Shinya Yamanaka, MD, PhD
Professor
Anatomy
School of Medicine

Dr. Yamanaka is also a Professor of Anatomy at the University of California, San Francisco, as well as the Director of the Center for iPS Cell Research and Application (CiRA) and a Principal Investigator at the Institute for Integrated Cell-Material Sciences, both at Kyoto University. Dr. Yamanaka’s research focuses on ways to generate cells resembling embryonic stem cells by reprogramming somatic, or skin, cells. He seeks to understand the molecular mechanisms that underlie pluripotency and the rapid proliferation of embryonic stem cells—they can become any type of cell in the body—and to identify the factors that induce reprogramming. Dr. Yamanaka’s discovery that adult somatic cells can be reprogrammed into pluripotent cells has had a profound effect on developmental and stem cell biology. By introducing the genes for four factors that turn genes on and off, he induced the skin cells of adult mice to become like embryonic stem cells, which he called induced pluripotent stem (iPS) cells. This iPS cell technology represents an entirely new platform for fundamental studies of developmental biology. Rather than using disease models made in yeast, flies, mice or other animals, iPS cells can be taken from patients with a specific disease. As a result, they contain a complete set of the genes that resulted in that disease—representing the potential of an almost perfect disease model for studying disease development, new drugs and treatments. In 1996, Dr. Yamanaka became an Assistant Professor at Osaka City University Medical School. In 1999, he was appointed Associate Professor at Nara Institute of Science and Technology, where he became a full professor in 2003. He took his current position as a professor at Kyoto University in 2004 and was appointed as a Senior Investigator at the Gladstone Institutes in 2007. Since 2008, he has directed CiRA. Dr. Yamanaka has received many awards and honors, including the Albert Lasker Basic Medical Research Award, the Wolf Prize in Medicine, the Millennium Technology Award, the Shaw Prize, the Kyoto Prize for Advanced Technology, the Gairdner International Award, the Robert Koch Award and the March of Dimes Prize. Dr. Yamanaka earned an MD from Kobe University in 1987 and a PhD from Osaka City University in 1993. From 1987 to 1989, he was a resident at the National Osaka Hospital. From 1993 to 1996, he was a postdoctoral fellow at GICD.

• A disease-specific iPS cell resource for studying rare and intractable diseases.
  Inflammation and regeneration 2023 Saito MK, Osawa M, Tsuchida N, Shiraishi K, Niwa A, Woltjen K, Asaka I, Ogata K, Ito S, Kobayashi S, Yamanaka S
• Pluripotent stem cell-based therapies and their path to the clinic.
  Stem cell reports 2023 Takayama K, Yamanaka S
• Loss of TJP1 disrupts gastrulation patterning and increases differentiation toward the germ cell lineage in human pluripotent stem cells.
  Developmental cell 2023 Vasic I, Libby ARG, Maslan A, Bulger EA, Zalazar D, Krakora Compagno MZ, Streets A, Tomoda K, Yamanaka S, McDevitt TC
• A clinical-grade HLA haplobank of human induced pluripotent stem cells matching approximately 40% of the Japanese population.
  Med (New York, N.Y.) 2022 Yoshida S, Kato TM, Sato Y, Umekage M, Ichisaka T, Tsukahara M, Takasu N, Yamanaka S
• Improved Sendai viral system for reprogramming to naive pluripotency.
  Cell reports methods 2022 Kunitomi A, Hirohata R, Arreola V, Osawa M, Kato TM, Nomura M, Kawaguchi J, Hara H, Kusano K, Takashima Y, Takahashi K, Fukuda K, Takasu N, Yamanaka S
• The subcommissural organ maintains features of neuroepithelial cells in the adult mouse.
  Journal of anatomy 2022 Corales LG, Inada H, Hiraoka K, Araki S, Yamanaka S, Kikkawa T, Osumi N
• Multi-omics approach reveals posttranscriptionally regulated genes are essential for human pluripotent stem cells.
  iScience 2022 Iwasaki M, Kawahara Y, Okubo C, Yamakawa T, Nakamura M, Tabata T, Nishi Y, Narita M, Ohta A, Saito H, Yamamoto T, Nakagawa M, Yamanaka S, Takahashi K
• A stress-reduced passaging technique improves the viability of human pluripotent cells.
  Cell reports methods 2022 Takahashi K, Okubo C, Nakamura M, Iwasaki M, Kawahara Y, Tabata T, Miyamoto Y, Woltjen K, Yamanaka S
• Dual inhibition of TMPRSS2 and Cathepsin Bprevents SARS-CoV-2 infection in iPS cells.
  Molecular therapy. Nucleic acids 2021 Hashimoto R, Sakamoto A, Deguchi S, Yi R, Sano E, Hotta A, Takahashi K, Yamanaka S, Takayama K
• First-in-human clinical trial of transplantation of iPSC-derived NS/PCs in subacute complete spinal cord injury: Study protocol.
  Regenerative therapy 2021 Sugai K, Sumida M, Shofuda T, Yamaguchi R, Tamura T, Kohzuki T, Abe T, Shibata R, Kamata Y, Ito S, Okubo T, Tsuji O, Nori S, Nagoshi N, Yamanaka S, Kawamata S, Kanemura Y, Nakamura M, Okano H
• Aging and CMV Infection Affect Pre-existing SARS-CoV-2-Reactive CD8+ T Cells in Unexposed Individuals.
  Frontiers in aging 2021 Jo N, Zhang R, Ueno H, Yamamoto T, Weiskopf D, Nagao M, Yamanaka S, Hamazaki Y
• Expression dynamics of HAND1/2 in in vitro human cardiomyocyte differentiation.
  Stem cell reports 2021 Okubo C, Narita M, Inagaki A, Nishikawa M, Hotta A, Yamanaka S, Yoshida Y
• The pluripotent stem cell-specific transcript ESRG is dispensable for human pluripotency.
  PLoS genetics 2021 Takahashi K, Nakamura M, Okubo C, Kliesmete Z, Ohnuki M, Narita M, Watanabe A, Ueda M, Takashima Y, Hellmann I, Yamanaka S
• Konnichiwa: Japanese scientists and their struggle to speak English: More research careers in Japan need less English.
  EMBO reports 2021 Karagiannis P, Yamanaka S
• Pluripotent Stem Cell-Based Cell Therapy-Promise and Challenges.
  Cell stem cell 2020 Yamanaka S
• Critical Roles of Translation Initiation and RNA Uridylation in Endogenous Retroviral Expression and Neural Differentiation in Pluripotent Stem Cells.
  Cell reports 2020 Takahashi K, Jeong D, Wang S, Narita M, Jin X, Iwasaki M, Perli SD, Conklin BR, Yamanaka S
• Base-Resolution Methylome of Retinal Pigment Epithelial Cells Used in the First Trial of Human Induced Pluripotent Stem Cell-Based Autologous Transplantation.
  Stem cell reports 2019 Araki H, Miura F, Watanabe A, Morinaga C, Kitaoka F, Kitano Y, Sakai N, Shibata Y, Terada M, Goto S, Yamanaka S, Takahashi M, Ito T
• Induced 2C Expression and Implantation-Competent Blastocyst-like Cysts from Primed Pluripotent Stem Cells.
  Stem cell reports 2019 Kime C, Kiyonari H, Ohtsuka S, Kohbayashi E, Asahi M, Yamanaka S, Takahashi M, Tomoda K
• Generation of a human induced pluripotent stem cell line, BRCi001-A, derived from a patient with mucopolysaccharidosis type I.
  Stem cell research 2019 Suga M, Kondo T, Imamura K, Shibukawa R, Okanishi Y, Sagara Y, Tsukita K, Enami T, Furujo M, Saijo K, Nakamura Y, Osawa M, Saito MK, Yamanaka S, Inoue H
• Application of induced pluripotent stem cells to primary immunodeficiency diseases.
  Experimental hematology 2019 Karagiannis P, Yamanaka S, Saito MK
• Induced Pluripotent Stem Cells and Their Use in Human Models of Disease and Development.
  Physiological reviews 2019 Karagiannis P, Takahashi K, Saito M, Yoshida Y, Okita K, Watanabe A, Inoue H, Yamashita JK, Todani M, Nakagawa M, Osawa M, Yashiro Y, Yamanaka S, Osafune K
• Concise Review: Laying the Groundwork for a First-In-Human Study of an Induced Pluripotent Stem Cell-Based Intervention for Spinal Cord Injury.
  Stem cells (Dayton, Ohio) 2018 Tsuji O, Sugai K, Yamaguchi R, Tashiro S, Nagoshi N, Kohyama J, Iida T, Ohkubo T, Itakura G, Isoda M, Shinozaki M, Fujiyoshi K, Kanemura Y, Yamanaka S, Nakamura M, Okano H
• Erratum for DOI: 10.31662/jmaj.2018-0005.
  JMA journal 2018 Karagiannis P, Nakauchi A, Yamanaka S
• Bringing Induced Pluripotent Stem Cell Technology to the Bedside.
  JMA journal 2018 Karagiannis P, Nakauchi A, Yamanaka S
• MYC Releases Early Reprogrammed Human Cells from Proliferation Pause via Retinoblastoma Protein Inhibition.
  Cell reports 2018 Rand TA, Sutou K, Tanabe K, Jeong D, Nomura M, Kitaoka F, Tomoda E, Narita M, Nakamura M, Nakamura M, Watanabe A, Rulifson E, Yamanaka S, Takahashi K
• Epigenetic foundations of pluripotent stem cells that recapitulate in vivo pluripotency.
  Laboratory investigation; a journal of technical methods and pathology 2017 Yagi M, Yamanaka S, Yamada Y
• MHC matching improves engraftment of iPSC-derived neurons in non-human primates.
  Nature communications 2017 Morizane A, Kikuchi T, Hayashi T, Mizuma H, Takara S, Doi H, Mawatari A, Glasser MF, Shiina T, Ishigaki H, Itoh Y, Okita K, Yamasaki E, Doi D, Onoe H, Ogasawara K, Yamanaka S, Takahashi J
• Enhanced Therapeutic Effects of Human iPS Cell Derived-Cardiomyocyte by Combined Cell-Sheets with Omental Flap Technique in Porcine Ischemic Cardiomyopathy Model.
  Scientific reports 2017 Kawamura M, Miyagawa S, Fukushima S, Saito A, Miki K, Funakoshi S, Yoshida Y, Yamanaka S, Shimizu T, Okano T, Daimon T, Toda K, Sawa Y
• Induced Pluripotent Stem Cells 10 Years Later: For Cardiac Applications.
  Circulation research 2017 Yoshida Y, Yamanaka S
• The Src/c-Abl pathway is a potential therapeutic target in amyotrophic lateral sclerosis.
  Science translational medicine 2017 Imamura K, Izumi Y, Watanabe A, Tsukita K, Woltjen K, Yamamoto T, Hotta A, Kondo T, Kitaoka S, Ohta A, Tanaka A, Watanabe D, Morita M, Takuma H, Tamaoka A, Kunath T, Wray S, Furuya H, Era T, Makioka K…
• Hybrid Cellular Metabolism Coordinated by Zic3 and Esrrb Synergistically Enhances Induction of Naive Pluripotency.
  Cell metabolism 2017 Sone M, Morone N, Nakamura T, Tanaka A, Okita K, Woltjen K, Nakagawa M, Heuser JE, Yamada Y, Yamanaka S, Yamamoto T
• New Models for Therapeutic Innovation from Japan.
  EBioMedicine 2017 Karagiannis P, Onodera A, Yamanaka S
• Nat1 promotes translation of specific proteins that induce differentiation of mouse embryonic stem cells.
  Proceedings of the National Academy of Sciences of the United States of America 2016 Sugiyama H, Takahashi K, Yamamoto T, Iwasaki M, Narita M, Nakamura M, Rand TA, Nakagawa M, Watanabe A, Yamanaka S
• Induced pluripotent stem cell technology: a decade of progress.
  Nature reviews. Drug discovery 2016 Shi Y, Inoue H, Wu JC, Yamanaka S
• BMP-SMAD-ID promotes reprogramming to pluripotency by inhibiting p16/INK4A-dependent senescence.
  Proceedings of the National Academy of Sciences of the United States of America 2016 Hayashi Y, Hsiao EC, Sami S, Lancero M, Schlieve CR, Nguyen T, Yano K, Nagahashi A, Ikeya M, Matsumoto Y, Nishimura K, Fukuda A, Hisatake K, Tomoda K, Asaka I, Toguchida J, Conklin BR, Yamanaka S
• Patient-Specific Human Induced Pluripotent Stem Cell Model Assessed with Electrical Pacing Validates S107 as a Potential Therapeutic Agent for Catecholaminergic Polymorphic Ventricular Tachycardia.
  PloS one 2016 Sasaki K, Makiyama T, Yoshida Y, Wuriyanghai Y, Kamakura T, Nishiuchi S, Hayano M, Harita T, Yamamoto Y, Kohjitani H, Hirose S, Chen J, Kawamura M, Ohno S, Itoh H, Takeuchi A, Matsuoka S, Miura M, …
• Autotaxin-mediated lipid signaling intersects with LIF and BMP signaling to promote the naive pluripotency transcription factor program.
  Proceedings of the National Academy of Sciences of the United States of America 2016 Kime C, Sakaki-Yumoto M, Goodrich L, Hayashi Y, Sami S, Derynck R, Asahi M, Panning B, Yamanaka S, Tomoda K
• MicroRNA-302 switch to identify and eliminate undifferentiated human pluripotent stem cells.
  Scientific reports 2016 Parr CJ, Katayama S, Miki K, Kuang Y, Yoshida Y, Morizane A, Takahashi J, Yamanaka S, Saito H
• Epigenetic Variation between Human Induced Pluripotent Stem Cell Lines Is an Indicator of Differentiation Capacity.
  Cell stem cell 2016 Nishizawa M, Chonabayashi K, Nomura M, Tanaka A, Nakamura M, Inagaki A, Nishikawa M, Takei I, Oishi A, Tanabe K, Ohnuki M, Yokota H, Koyanagi-Aoi M, Okita K, Watanabe A, Takaori-Kondo A, Yamanaka S, …
• Identification of MMP1 as a novel risk factor for intracranial aneurysms in ADPKD using iPSC models.
  Scientific reports 2016 Ameku T, Taura D, Sone M, Numata T, Nakamura M, Shiota F, Toyoda T, Matsui S, Araoka T, Yasuno T, Mae S, Kobayashi H, Kondo N, Kitaoka F, Amano N, Arai S, Ichisaka T, Matsuura N, Inoue S, Yamamoto T, …
• Screening of Human cDNA Library Reveals Two differentiation-Related Genes, HHEX and HLX, as Promoters of Early Phase Reprogramming toward Pluripotency.
  Stem cells (Dayton, Ohio) 2016 Yamakawa T, Sato Y, Matsumura Y, Kobayashi Y, Kawamura Y, Goshima N, Yamanaka S, Okita K
• Establishment of Human Neural Progenitor Cells from Human Induced Pluripotent Stem Cells with Diverse Tissue Origins.
  Stem cells international 2016 Fukusumi H, Shofuda T, Bamba Y, Yamamoto A, Kanematsu D, Handa Y, Okita K, Nakamura M, Yamanaka S, Okano H, Kanemura Y
• When Myc's asleep, embryonic stem cells are dormant.
  The EMBO journal 2016 Nakagawa M, Karagiannis P, Yamanaka S
• SOX2 O-GlcNAcylation alters its protein-protein interactions and genomic occupancy to modulate gene expression in pluripotent cells.
  eLife 2016 Myers SA, Peddada S, Chatterjee N, Friedrich T, Tomoda K, Krings G, Thomas S, Maynard J, Broeker M, Thomson M, Pollard K, Yamanaka S, Burlingame AL, Panning B
• Recent policies that support clinical application of induced pluripotent stem cell-based regenerative therapies.
  Regenerative therapy 2016 Azuma K, Yamanaka S
• A decade of transcription factor-mediated reprogramming to pluripotency.
  Nature reviews. Molecular cell biology 2016 Takahashi K, Yamanaka S
• Enhanced engraftment, proliferation, and therapeutic potential in heart using optimized human iPSC-derived cardiomyocytes.
  Scientific reports 2016 Funakoshi S, Miki K, Takaki T, Okubo C, Hatani T, Chonabayashi K, Nishikawa M, Takei I, Oishi A, Narita M, Hoshijima M, Kimura T, Yamanaka S, Yoshida Y
• Efficient CRISPR/Cas9-Based Genome Engineering in Human Pluripotent Stem Cells.
  Current protocols in human genetics 2016 Kime C, Mandegar MA, Srivastava D, Yamanaka S, Conklin BR, Rand TA
• Inducible Transgene Expression in Human iPS Cells Using Versatile All-in-One piggyBac Transposons.
  Methods in molecular biology (Clifton, N.J.) 2016 Kim SI, Oceguera-Yanez F, Sakurai C, Nakagawa M, Yamanaka S, Woltjen K
• A study on ensuring the quality and safety of pharmaceuticals and medical devices derived from processing of allogeneic human induced pluripotent stem(-Like) cells.
  Regenerative therapy 2015 Hayakawa T, Aoi T, Umezawa A, Ozawa K, Sato Y, Sawa Y, Matsuyama A, Yamanaka S, Yamato M
• A study on ensuring the quality and safety of pharmaceuticals and medical devices derived from the processing of autologous human somatic stem cells.
  Regenerative therapy 2015 Hayakawa T, Aoi T, Umezawa A, Ozawa K, Sato Y, Sawa Y, Matsuyama A, Yamanaka S, Yamato M
• A study on ensuring the quality and safety of pharmaceuticals and medical devices derived from processing of autologous human induced pluripotent stem(-like) cells.
  Regenerative therapy 2015 Hayakawa T, Aoi T, Umezawa A, Ozawa K, Sato Y, Sawa Y, Matsuyama A, Yamanaka S, Yamato M
• Practical Integration-Free Episomal Methods for Generating Human Induced Pluripotent Stem Cells.
  Current protocols in human genetics 2015 Kime C, Rand TA, Ivey KN, Srivastava D, Yamanaka S, Tomoda K
• A developmental framework for induced pluripotency.
  Development (Cambridge, England) 2015 Takahashi K, Yamanaka S
• From Genomics to Gene Therapy: Induced Pluripotent Stem Cells Meet Genome Editing.
  Annual review of genetics 2015 Hotta A, Yamanaka S
• Cell Therapy Using Human Induced Pluripotent Stem Cell-Derived Renal Progenitors Ameliorates Acute Kidney Injury in Mice.
  Stem cells translational medicine 2015 Toyohara T, Mae S, Sueta S, Inoue T, Yamagishi Y, Kawamoto T, Kasahara T, Hoshina A, Toyoda T, Tanaka H, Araoka T, Sato-Otsubo A, Takahashi K, Sato Y, Yamaji N, Ogawa S, Yamanaka S, Osafune K
• Robust In Vitro Induction of Human Germ Cell Fate from Pluripotent Stem Cells.
  Cell stem cell 2015 Sasaki K, Yokobayashi S, Nakamura T, Okamoto I, Yabuta Y, Kurimoto K, Ohta H, Moritoki Y, Iwatani C, Tsuchiya H, Nakamura S, Sekiguchi K, Sakuma T, Yamamoto T, Mori T, Woltjen K, Nakagawa M, Yamamoto …
• Efficient Detection and Purification of Cell Populations Using Synthetic MicroRNA Switches.
  Cell stem cell 2015 Miki K, Endo K, Takahashi S, Funakoshi S, Takei I, Katayama S, Toyoda T, Kotaka M, Takaki T, Umeda M, Okubo C, Nishikawa M, Oishi A, Narita M, Miyashita I, Asano K, Hayashi K, Osafune K, Yamanaka S, …
• Direct cardiac reprogramming: progress and challenges in basic biology and clinical applications.
  Circulation research 2015 Sadahiro T, Yamanaka S, Ieda M
• Structure-based discovery of NANOG variant with enhanced properties to promote self-renewal and reprogramming of pluripotent stem cells.
  Proceedings of the National Academy of Sciences of the United States of America 2015 Hayashi Y, Caboni L, Das D, Yumoto F, Clayton T, Deller MC, Nguyen P, Farr CL, Chiu HJ, Miller MD, Elsliger MA, Deacon AM, Godzik A, Lesley SA, Tomoda K, Conklin BR, Wilson IA, Yamanaka S, Fletterick …
• KLF4 N-terminal variance modulates induced reprogramming to pluripotency.
  Stem cell reports 2015 Kim SI, Oceguera-Yanez F, Hirohata R, Linker S, Okita K, Yamada Y, Yamamoto T, Yamanaka S, Woltjen K
• Development of a global network of induced pluripotent stem cell haplobanks.
  Regenerative medicine 2015 Wilmut I, Leslie S, Martin NG, Peschanski M, Rao M, Trounson A, Turner D, Turner ML, Yamanaka S, Taylor CJ
• The homeobox gene DLX4 promotes generation of human induced pluripotent stem cells.
  Scientific reports 2014 Tamaoki N, Takahashi K, Aoki H, Iida K, Kawaguchi T, Hatakeyama D, Inden M, Chosa N, Ishisaki A, Kunisada T, Shibata T, Goshima N, Yamanaka S, Tezuka K
• Precise correction of the dystrophin gene in duchenne muscular dystrophy patient induced pluripotent stem cells by TALEN and CRISPR-Cas9.
  Stem cell reports 2014 Li HL, Fujimoto N, Sasakawa N, Shirai S, Ohkame T, Sakuma T, Tanaka M, Amano N, Watanabe A, Sakurai H, Yamamoto T, Yamanaka S, Hotta A
• Computational image analysis of colony and nuclear morphology to evaluate human induced pluripotent stem cells.
  Scientific reports 2014 Tokunaga K, Saitoh N, Goldberg IG, Sakamoto C, Yasuda Y, Yoshida Y, Yamanaka S, Nakao M
• The fate of cell reprogramming.
  Nature methods 2014 Karagiannis P, Yamanaka S
• Dynamic regulation of human endogenous retroviruses mediates factor-induced reprogramming and differentiation potential.
  Proceedings of the National Academy of Sciences of the United States of America 2014 Ohnuki M, Tanabe K, Sutou K, Teramoto I, Sawamura Y, Narita M, Nakamura M, Tokunaga Y, Nakamura M, Watanabe A, Yamanaka S, Takahashi K
• Harmonizing standards for producing clinical-grade therapies from pluripotent stem cells.
  Nature biotechnology 2014 Andrews PW, Cavagnaro J, Cavanagro J, Deans R, Feigal E, Feigel E, Horowitz E, Keating A, Rao M, Turner M, Wilmut I, Yamanaka S
• Calcium transients closely reflect prolonged action potentials in iPSC models of inherited cardiac arrhythmia.
  Stem cell reports 2014 Spencer CI, Baba S, Nakamura K, Hua EA, Sears MA, Fu CC, Zhang J, Balijepalli S, Tomoda K, Hayashi Y, Lizarraga P, Wojciak J, Scheinman MM, Aalto-Setälä K, Makielski JC, January CT, Healy KE, Kamp TJ,…
• Focal transplantation of human iPSC-derived glial-rich neural progenitors improves lifespan of ALS mice.
  Stem cell reports 2014 Kondo T, Funayama M, Tsukita K, Hotta A, Yasuda A, Nori S, Kaneko S, Nakamura M, Takahashi R, Okano H, Yamanaka S, Inoue H
• Induction of pluripotency in human somatic cells via a transient state resembling primitive streak-like mesendoderm.
  Nature communications 2014 Takahashi K, Tanabe K, Ohnuki M, Narita M, Sasaki A, Yamamoto M, Nakamura M, Sutou K, Osafune K, Yamanaka S
• Involvement of ER stress in dysmyelination of Pelizaeus-Merzbacher Disease with PLP1 missense mutations shown by iPSC-derived oligodendrocytes.
  Stem cell reports 2014 Numasawa-Kuroiwa Y, Okada Y, Shibata S, Kishi N, Akamatsu W, Shoji M, Nakanishi A, Oyama M, Osaka H, Inoue K, Takahashi K, Yamanaka S, Kosaki K, Takahashi T, Okano H
• Generation and characterization of induced pluripotent stem cells from Aid-deficient mice.
  PloS one 2014 Shimamoto R, Amano N, Ichisaka T, Watanabe A, Yamanaka S, Okita K
• A chemical probe that labels human pluripotent stem cells.
  Cell reports 2014 Hirata N, Nakagawa M, Fujibayashi Y, Yamauchi K, Murata A, Minami I, Tomioka M, Kondo T, Kuo TF, Endo H, Inoue H, Sato SI, Ando S, Kawazoe Y, Aiba K, Nagata K, Kawase E, Chang YT, Suemori H, Eto K, …
• Expandable megakaryocyte cell lines enable clinically applicable generation of platelets from human induced pluripotent stem cells.
  Cell stem cell 2014 Nakamura S, Takayama N, Hirata S, Seo H, Endo H, Ochi K, Fujita K, Koike T, Harimoto K, Dohda T, Watanabe A, Okita K, Takahashi N, Sawaguchi A, Yamanaka S, Nakauchi H, Nishimura S, Eto K
• Premature termination of reprogramming in vivo leads to cancer development through altered epigenetic regulation.
  Cell 2014 Ohnishi K, Semi K, Yamamoto T, Shimizu M, Tanaka A, Mitsunaga K, Okita K, Osafune K, Arioka Y, Maeda T, Soejima H, Moriwaki H, Yamanaka S, Woltjen K, Yamada Y
• iPS cells: a game changer for future medicine.
  The EMBO journal 2014 Inoue H, Nagata N, Kurokawa H, Yamanaka S
• Perspectives for induced pluripotent stem cell technology: new insights into human physiology involved in somatic mosaicism.
  Circulation research 2014 Nagata N, Yamanaka S
• Efficient and rapid induction of human iPSCs/ESCs into nephrogenic intermediate mesoderm using small molecule-based differentiation methods.
  PloS one 2014 Araoka T, Mae S, Kurose Y, Uesugi M, Ohta A, Yamanaka S, Osafune K
• Cell-autonomous correction of ring chromosomes in human induced pluripotent stem cells.
  Nature 2014 Bershteyn M, Hayashi Y, Desachy G, Hsiao EC, Sami S, Tsang KM, Weiss LA, Kriegstein AR, Yamanaka S, Wynshaw-Boris A
• A novel efficient feeder-free culture system for the derivation of human induced pluripotent stem cells.
  Scientific reports 2014 Nakagawa M, Taniguchi Y, Senda S, Takizawa N, Ichisaka T, Asano K, Morizane A, Doi D, Takahashi J, Nishizawa M, Yoshida Y, Toyoda T, Osafune K, Sekiguchi K, Yamanaka S
• Induction of pluripotency by defined factors.
  Proceedings of the Japan Academy. Series B, Physical and biological sciences 2014 Tanabe K, Takahashi K, Yamanaka S
• Induced pluripotent stem cells from patients with human fibrodysplasia ossificans progressiva show increased mineralization and cartilage formation.
  Orphanet journal of rare diseases 2013 Matsumoto Y, Hayashi Y, Schlieve CR, Ikeya M, Kim H, Nguyen TD, Sami S, Baba S, Barruet E, Nasu A, Asaka I, Otsuka T, Yamanaka S, Conklin BR, Toguchida J, Hsiao EC
• Tsix RNA and the germline factor, PRDM14, link X reactivation and stem cell reprogramming.
  Molecular cell 2013 Payer B, Rosenberg M, Yamaji M, Yabuta Y, Koyanagi-Aoi M, Hayashi K, Yamanaka S, Saitou M, Lee JT
• Differentiation-defective phenotypes revealed by large-scale analyses of human pluripotent stem cells.
  Proceedings of the National Academy of Sciences of the United States of America 2013 Koyanagi-Aoi M, Ohnuki M, Takahashi K, Okita K, Noma H, Sawamura Y, Teramoto I, Narita M, Sato Y, Ichisaka T, Amano N, Watanabe A, Morizane A, Yamada Y, Sato T, Takahashi J, Yamanaka S
• The winding road to pluripotency (Nobel Lecture).
  Angewandte Chemie (International ed. in English) 2013 Yamanaka S
• The let-7/LIN-41 pathway regulates reprogramming to human induced pluripotent stem cells by controlling expression of prodifferentiation genes.
  Cell stem cell 2013 Worringer KA, Rand TA, Hayashi Y, Sami S, Takahashi K, Tanabe K, Narita M, Srivastava D, Yamanaka S
• Global splicing pattern reversion during somatic cell reprogramming.
  Cell reports 2013 Ohta S, Nishida E, Yamanaka S, Yamamoto T
• Toward the development of a global induced pluripotent stem cell library.
  Cell stem cell 2013 Turner M, Leslie S, Martin NG, Peschanski M, Rao M, Taylor CJ, Trounson A, Turner D, Yamanaka S, Wilmut I
• Direct comparison of autologous and allogeneic transplantation of iPSC-derived neural cells in the brain of a non-human primate.
  Stem cell reports 2013 Morizane A, Doi D, Kikuchi T, Okita K, Hotta A, Kawasaki T, Hayashi T, Onoe H, Shiina T, Yamanaka S, Takahashi J
• Tudor domain containing 12 (TDRD12) is essential for secondary PIWI interacting RNA biogenesis in mice.
  Proceedings of the National Academy of Sciences of the United States of America 2013 Pandey RR, Tokuzawa Y, Yang Z, Hayashi E, Ichisaka T, Kajita S, Asano Y, Kunieda T, Sachidanandam R, Chuma S, Yamanaka S, Pillai RS
• Maturation, not initiation, is the major roadblock during reprogramming toward pluripotency from human fibroblasts.
  Proceedings of the National Academy of Sciences of the United States of America 2013 Tanabe K, Nakamura M, Narita M, Takahashi K, Yamanaka S
• Making steady progress on direct cardiac reprogramming toward clinical application.
  Circulation research 2013 Miki K, Yoshida Y, Yamanaka S
• Response to comment on "Drug screening for ALS using patient-specific induced pluripotent stem cells".
  Science translational medicine 2013 Egawa N, Kitaoka S, Tsukita K, Naitoh M, Takahashi K, Yamamoto T, Adachi F, Kondo T, Okita K, Asaka I, Aoi T, Watanabe A, Yamada Y, Morizane A, Takahashi J, Ayaki T, Ito H, Yoshikawa K, Yamawaki S, …
• Induced pluripotent stem cells in medicine and biology.
  Development (Cambridge, England) 2013 Takahashi K, Yamanaka S
• To be immunogenic, or not to be: that's the iPSC question.
  Cell stem cell 2013 Kaneko S, Yamanaka S
• An efficient nonviral method to generate integration-free human-induced pluripotent stem cells from cord blood and peripheral blood cells.
  Stem cells (Dayton, Ohio) 2013 Okita K, Yamakawa T, Matsumura Y, Sato Y, Amano N, Watanabe A, Goshima N, Yamanaka S
• Modeling Alzheimer's disease with iPSCs reveals stress phenotypes associated with intracellular Aβ and differential drug responsiveness.
  Cell stem cell 2013 Kondo T, Asai M, Tsukita K, Kutoku Y, Ohsawa Y, Sunada Y, Imamura K, Egawa N, Yahata N, Okita K, Takahashi K, Asaka I, Aoi T, Watanabe A, Watanabe K, Kadoya C, Nakano R, Watanabe D, Maruyama K, Hori O…
• Ultrastructural maturation of human-induced pluripotent stem cell-derived cardiomyocytes in a long-term culture.
  Circulation journal : official journal of the Japanese Circulation Society 2013 Kamakura T, Makiyama T, Sasaki K, Yoshida Y, Wuriyanghai Y, Chen J, Hattori T, Ohno S, Kita T, Horie M, Yamanaka S, Kimura T
• Steps toward safe cell therapy using induced pluripotent stem cells.
  Circulation research 2013 Okano H, Nakamura M, Yoshida K, Okada Y, Tsuji O, Nori S, Ikeda E, Yamanaka S, Miura K
• Human induced pluripotent stem cell-derived ectodermal precursor cells contribute to hair follicle morphogenesis in vivo.
  The Journal of investigative dermatology 2013 Veraitch O, Kobayashi T, Imaizumi Y, Akamatsu W, Sasaki T, Yamanaka S, Amagai M, Okano H, Ohyama M
• Epigenetic regulation in pluripotent stem cells: a key to breaking the epigenetic barrier.
  Philosophical transactions of the Royal Society of London. Series B, Biological sciences 2013 Watanabe A, Yamada Y, Yamanaka S
• Cartilage tissue engineering identifies abnormal human induced pluripotent stem cells.
  Scientific reports 2013 Yamashita A, Liu S, Woltjen K, Thomas B, Meng G, Hotta A, Takahashi K, Ellis J, Yamanaka S, Rancourt DE
• Monitoring and robust induction of nephrogenic intermediate mesoderm from human pluripotent stem cells.
  Nature communications 2013 Mae SI, Shono A, Shiota F, Yasuno T, Kajiwara M, Gotoda-Nishimura N, Arai S, Sato-Otubo A, Toyoda T, Takahashi K, Nakayama N, Cowan CA, Aoi T, Ogawa S, McMahon AP, Yamanaka S, Osafune K
• Shinya Yamanaka: purveyor of pluripotency. Interview by Ruth Williams.
  Circulation research 2012 Yamanaka S
• Rapid and deep profiling of human induced pluripotent stem cell proteome by one-shot NanoLC-MS/MS analysis with meter-scale monolithic silica columns.
  Journal of proteome research 2012 Yamana R, Iwasaki M, Wakabayashi M, Nakagawa M, Yamanaka S, Ishihama Y
• Generation of naive-like porcine-induced pluripotent stem cells capable of contributing to embryonic and fetal development.
  Stem cells and development 2012 Fujishiro SH, Nakano K, Mizukami Y, Azami T, Arai Y, Matsunari H, Ishino R, Nishimura T, Watanabe M, Abe T, Furukawa Y, Umeyama K, Yamanaka S, Ema M, Nagashima H, Hanazono Y
• Drug screening for ALS using patient-specific induced pluripotent stem cells.
  Science translational medicine 2012 Egawa N, Kitaoka S, Tsukita K, Naitoh M, Takahashi K, Yamamoto T, Adachi F, Kondo T, Okita K, Asaka I, Aoi T, Watanabe A, Yamada Y, Morizane A, Takahashi J, Ayaki T, Ito H, Yoshikawa K, Yamawaki S, …
• Donor-dependent variations in hepatic differentiation from human-induced pluripotent stem cells.
  Proceedings of the National Academy of Sciences of the United States of America 2012 Kajiwara M, Aoi T, Okita K, Takahashi R, Inoue H, Takayama N, Endo H, Eto K, Toguchida J, Uemoto S, Yamanaka S
• Derivation conditions impact X-inactivation status in female human induced pluripotent stem cells.
  Cell stem cell 2012 Tomoda K, Takahashi K, Leung K, Okada A, Narita M, Yamada NA, Eilertson KE, Tsang P, Baba S, White MP, Sami S, Srivastava D, Conklin BR, Panning B, Yamanaka S
• Induced pluripotent stem cells from CINCA syndrome patients as a model for dissecting somatic mosaicism and drug discovery.
  Blood 2012 Tanaka T, Takahashi K, Yamane M, Tomida S, Nakamura S, Oshima K, Niwa A, Nishikomori R, Kambe N, Hara H, Mitsuyama M, Morone N, Heuser JE, Yamamoto T, Watanabe A, Sato-Otsubo A, Ogawa S, Asaka I, …
• Induced pluripotent stem cells: past, present, and future.
  Cell stem cell 2012 Yamanaka S
• Stem cells assessed.
  Nature reviews. Molecular cell biology 2012 Blanpain C, Daley GQ, Hochedlinger K, Passegué E, Rossant J, Yamanaka S
• Germline development from human pluripotent stem cells toward disease modeling of infertility.
  Fertility and sterility 2012 Hayashi Y, Saitou M, Yamanaka S
• Bioengineered myocardium derived from induced pluripotent stem cells improves cardiac function and attenuates cardiac remodeling following chronic myocardial infarction in rats.
  Stem cells translational medicine 2012 Miki K, Uenaka H, Saito A, Miyagawa S, Sakaguchi T, Higuchi T, Shimizu T, Okano T, Yamanaka S, Sawa Y
• [Research for cell therapy by induced pluripotent stem cell].
  Nihon rinsho. Japanese journal of clinical medicine 2011 Sakurai H, Yamanaka S
• Screening ethnically diverse human embryonic stem cells identifies a chromosome 20 minimal amplicon conferring growth advantage.
  Nature biotechnology 2011 International Stem Cell Initiative, Amps K, Andrews PW, Anyfantis G, Armstrong L, Avery S, Baharvand H, Baker J, Baker D, Munoz MB, Beil S, Benvenisty N, Ben-Yosef D, Biancotti JC, Bosman A, Brena RM,…
• Model for long QT syndrome type 2 using human iPS cells demonstrates arrhythmogenic characteristics in cell culture.
  Disease models & mechanisms 2011 Lahti AL, Kujala VJ, Chapman H, Koivisto AP, Pekkanen-Mattila M, Kerkelä E, Hyttinen J, Kontula K, Swan H, Conklin BR, Yamanaka S, Silvennoinen O, Aalto-Setälä K
• Glis1, a unique pro-reprogramming factor, may facilitate clinical applications of iPSC technology.
  Cell cycle (Georgetown, Tex.) 2011 Maekawa M, Yamanaka S
• Integration-free iPS cells engineered using human artificial chromosome vectors.
  PloS one 2011 Hiratsuka M, Uno N, Ueda K, Kurosaki H, Imaoka N, Kazuki K, Ueno E, Akakura Y, Katoh M, Osaki M, Kazuki Y, Nakagawa M, Yamanaka S, Oshimura M
• Anti-Aβ drug screening platform using human iPS cell-derived neurons for the treatment of Alzheimer's disease.
  PloS one 2011 Yahata N, Asai M, Kitaoka S, Takahashi K, Asaka I, Hioki H, Kaneko T, Maruyama K, Saido TC, Nakahata T, Asada T, Yamanaka S, Iwata N, Inoue H
• Grafted human-induced pluripotent stem-cell-derived neurospheres promote motor functional recovery after spinal cord injury in mice.
  Proceedings of the National Academy of Sciences of the United States of America 2011 Nori S, Okada Y, Yasuda A, Tsuji O, Takahashi Y, Kobayashi Y, Fujiyoshi K, Koike M, Uchiyama Y, Ikeda E, Toyama Y, Yamanaka S, Nakamura M, Okano H
• Immunogenicity of induced pluripotent stem cells.
  Circulation research 2011 Okita K, Nagata N, Yamanaka S
• Modeling familial Alzheimer's disease with induced pluripotent stem cells.
  Human molecular genetics 2011 Yagi T, Ito D, Okada Y, Akamatsu W, Nihei Y, Yoshizaki T, Yamanaka S, Okano H, Suzuki N
• Essential roles of ECAT15-2/Dppa2 in functional lung development.
  Molecular and cellular biology 2011 Nakamura T, Nakagawa M, Ichisaka T, Shiota A, Yamanaka S
• Specific lectin biomarkers for isolation of human pluripotent stem cells identified through array-based glycomic analysis.
  Cell research 2011 Wang YC, Nakagawa M, Garitaonandia I, Slavin I, Altun G, Lacharite RM, Nazor KL, Tran HT, Lynch CL, Leonardo TR, Liu Y, Peterson SE, Laurent LC, Yamanaka S, Loring JF
• Efficient and scalable purification of cardiomyocytes from human embryonic and induced pluripotent stem cells by VCAM1 surface expression.
  PloS one 2011 Uosaki H, Fukushima H, Takeuchi A, Matsuoka S, Nakatsuji N, Yamanaka S, Yamashita JK
• Induced pluripotent stem cells: opportunities and challenges.
  Philosophical transactions of the Royal Society of London. Series B, Biological sciences 2011 Okita K, Yamanaka S
• Direct reprogramming of somatic cells is promoted by maternal transcription factor Glis1.
  Nature 2011 Maekawa M, Yamaguchi K, Nakamura T, Shibukawa R, Kodanaka I, Ichisaka T, Kawamura Y, Mochizuki H, Goshima N, Yamanaka S
• The nomenclature system should be sustainable, but also practical.
  Cell stem cell 2011 Higashi H, Brüstle O, Daley GQ, Yamanaka S
• ECAT11/L1td1 is enriched in ESCs and rapidly activated during iPSC generation, but it is dispensable for the maintenance and induction of pluripotency.
  PloS one 2011 Iwabuchi KA, Yamakawa T, Sato Y, Ichisaka T, Takahashi K, Okita K, Yamanaka S
• A more efficient method to generate integration-free human iPS cells.
  Nature methods 2011 Okita K, Matsumura Y, Sato Y, Okada A, Morizane A, Okamoto S, Hong H, Nakagawa M, Tanabe K, Tezuka K, Shibata T, Kunisada T, Takahashi M, Takahashi J, Saji H, Yamanaka S
• Induction and enhancement of cardiac cell differentiation from mouse and human induced pluripotent stem cells with cyclosporin-A.
  PloS one 2011 Fujiwara M, Yan P, Otsuji TG, Narazaki G, Uosaki H, Fukushima H, Kuwahara K, Harada M, Matsuda H, Matsuoka S, Okita K, Takahashi K, Nakagawa M, Ikeda T, Sakata R, Mummery CL, Nakatsuji N, Yamanaka S, …
• Genome-sequencing anniversary. Of mice and humans.
  Science (New York, N.Y.) 2011 Yamanaka S
• Generation of human melanocytes from induced pluripotent stem cells.
  PloS one 2011 Ohta S, Imaizumi Y, Okada Y, Akamatsu W, Kuwahara R, Ohyama M, Amagai M, Matsuzaki Y, Yamanaka S, Okano H, Kawakami Y
• Transient activation of c-MYC expression is critical for efficient platelet generation from human induced pluripotent stem cells.
  The Journal of experimental medicine 2010 Takayama N, Nishimura S, Nakamura S, Shimizu T, Ohnishi R, Endo H, Yamaguchi T, Otsu M, Nishimura K, Nakanishi M, Sawaguchi A, Nagai R, Takahashi K, Yamanaka S, Nakauchi H, Eto K
• [Derivation of engraftable myogenic precursors from murine ES/iPS cells and generation of disease-specific iPS cells from patients with Duchenne muscular dystrophy (DMD) and other diseases].
  Rinsho shinkeigaku = Clinical neurology 2010 Nakahata T, Awaya T, Chang H, Mizuno Y, Niwa A, Fukada S, Takeda S, Yamanaka S, Heike T
• iPS cells: a source of cardiac regeneration.
  Journal of molecular and cellular cardiology 2010 Yoshida Y, Yamanaka S
• Gingival fibroblasts as a promising source of induced pluripotent stem cells.
  PloS one 2010 Egusa H, Okita K, Kayashima H, Yu G, Fukuyasu S, Saeki M, Matsumoto T, Yamanaka S, Yatani H
• Induction of primordial germ cells from mouse induced pluripotent stem cells derived from adult hepatocytes.
  Molecular reproduction and development 2010 Imamura M, Aoi T, Tokumasu A, Mise N, Abe K, Yamanaka S, Noce T
• Induced pluripotent stem cell-derived hepatocytes have the functional and proliferative capabilities needed for liver regeneration in mice.
  The Journal of clinical investigation 2010 Espejel S, Roll GR, McLaughlin KJ, Lee AY, Zhang JY, Laird DJ, Okita K, Yamanaka S, Willenbring H
• Promotion of direct reprogramming by transformation-deficient Myc.
  Proceedings of the National Academy of Sciences of the United States of America 2010 Nakagawa M, Takizawa N, Narita M, Ichisaka T, Yamanaka S
• Recent stem cell advances: induced pluripotent stem cells for disease modeling and stem cell-based regeneration.
  Circulation 2010 Yoshida Y, Yamanaka S
• Therapeutic potential of appropriately evaluated safe-induced pluripotent stem cells for spinal cord injury.
  Proceedings of the National Academy of Sciences of the United States of America 2010 Tsuji O, Miura K, Okada Y, Fujiyoshi K, Mukaino M, Nagoshi N, Kitamura K, Kumagai G, Nishino M, Tomisato S, Higashi H, Nagai T, Katoh H, Kohda K, Matsuzaki Y, Yuzaki M, Ikeda E, Toyama Y, Nakamura M, …
• Patient-specific pluripotent stem cells become even more accessible.
  Cell stem cell 2010 Yamanaka S
• miRNAs regulate SIRT1 expression during mouse embryonic stem cell differentiation and in adult mouse tissues.
  Aging 2010 Saunders LR, Sharma AD, Tawney J, Nakagawa M, Okita K, Yamanaka S, Willenbring H, Verdin E
• Cell line-dependent differentiation of induced pluripotent stem cells into cardiomyocytes in mice.
  Cardiovascular research 2010 Kaichi S, Hasegawa K, Takaya T, Yokoo N, Mima T, Kawamura T, Morimoto T, Ono K, Baba S, Doi H, Yamanaka S, Nakahata T, Heike T
• Nuclear reprogramming to a pluripotent state by three approaches.
  Nature 2010 Yamanaka S, Blau HM
• Genome-wide DNA methylation profile of tissue-dependent and differentially methylated regions (T-DMRs) residing in mouse pluripotent stem cells.
  Genes to cells : devoted to molecular & cellular mechanisms 2010 Sato S, Yagi S, Arai Y, Hirabayashi K, Hattori N, Iwatani M, Okita K, Ohgane J, Tanaka S, Wakayama T, Yamanaka S, Shiota K
• An interview with... Shinya Yamanaka. Interview by Mary Muers.
  Nature reviews. Genetics 2010 Yamanaka S
• Induction of pluripotency by defined factors.
  Experimental cell research 2010 Okita K, Yamanaka S
• Sirt1 plays an important role in mediating greater functionality of human ES/iPS-derived vascular endothelial cells.
  Atherosclerosis 2010 Homma K, Sone M, Taura D, Yamahara K, Suzuki Y, Takahashi K, Sonoyama T, Inuzuka M, Fukunaga Y, Tamura N, Itoh H, Yamanaka S, Nakao K
• Generation of skeletal muscle stem/progenitor cells from murine induced pluripotent stem cells.
  FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2010 Mizuno Y, Chang H, Umeda K, Niwa A, Iwasa T, Awaya T, Fukada S, Yamamoto H, Yamanaka S, Nakahata T, Heike T
• Generation of mouse-induced pluripotent stem cells with plasmid vectors.
  Nature protocols 2010 Okita K, Hong H, Takahashi K, Yamanaka S
• Reprogramming of somatic cells to pluripotency.
  Advances in experimental medicine and biology 2010 Nakagawa M, Yamanaka S
• Complete genetic correction of ips cells from Duchenne muscular dystrophy.
  Molecular therapy : the journal of the American Society of Gene Therapy 2009 Kazuki Y, Hiratsuka M, Takiguchi M, Osaki M, Kajitani N, Hoshiya H, Hiramatsu K, Yoshino T, Kazuki K, Ishihara C, Takehara S, Higaki K, Nakagawa M, Takahashi K, Yamanaka S, Oshimura M
• Human induced pluripotent stem cells on autologous feeders.
  PloS one 2009 Takahashi K, Narita M, Yokura M, Ichisaka T, Yamanaka S
• Efficient reprogramming of human and mouse primary extra-embryonic cells to pluripotent stem cells.
  Genes to cells : devoted to molecular & cellular mechanisms 2009 Nagata S, Toyoda M, Yamaguchi S, Hirano K, Makino H, Nishino K, Miyagawa Y, Okita H, Kiyokawa N, Nakagawa M, Yamanaka S, Akutsu H, Umezawa A, Tada T
• G(i)-coupled GPCR signaling controls the formation and organization of human pluripotent colonies.
  PloS one 2009 Nakamura K, Salomonis N, Tomoda K, Yamanaka S, Conklin BR
• Orderly hematopoietic development of induced pluripotent stem cells via Flk-1(+) hemoangiogenic progenitors.
  Journal of cellular physiology 2009 Niwa A, Umeda K, Chang H, Saito M, Okita K, Takahashi K, Nakagawa M, Yamanaka S, Nakahata T, Heike T
• Induced pluripotent stem cells and reprogramming: seeing the science through the hype.
  Nature reviews. Genetics 2009 Izpisúa Belmonte JC, Ellis J, Hochedlinger K, Yamanaka S
• Ekiden to iPS Cells.
  Nature medicine 2009 Yamanaka S
• Transplantation of mouse induced pluripotent stem cells into the cochlea.
  Neuroreport 2009 Nishimura K, Nakagawa T, Ono K, Ogita H, Sakamoto T, Yamamoto N, Okita K, Yamanaka S, Ito J
• Hypoxia enhances the generation of induced pluripotent stem cells.
  Cell stem cell 2009 Yoshida Y, Takahashi K, Okita K, Ichisaka T, Yamanaka S
• Suppression of induced pluripotent stem cell generation by the p53-p21 pathway.
  Nature 2009 Hong H, Takahashi K, Ichisaka T, Aoi T, Kanagawa O, Nakagawa M, Okita K, Yamanaka S
• The effects of cardioactive drugs on cardiomyocytes derived from human induced pluripotent stem cells.
  Biochemical and biophysical research communications 2009 Yokoo N, Baba S, Kaichi S, Niwa A, Mima T, Doi H, Yamanaka S, Nakahata T, Heike T
• Variation in the safety of induced pluripotent stem cell lines.
  Nature biotechnology 2009 Miura K, Okada Y, Aoi T, Okada A, Takahashi K, Okita K, Nakagawa M, Koyanagi M, Tanabe K, Ohnuki M, Ogawa D, Ikeda E, Okano H, Yamanaka S
• Elite and stochastic models for induced pluripotent stem cell generation.
  Nature 2009 Yamanaka S
• Generation and characterization of human induced pluripotent stem cells.
  Current protocols in stem cell biology 2009 Ohnuki M, Takahashi K, Yamanaka S
• In vitro pharmacologic testing using human induced pluripotent stem cell-derived cardiomyocytes.
  Biochemical and biophysical research communications 2009 Tanaka T, Tohyama S, Murata M, Nomura F, Kaneko T, Chen H, Hattori F, Egashira T, Seki T, Ohno Y, Koshimizu U, Yuasa S, Ogawa S, Yamanaka S, Yasuda K, Fukuda K
• Roles of Sall4 in the generation of pluripotent stem cells from blastocysts and fibroblasts.
  Genes to cells : devoted to molecular & cellular mechanisms 2009 Tsubooka N, Ichisaka T, Okita K, Takahashi K, Nakagawa M, Yamanaka S
• Induction and isolation of vascular cells from human induced pluripotent stem cells--brief report.
  Arteriosclerosis, thrombosis, and vascular biology 2009 Taura D, Sone M, Homma K, Oyamada N, Takahashi K, Tamura N, Yamanaka S, Nakao K
• Characterization of dendritic cells and macrophages generated by directed differentiation from mouse induced pluripotent stem cells.
  Stem cells (Dayton, Ohio) 2009 Senju S, Haruta M, Matsunaga Y, Fukushima S, Ikeda T, Takahashi K, Okita K, Yamanaka S, Nishimura Y
• Generation of retinal cells from mouse and human induced pluripotent stem cells.
  Neuroscience letters 2009 Hirami Y, Osakada F, Takahashi K, Okita K, Yamanaka S, Ikeda H, Yoshimura N, Takahashi M
• A fresh look at iPS cells.
  Cell 2009 Yamanaka S
• Broader implications of defining standards for the pluripotency of iPSCs.
  Cell stem cell 2009 Daley GQ, Lensch MW, Jaenisch R, Meissner A, Plath K, Yamanaka S
• Adipogenic differentiation of human induced pluripotent stem cells: comparison with that of human embryonic stem cells.
  FEBS letters 2009 Taura D, Noguchi M, Sone M, Hosoda K, Mori E, Okada Y, Takahashi K, Homma K, Oyamada N, Inuzuka M, Sonoyama T, Ebihara K, Tamura N, Itoh H, Suemori H, Nakatsuji N, Okano H, Yamanaka S, Nakao K
• ERas is expressed in primate embryonic stem cells but not related to tumorigenesis.
  Cell transplantation 2009 Tanaka Y, Ikeda T, Kishi Y, Masuda S, Shibata H, Takeuchi K, Komura M, Iwanaka T, Muramatsu S, Kondo Y, Takahashi K, Yamanaka S, Hanazono Y
• Defining developmental potency and cell lineage trajectories by expression profiling of differentiating mouse embryonic stem cells.
  DNA research : an international journal for rapid publication of reports on genes and genomes 2008 Aiba K, Nedorezov T, Piao Y, Nishiyama A, Matoba R, Sharova LV, Sharov AA, Yamanaka S, Niwa H, Ko MS
• Generation of mouse induced pluripotent stem cells without viral vectors.
  Science (New York, N.Y.) 2008 Okita K, Nakagawa M, Hyenjong H, Ichisaka T, Yamanaka S
• Directed and systematic differentiation of cardiovascular cells from mouse induced pluripotent stem cells.
  Circulation 2008 Narazaki G, Uosaki H, Teranishi M, Okita K, Kim B, Matsuoka S, Yamanaka S, Yamashita JK
• Pluripotency and nuclear reprogramming.
  Philosophical transactions of the Royal Society of London. Series B, Biological sciences 2008 Yamanaka S
• Generation of pluripotent stem cells from adult mouse liver and stomach cells.
  Science (New York, N.Y.) 2008 Aoi T, Yae K, Nakagawa M, Ichisaka T, Okita K, Takahashi K, Chiba T, Yamanaka S
• Generation of induced pluripotent stem cells without Myc from mouse and human fibroblasts.
  Nature biotechnology 2007 Nakagawa M, Koyanagi M, Tanabe K, Takahashi K, Ichisaka T, Aoi T, Okita K, Mochiduki Y, Takizawa N, Yamanaka S
• Induction of pluripotent stem cells from adult human fibroblasts by defined factors.
  Cell 2007 Takahashi K, Tanabe K, Ohnuki M, Narita M, Ichisaka T, Tomoda K, Yamanaka S
• New advances in iPS cell research do not obviate the need for human embryonic stem cells.
  Cell stem cell 2007 Hyun I, Hochedlinger K, Jaenisch R, Yamanaka S
• Reprogramming somatic cells towards pluripotency by defined factors.
  Current opinion in biotechnology 2007 Lewitzky M, Yamanaka S
• Drosophila NAT1, a homolog of the vertebrate translational regulator NAT1/DAP5/p97, is required for embryonic germband extension and metamorphosis.
  Development, growth & differentiation 2007 Yoshikane N, Nakamura N, Ueda R, Ueno N, Yamanaka S, Nakamura M
• Strategies and new developments in the generation of patient-specific pluripotent stem cells.
  Cell stem cell 2007 Yamanaka S
• Generation of germline-competent induced pluripotent stem cells.
  Nature 2007 Okita K, Ichisaka T, Yamanaka S
• Induction of pluripotent stem cells from fibroblast cultures.
  Nature protocols 2007 Takahashi K, Okita K, Nakagawa M, Yamanaka S
• [Induction of pluripotent stem cells from mouse fibroblast cultures].
  Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme 2006 Yamanaka S, Takahashi K
• Dnmt3a2 targets endogenous Dnmt3L to ES cell chromatin and induces regional DNA methylation.
  Genes to cells : devoted to molecular & cellular mechanisms 2006 Nimura K, Ishida C, Koriyama H, Hata K, Yamanaka S, Li E, Ura K, Kaneda Y
• Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors.
  Cell 2006 Takahashi K, Yamanaka S
• Esg1, expressed exclusively in preimplantation embryos, germline, and embryonic stem cells, is a putative RNA-binding protein with broad RNA targets.
  Development, growth & differentiation 2006 Tanaka TS, Lopez de Silanes I, Sharova LV, Akutsu H, Yoshikawa T, Amano H, Yamanaka S, Gorospe M, Ko MS
• Transcriptional repression and DNA hypermethylation of a small set of ES cell marker genes in male germline stem cells.
  BMC developmental biology 2006 Imamura M, Miura K, Iwabuchi K, Ichisaka T, Nakagawa M, Lee J, Kanatsu-Shinohara M, Shinohara T, Yamanaka S
• Identification and targeted disruption of the mouse gene encoding ESG1 (PH34/ECAT2/DPPA5).
  BMC developmental biology 2006 Amano H, Itakura K, Maruyama M, Ichisaka T, Nakagawa M, Yamanaka S
• Identification of genes involved in tumor-like properties of embryonic stem cells.
  Methods in molecular biology (Clifton, N.J.) 2006 Takahashi K, Ichisaka T, Yamanaka S
• Intracellular signaling pathways regulating pluripotency of embryonic stem cells.
  Current stem cell research & therapy 2006 Okita K, Yamanaka S
• Utilization of digital differential display to identify novel targets of Oct3/4.
  Methods in molecular biology (Clifton, N.J.) 2006 Tokuzawa Y, Maruyama M, Yamanaka S
• [Molecular mechanisms underlying pluripotency of embryonic stem cells].
  Seikagaku. The Journal of Japanese Biochemical Society 2006 Yamanaka S
• Differential membrane localization of ERas and Rheb, two Ras-related proteins involved in the phosphatidylinositol 3-kinase/mTOR pathway.
  The Journal of biological chemistry 2005 Takahashi K, Nakagawa M, Young SG, Yamanaka S
• Complete and durable remission of refractory mantle cell lymphoma with repeated rituximab monotherapy.
  International journal of hematology 2005 Ishiyama K, Takami A, Okumura H, Ozaki J, Shimadoi S, Yamanaka S, Nakao S
• [Mechanism for maintaining pluripotency in embryonic stem cells and inner cell mass].
  Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme 2005 Nakagawa M, Yamanaka S
• Differential roles for Sox15 and Sox2 in transcriptional control in mouse embryonic stem cells.
  The Journal of biological chemistry 2005 Maruyama M, Ichisaka T, Nakagawa M, Yamanaka S
• Evolutionarily conserved non-AUG translation initiation in NAT1/p97/DAP5 (EIF4G2).
  Genomics 2005 Takahashi K, Maruyama M, Tokuzawa Y, Murakami M, Oda Y, Yoshikane N, Makabe KW, Ichisaka T, Yamanaka S
• Multiple functions of Jab1 are required for early embryonic development and growth potential in mice.
  The Journal of biological chemistry 2004 Tomoda K, Yoneda-Kato N, Fukumoto A, Yamanaka S, Kato JY
• Expression profiling with arrays of randomly disrupted genes in mouse embryonic stem cells leads to in vivo functional analysis.
  Proceedings of the National Academy of Sciences of the United States of America 2004 Matsuda E, Shigeoka T, Iida R, Yamanaka S, Kawaichi M, Ishida Y
• The homeoprotein Nanog is required for maintenance of pluripotency in mouse epiblast and ES cells.
  Cell 2003 Mitsui K, Tokuzawa Y, Itoh H, Segawa K, Murakami M, Takahashi K, Maruyama M, Maeda M, Yamanaka S
• Role of ERas in promoting tumour-like properties in mouse embryonic stem cells.
  Nature 2003 Takahashi K, Mitsui K, Yamanaka S
• Fbx15 is a novel target of Oct3/4 but is dispensable for embryonic stem cell self-renewal and mouse development.
  Molecular and cellular biology 2003 Tokuzawa Y, Kaiho E, Maruyama M, Takahashi K, Mitsui K, Maeda M, Niwa H, Yamanaka S
• Low expression of the apolipoprotein B mRNA-editing transgene in mice reduces LDL levels but does not cause liver dysplasia or tumors.
  Arteriosclerosis, thrombosis, and vascular biology 1998 Qian X, Balestra ME, Yamanaka S, Borén J, Lee I, Innerarity TL
• A novel translational repressor mRNA is edited extensively in livers containing tumors caused by the transgene expression of the apoB mRNA-editing enzyme.
  Genes & development 1997 Yamanaka S, Poksay KS, Arnold KS, Innerarity TL
• Hyperediting of multiple cytidines of apolipoprotein B mRNA by APOBEC-1 requires auxiliary protein(s) but not a mooring sequence motif.
  The Journal of biological chemistry 1996 Yamanaka S, Poksay KS, Driscoll DM, Innerarity TL
• Cloning and mutagenesis of the rabbit ApoB mRNA editing protein. A zinc motif is essential for catalytic activity, and noncatalytic auxiliary factor(s) of the editing complex are widely distributed.
  The Journal of biological chemistry 1994 Yamanaka S, Poksay KS, Balestra ME, Zeng GQ, Innerarity TL