Senthilnath Lakshmana Chetty, PhD
Postdoctoral Scholar
Neurological Surgery
School of Medicine

Education & Training

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• Ph.D Cell biology, Stem cells, and Development University of Colorado Anschutz Medical Campus 12/2018
• M.S Biotechnology University of Texas at San Antonio 12/2011

Publications (17)

Top publication keywords:
Bacterial VaccinesSTAT3 Transcription FactorWnt Signaling PathwayGliomaMyeloid-Derived Suppressor CellsLymphatic MetastasisGlioblastomaEpitopes, T-LymphocyteHLA-DR4 AntigenBrain NeoplasmsPhosphoproteinsTranscription FactorsTumor Suppressor ProteinsTrans-ActivatorsMitogen-Activated Protein Kinases

• Challenges in the discovery of tumor-specific alternative splicing-derived cell-surface antigens in glioma.
  Scientific reports 2024 Nejo T, Wang L, Leung KK, Wang A, Lakshmanachetty S, Gallus M, Kwok DW, Hong C, Chen LH, Carrera DA, Zhang MY, Stevers NO, Maldonado GC, Yamamichi A, Watchmaker PB, Naik A, Shai A, Phillips JJ, Chang …
• Correction: Gallus et al. Immunotherapy Approaches in Isocitrate-Dehydrogenase-Mutant Low-Grade Glioma. Cancers 2023, 15, 3726.
  Cancers 2023 Gallus M, Kwok D, Lakshmanachetty S, Yamamichi A, Okada H
• Challenges in the discovery of tumor-specific alternative splicing-derived cell-surface antigens in glioma.
  bioRxiv : the preprint server for biology 2023 Nejo T, Wang L, Leung KK, Wang A, Lakshmanachetty S, Gallus M, Kwok DW, Hong C, Chen LH, Carrera DA, Zhang MY, Stevers NO, Maldonado GC, Yamamichi A, Watchmaker P, Naik A, Shai A, Phillips JJ, Chang …
• Tumor-wide RNA splicing aberrations generate immunogenic public neoantigens.
  bioRxiv : the preprint server for biology 2023 Kwok DW, Stevers NO, Nejo T, Chen LH, Etxeberria I, Jung J, Okada K, Cove MC, Lakshmanachetty S, Gallus M, Barpanda A, Hong C, Chan GKL, Wu SH, Ramos E, Yamamichi A, Liu J, Watchmaker P, Ogino H, …
• Glioma-neuronal circuit remodeling induces regional immunosuppression.
  bioRxiv : the preprint server for biology 2023 Nejo T, Krishna S, Jimenez C, Yamamichi A, Young JS, Lakshmanachetty S, Chen T, Phyu SSS, Ogino H, Watchmaker P, Diebold D, Choudhury A, Daniel AGS, Raleigh DR, Hervey-Jumper SL, Okada H

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• Immunotherapy Approaches in Isocitrate-Dehydrogenase-Mutant Low-Grade Glioma.
  Cancers 2023 Gallus M, Kwok D, Lakshmanachetty S, Yamamichi A, Okada H
• Mapping the tumor-infiltrating immune cells during glioblastoma progression.
  Nature immunology 2022 Lakshmanachetty S, Mitra SS
• Venetoclax Cooperates with Ionizing Radiation to Attenuate Diffuse Midline Glioma Tumor Growth.
  Clinical cancer research : an official journal of the American Association for Cancer Research 2022 Madhavan K, Balakrishnan I, Lakshmanachetty S, Pierce A, Sanford B, Fosmire S, Elajaili HB, Walker F, Wang D, Nozik ES, Mitra SS, Dahl NA, Vibhakar R, Venkataraman S
• Targeting the TP53/MDM2 axis enhances radiation sensitivity in atypical teratoid rhabdoid tumors.
  International journal of oncology 2022 Alimova I, Wang D, Danis E, Pierce A, Donson A, Serkova N, Madhavan K, Lakshmanachetty S, Balakrishnan I, Foreman NK, Mitra S, Venkataraman S, Vibhakar R
• New Insights into the Multifaceted Role of Myeloid-Derived Suppressor Cells (MDSCs) in High-Grade Gliomas: From Metabolic Reprograming, Immunosuppression, and Therapeutic Resistance to Current Strategies for Targeting MDSCs.
  Cells 2021 Lakshmanachetty S, Cruz-Cruz J, Hoffmeyer E, Cole AP, Mitra SS
• Microglia in the Brain Tumor Microenvironment.
  Advances in experimental medicine and biology 2020 Cole AP, Hoffmeyer E, Chetty SL, Cruz-Cruz J, Hamrick F, Youssef O, Cheshier S, Mitra SS
• Loss of TP63 Promotes the Metastasis of Head and Neck Squamous Cell Carcinoma by Activating MAPK and STAT3 Signaling.
  Molecular cancer research : MCR 2019 Lakshmanachetty S, Balaiya V, High WA, Koster MI
• TRP63/TP63 loss accelerates skin tumorigenesis through activation of Wnt/β-catenin signaling.
  Journal of dermatological science 2018 Lakshmanachetty S, Balaiya V, Johnson LK, Koster MI
• A Human Stem Cell-Based System to Study the Role of TP63 Mutations in Ectodermal Dysplasias.
  The Journal of investigative dermatology 2018 Dinella JD, Chen J, Webb S, Siegfried E, Bree AF, Lakshmanachetty S, Balaiya V, Koster MI, Koch PJ
• Emerging roles for collagen XV and XVIII in cancer progression.
  Experimental dermatology 2016 Lakshmanachetty S, Koster MI
• A T cell epitope-based vaccine protects against chlamydial infection in HLA-DR4 transgenic mice.
  Vaccine 2013 Li W, Murthy AK, Lanka GK, Chetty SL, Yu JJ, Chambers JP, Zhong G, Forsthuber TG, Guentzel MN, Arulanandam BP
• Francisella DnaK inhibits tissue-nonspecific alkaline phosphatase.
  The Journal of biological chemistry 2012 Arulanandam BP, Chetty SL, Yu JJ, Leonard S, Klose K, Seshu J, Cap A, Valdes JJ, Chambers JP