Shylaja Srinivasan, MD, MAS
Associate Professor
Pediatrics
School of Medicine

I lead the Progress in Diabetes Genetics in Youth (ProDiGY) study group, a genetics consortium that studies the genetics of type 2 diabetes and related traits in youth. I am also the PI at UCSF for the national multicenter DISCOVERY of Risk Factors for Type 2 Diabetes in Youth Study in addition to other NIH and industry sponsored studies. Clinically, I direct the type 2 diabetes program at the UCSF Madison Clinic for Pediatric Diabetes. I am also a Co-Program Director for the pediatric endocrinology fellowship training program.

• Type 2 Diabetes Mellitus in Youth.
  Pediatric Endocrinology 2024 Shylaja Srinivasan, Lynne L. Levitsky
• Desmopressin dosing in children using real-world data and pharmacokinetic/pharmacodynamic model simulations.
  Pediatric research 2024 Yen K, Hughes E, Savic R, Srinivasan S
• Measuring Up: Do Pediatric Endocrinology Fellows' Career Expectations Align with Workforce Reality?
  The Journal of pediatrics 2024 Nahata L, Srinivasan S, Roche CI, Leavens KF, Kim MS, Levenson A, Topor LS, Singer K, McCormack S
• Polygenic risk for obesity and body dissatisfaction: beyond BMI.
  Pediatric research 2024 Jeter KM, Srinivasan S, Tryggestad JB
• Increased Genetic Risk for β-Cell Failure Is Associated With β-Cell Function Decline in People With Prediabetes.
  Diabetes 2024 Billings LK, Jablonski KA, Pan Q, Florez JC, Franks PW, Goldberg RB, Hivert MF, Kahn SE, Knowler WC, Lee CG, Merino J, Huerta-Chagoya A, Mercader JM, Raghavan S, Shi Z, Srinivasan S, Xu J, Udler MS
• Predictors of weight and waist gain in US South Asians: Findings from the Mediators of Atherosclerosis in South Asians Living in America (MASALA) study.
  Obesity pillars 2024 Seetharaman S, Allen IE, Gadgil M, Srinivasan S, Topor LS, Kanaya AM
• Pubertal Timing Across Asian American, Native Hawaiian, and Pacific Islander Subgroups.
  JAMA network open 2024 Kubo A, Acker J, Aghaee S, Kushi LH, Quesenberry CP, Greenspan LC, Srinivasan S, Kanaya AM, Deardorff J
• Predictors of weight and waist gain in US South Asians: Findings from the Mediators of Atherosclerosis in South Asians Living in America (MASALA) Study.
  Research square 2024 Seetharaman S, Allen I, Gadgil M, Srinivasan S, Topor L, Kanaya A
• Genetic architecture and biology of youth-onset type 2 diabetes.
  Nature metabolism 2024 Kwak SH, Srinivasan S, Chen L, Todd J, Mercader JM, Jensen ET, Divers J, Mottl AK, Pihoker C, Gandica RG, Laffel LM, Isganaitis E, Haymond MW, Levitsky LL, Pollin TI, Florez JC, Flannick J, Progress …
• Re-analysis and meta-analysis of summary statistics from gene-environment interaction studies.
  Bioinformatics (Oxford, England) 2023 Pham DT, Westerman KE, Pan C, Chen L, Srinivasan S, Isganaitis E, Vajravelu ME, Bacha F, Chernausek S, Gubitosi-Klug R, Divers J, Pihoker C, Marcovina SM, Manning AK, Chen H
• A Type 1 Diabetes Polygenic Score Is Not Associated With Prevalent Type 2 Diabetes in Large Population Studies.
  Journal of the Endocrine Society 2023 Srinivasan S, Wu P, Mercader JM, Udler MS, Porneala BC, Bartz TM, Floyd JS, Sitlani C, Guo X, Haessler J, Kooperberg C, Liu J, Ahmad S, van Duijn C, Liu CT, Goodarzi MO, Florez JC, Meigs JB, Rotter JI…
• Current insights and emerging trends in early-onset type 2 diabetes.
  The lancet. Diabetes & endocrinology 2023 Misra S, Ke C, Srinivasan S, Goyal A, Nyriyenda MJ, Florez JC, Khunti K, Magliano DJ, Luk A
• Identification of Genetic Variation Influencing Metformin Response in a Multiancestry Genome-Wide Association Study in the Diabetes Prevention Program (DPP).
  Diabetes 2023 Li JH, Perry JA, Jablonski KA, Srinivasan S, Chen L, Todd JN, Harden M, Mercader JM, Pan Q, Dawed AY, Yee SW, Pearson ER, Giacomini KM, Giri A, Hung AM, Xiao S, Williams LK, Franks PW, Hanson RL, Kahn…
• Greater Improvement in Obesity Among Children With Prediabetes in a Clinical Weight Management Program.
  Childhood obesity (Print) 2023 Tester JM, Xiao L, Chau CA, Tinajero-Deck L, Srinivasan S, Rosas LG
• Initial Insights into the Genetic Variation Associated with Metformin Treatment Failure in Youth with Type 2 Diabetes.
  Pediatric diabetes 2023 Srinivasan S, Chen L, Udler M, Todd J, Kelsey MM, Haymond MW, Arslanian S, Zeitler P, Gubitosi-Klug R, Nadeau KJ, Kutney K, White NH, Li JH, Perry JA, Kaur V, Brenner L, Mercader JM, Dawed A, Pearson …
• Insights from rare variants into the genetic architecture and biology of youth-onset type 2 diabetes.
  Research square 2023 Kwak SH, Srinivasan S, Chen L, Todd J, Mercader J, Jensen E, Divers J, Mottl A, Pihoker C, Gandica R, Laffel L, Isganaitis E, Haymond M, Levitsky L, Pollin T, Florez J, Flannick J
• The power of TOPMed imputation for the discovery of Latino-enriched rare variants associated with type 2 diabetes.
  Diabetologia 2023 Huerta-Chagoya A, Schroeder P, Mandla R, Deutsch AJ, Zhu W, Petty L, Yi X, Cole JB, Udler MS, Dornbos P, Porneala B, DiCorpo D, Liu CT, Li JH, Szczerbinski L, Kaur V, Kim J, Lu Y, Martin A, Eizirik DL…
• Pancreatic autoantibodies in individuals with a clinical diagnosis of type 2 diabetes mellitus.
  Journal of Pediatric Endocrinology and Diabetes 2023 Jeffrey Ernest Ferrell, Michael A. Kohn, Shylaja Srinivasan
• Real-Time Continuous Glucose Monitoring in Adolescents and Young Adults With Type 2 Diabetes Can Improve Quality of Life.
  Journal of diabetes science and technology 2022 Chesser H, Srinivasan S, Puckett C, Gitelman SE, Wong JC
• The Coronavirus Disease 2019 Pandemic is Associated with a Substantial Rise in Frequency and Severity of Presentation of Youth-Onset Type 2 Diabetes.
  The Journal of pediatrics 2022 Magge SN, Wolf RM, Pyle L, Brown EA, Benavides VC, Bianco ME, Chao LC, Cymbaluk A, Balikcioglu PG, Halpin K, Hsia DS, Huerta-Saenz L, Kim JJ, Kumar S, Levitt Katz LE, Marks BE, Neyman A, O'Sullivan KL…
• Rickets in a child with prolonged acquired hypothyroidism secondary to Hashimoto's thyroiditis.
  Endocrinology, diabetes & metabolism case reports 2022 Schulmeister C, Lee J, Perwad F, Long R, Srinivasan S
• The Genetics of Type 2 Diabetes in Youth: Where We Are and the Road Ahead.
  The Journal of pediatrics 2022 Srinivasan S, Todd J
• Genome-wide Association Study of Lipid Traits in Youth With Type 2 Diabetes.
  Journal of the Endocrine Society 2021 Santoro N, Chen L, Todd J, Divers J, Shah AS, Gidding SS, Burke B, Haymond M, Lange L, Marcovina S, Flannick J, Caprio S, Florez JC, Srinivasan S
• Monogenic Diabetes in Youth With Presumed Type 2 Diabetes: Results From the Progress in Diabetes Genetics in Youth (ProDiGY) Collaboration.
  Diabetes care 2021 Todd JN, Kleinberger JW, Zhang H, Srinivasan S, Tollefsen SE, Levitsky LL, Levitt Katz LE, Tryggestad JB, Bacha F, Imperatore G, Lawrence JM, Pihoker C, Divers J, Flannick J, Dabelea D, Florez JC, …
• Adjunctive Therapies to Optimize Closed-loop Glucose Control.
  Journal of diabetes science and technology 2021 Srinivasan S, Ekhlaspour L, Cengiz E
• The First Genome-Wide Association Study for Type 2 Diabetes in Youth: The Progress in Diabetes Genetics in Youth (ProDiGY) Consortium.
  Diabetes 2021 Srinivasan S, Chen L, Todd J, Divers J, Gidding S, Chernausek S, Gubitosi-Klug RA, Kelsey MM, Shah R, Black MH, Wagenknecht LE, Manning A, Flannick J, Imperatore G, Mercader JM, Dabelea D, Florez JC, …
• Overview and Initial Management of Type 2 Diabetes in Youth.
  2020 Hannah Chesser, Shylaja Srinivasan
• A Polygenic Lipodystrophy Genetic Risk Score Characterizes Risk Independent of BMI in the Diabetes Prevention Program.
  Journal of the Endocrine Society 2019 Srinivasan S, Jablonski KA, Knowler WC, Dagogo-Jack S, E Kahn S, Boyko EJ, Bray GA, Horton ES, Hivert MF, Goldberg R, Chen L, Mercader J, Harden M, Florez JC, Diabetes Prevention Program Research …
• Advances in the Genetics of Youth-Onset Type 2 Diabetes.
  Current diabetes reports 2018 Todd JN, Srinivasan S, Pollin TI
• Pharmacogenetics of Antidiabetic Drugs.
  Advances in pharmacology (San Diego, Calif.) 2018 Srinivasan S, Yee SW, Giacomini KM
• TCF7L2 Genetic Variation Augments Incretin Resistance and Influences Response to a Sulfonylurea and Metformin: The Study to Understand the Genetics of the Acute Response to Metformin and Glipizide in Humans (SUGAR-MGH).
  Diabetes care 2018 Srinivasan S, Kaur V, Chamarthi B, Littleton KR, Chen L, Manning AK, Merino J, Thomas MK, Hudson M, Goldfine A, Florez JC
• In Advances in Pharmacology, Elsevier
  The Pharmacogenetics of Anti-Diabetic Drugs 2018 Srinivasan S., Yee SW., Giacomini K
• Radovick and Misra’s Pediatric Endocrinology: A Practical Clinical Guide, Springer International
  Type 2 diabetes in youth 2018 Srinivasan S., Levitsky L
• Type 2 Diabetes Mellitus in Youth.
  Pediatric Endocrinology 2018 Shylaja Srinivasan, Lynne L. Levitsky
• Calcium and Vitamin D Supplement Prescribing Practices among Providers Caring for Children with Autism Spectrum Disorders: Are We Addressing Bone Health?
  Autism research and treatment 2016 Srinivasan S, O'Rourke J, Bersche Golas S, Neumeyer A, Misra M
• Therapeutic Challenges in Diabetes Prevention: We Have Not Found the "Exercise Pill".
  Clinical pharmacology and therapeutics 2015 Srinivasan S, Florez JC
• Hyperthyroidism in children.
  Pediatrics in review 2015 Srinivasan S, Misra M
• Comparison of bone age readings by pediatric endocrinologists and pediatric radiologists using two bone age atlases.
  Pediatric radiology 2010 Kaplowitz P, Srinivasan S, He J, McCarter R, Hayeri MR, Sze R