI M. LAFFEL, ELVIRA M. ISGANAITIS, MOREY W. …
• 249-OR: Type 2 Diabetes (T2D) Genetic Clusters for Association with Glycemic Responses to Intervention for Diabetes Prevention.
  Diabetes 2021 LIANA K. BILLINGS, KATHLEEN A. JABLONSKI, PAUL W. FRANKS, RONALD B. GOLDBERG, MARIE-FRANCE HIVERT, STEVEN E. KAHN, WILLIAM C. KNOWLER, CHRISTINE LEE, JORDI MERINO, SRIDHARAN RAGHAVAN, SHYLAJA …
• 28-OR: Identification of Ancestry-Specific Alleles in a Genome-Wide Association Study (GWAS) for Metformin (MET) Response in the Diabetes Prevention Program (DPP).
  Diabetes 2021 JOSEPHINE H. LI, JAMES A. PERRY, KATHLEEN A. JABLONSKI, LING CHEN, SHYLAJA SRINIVASAN, JENNIFER N. TODD, MAEGAN HARDEN, JOSEP M. MERCADER, PAUL W. FRANKS, ROBERT L. HANSON, STEVEN E. KAHN, WILLIAM C. …
• 900-P: Continuous Glucose Monitoring in Youth with Type 2 Diabetes: A Pilot and Feasibility Study.
  Diabetes 2021 HANNAH CHESSER, SHYLAJA SRINIVASAN, JENISE C. WONG
• The First Genome-Wide Association Study for Type 2 Diabetes in Youth: The Progress in Diabetes Genetics in Youth (ProDiGY) Consortium.
  Diabetes 2021 Srinivasan S, Chen L, Todd J, Divers J, Gidding S, Chernausek S, Gubitosi-Klug RA, Kelsey MM, Shah R, Black MH, Wagenknecht LE, Manning A, Flannick J, Imperatore G, Mercader JM, Dabelea D, Florez JC, …
• Overview and Initial Management of Type 2 Diabetes in Youth.
  2020 Hannah Chesser, Shylaja Srinivasan
• A Polygenic Lipodystrophy Genetic Risk Score Characterizes Risk Independent of BMI in the Diabetes Prevention Program.
  Journal of the Endocrine Society 2019 Srinivasan S, Jablonski KA, Knowler WC, Dagogo-Jack S, E Kahn S, Boyko EJ, Bray GA, Horton ES, Hivert MF, Goldberg R, Chen L, Mercader J, Harden M, Florez JC, Diabetes Prevention Program Research …
• 177-OR: Genome-Wide Association Study of Lipid Traits in Youth with Type 2 Diabetes: The ProDiGY (Progress in Diabetes Genetics in Youth) Consortium.
  Diabetes 2019 LING CHEN, SHYLAJA SRINIVASAN, NICOLA SANTORO, JENNIFER TODD, JASMIN DIVERS, AMY SANGHAVI SHAH, SAMUEL GIDDING, BRIAN K. BURKE, MOREY W. HAYMOND, LESLIE LANGE, SANTICA M. MARCOVINA, ALAN CHAIT, JASON …
• MON-268 A Rare Case of Primary Hypoaldosteronism in a Newborn.
  Journal of the Endocrine Society 2019 Armaiti Mody, Janet Lee, Jessica Tenney, Shylaja Srinivasan
• A Comprehensive Type 1 Diabetes Genetic Risk Score Is Associated with Type 2 Diabetes in the Framingham Heart Study.
  Diabetes 2018 SHYLAJA SRINIVASAN, AARON LEONG, MIRIAM UDLER, BIANCA C. PORNEALA, JAMES B. MEIGS, STEPHEN S. RICH, JOSEE DUPUIS
• Advances in the Genetics of Youth-Onset Type 2 Diabetes.
  Current diabetes reports 2018 Todd JN, Srinivasan S, Pollin TI
• Pharmacogenetics of Antidiabetic Drugs.
  Advances in pharmacology (San Diego, Calif.) 2018 Srinivasan S, Yee SW, Giacomini KM
• Monogenic Diabetes in the Progress for Diabetes Genetics in Youth (ProDiGY) Collaboration.
  Diabetes 2018 JENNIFER TODD, JEFFREY W. KLEINBERGER, SHYLAJA SRINIVASAN, SHERIDA E. TOLLEFSEN, LYNNE L. LEVITSKY, LORRAINE E.L. KATZ, JEANIE B. TRYGGESTAD, FIDA BACHA, GIUSEPPINA IMPERATORE, JEAN M. LAWRENCE, …
• The First Genome-Wide Association Study (GWAS) for Type 2 Diabetes in Youth from the Progress in Diabetes Genetics in Youth (ProDiGY) Collaboration.
  Diabetes 2018 SHYLAJA SRINIVASAN, JENNIFER TODD, LING CHEN, JASMIN DIVERS, SAM GIDDING, STEVEN CHERNAUSEK, ROSE GUBITOSI-KLUG, MEGAN M. KELSEY, RACHANA SHAH, MARY HELEN BLACK, LYNNE E. WAGENKNECHT, JOSE M. MERCADER…
• TCF7L2 Genetic Variation Augments Incretin Resistance and Influences Response to a Sulfonylurea and Metformin: The Study to Understand the Genetics of the Acute Response to Metformin and Glipizide in Humans (SUGAR-MGH).
  Diabetes care 2018 Srinivasan S, Kaur V, Chamarthi B, Littleton KR, Chen L, Manning AK, Merino J, Thomas MK, Hudson M, Goldfine A, Florez JC
• In Advances in Pharmacology, Elsevier
  The Pharmacogenetics of Anti-Diabetic Drugs 2018 Srinivasan S., Yee SW., Giacomini K
• Radovick and Misra’s Pediatric Endocrinology: A Practical Clinical Guide, Springer International
  Type 2 diabetes in youth 2018 Srinivasan S., Levitsky L
• Type 2 Diabetes Mellitus in Youth.
  Pediatric Endocrinology 2018 Shylaja Srinivasan, Lynne L. Levitsky
• Calcium and Vitamin D Supplement Prescribing Practices among Providers Caring for Children with Autism Spectrum Disorders: Are We Addressing Bone Health?
  Autism research and treatment 2016 Srinivasan S, O'Rourke J, Bersche Golas S, Neumeyer A, Misra M
• Therapeutic Challenges in Diabetes Prevention: We Have Not Found the "Exercise Pill".
  Clinical pharmacology and therapeutics 2015 Srinivasan S, Florez JC
• Hyperthyroidism in Children.
  Pediatrics in Review 2015 Shylaja Srinivasan, Madhusmita Misra
• Hyperthyroidism in children.
  Pediatrics in review 2015 Srinivasan S, Misra M
• Comparison of bone age readings by pediatric endocrinologists and pediatric radiologists using two bone age atlases.
  Pediatric radiology 2010 Kaplowitz P, Srinivasan S, He J, McCarter R, Hayeri MR, Sze R