Shawn Douglas, PhD
Associate Professor
Cellular Molecular Pharmacology
School of Medicine

Websites

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• bionano.ucsf.edu (bionano.ucsf.edu)

Videos

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• What is Bionanotechnology? (youtube.com)

Grants and Projects

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• DNA Nanostructures for High-Throughput Cryo-EM Studies of Small Macromolecules, NIH, 2018-2028
• Probing mesoscale receptor organization in T cell signaling with DNA origami, NIH, 2023-2025

Publications (28)

Top publication keywords:
Receptors, Antigen, T-CellNanotechnologyEscherichia coliThermodynamicsDNADNA, Single-StrandedDatabases, BibliographicLiteratureBacteriophage M13NanostructuresCryoelectron MicroscopyNucleic Acid ConformationPhagocytosisLiquid CrystalsProtein Folding

• Using DNA Origami to Study Nanoscale Organization of Plasma Membranes.
  Nano letters 2026 Corradi E, Shen K, Karatas Z, Cercy M, Schlichthaerle T, Caumont M, Osouf M, Vialet B, Barthelemy P, Rosendale M, Radhakrishnan AV, Chen T, Jungmann R, Gissot A, Douglas SM, Giannone G
• Design principles for accurate folding of DNA origami.
  Proceedings of the National Academy of Sciences of the United States of America 2024 Aksel T, J Navarro E, Fong N, Douglas SM
• Engineering an Escherichia coli strain for production of long single-stranded DNA.
  Nucleic acids research 2024 Shen K, Flood JJ, Zhang Z, Ha A, Shy BR, Dueber JE, Douglas SM
• Design principles for accurate folding of DNA origami.
  bioRxiv : the preprint server for biology 2024 Aksel T, Navarro EJ, Fong N, Douglas SM
• Engineering an Escherichia coli strain for production of long single-stranded DNA.
  bioRxiv : the preprint server for biology 2024 Shen K, Flood JJ, Zhang Z, Ha A, Shy BR, Dueber JE, Douglas SM

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• Leveraging DNA Origami to Study Phagocytosis.
  Methods in molecular biology (Clifton, N.J.) 2023 Miller WD, Kern N, Douglas SM, Morrissey MA
• DNA origami patterning of synthetic T cell receptors reveals spatial control of the sensitivity and kinetics of signal activation.
  Proceedings of the National Academy of Sciences of the United States of America 2021 Dong R, Aksel T, Chan W, Germain RN, Vale RD, Douglas SM
• Tight nanoscale clustering of Fcγ receptors using DNA origami promotes phagocytosis.
  eLife 2021 Kern N, Dong R, Douglas SM, Vale RD, Morrissey MA
• Molecular goniometers for single-particle cryo-electron microscopy of DNA-binding proteins.
  Nature biotechnology 2020 Aksel T, Yu Z, Cheng Y, Douglas SM
• Amino and PEG-amino graphene oxide grids enrich and protect samples for high-resolution single particle cryo-electron microscopy.
  Journal of structural biology 2019 Wang F, Yu Z, Betegon M, Campbell MG, Aksel T, Zhao J, Li S, Douglas SM, Cheng Y, Agard DA
• Construction of a novel phagemid to produce custom DNA origami scaffolds.
  Synthetic biology (Oxford, England) 2018 Nafisi PM, Aksel T, Douglas SM
• Bringing proteins into the fold.
  Science (New York, N.Y.) 2017 Douglas SM
• Folding complex DNA nanostructures from limited sets of reusable sequences.
  Nucleic acids research 2016 Niekamp S, Blumer K, Nafisi PM, Tsui K, Garbutt J, Douglas SM
• A public resource facilitating clinical use of genomes.
  Proceedings of the National Academy of Sciences of the United States of America 2012 Ball MP, Thakuria JV, Zaranek AW, Clegg T, Rosenbaum AM, Wu X, Angrist M, Bhak J, Bobe J, Callow MJ, Cano C, Chou MF, Chung WK, Douglas SM, Estep PW, Gore A, Hulick P, Labarga A, Lee JH, Lunshof JE, …
• A logic-gated nanorobot for targeted transport of molecular payloads.
  Science (New York, N.Y.) 2012 Douglas SM, Bachelet I, Church GM
• Multilayer DNA origami packed on a square lattice.
  Journal of the American Chemical Society 2009 Ke Y, Douglas SM, Liu M, Sharma J, Cheng A, Leung A, Liu Y, Shih WM, Yan H
• Folding DNA into twisted and curved nanoscale shapes.
  Science (New York, N.Y.) 2009 Dietz H, Douglas SM, Shih WM
• Rapid prototyping of 3D DNA-origami shapes with caDNAno.
  Nucleic acids research 2009 Douglas SM, Marblestone AH, Teerapittayanon S, Vazquez A, Church GM, Shih WM
• Erratum: Self-assembly of DNA into nanoscale three-dimensional shapes.
  Nature 2009 Shawn M. Douglas, Hendrik Dietz, Tim Liedl, Björn Högberg, Franziska Graf, William M. Shih
• Self-assembly of DNA into nanoscale three-dimensional shapes.
  Nature 2009 Douglas SM, Dietz H, Liedl T, Högberg B, Graf F, Shih WM
• RNAi development.
  PLoS computational biology 2007 Gerstein M, Douglas SM
• DNA-nanotube-induced alignment of membrane proteins for NMR structure determination.
  Proceedings of the National Academy of Sciences of the United States of America 2007 Douglas SM, Chou JJ, Shih WM
• Network security and data integrity in academia: an assessment and a proposal for large-scale archiving.
  Genome biology 2005 Smith A, Greenbaum D, Douglas SM, Long M, Gerstein M
• PubNet: a flexible system for visualizing literature derived networks.
  Genome biology 2005 Douglas SM, Montelione GT, Gerstein M
• Robotic cloning and Protein Production Platform of the Northeast Structural Genomics Consortium.
  Methods in enzymology 2005 Acton TB, Gunsalus KC, Xiao R, Ma LC, Aramini J, Baran MC, Chiang YW, Climent T, Cooper B, Denissova NG, Douglas SM, Everett JK, Ho CK, Macapagal D, Rajan PK, Shastry R, Shih LY, Swapna GV, Wilson M, …
• Computer security in academia-a potential roadblock to distributed annotation of the human genome.
  Nature biotechnology 2004 Greenbaum D, Douglas SM, Smith A, Lim J, Fischer M, Schultz M, Gerstein M
• Mining the structural genomics pipeline: identification of protein properties that affect high-throughput experimental analysis.
  Journal of molecular biology 2004 Goh CS, Lan N, Douglas SM, Wu B, Echols N, Smith A, Milburn D, Montelione GT, Zhao H, Gerstein M
• SPINE 2: a system for collaborative structural proteomics within a federated database framework.
  Nucleic acids research 2003 Goh CS, Lan N, Echols N, Douglas SM, Milburn D, Bertone P, Xiao R, Ma LC, Zheng D, Wunderlich Z, Acton T, Montelione GT, Gerstein M