Shaeri Mukherjee, PhD
Professor
Microbiology and Immunology
School of Medicine
Awards
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- Bowes Biomedical Investigator, UCSF, 2023
- Chan Zuckerberg Investigator, Chan Zuckerberg Initiative, 2022
- Pew Scholar, Pew Charitable Trust, 2017
- Anna Fuller Fellowship, Yale University, 2010
- Julius Marmur Award for Outstanding Thesis, Albert Einstein College of Medicine, 2008
Education & Training
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- Post-Doc Microbiology Yale University 12/2013
- Ph.D Cell Biology Albert Einstein College of Medicine 06/2007
Websites
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- Department of Microbiology and Immunology (microbiology.ucsf.edu)
- BMS graduate program (bms.ucsf.edu)
- Tetrad graduate program (tetrad.ucsf.edu)
- Program in microbial pathogenesis and host defense (mphd.ucsf.edu)
- G.W Hooper Foundation (hooper.ucsf.edu)
- Lab Website (mukherjeelabucsf.com)
Grants and Projects
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- , Bowes Biomedical Investigator Program, 2023-2027
- Chan Zuckerberg Investigator, Chan Zuckerberg Initiative, 2022-2027
- Role of HSC70 in protein synthesis, NIH, 2022-2026
- Legionella effectors reveal novel signaling function for the ribosome quality control (RQC) pathway, NIH, 2016-2025
- Turning bacterial pathogens into cell-biology tools, Pew Charitable Trusts, 2017-2021
- Subversion of membrane transport pathways by Legionella pneumophila, NIH, 2016-2021
Publications (31)
Top publication keywords:
Golgi ApparatusLegionellaLegionnaires' DiseaseLegionella pneumophilaUnfolded Protein ResponseActivating Transcription Factor 6rab GTP-Binding ProteinsBacterial ProteinsEukaryotic CellsEndoplasmic Reticulum StressEndoplasmic ReticulumMonomeric GTP-Binding ProteinsHost-Pathogen InteractionsProtein Processing, Post-TranslationalVacuoles
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A conserved Hsp70 phosphorylation regulates cell cycle progression after DNA damage.
bioRxiv : the preprint server for biology 2025 Moss T, Wooldredge A, Bhakta K, Cronin M, Gestwicki JE, Mukherjee S -
Canonical and phosphoribosyl ubiquitination coordinate to stabilize a proteinaceous structure surrounding the Legionella-containing vacuole.
bioRxiv : the preprint server for biology 2025 Steinbach A, Mokkapati C, Mukherjee S -
Hsc70-4: An unanticipated mediator of dsRNA internalization in Drosophila.
Science advances 2025 Fletcher SJ, Bardossy ES, Tomé-Poderti L, Moss T, Mongelli V, Frangeul L, Blanc H, Verdier Y, Vinh J, Mukherjee S, Saleh MC -
Legionella uses host Rab GTPases and BAP31 to create a unique ER niche.
Cell reports 2024 Chadha A, Yanai Y, Oide H, Wakana Y, Inoue H, Saha S, Paul M, Tagaya M, Arasaki K, Mukherjee S -
Serine ubiquitination of SQSTM1 regulates NFE2L2-dependent redox homeostasis.
Autophagy 2024 Mukherjee R, Bhattacharya A, Mello-Vieira J, Kuncha SK, Hoffmann M, Gonzalez A, Rathore R, Chadha A, Shin D, Colby T, Matic I, Mukherjee S, Misra M, Dikic I
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Legionella uses host Rab GTPases and BAP31 to create a unique ER niche.
bioRxiv : the preprint server for biology 2024 Chadha A, Yanai Y, Oide H, Wakana Y, Inoue H, Saha S, Tagaya M, Arasaki K, Mukherjee S -
Cross-family small GTPase ubiquitination by the intracellular pathogen Legionella pneumophila.
Molecular biology of the cell 2023 Steinbach A, Bhadkamkar V, Jimenez-Morales D, Stevenson E, Jang GM, Krogan NJ, Swaney DL, Mukherjee S -
A Legionella toxin exhibits tRNA mimicry and glycosyl transferase activity to target the translation machinery and trigger a ribotoxic stress response.
Nature cell biology 2023 Subramanian A, Wang L, Moss T, Voorhies M, Sangwan S, Stevenson E, Pulido EH, Kwok S, Chalkley RJ, Li KH, Krogan NJ, Swaney DL, Burlingame AL, Floor SN, Sil A, Walter P, Mukherjee S -
Cross-family small GTPase ubiquitination by the intracellular pathogen Legionella pneumophila.
bioRxiv : the preprint server for biology 2023 Steinbach AM, Bhadkamkar VL, Jimenez-Morales D, Stevenson E, Jang GM, Krogan NJ, Swaney DL, Mukherjee S -
A conserved megaprotein-based molecular bridge critical for lipid trafficking and cold resilience.
Nature communications 2022 Wang C, Wang B, Pandey T, Long Y, Zhang J, Oh F, Sima J, Guo R, Liu Y, Zhang C, Mukherjee S, Bassik M, Lin W, Deng H, Vale G, McDonald JG, Shen K, Ma DK -
Non-canonical activation of the ER stress sensor ATF6 by Legionella pneumophila effectors.
Life science alliance 2021 Ibe NU, Subramanian A, Mukherjee S -
A SARS-CoV-2 protein interaction map reveals targets for drug repurposing.
Nature 2020 Gordon DE, Jang GM, Bouhaddou M, Xu J, Obernier K, White KM, O'Meara MJ, Rezelj VV, Guo JZ, Swaney DL, Tummino TA, Hüttenhain R, Kaake RM, Richards AL, Tutuncuoglu B, Foussard H, Batra J, Haas K, … -
"Make way": Pathogen exploitation of membrane traffic.
Current opinion in cell biology 2020 Noack J, Mukherjee S -
A SARS-CoV-2-Human Protein-Protein Interaction Map Reveals Drug Targets and Potential Drug-Repurposing.
bioRxiv : the preprint server for biology 2020 Gordon DE, Jang GM, Bouhaddou M, Xu J, Obernier K, O'Meara MJ, Guo JZ, Swaney DL, Tummino TA, Huettenhain R, Kaake RM, Richards AL, Tutuncuoglu B, Foussard H, Batra J, Haas K, Modak M, Kim M, Haas P, … -
CHC22 clathrin mediates traffic from early secretory compartments for human GLUT4 pathway biogenesis.
The Journal of cell biology 2020 Camus SM, Camus MD, Figueras-Novoa C, Boncompain G, Sadacca LA, Esk C, Bigot A, Gould GW, Kioumourtzoglou D, Perez F, Bryant NJ, Mukherjee S, Brodsky FM -
Systematic Identification of Host Cell Regulators of Legionella pneumophila Pathogenesis Using a Genome-wide CRISPR Screen.
Cell host & microbe 2019 Jeng EE, Bhadkamkar V, Ibe NU, Gause H, Jiang L, Chan J, Jian R, Jimenez-Morales D, Stevenson E, Krogan NJ, Swaney DL, Snyder MP, Mukherjee S, Bassik MC -
A Legionella pneumophila Kinase Phosphorylates the Hsp70 Chaperone Family to Inhibit Eukaryotic Protein Synthesis.
Cell host & microbe 2019 Moss SM, Taylor IR, Ruggero D, Gestwicki JE, Shokat KM, Mukherjee S -
How to rewire the host cell: A home improvement guide for intracellular bacteria.
The Journal of cell biology 2017 Cornejo E, Schlaermann P, Mukherjee S -
Innate immunity kinase TAK1 phosphorylates Rab1 on a hotspot for posttranslational modifications by host and pathogen.
Proceedings of the National Academy of Sciences of the United States of America 2016 Levin RS, Hertz NT, Burlingame AL, Shokat KM, Mukherjee S -
Legionella suppresses the host unfolded protein response via multiple mechanisms.
Nature communications 2015 Treacy-Abarca S, Mukherjee S -
Legionella pneumophila subversion of host vesicular transport by SidC effector proteins.
Traffic (Copenhagen, Denmark) 2014 Horenkamp FA, Mukherjee S, Alix E, Schauder CM, Hubber AM, Roy CR, Reinisch KM -
Structure of the Legionella effector AnkX reveals the mechanism of phosphocholine transfer by the FIC domain.
The EMBO journal 2013 Campanacci V, Mukherjee S, Roy CR, Cherfils J -
Subversion of membrane transport pathways by vacuolar pathogens.
The Journal of cell biology 2011 Alix E, Mukherjee S, Roy CR -
Modulation of Rab GTPase function by a protein phosphocholine transferase.
Nature 2011 Mukherjee S, Liu X, Arasaki K, McDonough J, Galán JE, Roy CR -
The Golgi protein p115 associates with gamma-tubulin and plays a role in Golgi structure and mitosis progression.
The Journal of biological chemistry 2011 Radulescu AE, Mukherjee S, Shields D -
Opposing action of casein kinase 1 and calcineurin in nucleo-cytoplasmic shuttling of mammalian translation initiation factor eIF6.
The Journal of biological chemistry 2010 Biswas A, Mukherjee S, Das S, Shields D, Chow CW, Maitra U -
Bacterial FIC Proteins AMP Up Infection.
Science signaling 2009 Roy CR, Mukherjee S -
Nuclear import is required for the pro-apoptotic function of the Golgi protein p115.
The Journal of biological chemistry 2008 Mukherjee S, Shields D -
Fragmentation of the Golgi apparatus: an early apoptotic event independent of the cytoskeleton.
Traffic (Copenhagen, Denmark) 2007 Mukherjee S, Chiu R, Leung SM, Shields D -
Characterization of Drosophila nitric oxide synthase: a biochemical study.
Biochemical and biophysical research communications 2003 Sengupta R, Sahoo R, Mukherjee S, Regulski M, Tully T, Stuehr DJ, Ghosh S -
A caspase cleavage fragment of p115 induces fragmentation of the Golgi apparatus and apoptosis.
The Journal of cell biology 2002 Chiu R, Novikov L, Mukherjee S, Shields D