Sheila Keating, PhD
Associate Professor
Laboratory Medicine
School of Medicine

I have done this by caputuring the ENTIRE antibody repertoire from vaccine recipients, convalescent donors or immunized humanized mice. These drugs are created quickly - A covid polyclonal antibody therapeutic was made in 3 months from the receipt of donor specimens, and this therapeutic contains over 12,500 unique and COVID-specific antibodies - providing diverse neutralizing antibodies that will be resistant to viral evasion. We are looking forward to developing the next drugs for the next difficult to treat disease requiring a multi-specific poly-valent antibody therapeutic. My research has been diverse, as the Director of the Core Immunology Laboratory, I focused on biomarker discovery using low volume, high throughput immune assays to measure cytokines, chemokines, growth factors and other biomarkers of immune response or pathology in a number of studies ranging from HIV, HCV, HBV vaccine breakthrough, Chagas, West Nile Virus, cardiovascular disease, neuropathology and many other areas. Discovering biomarkers of infection enables understanding of detection of infection, protection from pathology, and development of therapeutics that will prevent disease.

• Structural, Ionic, and Electronic Properties of Solid-State Phthalimide-Containing Polymers for All-Organic Batteries.
  JACS Au 2024 Alessandri R, Li CH, Keating S, Mohanty KT, Peng A, Lutkenhaus JL, Rowan SJ, Tabor DP, de Pablo JJ
• New technologies in therapeutic antibody development: The next frontier for treating infectious diseases.
  Antiviral research 2024 Keating SM, Higgins BW
• A Potent Recombinant Polyclonal Antibody Therapeutic for Protection Against New Severe Acute Respiratory Syndrome Coronavirus 2 Variants of Concern.
  The Journal of infectious diseases 2023 Wayham NP, Niedecken AR, Simons JF, Chiang YY, Medina-Cucurella AV, Mizrahi RA, Wagner EK, Gras A, Segal I, Witte P, Enstrom A, Bountouvas A, Nelson SM, Weinberger T, Tan D, Asensio MA, Subramanian A,…
• Early Life Trauma and Social Processing in HIV: The Role of Neuroendocrine Factors and Inflammation.
  Psychosomatic medicine 2022 Rubin LH, Bhattacharya D, Fuchs J, Matthews A, Abdellah S, Veenhuis RT, Langenecker SA, Weber KM, Nazarloo HP, Keating SM, Carter CS, Maki PM
• GMP Manufacturing and IND-Enabling Studies of a Recombinant Hyperimmune Globulin Targeting SARS-CoV-2.
  Pathogens (Basel, Switzerland) 2022 Mizrahi RA, Lin WY, Gras A, Niedecken AR, Wagner EK, Keating SM, Ikon N, Manickam VA, Asensio MA, Leong J, Medina-Cucurella AV, Benzie E, Carter KP, Chiang Y, Edgar RC, Leong R, Lim YW, Simons JF, …
• No evidence that circulating HIV-specific immune responses contribute to persistent inflammation and immune activation in persons on long-term ART.
  AIDS (London, England) 2022 Ward AR, Thomas AS, Stevenson EM, Huang SH, Keating SM, Gandhi RT, McMahon DK, Bosch RJ, Macatangay BJ, Cyktor JC, Eron JJ, Mellors JW, Jones RB, ACTG A5321 Team
• Body Mass Index and Leptin Are Related to Cognitive Performance Over 10 Years in Women With and Without HIV Infection.
  The Journal of clinical endocrinology and metabolism 2022 Macaluso F, Weber KM, Rubin LH, Dellinger E, Holman S, Minkoff H, Keating S, Merlin LR, Gustafson DR
• HIV Disease Dynamics and Markers of Inflammation and CNS Injury During Primary HIV Infection and Their Relationship to Cognitive Performance.
  Journal of acquired immune deficiency syndromes (1999) 2022 Longino AA, Paul R, Wang Y, Lama JR, Brandes P, Ruiz E, Correa C, Keating S, Spudich SS, Pilcher C, Vecchio A, Pasalar S, Bender Ignacio RA, Valdez R, Dasgupta S, Robertson K, Duerr A
• Assessing the Suitability of Next-Generation Viral Outgrowth Assays to Measure Human Immunodeficiency Virus 1 Latent Reservoir Size.
  The Journal of infectious diseases 2021 Stone M, Rosenbloom DIS, Bacchetti P, Deng X, Dimapasoc M, Keating S, Bakkour S, Richman DD, Mellors JW, Deeks SG, Lai J, Beg S, Siliciano JD, Pagliuzza A, Chomont N, Lackman-Smith C, Ptak RG, Busch …
• Compartmentalization of cerebrospinal fluid inflammation across the spectrum of untreated HIV-1 infection, central nervous system injury and viral suppression.
  PloS one 2021 Gisslen M, Keating SM, Spudich S, Arechiga V, Stephenson S, Zetterberg H, Di Germanio C, Blennow K, Fuchs D, Hagberg L, Norris PJ, Peterson J, Shacklett BL, Yiannoutsos CT, Price RW
• Generation of recombinant hyperimmune globulins from diverse B-cell repertoires.
  Nature biotechnology 2021 Keating SM, Mizrahi RA, Adams MS, Asensio MA, Benzie E, Carter KP, Chiang Y, Edgar RC, Gautam BK, Gras A, Leong J, Leong R, Lim YW, Manickam VA, Medina-Cucurella AV, Niedecken AR, Saini J, Simons JF, …
• Bedside Allogeneic Erythrocyte Washing with a Cell Saver to Remove Cytokines, Chemokines, and Cell-derived Microvesicles.
  Anesthesiology 2021 Welsby IJ, Norris PJ, Mauermann WJ, Podgoreanu MV, Conn CM, Meade L, Cannon T, Keating SM, Silliman CC, Kehler M, Schulte PJ, Kor DJ
• Galectin-3 Associated with Severe Forms and Long-term Mortality in Patients with Chagas Disease.
  Arquivos brasileiros de cardiologia 2021 Fernandes F, Moreira CHV, Oliveira LC, Souza-Basqueira M, Ianni BM, Lorenzo CD, Ramires FJA, Nastari L, Cunha-Neto E, Ribeiro AL, Lopes RD, Keating SM, Sabino EC, Mady C
• Blood transfusion safety in the country of Georgia: collateral benefit from a national hepatitis C elimination program.
  Transfusion 2020 Bloch EM, Kipiani E, Shadaker S, Alkhazashvili M, Gvinjilia L, Kuchuloria T, Chitadze N, Keating SM, Gamkrelidze A, Turdziladze A, Getia V, Nasrullah M, Averhoff F, Izoria M, Skaggs B
• Early Inflammatory Signatures Predict Subsequent Cognition in Long-Term Virally Suppressed Women With HIV.
  Frontiers in integrative neuroscience 2020 Rubin LH, Xu Y, Norris PJ, Wang X, Dastgheyb R, Fitzgerald KC, Keating SM, Kaplan RC, Maki PM, Anastos K, Springer G, Benning L, Kassaye S, Gustafson DR, Valcour VG, Williams DW
• Influence of sickle cell disease on susceptibility to HIV infection.
  PloS one 2020 Kelly S, Jacobs ES, Stone M, Keating SM, Lee TH, Chafets D, Heitman J, Dimapasoc M, Operskalski E, Hagar W, Vichinsky E, Busch MP, Norris PJ, Custer B, Recipient Epidemiology and Donor Evaluation …
• Remitted depression and cognition in HIV: The role of cortisol and inflammation.
  Psychoneuroendocrinology 2020 Rubin LH, Langenecker SA, Phan KL, Keating SM, Neigh GN, Weber KM, Maki PM
• A New Perspective on HIV Diagnostics: Reinterpretation in the Age of Early Treatment.
  Journal of clinical microbiology 2019 Keating SM
• Development of an international external quality assurance program for HIV-1 incidence using the Limiting Antigen Avidity assay.
  PloS one 2019 Keating SM, Rountree W, Grebe E, Pappas AL, Stone M, Hampton D, Todd CA, Poniewierski MS, Sanchez A, Porth CG, Denny TN, Busch MP, EQAPOL Limiting Antigen (LAg) Incidence Assay External Quality …
• Performance comparison of the Maxim and Sedia Limiting Antigen Avidity assays for HIV incidence surveillance.
  PloS one 2019 Sempa JB, Welte A, Busch MP, Hall J, Hampton D, Facente SN, Keating SM, Marson K, Parkin N, Pilcher CD, Murphy G, Grebe E, Consortium for the Evaluation and Performance of HIV Incidence Assays (CEPHIA…
• Assessing intra-lab precision and inter-lab repeatability of outgrowth assays of HIV-1 latent reservoir size.
  PLoS computational biology 2019 Rosenbloom DIS, Bacchetti P, Stone M, Deng X, Bosch RJ, Richman DD, Siliciano JD, Mellors JW, Deeks SG, Ptak RG, Hoh R, Keating SM, Dimapasoc M, Massanella M, Lai J, Sobolewski MD, Kulpa DA, Busch MP,…
• Influence of blood storage age on immune and coagulation parameters in critically ill transfused patients.
  Transfusion 2019 Norris PJ, Schechtman K, Inglis HC, Adelman A, Heitman JW, Vilardi R, Shah A, Roubinian NH, Danesh A, Guiltinan AM, Keating SM, Lacroix J, Cohen MJ, Spinella PC
• Therapeutic impact of red blood cell transfusion on anemic outpatients: the RETRO study.
  Transfusion 2019 St Lezin E, Karafin MS, Bruhn R, Chowdhury D, Qu L, Bialkowski W, Merenda S, D'Andrea P, McCalla AL, Anderson L, Keating SM, Stone M, Snyder EL, Brambilla D, Murphy EL, Norris PJ, Hilton JF, Spencer …
• Effects of blood storage age on immune, coagulation, and nitric oxide parameters in transfused patients undergoing cardiac surgery.
  Transfusion 2019 Spinella PC, Sniecinski RM, Trachtenberg F, Inglis HC, Ranganathan G, Heitman JW, Szlam F, Danesh A, Stone M, Keating SM, Levy JH, Assmann SF, Steiner ME, Doctor A, Norris PJ
• Integration of a recent infection testing algorithm into HIV surveillance in Ireland: improving HIV knowledge to target prevention.
  Epidemiology and infection 2019 Robinson E, Moran J, O'Donnell K, Hassan J, Tuite H, Ennis O, Cooney F, Nugent E, Preston L, O'Dea S, Doyle S, Keating S, Connell J, De Gascun C, Igoe D
• Piloting and implementation of quality assessment and quality control procedures in RBC-Omics: a large multi-center study of red blood cell hemolysis during storage.
  Transfusion 2018 Stone M, Keating SM, Kanias T, Lanteri MC, Lebedeva M, Sinchar D, Hampton D, Jakub A, Rychka V, Brewer G, Bakkour S, Gefter N, Murcia K, Page GP, Endres-Dighe S, Bialkowski W, Fu X, Zimring J, Raife …
• Intradonor reproducibility and changes in hemolytic variables during red blood cell storage: results of recall phase of the REDS-III RBC-Omics study.
  Transfusion 2018 Lanteri MC, Kanias T, Keating S, Stone M, Guo Y, Page GP, Brambilla DJ, Endres-Dighe SM, Mast AE, Bialkowski W, D'Andrea P, Cable RG, Spencer BR, Triulzi DJ, Murphy EL, Kleinman S, Gladwin MT, Busch …
• A single low dose of hydrocortisone enhances cognitive functioning in HIV-infected women.
  AIDS (London, England) 2018 Rubin LH, Phan KL, Keating SM, Maki PM
• Comparison of Detection Limits of Fourth- and Fifth-Generation Combination HIV Antigen-Antibody, p24 Antigen, and Viral Load Assays on Diverse HIV Isolates.
  Journal of clinical microbiology 2018 Stone M, Bainbridge J, Sanchez AM, Keating SM, Pappas A, Rountree W, Todd C, Bakkour S, Manak M, Peel SA, Coombs RW, Ramos EM, Shriver MK, Contestable P, Nair SV, Wilson DH, Stengelin M, Murphy G, …
• Elevated plasma levels of TIMP-3 are associated with a higher risk of acute respiratory distress syndrome and death following severe isolated traumatic brain injury.
  Trauma surgery & acute care open 2018 Hendrickson CM, Gibb SL, Miyazawa BY, Keating SM, Ross E, Conroy AS, Calfee CS, Pati S, Cohen MJ
• Evolution of Validated Biomarkers and Intraoperative Parameters in the Development of Postoperative ARDS.
  Respiratory care 2018 Yadav H, Bartley A, Keating S, Meade LA, Norris PJ, Carter RE, Gajic O, Kor DJ
• Neopterin is associated with hippocampal subfield volumes and cognition in HIV.
  Neurology(R) neuroimmunology & neuroinflammation 2018 Fleischman DA, Arfanakis K, Leurgans S, Keating SM, Lamar M, Bennett DA, Adeyemi OM, Barnes LL
• Granulocyte-Derived Extracellular Vesicles Activate Monocytes and Are Associated With Mortality in Intensive Care Unit Patients.
  Frontiers in immunology 2018 Danesh A, Inglis HC, Abdel-Mohsen M, Deng X, Adelman A, Schechtman KB, Heitman JW, Vilardi R, Shah A, Keating SM, Cohen MJ, Jacobs ES, Pillai SK, Lacroix J, Spinella PC, Norris PJ
• Alloreactive fetal T cells promote uterine contractility in preterm labor via IFN-γ and TNF-α.
  Science translational medicine 2018 Frascoli M, Coniglio L, Witt R, Jeanty C, Fleck-Derderian S, Myers DE, Lee TH, Keating S, Busch MP, Norris PJ, Tang Q, Cruz G, Barcellos LF, Gomez-Lopez N, Romero R, MacKenzie TC
• Computational analysis of antibody dynamics identifies recent HIV-1 infection.
  JCI insight 2017 Seaton KE, Vandergrift NA, Deal AW, Rountree W, Bainbridge J, Grebe E, Anderson DA, Sawant S, Shen X, Yates NL, Denny TN, Liao HX, Haynes BF, Robb ML, Parkin N, Santos BR, Garrett N, Price MA, Naniche…
• Infection Staging and Incidence Surveillance Applications of High Dynamic Range Diagnostic Immuno-Assay Platforms.
  Journal of acquired immune deficiency syndromes (1999) 2017 Grebe E, Welte A, Hall J, Keating SM, Facente SN, Marson K, Martin JN, Little SJ, Price MA, Kallas EG, Busch MP, Pilcher CD, Murphy G
• Extensive virologic and immunologic characterization in an HIV-infected individual following allogeneic stem cell transplant and analytic cessation of antiretroviral therapy: A case study.
  PLoS medicine 2017 Cummins NW, Rizza S, Litzow MR, Hua S, Lee GQ, Einkauf K, Chun TW, Rhame F, Baker JV, Busch MP, Chomont N, Dean PG, Fromentin R, Haase AT, Hampton D, Keating SM, Lada SM, Lee TH, Natesampillai S, …
• Variability in C-reactive protein is associated with cognitive impairment in women living with and without HIV: a longitudinal study.
  Journal of neurovirology 2017 Rubin LH, Benning L, Keating SM, Norris PJ, Burke-Miller J, Savarese A, Kumanan KN, Awadalla S, Springer G, Anastos K, Young M, Milam J, Valcour VG, Weber KM, Maki PM
• Brief Report: Low-Dose Hydrocortisone Has Acute Enhancing Effects on Verbal Learning in HIV-Infected Men.
  Journal of acquired immune deficiency syndromes (1999) 2017 Rubin LH, Phan KL, Keating SM, Weber KM, Maki PM
• Impact of Allogeneic Hematopoietic Stem Cell Transplantation on the HIV Reservoir and Immune Response in 3 HIV-Infected Individuals.
  Journal of acquired immune deficiency syndromes (1999) 2017 Koelsch KK, Rasmussen TA, Hey-Nguyen WJ, Pearson C, Xu Y, Bailey M, Marks KH, Sasson SC, Taylor MS, Tantau R, Obeid S, Milner B, Morrissey O, Pinto AN, Suzuki K, Busch MP, Keating SM, Kaiser P, Yukl S…
• Ethnicity, sex, and age are determinants of red blood cell storage and stress hemolysis: results of the REDS-III RBC-Omics study.
  Blood advances 2017 Kanias T, Lanteri MC, Page GP, Guo Y, Endres SM, Stone M, Keating S, Mast AE, Cable RG, Triulzi DJ, Kiss JE, Murphy EL, Kleinman S, Busch MP, Gladwin MT
• The infection staging and profile of genotypic distribution and drug resistance mutation among the human immunodeficiency virus-1 infected blood donors from five Chinese blood centers, 2012-2014.
  PloS one 2017 Zeng P, Liu Y, He M, Wang J, Keating S, Mao W, Huang M, Ma H, He W, Bi X, Liao D, Busch M, Ness P, Liu J, Shan H, NHLBI Recipient Epidemiology and Donor Evaluation Study-III program
• Serum from dengue virus-infected patients with and without plasma leakage differentially affects endothelial cells barrier function in vitro.
  PloS one 2017 Tramontini Gomes de Sousa Cardozo F, Baimukanova G, Lanteri MC, Keating SM, Moraes Ferreira F, Heitman J, Pannuti CS, Pati S, Romano CM, Cerdeira Sabino E
• Differentiating pulmonary transfusion reactions using recipient and transfusion factors.
  Transfusion 2017 Roubinian NH, Looney MR, Keating S, Kor DJ, Lowell CA, Gajic O, Hubmayr R, Gropper M, Koenigsberg M, Wilson GA, A Matthay M, Toy P, Murphy EL, TRALI Study Group
• Plasminogen Activator Inhibitor-1 Predicts Negative Alterations in Whole-Body Insulin Sensitivity in Chronic HIV Infection.
  AIDS research and human retroviruses 2017 Wirunsawanya K, Belyea L, Shikuma C, Watanabe RM, Kohorn L, Shiramizu B, Mitchell BI, Souza SA, Keating SM, Norris PJ, Ndhlovu LC, Chow D
• The association of maternal lymphatic markers and critical congenital heart defects in the fetus-A population based case-control study.
  American journal of medical genetics. Part A 2017 Steurer MA, Norton ME, Baer RJ, Shaw GM, Keating S, Moon-Grady AJ, Chambers CD, Jelliffe-Pawlowski LL
• Comparison of cross-sectional HIV incidence assay results from dried blood spots and plasma.
  PloS one 2017 Schlusser KE, Pilcher C, Kallas EG, Santos BR, Deeks SG, Facente S, Keating SM, Busch MP, Murphy G, Welte A, Quinn T, Eshleman SH, Laeyendecker O
• Ghrelin, Amylin, Gastric Inhibitory Peptide and Cognition in Middle-Aged HIV-Infected and Uninfected Women: The Women's Interagency HIV Study.
  Journal of neurology & neurophysiology 2017 McFarlane SI, Mielke MM, Uglialoro A, Keating SM, Holman S, Minkoff H, Crystal HA, Gustafson DR
• Moving towards a reliable HIV incidence test - current status, resources available, future directions and challenges ahead.
  Epidemiology and infection 2016 Murphy G, Pilcher CD, Keating SM, Kassanjee R, Facente SN, Welte A, Grebe E, Marson K, Busch MP, Dailey P, Parkin N, Osborn J, Ongarello S, Marsh K, Garcia-Calleja JM, Consortium for the Evaluation …
• Brief Report: Association of Adipokines With Bone Mineral Density in HIV-Infected and HIV-Uninfected Women.
  Journal of acquired immune deficiency syndromes (1999) 2016 Sharma A, Ma Y, Scherzer R, Wheeler AL, Cohen M, Gustafson DR, Keating SM, Yin MT, Tien PC
• High 25-hydroxyvitamin D is associated with unexpectedly high plasma inflammatory markers in HIV patients on antiretroviral therapy.
  Medicine 2016 Gangcuangco LMA, Kohorn LB, Chow DC, Keating SM, Norris PJ, Nagamine LS, Ndhlovu LC, Souza SA, Kallianpur KJ, Shikuma CM
• Viral load criteria and threshold optimization to improve HIV incidence assay characteristics.
  AIDS (London, England) 2016 Kassanjee R, Pilcher CD, Busch MP, Murphy G, Facente SN, Keating SM, Mckinney E, Marson K, Price MA, Martin JN, Little SJ, Hecht FM, Kallas EG, Welte A, Consortium for the Evaluation and Performance …
• Characterization of Simian Immunodeficiency Virus Variants Anatomically Compartmentalized in Plasma and Milk in Chronically Infected African Green Monkeys.
  Journal of virology 2016 Himes JE, Ho C, Nguyen QN, Amos JD, Xu H, Chan C, Chow SC, Ochsenbauer C, Kaidarova Z, Keating SM, Fouda GG, Permar SR
• Extensive Genetic Diversity of HIV-1 in Incident and Prevalent Infections among Malaysian Blood Donors: Multiple Introductions of HIV-1 Genotypes from Highly Prevalent Countries.
  PloS one 2016 Chow WZ, Bon AH, Keating S, Anderios F, Halim HA, Takebe Y, Kamarulzaman A, Busch MP, Tee KK
• Genetic Characterization of a Panel of Diverse HIV-1 Isolates at Seven International Sites.
  PloS one 2016 Hora B, Keating SM, Chen Y, Sanchez AM, Sabino E, Hunt G, Ledwaba J, Hackett J, Swanson P, Hewlett I, Ragupathy V, Vikram Vemula S, Zeng P, Tee KK, Chow WZ, Ji H, Sandstrom P, Denny TN, Busch MP, Gao …
• Human Galectin-9 Is a Potent Mediator of HIV Transcription and Reactivation.
  PLoS pathogens 2016 Abdel-Mohsen M, Chavez L, Tandon R, Chew GM, Deng X, Danesh A, Keating S, Lanteri M, Samuels ML, Hoh R, Sacha JB, Norris PJ, Niki T, Shikuma CM, Hirashima M, Deeks SG, Ndhlovu LC, Pillai SK
• Heightened Immune Activation in Fetuses with Gastroschisis May Be Blocked by Targeting IL-5.
  Journal of immunology (Baltimore, Md. : 1950) 2016 Frascoli M, Jeanty C, Fleck S, Moradi PW, Keating S, Mattis AN, Tang Q, MacKenzie TC
• Non-classical monocytes predict progression of carotid artery bifurcation intima-media thickness in HIV-infected individuals on stable antiretroviral therapy.
  HIV clinical trials 2016 Chow DC, Kagihara JM, Zhang G, Souza SA, Hodis HN, Li Y, Mitchell BI, Nakamoto BK, Kallianpur KJ, Keating SM, Norris PJ, Kohorn LB, Ndhlovu LC, Shikuma CM
• The effects of 22°C and 4°C storage of platelets on vascular endothelial integrity and function.
  Transfusion 2016 Baimukanova G, Miyazawa B, Potter DR, Gibb SL, Keating S, Danesh A, Beyer A, Dayter Y, Bruhn R, Muench MO, Cap AP, Norris PJ, Spinella P, Cohen M, Pati S
• Non-Classical Monocytes and Monocyte Chemoattractant Protein-1 (MCP-1) Correlate with Coronary Artery Calcium Progression in Chronically HIV-1 Infected Adults on Stable Antiretroviral Therapy.
  PloS one 2016 Zungsontiporn N, Tello RR, Zhang G, Mitchell BI, Budoff M, Kallianpur KJ, Nakamoto BK, Keating SM, Norris PJ, Ndhlovu LC, Souza SA, Shikuma CM, Chow DC
• Systemic Cytokine Levels Do Not Predict CD4(+) T-Cell Recovery After Suppressive Combination Antiretroviral Therapy in Chronic Human Immunodeficiency Virus Infection.
  Open forum infectious diseases 2016 Norris PJ, Zhang J, Worlock A, Nair SV, Anastos K, Minkoff HL, Villacres MC, Young M, Greenblatt RM, Desai S, Landay AL, Gange SJ, Nugent CT, Golub ET, Keating SM
• Soluble CD163 But Not Soluble CD14 Is Associated With Cytomegalovirus Immunoglobulin G Antibody Levels in Virologically Suppressed HIV+ Individuals.
  Journal of acquired immune deficiency syndromes (1999) 2015 Hodowanec A, Williams B, Hanson B, Livak B, Keating S, Lurain N, Adeyemi OM
• Neutralizing Monoclonal Antibodies Block Chikungunya Virus Entry and Release by Targeting an Epitope Critical to Viral Pathogenesis.
  Cell reports 2015 Jin J, Liss NM, Chen DH, Liao M, Fox JM, Shimak RM, Fong RH, Chafets D, Bakkour S, Keating S, Fomin ME, Muench MO, Sherman MB, Doranz BJ, Diamond MS, Simmons G
• Serum amyloid P (SAP) is associated with impaired brachial artery flow-mediated dilation in chronically HIV-1 infected adults on stable antiretroviral therapy.
  HIV clinical trials 2015 Zungsontiporn N, Ndhlovu LC, Mitchell BI, Stein JH, Kallianpur KJ, Nakamoto B, Keating SM, Norris PJ, Souza SA, Shikuma CM, Chow DC
• Short Communication: SCD14 and SCD163 Levels Are Correlated with VACS Index Scores: Initial Data from the Blunted Immune Recovery in CORE Patients with HIV (BIRCH) Cohort.
  AIDS research and human retroviruses 2015 Williams B, Livak B, Bahk M, Keating SM, Adeyemi OM
• Fresh frozen plasma and spray-dried plasma mitigate pulmonary vascular permeability and inflammation in hemorrhagic shock.
  The journal of trauma and acute care surgery 2015 Potter DR, Baimukanova G, Keating SM, Deng X, Chu JA, Gibb SL, Peng Z, Muench MO, Fomin ME, Spinella PC, Kozar R, Pati S
• Effect of integrating HIV and addiction care for non-engaging HIV-infected opiate-dependent patients.
  Irish journal of medical science 2015 Kinahan JC, Surah S, Keating S, Bergin C, Mulcahy F, Lyons F, Keenan E
• Brain alterations within the first 100 days of HIV infection.
  Annals of clinical and translational neurology 2014 Ragin AB, Wu Y, Gao Y, Keating S, Du H, Sammet C, Kettering CS, Epstein LG
• Albuminuria is associated with elevated acute phase reactants and proinflammatory markers in HIV-infected patients receiving suppressive combination antiretroviral therapy.
  AIDS research and human retroviruses 2014 O-charoen P, Ndhlovu LC, Gangcuangco LM, Keating SM, Norris PJ, Ng RC, Mitchell BI, Shikuma CM, Chow DC
• Downregulation of Cytokines and Chemokines by GB Virus C After Transmission Via Blood Transfusion in HIV-Positive Blood Recipients.
  The Journal of infectious diseases 2014 Lanteri MC, Vahidnia F, Tan S, Stapleton JT, Norris PJ, Heitman J, Deng X, Keating SM, Brambilla D, Busch MP, Custer B, NHLBI REDS III Study
• Independent assessment of candidate HIV incidence assays on specimens in the CEPHIA repository.
  AIDS (London, England) 2014 Kassanjee R, Pilcher CD, Keating SM, Facente SN, McKinney E, Price MA, Martin JN, Little S, Hecht FM, Kallas EG, Welte A, Busch MP, Murphy G, Consortium for the Evaluation and Performance of HIV …
• Antiretroviral-free HIV-1 remission and viral rebound after allogeneic stem cell transplantation: report of 2 cases.
  Annals of internal medicine 2014 Henrich TJ, Hanhauser E, Marty FM, Sirignano MN, Keating S, Lee TH, Robles YP, Davis BT, Li JZ, Heisey A, Hill AL, Busch MP, Armand P, Soiffer RJ, Altfeld M, Kuritzkes DR
• Monocytes expand with immune dysregulation and is associated with insulin resistance in older individuals with chronic HIV.
  PloS one 2014 Shikuma CM, Chow DC, Gangcuangco LM, Zhang G, Keating SM, Norris PJ, Seto TB, Parikh N, Kallianpur KJ, Nakamoto BK, Nagamine LS, Ndhlovu LC, Barbour JD
• Development of a contemporary globally diverse HIV viral panel by the EQAPOL program.
  Journal of immunological methods 2014 Sanchez AM, DeMarco CT, Hora B, Keinonen S, Chen Y, Brinkley C, Stone M, Tobler L, Keating S, Schito M, Busch MP, Gao F, Denny TN
• Performance of rapid point-of-care and laboratory tests for acute and established HIV infection in San Francisco.
  PloS one 2013 Pilcher CD, Louie B, Facente S, Keating S, Hackett J, Vallari A, Hall C, Dowling T, Busch MP, Klausner JD, Hecht FM, Liska S, Pandori MW
• Reduced CD14 expression on classical monocytes and vascular endothelial adhesion markers independently associate with carotid artery intima media thickness in chronically HIV-1 infected adults on virologically suppressive anti-retroviral therapy.
  Atherosclerosis 2013 Barbour JD, Jalbert EC, Chow DC, Gangcuangco LM, Norris PJ, Keating SM, Heitman J, Nagamine L, Seto T, Ndhlovu LC, Nakamoto BK, Hodis HN, Parikh NI, Shikuma CM
• Inter-laboratory assessment of a prototype multiplex kit for determination of recent HIV-1 infection.
  PloS one 2013 Curtis KA, Longosz AF, Kennedy MS, Keating S, Heitman J, Laeyendecker O, Owen SM
• IL-1Β enriched monocytes mount massive IL-6 responses to common inflammatory triggers among chronically HIV-1 infected adults on stable anti-retroviral therapy at risk for cardiovascular disease.
  PloS one 2013 Jalbert E, Crawford TQ, D'Antoni ML, Keating SM, Norris PJ, Nakamoto BK, Seto T, Parikh NI, Shikuma CM, Ndhlovu LC, Barbour JD
• Plasma monocyte chemoattractant protein-1 and tumor necrosis factor-α levels predict the presence of coronary artery calcium in HIV-infected individuals independent of traditional cardiovascular risk factors.
  AIDS research and human retroviruses 2013 Shikuma CM, Barbour JD, Ndhlovu LC, Keating SM, Norris PJ, Budoff M, Parikh N, Seto T, Gangcuangco LM, Ogata-Arakaki D, Chow D
• Matrix metalloproteinase levels in early HIV infection and relation to in vivo brain status.
  Journal of neurovirology 2013 Li S, Wu Y, Keating SM, Du H, Sammet CL, Zadikoff C, Mahadevia R, Epstein LG, Ragin AB
• Health-related quality of life of HIV-infected intravenous drug users.
  International journal of STD & AIDS 2013 Surah S, Adams R, Townsend L, Reynolds I, Kinahan JC, Keating S, Mulcahy F, Keenan E, Barry M, Lyons F
• HIV genotypes and primary drug resistance among HIV-seropositive blood donors in Brazil: role of infected blood donors as sentinel populations for molecular surveillance of HIV.
  Journal of acquired immune deficiency syndromes (1999) 2013 Alencar CS, Sabino EC, Carvalho SM, Leao SC, Carneiro-Proietti AB, Capuani L, Oliveira CL, Carrick D, Birch RJ, Gonçalez TT, Keating S, Swanson PA, Hackett J, Busch MP, NHLBI Retrovirus Epidemiology …
• Fetal production of growth factors and inflammatory mediators predicts pulmonary hypertension in congenital diaphragmatic hernia.
  Pediatric research 2013 Fleck S, Bautista G, Keating SM, Lee TH, Keller RL, Moon-Grady AJ, Gonzales K, Norris PJ, Busch MP, Kim CJ, Romero R, Lee H, Miniati D, MacKenzie TC
• Challenges in detecting HIV persistence during potentially curative interventions: a study of the Berlin patient.
  PLoS pathogens 2013 Yukl SA, Boritz E, Busch M, Bentsen C, Chun TW, Douek D, Eisele E, Haase A, Ho YC, Hütter G, Justement JS, Keating S, Lee TH, Li P, Murray D, Palmer S, Pilcher C, Pillai S, Price RW, Rothenberger M, …
• Long-term reduction in peripheral blood HIV type 1 reservoirs following reduced-intensity conditioning allogeneic stem cell transplantation.
  The Journal of infectious diseases 2013 Henrich TJ, Hu Z, Li JZ, Sciaranghella G, Busch MP, Keating SM, Gallien S, Lin NH, Giguel FF, Lavoie L, Ho VT, Armand P, Soiffer RJ, Sagar M, Lacasce AS, Kuritzkes DR
• CD57 expression and cytokine production by T cells in lesional and unaffected skin from patients with psoriasis.
  PloS one 2013 Batista MD, Tincati C, Milush JM, Ho EL, Ndhlovu LC, York VA, Kallas EG, Kalil J, Keating SM, Norris PJ, Chang D, Unemori P, Leslie KS, Maurer T, Liao W, Nixon DF
• Detection of host immune responses in acute phase sera of spontaneous resolution versus persistent hepatitis C virus infection.
  The Journal of general virology 2012 Selvarajah S, Keating S, Heitman J, Lu K, Simmons G, Norris PJ, Operskalski E, Mosley JW, Busch MP
• Expansion of CD8+ T cells lacking Sema4D/CD100 during HIV-1 infection identifies a subset of T cells with decreased functional capacity.
  Blood 2011 Eriksson EM, Milush JM, Ho EL, Batista MD, Holditch SJ, Keh CE, Norris PJ, Keating SM, Deeks SG, Hunt PW, Martin JN, Rosenberg MG, Hecht FM, Nixon DF
• Seroconverting blood donors as a resource for characterising and optimising recent infection testing algorithms for incidence estimation.
  PloS one 2011 Kassanjee R, Welte A, McWalter TA, Keating SM, Vermeulen M, Stramer SL, Busch MP
• Immune and Genetic Correlates of Vaccine Protection Against Mucosal Infection by SIV in Monkeys.
  Science translational medicine 2011 Letvin NL, Rao SS, Montefiori DC, Seaman MS, Sun Y, Lim SY, Yeh WW, Asmal M, Gelman RS, Shen L, Whitney JB, Seoighe C, Lacerda M, Keating S, Norris PJ, Hudgens MG, Gilbert PB, Buzby AP, Mach LV, Zhang…
• MIG and the regulatory cytokines IL-10 and TGF-β1 correlate with malaria vaccine immunogenicity and efficacy.
  PloS one 2010 Dunachie SJ, Berthoud T, Keating SM, Hill AV, Fletcher HA
• Circulating pneumococcal specific plasma and memory B cells in the elderly two years after pneumococcal conjugate versus polysaccharide vaccination.
  Vaccine 2010 Baxendale HE, Johnson M, Keating SM, Ashton L, Burbidge P, Woodgate S, Southern J, Miller E, Goldblatt D
• Low-dose mucosal simian immunodeficiency virus infection restricts early replication kinetics and transmitted virus variants in rhesus monkeys.
  Journal of virology 2010 Liu J, Keele BF, Li H, Keating S, Norris PJ, Carville A, Mansfield KG, Tomaras GD, Haynes BF, Kolodkin-Gal D, Letvin NL, Hahn BH, Shaw GM, Barouch DH
• The relationship between human effector and memory T cells measured by ex vivo and cultured ELISPOT following recent and distal priming.
  Immunology 2009 Todryk SM, Pathan AA, Keating S, Porter DW, Berthoud T, Thompson F, Klenerman P, Hill AV
• The induction and persistence of T cell IFN-gamma responses after vaccination or natural exposure is suppressed by Plasmodium falciparum.
  Journal of immunology (Baltimore, Md. : 1950) 2007 Bejon P, Mwacharo J, Kai O, Todryk S, Keating S, Lowe B, Lang T, Mwangi TW, Gilbert SC, Peshu N, Marsh K, Hill AV
• A phase 2b randomised trial of the candidate malaria vaccines FP9 ME-TRAP and MVA ME-TRAP among children in Kenya.
  PLoS clinical trials 2006 Bejon P, Mwacharo J, Kai O, Mwangi T, Milligan P, Todryk S, Keating S, Lang T, Lowe B, Gikonyo C, Molyneux C, Fegan G, Gilbert SC, Peshu N, Marsh K, Hill AV
• A DNA prime-modified vaccinia virus ankara boost vaccine encoding thrombospondin-related adhesion protein but not circumsporozoite protein partially protects healthy malaria-naive adults against Plasmodium falciparum sporozoite challenge.
  Infection and immunity 2006 Dunachie SJ, Walther M, Epstein JE, Keating S, Berthoud T, Andrews L, Andersen RF, Bejon P, Goonetilleke N, Poulton I, Webster DP, Butcher G, Watkins K, Sinden RE, Levine GL, Richie TL, Schneider J, …
• Early gamma interferon and interleukin-2 responses to vaccination predict the late resting memory in malaria-naïve and malaria-exposed individuals.
  Infection and immunity 2006 Bejon P, Keating S, Mwacharo J, Kai OK, Dunachie S, Walther M, Berthoud T, Lang T, Epstein J, Carucci D, Moris P, Cohen J, Gilbert SC, Peshu N, Marsh K, Hill AV
• Alternating vector immunizations encoding pre-erythrocytic malaria antigens enhance memory responses in a malaria endemic area.
  European journal of immunology 2006 Bejon P, Kai OK, Mwacharo J, Keating S, Lang T, Gilbert SC, Peshu N, Marsh K, Hill AV
• Safety and immunogenicity of the malaria candidate vaccines FP9 CS and MVA CS in adult Gambian men.
  Vaccine 2006 Imoukhuede EB, Berthoud T, Milligan P, Bojang K, Ismaili J, Keating S, Nwakanma D, Keita S, Njie F, Sowe M, Todryk S, Laidlaw SM, Skinner MA, Lang T, Gilbert S, Greenwood BM, Hill AV
• Safety, immunogenicity, and efficacy of prime-boost immunization with recombinant poxvirus FP9 and modified vaccinia virus Ankara encoding the full-length Plasmodium falciparum circumsporozoite protein.
  Infection and immunity 2006 Walther M, Thompson FM, Dunachie S, Keating S, Todryk S, Berthoud T, Andrews L, Andersen RF, Moore A, Gilbert SC, Poulton I, Dubovsky F, Tierney E, Correa S, Huntcooke A, Butcher G, Williams J, Sinden…
• Immunogenicity of the candidate malaria vaccines FP9 and modified vaccinia virus Ankara encoding the pre-erythrocytic antigen ME-TRAP in 1-6 year old children in a malaria endemic area.
  Vaccine 2006 Bejon P, Mwacharo J, Kai OK, Todryk S, Keating S, Lang T, Gilbert SC, Peshu N, Marsh K, Hill AV
• A clinical trial of prime-boost immunisation with the candidate malaria vaccines RTS,S/AS02A and MVA-CS.
  Vaccine 2006 Dunachie SJ, Walther M, Vuola JM, Webster DP, Keating SM, Berthoud T, Andrews L, Bejon P, Poulton I, Butcher G, Watkins K, Sinden RE, Leach A, Moris P, Tornieporth N, Schneider J, Dubovsky F, Tierney …
• Synergistic DNA-MVA prime-boost vaccination regimes for malaria and tuberculosis.
  Vaccine 2005 Gilbert SC, Moorthy VS, Andrews L, Pathan AA, McConkey SJ, Vuola JM, Keating SM, Berthoud T, Webster D, McShane H, Hill AV
• Enhanced T cell-mediated protection against malaria in human challenges by using the recombinant poxviruses FP9 and modified vaccinia virus Ankara.
  Proceedings of the National Academy of Sciences of the United States of America 2005 Webster DP, Dunachie S, Vuola JM, Berthoud T, Keating S, Laidlaw SM, McConkey SJ, Poulton I, Andrews L, Andersen RF, Bejon P, Butcher G, Sinden R, Skinner MA, Gilbert SC, Hill AV
• Safety, immunogenicity and efficacy of a pre-erythrocytic malaria candidate vaccine, ICC-1132 formulated in Seppic ISA 720.
  Vaccine 2005 Walther M, Dunachie S, Keating S, Vuola JM, Berthoud T, Schmidt A, Maier C, Andrews L, Andersen RF, Gilbert S, Poulton I, Webster D, Dubovsky F, Tierney E, Sarpotdar P, Correa S, Huntcooke A, Butcher …
• Hepatitis C viral clearance in an intravenous drug-using cohort in the Dublin area.
  Irish journal of medical science 2005 Keating S, Coughlan S, Connell J, Sweeney B, Keenan E
• A randomised, double-blind, controlled vaccine efficacy trial of DNA/MVA ME-TRAP against malaria infection in Gambian adults.
  PLoS medicine 2004 Moorthy VS, Imoukhuede EB, Milligan P, Bojang K, Keating S, Kaye P, Pinder M, Gilbert SC, Walraven G, Greenwood BM, Hill AS
• Recombinant modified vaccinia virus Ankara expressing antigen 85A boosts BCG-primed and naturally acquired antimycobacterial immunity in humans.
  Nature medicine 2004 McShane H, Pathan AA, Sander CR, Keating SM, Gilbert SC, Huygen K, Fletcher HA, Hill AV
• Hepatitis C among drug users: consensus guidelines on management in general practice.
  Irish journal of medical science 2004 Barry J, Bourke M, Buckley M, Coughlan B, Crowley D, Cullen W, Dooley S, Keating S, Kelleher D, Moloney J, Murray F, McCormick PA, MacMathuna P, O'Connor J, O'Grady J, O'Sullivan C, O'Sullivan P, …
• Phase 1 evaluation of 3 highly immunogenic prime-boost regimens, including a 12-month reboosting vaccination, for malaria vaccination in Gambian men.
  The Journal of infectious diseases 2004 Moorthy VS, Imoukhuede EB, Keating S, Pinder M, Webster D, Skinner MA, Gilbert SC, Walraven G, Hill AV
• Association of Gag-specific T lymphocyte responses during the early phase of human immunodeficiency virus type 1 infection and lower virus load set point.
  The Journal of infectious diseases 2002 Patke DS, Langan SJ, Carruth LM, Keating SM, Sabundayo BP, Margolick JB, Quinn TC, Bollinger RC
• Detection of benzodiazepine abuse in opiate addicts.
  Irish medical journal 1998 Browne R, Sloan D, Fahy S, Keating S, Moran C, O'Connor J