Shea Andrews, PhD
Assistant Professor
Psychiatry
School of Medicine

Currently funded NIH-NIA and Alzheimer’s Association projects include (1) identifying causal risk factors for ADRD using genetic correlations, polygenic risk scores, and mendelian randomization; (2) understanding the role of mitochondrial genomics in ADRD pathogenesis; and (3) evaluating ancestry specific effects of AD genetic variants on AD endophenotypes.

• Genetic associations with age at dementia onset in the PSEN1 E280A Colombian kindred.
  Alzheimer's & dementia : the journal of the Alzheimer's Association 2023 Cochran JN, Acosta-Uribe J, Esposito BT, Madrigal L, Aguillón D, Giraldo MM, Taylor JW, Bradley J, Fulton-Howard B, Andrews SJ, Acosta-Baena N, Alzate D, Garcia GP, Piedrahita F, Lopez HE, Anderson AG…
• The complex genetic architecture of Alzheimer's disease: novel insights and future directions.
  EBioMedicine 2023 Andrews SJ, Renton AE, Fulton-Howard B, Podlesny-Drabiniok A, Marcora E, Goate AM
• Microglial efferocytosis: Diving into the Alzheimer's disease gene pool.
  Neuron 2022 Romero-Molina C, Garretti F, Andrews SJ, Marcora E, Goate AM
• The role of mitochondrial genome abundance in Alzheimer's disease.
  Alzheimer's & dementia : the journal of the Alzheimer's Association 2022 Harerimana NV, Paliwali D, Romero-Molina C, Bennett DA, Pa J, Goate A, Swerdlow RH, Andrews SJ
• Sex differences in the genetic architecture of cognitive resilience to Alzheimer's disease.
  Brain : a journal of neurology 2022 Eissman JM, Dumitrescu L, Mahoney ER, Smith AN, Mukherjee S, Lee ML, Scollard P, Choi SE, Bush WS, Engelman CD, Lu Q, Fardo DW, Trittschuh EH, Mez J, Kaczorowski CC, Hernandez Saucedo H, Widaman KF, …
• A Mitochondrial DNA Haplogroup Defines Patterns of Five-Year Cognitive Change.
  Journal of Alzheimer's disease : JAD 2022 Watts A, Chalise P, Hu J, Hui D, Pa J, Andrews SJ, Michaelis EK, Swerdlow RH
• Integrative metabolomics-genomics approach reveals key metabolic pathways and regulators of Alzheimer's disease.
  Alzheimer's & dementia : the journal of the Alzheimer's Association 2021 Horgusluoglu E, Neff R, Song WM, Wang M, Wang Q, Arnold M, Krumsiek J, Galindo-Prieto B, Ming C, Nho K, Kastenmüller G, Han X, Baillie R, Zeng Q, Andrews S, Cheng H, Hao K, Goate A, Bennett DA, Saykin…
• Genome-wide association study and functional validation implicates JADE1 in tauopathy.
  Acta neuropathologica 2021 Farrell K, Kim S, Han N, Iida MA, Gonzalez EM, Otero-Garcia M, Walker JM, Richardson TE, Renton AE, Andrews SJ, Fulton-Howard B, Humphrey J, Vialle RA, Bowles KR, de Paiva Lopes K, Whitney K, Dangoor …
• A globally diverse reference alignment and panel for imputation of mitochondrial DNA variants.
  BMC bioinformatics 2021 McInerney TW, Fulton-Howard B, Patterson C, Paliwal D, Jermiin LS, Patel HR, Pa J, Swerdlow RH, Goate A, Easteal S, Andrews SJ, for the Alzheimer’s Disease Neuroimaging Initiative
• Mitochondrial pathway polygenic risk scores are associated with Alzheimer's Disease.
  Neurobiology of aging 2021 Paliwal D, McInerney TW, Pa J, Swerdlow RH, Easteal S, Andrews SJ, Alzheimer's Disease Neuroimaging Initiative
• Mapping the human genetic architecture of COVID-19.
  Nature 2021 COVID-19 Host Genetics Initiative
• Beyond association: successes and challenges in linking non-coding genetic variation to functional consequences that modulate Alzheimer's disease risk.
  Molecular neurodegeneration 2021 Novikova G, Andrews SJ, Renton AE, Marcora E
• Shared genetic etiology between idiopathic pulmonary fibrosis and COVID-19 severity.
  EBioMedicine 2021 Fadista J, Kraven LM, Karjalainen J, Andrews SJ, Geller F, COVID-19 Host Genetics Initiative, Baillie JK, Wain LV, Jenkins RG, Feenstra B
• The variant call format provides efficient and robust storage of GWAS summary statistics.
  Genome biology 2021 Lyon MS, Andrews SJ, Elsworth B, Gaunt TR, Hemani G, Marcora E
• Causal Associations Between Modifiable Risk Factors and the Alzheimer's Phenome.
  Annals of neurology 2020 Andrews SJ, Fulton-Howard B, O'Reilly P, Marcora E, Goate AM, collaborators of the Alzheimer's Disease Genetics Consortium
• Genetic variants and functional pathways associated with resilience to Alzheimer's disease.
  Brain : a journal of neurology 2020 Dumitrescu L, Mahoney ER, Mukherjee S, Lee ML, Bush WS, Engelman CD, Lu Q, Fardo DW, Trittschuh EH, Mez J, Kaczorowski C, Hernandez Saucedo H, Widaman KF, Buckley R, Properzi M, Mormino E, Yang HS, …
• Exploratory analysis of mtDNA haplogroups in two Alzheimer's longitudinal cohorts.
  Alzheimer's & dementia : the journal of the Alzheimer's Association 2020 Swerdlow RH, Hui D, Chalise P, Sharma P, Wang X, Andrews SJ, Pa J, Mahnken JD, Morris J, Wilkins HM, Burns JM, Michaelis ML, Michaelis EK, Alzheimer's Disease Neuroimaging Initiative (ADNI)
• Role of apolipoprotein E epsilon 4 (APOE*ε4) as an independent risk factor for incident depression over a 12-year period in cognitively intact adults across the lifespan.
  BJPsych open 2020 Burns RA, Andrews S, Cherbuin N, Anstey KJ
• Interpretation of risk loci from genome-wide association studies of Alzheimer's disease.
  The Lancet. Neurology 2020 Andrews SJ, Fulton-Howard B, Goate A
• Association between alcohol consumption and Alzheimer's disease: A Mendelian randomization study.
  Alzheimer's & dementia : the journal of the Alzheimer's Association 2020 Andrews SJ, Goate A, Anstey KJ
• Investigation of antihypertensive class, dementia, and cognitive decline: A meta-analysis.
  Neurology 2019 Peters R, Yasar S, Anderson CS, Andrews S, Antikainen R, Arima H, Beckett N, Beer JC, Bertens AS, Booth A, van Boxtel M, Brayne C, Brodaty H, Carlson MC, Chalmers J, Corrada M, DeKosky S, Derby C, …
• Mitonuclear interactions influence Alzheimer's disease risk.
  Neurobiology of aging 2019 Andrews SJ, Fulton-Howard B, Patterson C, McFall GP, Gross A, Michaelis EK, Goate A, Swerdlow RH, Pa J, Alzheimer's Disease Neuroimaging Initiative
• Mendelian randomization indicates that TNF is not causally associated with Alzheimer's disease.
  Neurobiology of aging 2019 Andrews SJ, Goate A
• Mitochondria and Alzheimer's: Is PTCD1 the Smoking Gun?
  Trends in neurosciences 2019 Pa J, Andrews SJ, Swerdlow RH
• Alzheimer's Environmental and Genetic Risk Scores are Differentially Associated With General Cognitive Ability and Dementia Severity.
  Alzheimer disease and associated disorders 2019 Andrews SJ, McFall GP, Dixon RA, Cherbuin N, Eramudugolla R, Anstey KJ
• Protective Variants in Alzheimer's Disease.
  Current genetic medicine reports 2019 Andrews SJ, Fulton-Howard B, Goate A
• Association of Alzheimer's Disease Genetic Risk Loci with Cognitive Performance and Decline: A Systematic Review.
  Journal of Alzheimer's disease : JAD 2019 Andrews SJ, McFall GP, Booth A, Dixon RA, Anstey KJ
• Association of Alzheimer's genetic loci with mild behavioral impairment.
  American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics 2018 Andrews SJ, Ismail Z, Anstey KJ, Mortby M
• Sex Differences in the Impact of BDNF Genotype on the Longitudinal Relationship between Physical Activity and Cognitive Performance.
  Gerontology 2018 Watts A, Andrews SJ, Anstey KJ
• Memory Resilience to Alzheimer's Genetic Risk: Sex Effects in Predictor Profiles.
  The journals of gerontology. Series B, Psychological sciences and social sciences 2017 McDermott KL, McFall GP, Andrews SJ, Anstey KJ, Dixon RA
• Validating the role of the Australian National University Alzheimer's Disease Risk Index (ANU-ADRI) and a genetic risk score in progression to cognitive impairment in a population-based cohort of older adults followed for 12 years.
  Alzheimer's research & therapy 2017 Andrews SJ, Eramudugolla R, Velez JI, Cherbuin N, Easteal S, Anstey KJ
• Late Onset Alzheimer's Disease Risk Variants in Cognitive Decline: The PATH Through Life Study.
  Journal of Alzheimer's disease : JAD 2017 Andrews SJ, Das D, Anstey KJ, Easteal S
• Association of genetic risk factors with cognitive decline: the PATH through life project.
  Neurobiology of aging 2016 Andrews SJ, Das D, Cherbuin N, Anstey KJ, Easteal S
• Interactive effect of APOE genotype and blood pressure on cognitive decline: the PATH through life study.
  Journal of Alzheimer's disease : JAD 2015 Andrews S, Das D, Anstey KJ, Easteal S
• Emerging evidence for functional peptides encoded by short open reading frames.
  Nature reviews. Genetics 2014 Andrews SJ, Rothnagel JA