Shane Falcinelli, MD, PhD
RESIDENT
Pathology
School of Medicine
Education & Training
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- MD/PhD Microbiology & Immunology University of North Carolina 05/2024
Websites
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- LinkedIn (linkedin.com)
Grants and Projects
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Publications (32)
Top publication keywords:
Anti-Retroviral AgentsHemorrhagic Fever, AmericanPichinde virusVirus LatencyHIVTeaVirus DiseasesHIV InfectionsVirus Physiological PhenomenaBacillus anthracisHIV-1ProvirusesDNA, ViralVirus ActivationCD4-Positive T-Lymphocytes
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Machine learning approaches identify immunologic signatures of total and intact HIV DNA during long-term antiretroviral therapy.
bioRxiv : the preprint server for biology 2024 Semenova L, Wang Y, Falcinelli S, Archin N, Cooper-Volkheimer AD, Margolis DM, Goonetilleke N, Murdoch DM, Rudin CD, Browne EP -
Nanoparticle delivery of Tat synergizes with classical latency reversal agents to express HIV antigen targets.
Antimicrobial agents and chemotherapy 2024 Raines SLM, Falcinelli SD, Peterson JJ, Van Gulck E, Allard B, Kirchherr J, Vega J, Najera I, Boden D, Archin NM, Margolis DM -
The Effects of Human Immunodeficiency Virus Type 1 (HIV-1) Antigen-Expanded Specific T-Cell Therapy and Vorinostat on Persistent HIV-1 Infection in People With HIV on Antiretroviral Therapy.
The Journal of infectious diseases 2024 Gay CL, Hanley PJ, Falcinelli SD, Kuruc JD, Pedersen SM, Kirchherr J, Raines SLM, Motta CM, Lazarski C, Chansky P, Tanna J, Shibli A, Datar A, McCann CD, Sili U, Ke R, Eron JJ, Archin N, Goonetilleke … -
Assessing the impact of AGS-004, a dendritic cell-based immunotherapy, and vorinostat on persistent HIV-1 Infection.
Scientific reports 2020 Gay CL, Kuruc JD, Falcinelli SD, Warren JA, Reifeis SA, Kirchherr JL, James KS, Dewey MG, Helms A, Allard B, Stuelke E, Gamble A, Plachco A, Gorelick RJ, Eron JJ, Hudgens M, Garrido C, Goonetilleke N,… -
Reduction of resources with mRNA host-response whole blood testing on patients presenting to the emergency department with suspected infections: a retrospective analysis of 30 cases.
Journal of medical microbiology 2025 Wu AHB, Falcinelli S, Yakubu R
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Correction for Raines et al., "Nanoparticle delivery of Tat synergizes with classical latency reversal agents to express HIV antigen targets".
Antimicrobial agents and chemotherapy 2025 Raines SLM, Falcinelli SD, Peterson JJ, Van Gulck E, Allard B, Kirchherr J, Vega J, Najera I, Boden D, Archin NM, Margolis DM -
BET degraders reveal BRD4 disruption of 7SK and P-TEFb is critical for effective reactivation of latent HIV in CD4+ T-cells.
Journal of virology 2025 Turner A-MW, Bashore FM, Falcinelli SD, Fox JA, Keller AL, Fenton AD, Geyer RF, Allard B, Kirchherr JL, Archin NM, James LI, Margolis DM -
Recurrent Fever and Back Pain Associated With Septic Shock in a Healthy 16-Year-Old Girl.
Pediatrics in review 2025 Falcinelli SD, Hignett E, Zwemer E, O'Shea P -
Machine learning approaches identify immunologic signatures of total and intact HIV DNA during long-term antiretroviral therapy.
eLife 2024 Semenova L, Wang Y, Falcinelli S, Archin N, Cooper-Volkheimer AD, Margolis DM, Goonetilleke N, Murdoch DM, Rudin CD, Browne EP -
Transient CD4+ T cell depletion during suppressive ART reduces the HIV reservoir in humanized mice.
PLoS pathogens 2023 Ling L, De C, Spagnuolo RA, Begum N, Falcinelli SD, Archin NM, Kovarova M, Silvestri G, Wahl A, Margolis DM, Garcia JV -
Impact of Cannabis Use on Immune Cell Populations and the Viral Reservoir in People With HIV on Suppressive Antiretroviral Therapy.
The Journal of infectious diseases 2023 Falcinelli SD, Cooper-Volkheimer AD, Semenova L, Wu E, Richardson A, Ashokkumar M, Margolis DM, Archin NM, Rudin CD, Murdoch D, Browne EP -
HIVepsilon-seq-scalable characterization of intact persistent proviral HIV reservoirs in women.
Journal of virology 2023 Barton K, Ferguson JM, Deveson IW, Falcinelli SD, James KS, Kirchherr J, Ramirez C, Gay CL, Hammond JM, Bevear B, Carswell SL, Margolis DM, Smith MA, Adimora AA, Archin NM -
AZD5582 plus SIV-specific antibodies reduce lymph node viral reservoirs in antiretroviral therapy-suppressed macaques.
Nature medicine 2023 Dashti A, Sukkestad S, Horner AM, Neja M, Siddiqi Z, Waller C, Goldy J, Monroe D, Lin A, Schoof N, Singh V, Mavigner M, Lifson JD, Deleage C, Tuyishime M, Falcinelli SD, King HAD, Ke R, Mason RD, … -
Combined noncanonical NF-κB agonism and targeted BET bromodomain inhibition reverse HIV latency ex vivo.
The Journal of clinical investigation 2022 Falcinelli SD, Peterson JJ, Turner AW, Irlbeck D, Read J, Raines SL, James KS, Sutton C, Sanchez A, Emery A, Sampey G, Ferris R, Allard B, Ghofrani S, Kirchherr JL, Baker C, Kuruc JD, Gay CL, James LI… -
Stable Latent HIV Infection and Low-level Viremia Despite Treatment With the Broadly Neutralizing Antibody VRC07-523LS and the Latency Reversal Agent Vorinostat.
The Journal of infectious diseases 2022 Gay CL, James KS, Tuyishime M, Falcinelli SD, Joseph SB, Moeser MJ, Allard B, Kirchherr JL, Clohosey M, Raines SLM, Montefiori DC, Shen X, Gorelick RJ, Gama L, McDermott AB, Koup RA, Mascola JR, … -
Crotonylation sensitizes IAPi-induced disruption of latent HIV by enhancing p100 cleavage into p52.
iScience 2021 Li D, Dewey MG, Wang L, Falcinelli SD, Wong LM, Tang Y, Browne EP, Chen X, Archin NM, Margolis DM, Jiang G -
Longitudinal Dynamics of Intact HIV Proviral DNA and Outgrowth Virus Frequencies in a Cohort of Individuals Receiving Antiretroviral Therapy.
The Journal of infectious diseases 2021 Falcinelli SD, Kilpatrick KW, Read J, Murtagh R, Allard B, Ghofrani S, Kirchherr J, James KS, Stuelke E, Baker C, Kuruc JD, Eron JJ, Hudgens MG, Gay CL, Margolis DM, Archin NM -
Sequence Evaluation and Comparative Analysis of Novel Assays for Intact Proviral HIV-1 DNA.
Journal of virology 2021 Gaebler C, Falcinelli SD, Stoffel E, Read J, Murtagh R, Oliveira TY, Ramos V, Lorenzi JCC, Kirchherr J, James KS, Allard B, Baker C, Kuruc JD, Caskey M, Archin NM, Siliciano RF, Margolis DM, … -
Impact of Biological Sex on Immune Activation and Frequency of the Latent HIV Reservoir During Suppressive Antiretroviral Therapy.
The Journal of infectious diseases 2020 Falcinelli SD, Shook-Sa BE, Dewey MG, Sridhar S, Read J, Kirchherr J, James KS, Allard B, Ghofrani S, Stuelke E, Baker C, Roan NR, Eron JJ, Kuruc JD, Ramirez C, Gay C, Mollan KR, Margolis DM, Adimora … -
Cellular Gene Modulation of HIV-Infected CD4 T Cells in Response to Serial Treatment with the Histone Deacetylase Inhibitor Vorinostat.
Journal of virology 2020 Maxwell JW, Falcinelli SD, Nefedov A, Dorfmeier C, Wu G, Dewey M, Webber AL, Archin NM, Margolis DM, Hazuda DJ, Barnard RJO, Howell BJ -
CTLA-4 and PD-1 dual blockade induces SIV reactivation without control of rebound after antiretroviral therapy interruption.
Nature medicine 2020 Harper J, Gordon S, Chan CN, Wang H, Lindemuth E, Galardi C, Falcinelli SD, Raines SLM, Read JL, Nguyen K, McGary CS, Nekorchuk M, Busman-Sahay K, Schawalder J, King C, Pino M, Micci L, Cervasi B, … -
Systemic HIV and SIV latency reversal via non-canonical NF-κB signalling in vivo.
Nature 2020 Nixon CC, Mavigner M, Sampey GC, Brooks AD, Spagnuolo RA, Irlbeck DM, Mattingly C, Ho PT, Schoof N, Cammon CG, Tharp GK, Kanke M, Wang Z, Cleary RA, Upadhyay AA, De C, Wills SR, Falcinelli SD, Galardi… -
New Frontiers in Measuring and Characterizing the HIV Reservoir.
Frontiers in microbiology 2019 Falcinelli SD, Ceriani C, Margolis DM, Archin NM -
Characterization of Host and Bacterial Contributions to Lung Barrier Dysfunction Following Co-infection with 2009 Pandemic Influenza and Methicillin Resistant Staphylococcus aureus.
Viruses 2019 Nickol ME, Ciric J, Falcinelli SD, Chertow DS, Kindrachuk J -
The Madagascar Hissing Cockroach as an Alternative Non-mammalian Animal Model to Investigate Virulence, Pathogenesis, and Drug Efficacy.
Journal of visualized experiments : JoVE 2017 Chua J, Fisher NA, Falcinelli SD, DeShazer D, Friedlander AM -
Green tea and epigallocatechin-3-gallate are bactericidal against Bacillus anthracis.
FEMS microbiology letters 2017 Falcinelli SD, Shi MC, Friedlander AM, Chua J -
Integration of Global Analyses of Host Molecular Responses with Clinical Data To Evaluate Pathogenesis and Advance Therapies for Emerging and Re-emerging Viral Infections.
ACS infectious diseases 2016 Falcinelli SD, Chertow DS, Kindrachuk J -
A Novel Strategy to Reverse General Anesthesia by Scavenging with the Acyclic Cucurbit[n]uril-type Molecular Container Calabadion 2.
Anesthesiology 2016 Diaz-Gil D, Haerter F, Falcinelli S, Ganapati S, Hettiarachchi GK, Simons JC, Zhang B, Grabitz SD, Moreno Duarte I, Cotten JF, Eikermann-Haerter K, Deng H, Chamberlin NL, Isaacs L, Briken V, Eikermann… -
Acyclic Cucurbit[n]uril-Type Molecular Containers: Influence of Linker Length on Their Function as Solubilizing Agents.
ChemMedChem 2016 Sigwalt D, Moncelet D, Falcinelli S, Mandadapu V, Zavalij PY, Day A, Briken V, Isaacs L -
Acyclic Cucurbit[n]uril-Type Molecular Container Enables Systemic Delivery of Effective Doses of Albendazole for Treatment of SK-OV-3 Xenograft Tumors.
Molecular pharmaceutics 2016 Hettiarachchi G, Samanta SK, Falcinelli S, Zhang B, Moncelet D, Isaacs L, Briken V -
Characterization of the host response to pichinde virus infection in the Syrian golden hamster by species-specific kinome analysis.
Molecular & cellular proteomics : MCP 2015 Falcinelli S, Gowen BB, Trost B, Napper S, Kusalik A, Johnson RF, Safronetz D, Prescott J, Wahl-Jensen V, Jahrling PB, Kindrachuk J -
Systems kinomics for characterizing host responses to high-consequence pathogens at the NIH/NIAID Integrated Research Facility-Frederick.
Pathogens and disease 2014 Kindrachuk J, Falcinelli S, Wada J, Kuhn JH, Hensley LE, Jahrling PB