Sheng Ding, PhD
Professor
Pharmaceutical Chemistry
School of Pharmacy

Before moving to Gladstone/UCSF in early 2011, Ding was an Assistant Professor and then Associate Professor of Chemistry at Scripps from 2003 to 2011. Dr. Ding has pioneered on developing and applying innovative chemical approaches to stem cell biology and regeneration, with a focus on discovering and characterizing novel small molecules that can control various cell fate/function, including stem cell maintenance, activation, differentiation and reprogramming in various developmental stages and tissues. Ding has published over 100 research articles, reviews and book chapters, and made several seminal contributions to the stem cell field. Ding is a cofounder of Fate Therapeutics and Stemgent.

• Chemical Enhancement of In Vitro and In Vivo Direct Cardiac Reprogramming.
  Circulation 2016 Mohamed TM, Stone NR, Berry EC, Radzinsky E, Huang Y, Pratt K, Ang YS, Yu P, Wang H, Tang S, Magnitsky S, Ding S, Ivey KN, Srivastava D
• Chemical Modulation of Cell Fate in Stem Cell Therapeutics and Regenerative Medicine.
  Cell chemical biology 2016 Liu K, Yu C, Xie M, Li K, Ding S
• Conversion of human fibroblasts into functional cardiomyocytes by small molecules.
  Science (New York, N.Y.) 2016 Cao N, Huang Y, Zheng J, Spencer CI, Zhang Y, Fu JD, Nie B, Xie M, Zhang M, Wang H, Ma T, Xu T, Shi G, Srivastava D, Ding S
• Pharmacological Reprogramming of Fibroblasts into Neural Stem Cells by Signaling-Directed Transcriptional Activation.
  Cell stem cell 2016 Zhang M, Lin YH, Sun YJ, Zhu S, Zheng J, Liu K, Cao N, Li K, Huang Y, Ding S
• Expandable Cardiovascular Progenitor Cells Reprogrammed from Fibroblasts.
  Cell stem cell 2016 Zhang Y, Cao N, Huang Y, Spencer CI, Fu JD, Yu C, Liu K, Nie B, Xu T, Li K, Xu S, Bruneau BG, Srivastava D, Ding S
• Human pancreatic beta-like cells converted from fibroblasts.
  Nature communications 2016 Zhu S, Russ HA, Wang X, Zhang M, Ma T, Xu T, Tang S, Hebrok M, Ding S
• Abstract 11415: Enhancing Direct Cardiac Reprogramming Efficiency Using Small Molecules.
  Circulation 2015 Tamer M Mohamed, Nicole Stone, Emily Berry, Haixia Wang, Sheng Ding, Deepak Srivastava
• 458. Sensitizing Ovarian Cancer Cells To Chemotherapy By Interfering With Pathways That Are Involved in the Formation and Maintenance of Cancer Stem Cells.
  Molecular Therapy 2015 Kamola Saydaminova, Robert Strauss, Min Xie, Charles Dreshner, Sheng Ding, Andre Lieber
• Chapter 4 Chemical Approaches to Controlling Cell Fate.
  Principles of Developmental Genetics 2015 Mingliang Zhang, Ke Li, Min Xie, Sheng Ding
• Chemical approaches to cell reprogramming.
  Current opinion in genetics & development 2014 Yu C, Liu K, Tang S, Ding S
• Small molecules facilitate the reprogramming of mouse fibroblasts into pancreatic lineages.
  Cell stem cell 2014 Li K, Zhu S, Russ HA, Xu S, Xu T, Zhang Y, Ma T, Hebrok M, Ding S
• Small molecules enable OCT4-mediated direct reprogramming into expandable human neural stem cells.
  Cell research 2013 Zhu S, Ambasudhan R, Sun W, Kim HJ, Talantova M, Wang X, Zhang M, Zhang Y, Laurent T, Parker J, Kim HS, Zaremba JD, Saleem S, Sanz-Blasco S, Masliah E, McKercher SR, Cho YS, Lipton SA, Kim J, Ding S
• Dual-color HIV reporters trace a population of latently infected cells and enable their purification.
  Virology 2013 Calvanese V, Chavez L, Laurent T, Ding S, Verdin E
• Direct reprogramming of human fibroblasts toward a cardiomyocyte-like state.
  Stem cell reports 2013 Fu JD, Stone NR, Liu L, Spencer CI, Qian L, Hayashi Y, Delgado-Olguin P, Ding S, Bruneau BG, Srivastava D
• Toward directed reprogramming through exogenous factors.
  Current opinion in genetics & development 2013 Lin C, Yu C, Ding S
• Concise review: chemical approaches for modulating lineage-specific stem cells and progenitors.
  Stem cells translational medicine 2013 Xu T, Zhang M, Laurent T, Xie M, Ding S
• Conversion of human fibroblasts to functional endothelial cells by defined factors.
  Arteriosclerosis, thrombosis, and vascular biology 2013 Li J, Huang NF, Zou J, Laurent TJ, Lee JC, Okogbaa J, Cooke JP, Ding S
• Progress in the reprogramming of somatic cells.
  Circulation research 2013 Ma T, Xie M, Laurent T, Ding S
• Small molecules, big roles -- the chemical manipulation of stem cell fate and somatic cell reprogramming.
  Journal of cell science 2012 Zhang Y, Li W, Laurent T, Ding S
• Cellular reprogramming: a small molecule perspective.
  Current opinion in cell biology 2012 Nie B, Wang H, Laurent T, Ding S
• Target practice: modeling tumors with stem cells.
  Cell 2012 Liu K, Ding S
• Ursolic acid suppresses interleukin-17 (IL-17) production by selectively antagonizing the function of RORgamma t protein.
  The Journal of biological chemistry 2011 Xu T, Wang X, Zhong B, Nurieva RI, Ding S, Dong C
• Small Molecules in Cellular Reprogramming and Differentiation.
  Epigenetics and Disease 2011 Xu Yuan, Wenlin Li, Sheng Ding
• Generation of Induced Pluripotent Stem Cells Using Recombinant Proteins.
  Cell Stem Cell 2009 Hongyan Zhou, Shili Wu, Jin Young Joo, Saiyong Zhu, Dong Wook Han, Tongxiang Lin, Sunia Trauger, Geoffery Bien, Susan Yao, Yong Zhu, Gary Siuzdak, Hans R. Schöler, Lingxun Duan, Sheng Ding
• Generation of Rat and Human Induced Pluripotent Stem Cells by Combining Genetic Reprogramming and Chemical Inhibitors.
  Cell Stem Cell 2009 Wenlin Li, Wei Wei, Saiyong Zhu, Jinliang Zhu, Yan Shi, Tongxiang Lin, Ergeng Hao, Alberto Hayek, Hongkui Deng, Sheng Ding
• A chemical approach to stem cell biology.
  Cell Research 2008 Sheng Ding
• A Combined Chemical and Genetic Approach for the Generation of Induced Pluripotent Stem Cells.
  Cell Stem Cell 2008 Yan Shi, Jeong Tae, Caroline Desponts, Heung Sik Hahm, Hans R. Schöler, Sheng Ding
• Stem Cell Fates: Control by Small Molecules.
  Wiley Encyclopedia of Chemical Biology 2008 Simon Hilcove, Yue Xu, Sheng Ding
• Exploring Stem Cell Biology with Small Molecules and Functional Genomics.
  Chemical and Functional Genomic Approaches to Stem Cell Biology and Regenerative Medicine 2008 Julie Clark, Yue Xu, Simon Hilcove, Sheng Ding
• 2 TARGET VALIDATION IN CHEMOGENOMICS.
  Target Validation in Drug Discovery 2007 TOM Y-H. WU, SHENG DING
• GSK-3 and Stem Cells.
  Glycogen Synthase Kinase 3 (GSK-3) and Its Inhibitors 2006 Shuibing Chen, Sheng Ding
• A Synthetic Small Molecule That Induces Neuronal Differentiation of Adult Hippocampal Neural Progenitor Cells.
  Angewandte Chemie 2006 Masaki Warashina, Kyung Hoon Min, Tomoko Kuwabara, Alexis Huynh, Fred H. Gage, Peter G. Schultz, Sheng Ding
• A Small-Molecule Agonist of the Wnt Signaling Pathway.
  Angewandte Chemie 2005 Jun Liu, Xu Wu, Brian Mitchell, Chris Kintner, Sheng Ding, Peter G. Schultz
• One-Pot Two-Step Microwave-Assisted Reaction in Constructing 4,5-Disubstituted Pyrazolopyrimidines.
  ChemInform 2004 Tom Y. H. Wu, Peter G. Schultz, Sheng Ding
• ChemInform Abstract: Expanding the Diversity of Purine Libraries.
  ChemInform 2002 Sheng Ding, Nathanael S. Gray, Qiang Ding, Peter G. Schultz
• Expanding the diversity of purine libraries.
  Tetrahedron Letters 2001 Sheng Ding, Nathanael S Gray, Qiang Ding, Peter G Schultz
• Prediction of retention indexes. II. Structure-retention index relationship on polar columns.
  Journal of chromatography 1991 Peng CT, Yang ZC, Ding SF
• Prediction of retention indexes. I. Structure-retention index relationship on apolar columns.
  Journal of chromatography 1988 Peng CT, Ding SF, Hua RL, Yang ZC