Shomyseh Sanjabi, PhD
Associate Professor
Microbiology and Immunology
School of Medicine

Education & Training

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• Postdoctoral Immunobiology Yale University 2010
• PhD Microbiology, Immunology, and Molecular Genetics University of California, Los Angeles 2003
• BS Microbiology and Molecular Genetics University of California, Los Angeles 1997

Interests

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• Tumor immunity

Websites

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• LinkedIn (linkedin.com)
• Posts on X shomyseh (X.com)

Grants and Projects

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• Characterizing HIV latent reservoir in vivo, NIH, 2013-2018

Publications (49)

Top publication keywords:
Lymphocytic choriomeningitis virusCD8-Positive T-LymphocytesZika Virus InfectionCD4-Positive T-LymphocytesLymphoid TissueArenaviridae InfectionsInterleukin-15Integrin alpha ChainsTransforming Growth Factor betaZika VirusT-Lymphocytes, RegulatoryGastrointestinal TractGenitalia, FemaleLymphocyte ActivationVagina

• Low expression of RNA sensors impacts Zika virus infection in the lower female reproductive tract.
  Nature communications 2019 Khan S, Lew I, Wu F, Fritts L, Fontaine KA, Tomar S, Trapecar M, Shehata HM, Ott M, Miller CJ, Sanjabi S
• Lack of Sprouty 1 and 2 enhances survival of effector CD8+ T cells and yields more protective memory cells.
  Proceedings of the National Academy of Sciences of the United States of America 2018 Shehata HM, Khan S, Chen E, Fields PE, Flavell RA, Sanjabi S
• B cells are the predominant mediators of early systemic viral dissemination during rectal LCMV infection.
  Mucosal immunology 2018 Trapecar M, Khan S, Cohn BL, Wu F, Sanjabi S
• An Optimized and Validated Method for Isolation and Characterization of Lymphocytes from HIV+ Human Gut Biopsies.
  AIDS research and human retroviruses 2017 Trapecar M, Khan S, Roan NR, Chen TH, Telwatte S, Deswal M, Pao M, Somsouk M, Deeks SG, Hunt PW, Yukl S, Sanjabi S
• Sugar or Fat?-Metabolic Requirements for Immunity to Viral Infections.
  Frontiers in immunology 2017 Shehata HM, Murphy AJ, Lee MKS, Gardiner CM, Crowe SM, Sanjabi S, Finlay DK, Palmer CS
• Development of Inflammatory Bowel Disease Is Linked to a Longitudinal Restructuring of the Gut Metagenome in Mice.
  mSystems 2017 Sharpton T, Lyalina S, Luong J, Pham J, Deal EM, Armour C, Gaulke C, Sanjabi S, Pollard KS
• Dampened antiviral immunity to intravaginal exposure to RNA viral pathogens allows enhanced viral replication.
  The Journal of experimental medicine 2016 Khan S, Woodruff EM, Trapecar M, Fontaine KA, Ezaki A, Borbet TC, Ott M, Sanjabi S
• Opposing effects of TGF-beta and IL-15 cytokines control the number of short-lived effector CD8+ T cells.
  Immunity 2009 Sanjabi S, Mosaheb MM, Flavell RA
• Transforming growth factor-beta controls development, homeostasis, and tolerance of T cells by regulatory T cell-dependent and -independent mechanisms.
  Immunity 2006 Li MO, Sanjabi S, Flavell RA

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• Effectorless Fc-fusion improves FLT3L drug-like properties for cancer immunotherapy combinations.
  EBioMedicine 2025 Decalf J, Toy E, He D, Kenkre R, Berkley AM, Wong D, Kwong M, Kee YS, Sun Y, Myneni S, Wang X, Ebtikar A, Ancheta A, Yang Y, Kim HS, Tang N, Banerji D, Mai E, Dogra P, McLerie M, Gutierrez AG, …
• Abstract CT075: Phase 1a/1b dose-escalation study of efbalropendekin alfa (XmAb24306) as single-agent and with atezolizumab in solid tumors.
  Cancer Research 2025 Ben Tran, Anna Spreafico, Daan G. Knapen, Do-Youn Oh, Erika Hamilton, Bridget P. Keenan, Saad A. Khan, Patricia LoRusso, Marwan Fakih, Michael Gordon, Jing Jing, Yanqiu Liu, Patrick Holder, Pranay …
• Different PD-L1 Assays Reveal Distinct Immunobiology and Clinical Outcomes in Urothelial Cancer.
  Cancer immunology research 2025 Galsky MD, Kockx M, Roels J, Van Elzen R, Guan X, Yuen K, Rishipathak D, Anker JF, Gnjatic S, Izadmehr S, Sanjabi S, Johnston RJ, Peterson M, Koeppen H, David JM, Gupta S, Bamias A, Arranz JA, Kikuchi…
• Immune Monitoring during Cancer Immunotherapy.
  Manual of Molecular and Clinical Laboratory Immunology 2024 Hesham M. Shehata, Pranay Dogra, Shomyseh Sanjabi
• Translational PK/PD and the first-in-human dose selection of a PD1/IL15: an engineered recombinant targeted cytokine for cancer immunotherapy.
  Frontiers in pharmacology 2024 Yadav R, Schubbert S, Holder PG, Chiang EY, Kiabi N, Bogaert L, Leung I, Rashid R, Avery KN, Bonzon C, Desjarlais JR, Sanjabi S, Sharma A, Lepherd M, Shelton A, Chan P, Liu Y, Joslyn L, Hosseini I, …
• Efbalropendekin Alfa enhances human natural killer cell cytotoxicity against tumor cell lines in vitro.
  Frontiers in immunology 2024 Shehata HM, Dogra P, Gierke S, Holder P, Sanjabi S
• Immunomodulatory effects and improved outcomes with cisplatin- versus carboplatin-based chemotherapy plus atezolizumab in urothelial cancer.
  Cell reports. Medicine 2024 Galsky MD, Guan X, Rishipathak D, Rapaport AS, Shehata HM, Banchereau R, Yuen K, Varfolomeev E, Hu R, Han CJ, Li H, Liang Y, Vucic D, Wang L, Zhu J, Yu H, Herbst RH, Hajaj E, Kiner E, Bamias A, De …
• Combined PD-L1/TGFβ blockade allows expansion and differentiation of stem cell-like CD8 T cells in immune excluded tumors.
  Nature communications 2023 Castiglioni A, Yang Y, Williams K, Gogineni A, Lane RS, Wang AW, Shyer JA, Zhang Z, Mittman S, Gutierrez A, Astarita JL, Thai M, Hung J, Yang YA, Pourmohamad T, Himmels P, De Simone M, Elstrott J, …
• Complex PK-PD of an engineered IL-15/IL-15Rα-Fc fusion protein in cynomolgus monkeys: QSP modeling of lymphocyte dynamics.
  European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 2023 Lu D, Yadav R, Holder P, Chiang E, Sanjabi S, Poon V, Bernett M, Varma R, Liu K, Leung I, Bogaert L, Desjarlais J, Shivva V, Hosseini I, Ramanujan S
• Single-cell analysis reveals clonally expanded tumor-associated CD57+ CD8 T cells are enriched in the periphery of patients with metastatic urothelial cancer responding to PD-L1 blockade.
  Journal for immunotherapy of cancer 2022 Fehlings M, Kim L, Guan X, Yuen K, Tafazzol A, Sanjabi S, Zill OA, Rishipathak D, Wallace A, Nardin A, Ma S, Milojkovic A, Newell EW, Mariathasan S, Yadav M
• Single cell genome sequencing of laboratory mouse microbiota improves taxonomic and functional resolution of this model microbial community.
  PloS one 2022 Lyalina S, Stepanauskas R, Wu F, Sanjabi S, Pollard KS
• Expert Roundtable: leveraging cutting edge tools to convert I-O data into knowledge.
  Immuno Oncology Insights 2021 Anil K Sood, Sandhya Prabhakaran, Gregory Goldmacher, Shomyseh Sanjabi
• Molecular determinants of response to PD-L1 blockade across tumor types.
  Nature communications 2021 Banchereau R, Leng N, Zill O, Sokol E, Liu G, Pavlick D, Maund S, Liu LF, Kadel E, Baldwin N, Jhunjhunwala S, Nickles D, Assaf ZJ, Bower D, Patil N, McCleland M, Shames D, Molinero L, Huseni M, …
• New cytometry tools for immune monitoring during cancer immunotherapy.
  Cytometry. Part B, Clinical cytometry 2021 Sanjabi S, Lear S
• Shared Mechanisms Govern HIV Transcriptional Suppression in Circulating CD103+ and Gut CD4+ T Cells.
  Journal of virology 2020 Yukl SA, Khan S, Chen TH, Trapecar M, Wu F, Xie G, Telwatte S, Fulop D, Pico AR, Laird GM, Ritter KD, Jones NG, Lu CM, Siliciano RF, Roan NR, Milush JM, Somsouk M, Deeks SG, Hunt PW, Sanjabi S
• miR-15/16 Restrain Memory T Cell Differentiation, Cell Cycle, and Survival.
  Cell reports 2019 Gagnon JD, Kageyama R, Shehata HM, Fassett MS, Mar DJ, Wigton EJ, Johansson K, Litterman AJ, Odorizzi P, Simeonov D, Laidlaw BJ, Panduro M, Patel S, Jeker LT, Feeney ME, McManus MT, Marson A, …
• Increased HIV-1 transcriptional activity and infectious burden in peripheral blood and gut-associated CD4+ T cells expressing CD30.
  PLoS pathogens 2018 Hogan LE, Vasquez J, Hobbs KS, Hanhauser E, Aguilar-Rodriguez B, Hussien R, Thanh C, Gibson EA, Carvidi AB, Smith LCB, Khan S, Trapecar M, Sanjabi S, Somsouk M, Stoddart CA, Kuritzkes DR, Deeks SG, …
• Differentiating Immune Cell Targets in Gut-Associated Lymphoid Tissue for HIV Cure.
  AIDS research and human retroviruses 2017 Khan S, Telwatte S, Trapecar M, Yukl S, Sanjabi S
• Regulation of the Immune Response by TGF-β: From Conception to Autoimmunity and Infection.
  Cold Spring Harbor perspectives in biology 2017 Sanjabi S, Oh SA, Li MO
• Delay in CD8 T-cell priming impairs viral control after vaginal LCMV transmission.
  The Journal of Immunology 2016 Shahzada Khan, Erik M. Woodruff, Martin Trapecar, Shomyseh Sanjabi
• Generation of colonic T-cell mediated protective immunity after rectal infection with LCMV.
  The Journal of Immunology 2016 Martin Trapecar, Benjamin Cohen, Shahzada Khan, Erik Woodruff, Julie Luong, Shomyseh Sanjabi
• 127 Role of TGF-beta signaling in circulating and tissue resident memory CD8+ T cells.
  Cytokine 2013 Harumichi Ishigame, Shomyseh Sanjabi, Richard A. Flavell
• 128 Truncated form of transforming growth factor-ß receptor II, but not its absence, induces memory CD8+ T cell expansion and lymphoproliferative disorder in mice.
  Cytokine 2013 Harumichi Ishigame, Munir M. Mosaheb, Shomyseh Sanjabi, Richard A. Flavell
• 54 Role of transforming growth factor-beta signaling in CD8+ T cells in mucosal anti-viral immune responses.
  Cytokine 2013 Benjamin L. Cohn, Joey Pham, Shomyseh Sanjabi
• Truncated form of TGF-βRII, but not its absence, induces memory CD8+ T cell expansion and lymphoproliferative disorder in mice.
  Journal of immunology (Baltimore, Md. : 1950) 2013 Ishigame H, Mosaheb MM, Sanjabi S, Flavell RA
• Excessive Th1 responses due to the absence of TGF-β signaling cause autoimmune diabetes and dysregulated Treg cell homeostasis.
  Proceedings of the National Academy of Sciences of the United States of America 2013 Ishigame H, Zenewicz LA, Sanjabi S, Licona-Limón P, Nakayama M, Leonard WJ, Flavell RA
• The interplay between TGFß and c?c cytokine signaling in CD8+ T cell biology (46.19).
  The Journal of Immunology 2011 Shomyseh Sanjabi, Joey Pham, Munir Mosaheb, Harumichi Ishigame, Richard Flavell
• The polarization of immune cells in the tumour environment by TGFbeta.
  Nature reviews. Immunology 2010 Flavell RA, Sanjabi S, Wrzesinski SH, Licona-Limón P
• Interaction between TGFbeta and the common gamma chain cytokines during an inflammatory immune response.
  Cell cycle (Georgetown, Tex.) 2010 Sanjabi S, Flavell RA
• Overcoming the hurdles in using mouse genetic models that block TGF-beta signaling.
  Journal of immunological methods 2010 Sanjabi S, Flavell RA
• Requirement for AHNAK1-mediated calcium signaling during T lymphocyte cytolysis.
  Proceedings of the National Academy of Sciences of the United States of America 2009 Matza D, Badou A, Jha MK, Willinger T, Antov A, Sanjabi S, Kobayashi KS, Marchesi VT, Flavell RA
• Anti-inflammatory and pro-inflammatory roles of TGF-beta, IL-10, and IL-22 in immunity and autoimmunity.
  Current opinion in pharmacology 2009 Sanjabi S, Zenewicz LA, Kamanaka M, Flavell RA
• Distinct roles of different NF-kappa B subunits in regulating inflammatory and T cell stimulatory gene expression in dendritic cells.
  Journal of immunology (Baltimore, Md. : 1950) 2007 Wang J, Wang X, Hussain S, Zheng Y, Sanjabi S, Ouaaz F, Beg AA
• Transforming growth factor-beta: recent advances on its role in immune tolerance.
  Current rheumatology reports 2006 Kriegel MA, Li MO, Sanjabi S, Wan YY, Flavell RA
• Gene Regulation and Function: It's Rocking Science.
  Immunity 2006 Chen Dong, Shomyseh Sanjabi, Elizabeth Eynon
• Transforming growth factor-beta regulation of immune responses.
  Annual review of immunology 2006 Li MO, Wan YY, Sanjabi S, Robertson AK, Flavell RA
• Gene regulation and function: its rocking science.
  Immunity 2005 Dong C, Sanjabi S, Eynon E
• A c-Rel subdomain responsible for enhanced DNA-binding affinity and selective gene activation.
  Genes & development 2005 Sanjabi S, Williams KJ, Saccani S, Zhou L, Hoffmann A, Ghosh G, Gerondakis S, Natoli G, Smale ST
• Nucleosome remodeling at the IL-12 p40 promoter is a TLR-dependent, Rel-independent event.
  Nature immunology 2001 Weinmann AS, Mitchell DM, Sanjabi S, Bradley MN, Hoffmann A, Liou HC, Smale ST
• Selective requirement for c-Rel during IL-12 P40 gene induction in macrophages.
  Proceedings of the National Academy of Sciences of the United States of America 2000 Sanjabi S, Hoffmann A, Liou HC, Baltimore D, Smale ST