Seokjoon Won, PhD
Associate Professor
Neurology
School of Medicine

Publications (36)

Top publication keywords:
NeuronsZincHypoglycemiaMotor CortexNADBrain IschemiaMinocyclineProtein Aggregation, PathologicalBrain Damage, ChronicCofilin 1MicrogliaNerve DegenerationCell DeathExcitatory Amino Acid Transporter 3Glutathione

• Neuronal Oxidative Stress Promotes α-Synuclein Aggregation In Vivo.
  Antioxidants (Basel, Switzerland) 2022 Won SJ, Fong R, Butler N, Sanchez J, Zhang Y, Wong C, Tambou Nzoutchoum O, Huynh A, Pan J, Swanson RA
• Recovery of consolidation after sleep following stroke-interaction of slow waves, spindles, and GABA.
  Cell reports 2022 Kim J, Guo L, Hishinuma A, Lemke S, Ramanathan DS, Won SJ, Ganguly K
• Blast-induced axonal degeneration in the rat cerebellum in the absence of head movement.
  Scientific reports 2022 Bishop R, Won SJ, Irvine KA, Basu J, Rome ES, Swanson RA
• Coordinated increase of reliable cortical and striatal ensemble activations during recovery after stroke.
  Cell reports 2021 Guo L, Kondapavulur S, Lemke SM, Won SJ, Ganguly K
• α-synuclein aggregates induce c-Abl activation and dopaminergic neuronal loss by a feed-forward redox stress mechanism.
  Progress in neurobiology 2021 Ghosh S, Won SJ, Wang J, Fong R, Butler NJM, Moss A, Wong C, Pan J, Sanchez J, Huynh A, Wu L, Manfredsson FP, Swanson RA

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• Cofilin-actin rod formation in experimental stroke is attenuated by therapeutic hypothermia and overexpression of the inducible 70 kD inducible heat shock protein (Hsp70).
  Brain circulation 2019 Kurisu K, You J, Zheng Z, Won SJ, Swanson RA, Yenari MA
• Emergent modular neural control drives coordinated motor actions.
  Nature neuroscience 2019 Lemke SM, Ramanathan DS, Guo L, Won SJ, Ganguly K
• Cofilin-actin rod formation in neuronal processes after brain ischemia.
  PloS one 2018 Won SJ, Minnella AM, Wu L, Eun CH, Rome E, Herson PS, Shaw AE, Bamburg JR, Swanson RA
• Low-frequency cortical activity is a neuromodulatory target that tracks recovery after stroke.
  Nature medicine 2018 Ramanathan DS, Guo L, Gulati T, Davidson G, Hishinuma AK, Won SJ, Knight RT, Chang EF, Swanson RA, Ganguly K
• Effects of Veliparib on Microglial Activation and Functional Outcomes after Traumatic Brain Injury in the Rat and Pig.
  Journal of neurotrauma 2018 Irvine KA, Bishop RK, Won SJ, Xu J, Hamel KA, Coppes V, Singh P, Sondag A, Rome E, Basu J, Cittolin-Santos GF, Panter SS, Swanson RA
• Bioenergetic state regulates innate inflammatory responses through the transcriptional co-repressor CtBP.
  Nature communications 2017 Shen Y, Kapfhamer D, Minnella AM, Kim JE, Won SJ, Chen Y, Huang Y, Low LH, Massa SM, Swanson RA
• A data-driven approach for evaluating multi-modal therapy in traumatic brain injury.
  Scientific reports 2017 Haefeli J, Ferguson AR, Bingham D, Orr A, Won SJ, Lam TI, Shi J, Hawley S, Liu J, Swanson RA, Massa SM
• Erratum to: Neuronal Glutathione Content and Antioxidant Capacity can be Normalized In Situ by N-acetyl Cysteine Concentrations Attained in Human Cerebrospinal Fluid.
  Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics 2016 Reyes RC, Cittolin-Santos GF, Kim JE, Won SJ, Brennan-Minnella AM, Katz M, Glass GA, Swanson RA
• Neuronal Glutathione Content and Antioxidant Capacity can be Normalized In Situ by N-acetyl Cysteine Concentrations Attained in Human Cerebrospinal Fluid.
  Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics 2016 Reyes RC, Cittolin-Santos GF, Kim JE, Won SJ, Brennan-Minnella AM, Katz M, Glass GA, Swanson RA
• Melatonin Reduces Hypoglycemia-Induced Neuronal Death in Rats.
  Neuroendocrinology 2015 Kim JH, Yoo BH, Won SJ, Choi BY, Lee BE, Kim IY, Kho A, Lee SH, Sohn M, Suh SW
• Robust neuroprosthetic control from the stroke perilesional cortex.
  The Journal of neuroscience : the official journal of the Society for Neuroscience 2015 Gulati T, Won SJ, Ramanathan DS, Wong CC, Bodepudi A, Swanson RA, Ganguly K
• Assessment at the single-cell level identifies neuronal glutathione depletion as both a cause and effect of ischemia-reperfusion oxidative stress.
  The Journal of neuroscience : the official journal of the Society for Neuroscience 2015 Won SJ, Kim JE, Cittolin-Santos GF, Swanson RA
• An automated behavioral box to assess forelimb function in rats.
  Journal of neuroscience methods 2015 Wong CC, Ramanathan DS, Gulati T, Won SJ, Ganguly K
• Cerebrospinal fluid concentrations of N-acetylcysteine after oral administration in Parkinson's disease.
  Parkinsonism & related disorders 2015 Katz M, Won SJ, Park Y, Orr A, Jones DP, Swanson RA, Glass GA
• NADPH oxidase-2: linking glucose, acidosis, and excitotoxicity in stroke.
  Antioxidants & redox signaling 2015 Brennan-Minnella AM, Won SJ, Swanson RA
• Intracellular pH reduction prevents excitotoxic and ischemic neuronal death by inhibiting NADPH oxidase.
  Proceedings of the National Academy of Sciences of the United States of America 2013 Lam TI, Brennan-Minnella AM, Won SJ, Shen Y, Hefner C, Shi Y, Sun D, Swanson RA
• Prevention of hypoglycemia-induced neuronal death by minocycline.
  Journal of neuroinflammation 2012 Won SJ, Kim JH, Yoo BH, Sohn M, Kauppinen TM, Park MS, Kwon HJ, Liu J, Suh SW
• Recurrent/moderate hypoglycemia induces hippocampal dendritic injury, microglial activation, and cognitive impairment in diabetic rats.
  Journal of neuroinflammation 2012 Won SJ, Yoo BH, Kauppinen TM, Choi BY, Kim JH, Jang BG, Lee MW, Sohn M, Liu J, Swanson RA, Suh SW
• Prevention of traumatic brain injury-induced neuron death by intranasal delivery of nicotinamide adenine dinucleotide.
  Journal of neurotrauma 2012 Won SJ, Choi BY, Yoo BH, Sohn M, Ying W, Swanson RA, Suh SW
• Prevention of acute/severe hypoglycemia-induced neuron death by lactate administration.
  Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 2012 Won SJ, Jang BG, Yoo BH, Sohn M, Lee MW, Choi BY, Kim JH, Song HK, Suh SW
• Microglial activation induced by brain trauma is suppressed by post-injury treatment with a PARP inhibitor.
  Journal of neuroinflammation 2012 d'Avila JC, Lam TI, Bingham D, Shi J, Won SJ, Kauppinen TM, Massa S, Liu J, Swanson RA
• Poly(ADP-ribose)polymerase-1 modulates microglial responses to amyloid β.
  Journal of neuroinflammation 2011 Kauppinen TM, Suh SW, Higashi Y, Berman AE, Escartin C, Won SJ, Wang C, Cho SH, Gan L, Swanson RA
• Hyperglycemia promotes tissue plasminogen activator-induced hemorrhage by Increasing superoxide production.
  Annals of neurology 2011 Won SJ, Tang XN, Suh SW, Yenari MA, Swanson RA
• Nuclear factor erythroid 2-related factor 2 facilitates neuronal glutathione synthesis by upregulating neuronal excitatory amino acid transporter 3 expression.
  The Journal of neuroscience : the official journal of the Society for Neuroscience 2011 Escartin C, Won SJ, Malgorn C, Auregan G, Berman AE, Chen PC, Déglon N, Johnson JA, Suh SW, Swanson RA
• EAAC1 gene deletion alters zinc homeostasis and exacerbates neuronal injury after transient cerebral ischemia.
  The Journal of neuroscience : the official journal of the Society for Neuroscience 2010 Won SJ, Yoo BH, Brennan AM, Shin BS, Kauppinen TM, Berman AE, Swanson RA, Suh SW
• Prevention of hypoglycemia-induced neuronal death by hypothermia.
  Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 2009 Shin BS, Won SJ, Yoo BH, Kauppinen TM, Suh SW
• Decreased brain zinc availability reduces hippocampal neurogenesis in mice and rats.
  Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 2009 Suh SW, Won SJ, Hamby AM, Yoo BH, Fan Y, Sheline CT, Tamano H, Takeda A, Liu J
• NADPH oxidase is the primary source of superoxide induced by NMDA receptor activation.
  Nature neuroscience 2009 Brennan AM, Suh SW, Won SJ, Narasimhan P, Kauppinen TM, Lee H, Edling Y, Chan PH, Swanson RA
• Sequential release of nitric oxide, zinc, and superoxide in hypoglycemic neuronal death.
  Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 2008 Suh SW, Hamby AM, Gum ET, Shin BS, Won SJ, Sheline CT, Chan PH, Swanson RA
• Reduced hippocampal neurogenesis and skill reaching performance in adult Emx1 mutant mice.
  Experimental neurology 2007 Hong SM, Liu Z, Fan Y, Neumann M, Won SJ, Lac D, Lum X, Weinstein PR, Liu J
• Chronic treatment with minocycline preserves adult new neurons and reduces functional impairment after focal cerebral ischemia.
  Stroke 2006 Liu Z, Fan Y, Won SJ, Neumann M, Hu D, Zhou L, Weinstein PR, Liu J