Scott Zamvil, MD, PhD
Professor
Neurology
School of Medicine

Zamvil earned his medical degree and a doctorate in microbiology and immunology from Stanford University. He then completed a residency in internal medicine at Stanford University and a residency in neurology at Brigham and Women's Hospital. Before coming to UCSF, he was a neurologist at Brigham and Women's Hospital.

Zamvil is a board member of the International Society of Neuroimmunology. He is also an adviser for America's Committee for Treatment and Research in Multiple Sclerosis. He serves as deputy editor of the journal Neurology: Neuroimmunology & Neuroinflammation.

• Targeting PGLYRP1 in cancer and autoimmunity.
  Nature immunology 2023 Moseley CE, Zamvil SS
• Susceptibility-based imaging aids accurate distinction of pediatric-onset MS from myelin oligodendrocyte glycoprotein antibody-associated disease.
  Multiple sclerosis (Houndmills, Basingstoke, England) 2023 Sacco S, Virupakshaiah A, Papinutto N, Schoeps VA, Akula A, Zhao H, Arona J, Stern WA, Chong J, Hart J, Zamvil SS, Sati P, Henry RG, Waubant E
• A 28-Year-Old Woman With Left-Sided Weakness and Atypical MRI Lesions: From the National Multiple Sclerosis Society Case Conference Proceedings.
  Neurology(R) neuroimmunology & neuroinflammation 2023 Safadi AL, Osborne B, Chitnis T, Graves JS, Newsome SD, Zamvil SS, Solomon IH, Shin RK
• T cell deletional tolerance restricts AQP4 but not MOG CNS autoimmunity.
  Proceedings of the National Academy of Sciences of the United States of America 2023 Sagan SA, Moinfar Z, Moseley CE, Dandekar R, Spencer CM, Verkman AS, Ottersen OP, Sobel RA, Sidney J, Sette A, Anderson MS, Steinman L, Wilson MR, Sabatino JJ, Zamvil SS
• Defining blood-induced microglia functions in neurodegeneration through multiomic profiling.
  Nature immunology 2023 Mendiola AS, Yan Z, Dixit K, Johnson JR, Bouhaddou M, Meyer-Franke A, Shin MG, Yong Y, Agrawal A, MacDonald E, Muthukumar G, Pearce C, Arun N, Cabriga B, Meza-Acevedo R, Alzamora MDPS, Zamvil SS, Pico…
• A Predictive Autoantibody Signature in Multiple Sclerosis.
  medRxiv : the preprint server for health sciences 2023 Zamecnik CR, Sowa GM, Abdelhak A, Dandekar R, Bair RD, Wade KJ, Bartley CM, Tubati A, Gomez R, Fouassier C, Gerungan C, Alexander J, Wapniarski AE, Loudermilk RP, Eggers EL, Zorn KC, Ananth K, …
• Low protection from breakthrough SARS-CoV-2 infection and mild disease course in ocrelizumab-treated patients with multiple sclerosis after three mRNA vaccine doses.
  Journal of neurology, neurosurgery, and psychiatry 2023 Novak F, Bajwa HM, Coia JE, Nilsson AC, Nielsen C, Holm DK, Østergaard K, Hvidt MVM, Byg KE, Johansen IS, Mittl K, Rowles W, Zamvil SS, Bove R, Sabatino JJ, Sejbaek T
• Relapsing Encephalomyelitis After COVID-19 Infection and Vaccination: From the National MS Society Case Conference Proceedings.
  Neurology(R) neuroimmunology & neuroinflammation 2023 Roy S, Barreras P, Pardo CA, Graves JS, Zamvil SS, Newsome SD
• SAkuraBONSAI: Protocol design of a novel, prospective study to explore clinical, imaging, and biomarker outcomes in patients with AQP4-IgG-seropositive neuromyelitis optica spectrum disorder receiving open-label satralizumab.
  Frontiers in neurology 2023 Bennett JL, Fujihara K, Kim HJ, Marignier R, O'Connor KC, Sergott RC, Traboulsee A, Wiendl H, Wuerfel J, Zamvil SS, Anania VG, Buffels R, Künzel T, Lekkerkerker AN, Lennon-Chrimes S, Pittock SJ
• CAR-T Cell-Mediated B-Cell Depletion in Central Nervous System Autoimmunity.
  Neurology(R) neuroimmunology & neuroinflammation 2023 Gupta S, Simic M, Sagan SA, Shepherd C, Duecker J, Sobel RA, Dandekar R, Wu GF, Wu W, Pak JE, Hauser SL, Lim W, Wilson MR, Zamvil SS
• N2 Year in Review.
  Neurology(R) neuroimmunology & neuroinflammation 2023 Dalmau J, Dalakas MC, Kolson DL, Paul F, Sánchez-Valle R, Zamvil SS
• Longitudinal adaptive immune responses following sequential SARS-CoV-2 vaccinations in MS patients on anti-CD20 therapies and sphingosine-1-phosphate receptor modulators.
  Multiple sclerosis and related disorders 2022 Sabatino JJ, Mittl K, Rowles W, Zamecnik CR, Loudermilk RP, Gerungan C, Spencer CM, Sagan SA, Alexander J, Mcpolin K, Chen P, Deshpande C, Wyse K, Maiese EM, Wilson MR, Zamvil SS, Bove R
• MOG Antibody-Associated Disease and Thymic Hyperplasia: From the National Multiple Sclerosis Society Case Conference Proceedings.
  Neurology(R) neuroimmunology & neuroinflammation 2022 Hurtubise B, Frohman EM, Galetta S, Balcer LJ, Frohman TC, Lisak RP, Newsome SD, Graves JS, Zamvil SS, Amezcua L
• Recurrent Optic Neuritis and Perineuritis Followed by an Unexpected Discovery: From the National Multiple Sclerosis Society Case Conference Proceedings.
  Neurology(R) neuroimmunology & neuroinflammation 2022 Pimentel Maldonado DA, Lisak R, Galetta S, Balcer L, Varkey T, Goodman A, Graves J, Racke M, Zamvil SS, Newsome S, Frohman EM, Frohman TC
• Multiple Sclerosis Followed by Neuromyelitis Optica Spectrum Disorder: From the National Multiple Sclerosis Society Case Conference Proceedings.
  Neurology(R) neuroimmunology & neuroinflammation 2022 Goldschmidt C, Galetta SL, Lisak RP, Balcer LJ, Hellman A, Racke MK, Lovett-Racke AE, Cruz R, Parsons MS, Sattarnezhad N, Steinman L, Zamvil SS, Frohman EM, Frohman TC
• Reply to "Spinal Cord Atrophy Is a Preclinical Marker of Progressive MS".
  Annals of neurology 2022 Bischof A, Papinutto N, Keshavan A, Rajesh A, Kirkish G, Zhang X, Mallott JM, Asteggiano C, Sacco S, Gundel TJ, Zhao C, Stern WA, Caverzasi E, Zhou Y, Gomez R, Ragan NR, Santaniello A, Zhu AH, Juwono …
• A hormonal therapy for menopausal women with MS: A phase Ib/IIa randomized controlled trial.
  Multiple sclerosis and related disorders 2022 Bove R, Anderson A, Rowles W, Rankin KA, Hills NK, Carleton M, Cooper J, Cree BAC, Gelfand JM, Graves JS, Henry RG, Krysko KM, Rush G, Zamvil SS, Joffe H, Chan JR, Green AJ
• Persistently reduced humoral and sustained cellular immune response from first to third SARS-CoV-2 mRNA vaccination in anti-CD20-treated multiple sclerosis patients.
  Multiple sclerosis and related disorders 2022 Bajwa HM, Novak F, Nilsson AC, Nielsen C, Holm DK, Østergaard K, Witt AH, Byg KE, Johansen IS, Mittl K, Rowles W, Zamvil SS, Bove R, Sabatino JJ, Sejbaek T
• Multiple sclerosis therapies differentially affect SARS-CoV-2 vaccine-induced antibody and T cell immunity and function.
  JCI insight 2022 Sabatino JJ, Mittl K, Rowles WM, McPolin K, Rajan JV, Laurie MT, Zamecnik CR, Dandekar R, Alvarenga BD, Loudermilk RP, Gerungan C, Spencer CM, Sagan SA, Augusto DG, Alexander JR, DeRisi JL, Hollenbach…
• Spinal Cord Atrophy Predicts Progressive Disease in Relapsing Multiple Sclerosis.
  Annals of neurology 2022 Bischof A, Papinutto N, Keshavan A, Rajesh A, Kirkish G, Zhang X, Mallott JM, Asteggiano C, Sacco S, Gundel TJ, Zhao C, Stern WA, Caverzasi E, Zhou Y, Gomez R, Ragan NR, Santaniello A, Zhu AH, Juwono …
• Lymph node-resident dendritic cells drive TH2 cell development involving MARCH1.
  Science immunology 2021 Castellanos CA, Ren X, Gonzalez SL, Li HK, Schroeder AW, Liang HE, Laidlaw BJ, Hu D, Mak ACY, Eng C, Rodríguez-Santana JR, LeNoir M, Yan Q, Celedón JC, Burchard EG, Zamvil SS, Ishido S, Locksley RM, …
• SARS-CoV-2 spike protein induces abnormal inflammatory blood clots neutralized by fibrin immunotherapy.
  bioRxiv : the preprint server for biology 2021 Ryu JK, Sozmen EG, Dixit K, Montano M, Matsui Y, Liu Y, Helmy E, Deerinck TJ, Yan Z, Schuck R, Acevedo RM, Spencer CM, Thomas R, Pico AR, Zamvil SS, Lynch KL, Ellisman MH, Greene WC, Akassoglou K
• Impact of multiple sclerosis disease-modifying therapies on SARS-CoV-2 vaccine-induced antibody and T cell immunity.
  medRxiv : the preprint server for health sciences 2021 Sabatino JJ, Mittl K, Rowles W, Mcpolin K, Rajan JV, Zamecnik CR, Dandekar R, Alvarenga BD, Loudermilk RP, Gerungan C, Spencer CM, Sagan SA, Augusto DG, Alexander J, Hollenbach JA, Wilson MR, Zamvil …
• Humoral immune response following SARS-CoV-2 mRNA vaccination concomitant to anti-CD20 therapy in multiple sclerosis.
  Multiple sclerosis and related disorders 2021 Novak F, Nilsson AC, Nielsen C, Holm DK, Østergaard K, Bystrup A, Byg KE, Johansen IS, Mittl K, Rowles W, Mcpolin K, Spencer C, Sagan S, Gerungan C, Wilson MR, Zamvil SS, Bove R, Sabatino JJ, Sejbaek …
• Encephalitis and Myelitis in a Young Woman: Overlap Syndrome, Thyroiditis, and Occult Tumor From the National Multiple Sclerosis Society Case Conference Proceedings.
  Neurology(R) neuroimmunology & neuroinflammation 2021 Zarghami Esfanhani N, Wundes A, Varkey T, Lisak RP, Goodman A, Graves J, Zamvil SS, Frohman EM, Frohman TC, Newsome SD
• Can Systemic Anti-CD20 B Cell-Depleting Antibodies Eliminate Meningeal Follicles in Multiple Sclerosis?
  Neurology(R) neuroimmunology & neuroinflammation 2021 Gupta S, Zamvil SS
• Application of an evidence-based, out-patient treatment strategy for COVID-19: Multidisciplinary medical practice principles to prevent severe disease.
  Journal of the neurological sciences 2021 Frohman EM, Villemarette-Pittman NR, Rodriguez A, Glanzman R, Rugheimer S, Komogortsev O, Zamvil SS, Cruz RA, Varkey TC, Frohman AN, Frohman AR, Parsons MS, Konkle EH, Frohman TC
• CNS Autoimmune Responses in BCMA-Deficient Mice Provide Insight for the Failure of Atacicept in MS.
  Neurology(R) neuroimmunology & neuroinflammation 2021 Kumar G, Maria Z, Kohli U, Agasing A, Quinn JL, Ko RM, Zamvil SS, Axtell RC
• Antigen Presentation by B Cells in Multiple Sclerosis.
  The New England journal of medicine 2021 Zamvil SS, Hauser SL
• A CD8+ NK cell transcriptomic signature associated with clinical outcome in relapsing remitting multiple sclerosis.
  Nature communications 2021 McKinney EF, Cuthbertson I, Harris KM, Smilek DE, Connor C, Manferrari G, Carr EJ, Zamvil SS, Smith KGC
• N2 year in review.
  Neurology(R) neuroimmunology & neuroinflammation 2020 Dalmau J, Dalakas MC, Kolson DL, Paul F, Zamvil SS
• Targeting B Cells to Modify MS, NMOSD, and MOGAD: Part 1.
  Neurology(R) neuroimmunology & neuroinflammation 2020 Graf J, Mares J, Barnett M, Aktas O, Albrecht P, Zamvil SS, Hartung HP
• Targeting B cells to modify MS, NMOSD, and MOGAD: Part 2.
  Neurology(R) neuroimmunology & neuroinflammation 2020 Graf J, Mares J, Barnett M, Aktas O, Albrecht P, Zamvil SS, Hartung HP
• Treating MS after surviving PML: Discrete strategies for rescue, remission, and recovery patient 1: From the National Multiple Sclerosis Society Case Conference Proceedings.
  Neurology(R) neuroimmunology & neuroinflammation 2020 Anadani N, Hyland M, Cruz RA, Lisak R, Costello K, Major EO, Jassam Y, Meltzer E, Varkey TC, Parsons MS, Goodman AD, Graves JS, Newsome S, Zamvil SS, Frohman EM, Frohman TC
• Treating MS after surviving PML: Discrete strategies for rescue, remission, and recovery patient 2: From the National Multiple Sclerosis Society Case Conference Proceedings.
  Neurology(R) neuroimmunology & neuroinflammation 2020 Cruz RA, Hogan N, Sconzert J, Sconzert M, Major EO, Lisak RP, Melamed E, Varkey TC, Meltzer E, Goodman A, Komogortsev O, Parsons MS, Costello K, Graves JS, Newsome S, Zamvil SS, Frohman EM, Frohman TC
• Neurite Orientation Dispersion and Density Imaging for Assessing Acute Inflammation and Lesion Evolution in MS.
  AJNR. American journal of neuroradiology 2020 Sacco S, Caverzasi E, Papinutto N, Cordano C, Bischof A, Gundel T, Cheng S, Asteggiano C, Kirkish G, Mallott J, Stern WA, Bastianello S, Bove RM, Gelfand JM, Goodin DS, Green AJ, Waubant E, Wilson MR,…
• The immune signatures of multiple sclerosis: Lessons from twin studies.
  Proceedings of the National Academy of Sciences of the United States of America 2020 Villoslada P, Zamvil SS
• Ataxin-1 regulates B cell function and the severity of autoimmune experimental encephalomyelitis.
  Proceedings of the National Academy of Sciences of the United States of America 2020 Didonna A, Canto Puig E, Ma Q, Matsunaga A, Ho B, Caillier SJ, Shams H, Lee N, Hauser SL, Tan Q, Zamvil SS, Oksenberg JR
• Author Correction: Transcriptional profiling and therapeutic targeting of oxidative stress in neuroinflammation.
  Nature immunology 2020 Mendiola AS, Ryu JK, Bardehle S, Meyer-Franke A, Ang KK, Wilson C, Baeten KM, Hanspers K, Merlini M, Thomas S, Petersen MA, Williams A, Thomas R, Rafalski VA, Meza-Acevedo R, Tognatta R, Yan Z, Pfaff …
• A pathogenic and clonally expanded B cell transcriptome in active multiple sclerosis.
  Proceedings of the National Academy of Sciences of the United States of America 2020 Ramesh A, Schubert RD, Greenfield AL, Dandekar R, Loudermilk R, Sabatino JJ, Koelzer MT, Tran EB, Koshal K, Kim K, Pröbstel AK, Banerji D, University of California, San Francisco MS-EPIC Team, Guo CY,…
• Mitigating alemtuzumab-associated autoimmunity in MS: A "whack-a-mole" B-cell depletion strategy.
  Neurology(R) neuroimmunology & neuroinflammation 2020 Meltzer E, Campbell S, Ehrenfeld B, Cruz RA, Steinman L, Parsons MS, Zamvil SS, Frohman EM, Frohman TC
• Microglia complement astrocytes in neuromyelitis optica.
  The Journal of clinical investigation 2020 Moinfar Z, Zamvil SS
• Effect of the sphingosine-1-phosphate receptor modulator ozanimod on leukocyte subtypes in relapsing MS.
  Neurology(R) neuroimmunology & neuroinflammation 2020 Harris S, Tran JQ, Southworth H, Spencer CM, Cree BAC, Zamvil SS
• Should interferons take front stage as an essential MS disease-modifying therapy in the era of coronavirus disease 2019?
  Neurology(R) neuroimmunology & neuroinflammation 2020 Maguire C, Frohman T, Zamvil SS, Frohman E, Melamed E
• Part I. SARS-CoV-2 triggered 'PANIC' attack in severe COVID-19.
  Journal of the neurological sciences 2020 Frohman EM, Villemarette-Pittman NR, Melamed E, Cruz RA, Longmuir R, Varkey TC, Steinman L, Zamvil SS, Frohman TC
• Part II. high-dose methotrexate with leucovorin rescue for severe COVID-19: An immune stabilization strategy for SARS-CoV-2 induced 'PANIC' attack.
  Journal of the neurological sciences 2020 Frohman EM, Villemarette-Pittman NR, Cruz RA, Longmuir R, Rowe V, Rowe ES, Varkey TC, Steinman L, Zamvil SS, Frohman TC
• Transcriptional profiling and therapeutic targeting of oxidative stress in neuroinflammation.
  Nature immunology 2020 Mendiola AS, Ryu JK, Bardehle S, Meyer-Franke A, Ang KK, Wilson C, Baeten KM, Hanspers K, Merlini M, Thomas S, Petersen MA, Williams A, Thomas R, Rafalski VA, Meza-Acevedo R, Tognatta R, Yan Z, Pfaff …
• Glatiramer acetate immune modulates B-cell antigen presentation in treatment of MS.
  Neurology(R) neuroimmunology & neuroinflammation 2020 Häusler D, Hajiyeva Z, Traub JW, Zamvil SS, Lalive PH, Brück W, Weber MS
• New cases of vasculitis after alemtuzumab.
  Multiple sclerosis (Houndmills, Basingstoke, England) 2020 Azevedo CJ, Zamvil SS
• Intrathecal B-cell activation in LGI1 antibody encephalitis.
  Neurology(R) neuroimmunology & neuroinflammation 2020 Lehmann-Horn K, Irani SR, Wang S, Palanichamy A, Jahn S, Greenfield AL, Dandekar R, Lepennetier G, Michael S, Gelfand JM, Geschwind MD, Wilson MR, Zamvil SS, von Büdingen HC
• Reply: Neither human nor mouse is hypercalcaemic with 250 nmol/l 25-hydroxyvitamin D.
  Brain : a journal of neurology 2020 Häusler D, Torke S, Peelen E, Bertsch T, Weber M, Heilmann M, Djukic M, Nau R, Larochelle C, Zamvil SS, Brück W, Weber MS
• Publisher Correction: B cells in autoimmune and neurodegenerative central nervous system diseases.
  Nature reviews. Neuroscience 2020 Sabatino JJ, Pröbstel AK, Zamvil SS
• N2 year in review.
  Neurology(R) neuroimmunology & neuroinflammation 2019 Dalmau J, Dalakas MC, Kolson DL, Paul F, Zamvil SS
• Reply: Hypercalcaemia rather than high dose vitamin D3 supplements could exacerbate multiple sclerosis.
  Brain : a journal of neurology 2019 Häusler D, Torke S, Peelen E, Bertsch T, Djukic M, Nau R, Larochelle C, Zamvil SS, Brück W, Weber MS
• Anti-CD20 therapy depletes activated myelin-specific CD8+ T cells in multiple sclerosis.
  Proceedings of the National Academy of Sciences of the United States of America 2019 Sabatino JJ, Wilson MR, Calabresi PA, Hauser SL, Schneck JP, Zamvil SS
• B cells in autoimmune and neurodegenerative central nervous system diseases.
  Nature reviews. Neuroscience 2019 Sabatino JJ, Pröbstel AK, Zamvil SS
• Monitoring retinal changes with optical coherence tomography predicts neuronal loss in experimental autoimmune encephalomyelitis.
  Journal of neuroinflammation 2019 Cruz-Herranz A, Dietrich M, Hilla AM, Yiu HH, Levin MH, Hecker C, Issberner A, Hallenberger A, Cordano C, Lehmann-Horn K, Balk LJ, Aktas O, Ingwersen J, von Gall C, Hartung HP, Zamvil SS, Fischer D, …
• Do maternal anti-N-methyl-D-aspartate receptor antibodies promote development of neuropsychiatric disease in children?
  Annals of neurology 2019 Pröbstel AK, Zamvil SS
• High dose vitamin D exacerbates central nervous system autoimmunity by raising T-cell excitatory calcium.
  Brain : a journal of neurology 2019 Häusler D, Torke S, Peelen E, Bertsch T, Djukic M, Nau R, Larochelle C, Zamvil SS, Brück W, Weber MS
• Cataclysmically disseminating neurologic presentation in an immunosuppressed lupus patient: From the National Multiple Sclerosis Society Case Conference Proceedings.
  Neurology(R) neuroimmunology & neuroinflammation 2019 Perrone CM, Lisak RP, Meltzer EI, Sguigna P, Tizazu E, Jacobs D, Melamed E, Lucas A, Freeman L, Pardo G, Goodman A, Fox EJ, Costello K, Parsons MS, Zamvil SS, Frohman EM, Frohman TC
• Recirculating Intestinal IgA-Producing Cells Regulate Neuroinflammation via IL-10.
  Cell 2019 Rojas OL, Pröbstel AK, Porfilio EA, Wang AA, Charabati M, Sun T, Lee DSW, Galicia G, Ramaglia V, Ward LA, Leung LYT, Najafi G, Khaleghi K, Garcillán B, Li A, Besla R, Naouar I, Cao EY, Chiaranunt P, …
• Silent progression in disease activity-free relapsing multiple sclerosis.
  Annals of neurology 2019 University of California, San Francisco MS-EPIC Team, Cree BAC, Hollenbach JA, Bove R, Kirkish G, Sacco S, Caverzasi E, Bischof A, Gundel T, Zhu AH, Papinutto N, Stern WA, Bevan C, Romeo A, Goodin DS,…
• Cerebellar syndrome in a man treated with natalizumab: From the National Multiple Sclerosis Society Case Conference Proceedings.
  Neurology(R) neuroimmunology & neuroinflammation 2019 Lapides DA, Batchala PP, Donahue JH, Lisak RP, Meltzer EI, Narayan RN, Nath A, Frohman TC, Costello K, Goldman MD, Zamvil SS, Frohman EM
• B-Cell Therapies in Multiple Sclerosis.
  Cold Spring Harbor perspectives in medicine 2019 Sabatino JJ, Zamvil SS, Hauser SL
• The Evolving Mechanisms of Action of Glatiramer Acetate.
  Cold Spring Harbor perspectives in medicine 2019 Prod'homme T, Zamvil SS
• Recirculating Intestinal IgA-Producing Cells Regulate Neuroinflammation via IL-10.
  Cell 2019 Rojas OL, Pröbstel AK, Porfilio EA, Wang AA, Charabati M, Sun T, Lee DSW, Galicia G, Ramaglia V, Ward LA, Leung LYT, Najafi G, Khaleghi K, Garcillán B, Li A, Besla R, Naouar I, Cao EY, Chiaranunt P, …
• A young man in "double-trouble": Hallucinations and cranial nerve palsies: From the National Multiple Sclerosis Society Case Conference Proceedings.
  Neurology(R) neuroimmunology & neuroinflammation 2018 Bradshaw MJ, Lisak RP, Meltzer E, Melamed E, Lucas A, Freeman L, Frohman TC, Costello K, Balcer L, Galetta S, Chitnis T, Zamvil SS, Frohman EM
• N2 year in review and message from the editor to our reviewers.
  Neurology(R) neuroimmunology & neuroinflammation 2018 Dalmau J, Kolson DL, Paul F, Zamvil SS
• Multiple Sclerosis-Associated Changes in the Composition and Immune Functions of Spore-Forming Bacteria.
  mSystems 2018 Cekanaviciute E, Pröbstel AK, Thomann A, Runia TF, Casaccia P, Katz Sand I, Crabtree E, Singh S, Morrissey J, Barba P, Gomez R, Knight R, Mazmanian S, Graves J, Cree BAC, Zamvil SS, Baranzini SE
• A young man with numbness in arms and legs: From the National Multiple Sclerosis Society Case Conference Proceedings.
  Neurology(R) neuroimmunology & neuroinflammation 2018 Romeo AR, Lisak RP, Meltzer E, Fox EJ, Melamed E, Lucas A, Freeman L, Frohman TC, Costello K, Zamvil SS, Frohman EM, Gelfand JM
• Fibrin-targeting immunotherapy protects against neuroinflammation and neurodegeneration.
  Nature immunology 2018 Ryu JK, Rafalski VA, Meyer-Franke A, Adams RA, Poda SB, Rios Coronado PE, Pedersen LØ, Menon V, Baeten KM, Sikorski SL, Bedard C, Hanspers K, Bardehle S, Mendiola AS, Davalos D, Machado MR, Chan JP, …
• T cells take aim at a ubiquitous autoantigen in multiple sclerosis.
  Science translational medicine 2018 Sabatino JJ, Zamvil SS
• Functional characterization of reappearing B cells after anti-CD20 treatment of CNS autoimmune disease.
  Proceedings of the National Academy of Sciences of the United States of America 2018 Häusler D, Häusser-Kinzel S, Feldmann L, Torke S, Lepennetier G, Bernard CCA, Zamvil SS, Brück W, Lehmann-Horn K, Weber MS
• Vascular niche IL-6 induces alternative macrophage activation in glioblastoma through HIF-2α.
  Nature communications 2018 Wang Q, He Z, Huang M, Liu T, Wang Y, Xu H, Duan H, Ma P, Zhang L, Zamvil SS, Hidalgo J, Zhang Z, O'Rourke DM, Dahmane N, Brem S, Mou Y, Gong Y, Fan Y
• The Gut Microbiome in Neuromyelitis Optica.
  Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics 2018 Zamvil SS, Spencer CM, Baranzini SE, Cree BAC
• Induction of Paralysis and Visual System Injury in Mice by T Cells Specific for Neuromyelitis Optica Autoantigen Aquaporin-4.
  Journal of visualized experiments : JoVE 2017 Sagan SA, Cruz-Herranz A, Spencer CM, Ho PP, Steinman L, Green AJ, Sobel RA, Zamvil SS
• Aryl hydrocarbon receptor activity may serve as a surrogate marker for MS disease activity.
  Neurology(R) neuroimmunology & neuroinflammation 2017 Sabatino JJ, Zamvil SS
• Acute liver injury in a Glatopa-treated patient with MS.
  Neurology(R) neuroimmunology & neuroinflammation 2017 Sabatino JJ, Mehta NJ, Kakar S, Zamvil SS, Cree BAC
• T cells targeting neuromyelitis optica autoantigen aquaporin-4 cause paralysis and visual system injury.
  Journal of nature and science 2017 Cruz-Herranz A, Sagan SA, Sobel RA, Green AJ, Zamvil SS
• B cell repertoire expansion occurs in meningeal ectopic lymphoid tissue.
  JCI insight 2016 Lehmann-Horn K, Wang SZ, Sagan SA, Zamvil SS, von Büdingen HC
• Tolerance checkpoint bypass permits emergence of pathogenic T cells to neuromyelitis optica autoantigen aquaporin-4.
  Proceedings of the National Academy of Sciences of the United States of America 2016 Sagan SA, Winger RC, Cruz-Herranz A, Nelson PA, Hagberg S, Miller CN, Spencer CM, Ho PP, Bennett JL, Levy M, Levin MH, Verkman AS, Steinman L, Green AJ, Anderson MS, Sobel RA, Zamvil SS
• Accelerated remyelination during inflammatory demyelination prevents axonal loss and improves functional recovery.
  eLife 2016 Mei F, Lehmann-Horn K, Shen YA, Rankin KA, Stebbins KJ, Lorrain DS, Pekarek K, A Sagan S, Xiao L, Teuscher C, von Büdingen HC, Wess J, Lawrence JJ, Green AJ, Fancy SP, Zamvil SS, Chan JR
• Associations between the gut microbiota and host immune markers in pediatric multiple sclerosis and controls.
  BMC neurology 2016 Tremlett H, Fadrosh DW, Faruqi AA, Hart J, Roalstad S, Graves J, Spencer CM, Lynch SV, Zamvil SS, Waubant E, US Network of Pediatric MS Centers
• Treatment of spontaneous EAE by laquinimod reduces Tfh, B cell aggregates, and disease progression.
  Neurology(R) neuroimmunology & neuroinflammation 2016 Varrin-Doyer M, Pekarek KL, Spencer CM, Bernard CC, Sobel RA, Cree BA, Schulze-Topphoff U, Zamvil SS
• Restoring immune tolerance in neuromyelitis optica: Part I.
  Neurology(R) neuroimmunology & neuroinflammation 2016 Steinman L, Bar-Or A, Behne JM, Benitez-Ribas D, Chin PS, Clare-Salzler M, Healey D, Kim JI, Kranz DM, Lutterotti A, Martin R, Schippling S, Villoslada P, Wei CH, Weiner HL, Zamvil SS, Yeaman MR, …
• Restoring immune tolerance in neuromyelitis optica: Part II.
  Neurology(R) neuroimmunology & neuroinflammation 2016 Bar-Or A, Steinman L, Behne JM, Benitez-Ribas D, Chin PS, Clare-Salzler M, Healey D, Kim JI, Kranz DM, Lutterotti A, Martin R, Schippling S, Villoslada P, Wei CH, Weiner HL, Zamvil SS, Smith TJ, …
• Long-term evolution of multiple sclerosis disability in the treatment era.
  Annals of neurology 2016 University of California, San Francisco MS-EPIC Team:, Cree BA, Gourraud PA, Oksenberg JR, Bevan C, Crabtree-Hartman E, Gelfand JM, Goodin DS, Graves J, Green AJ, Mowry E, Okuda DT, Pelletier D, von …
• Gut microbiome analysis in neuromyelitis optica reveals overabundance of Clostridium perfringens.
  Annals of neurology 2016 Cree BA, Spencer CM, Varrin-Doyer M, Baranzini SE, Zamvil SS
• Your nose knows how to target brain inflammation.
  Brain : a journal of neurology 2016 Winger RC, Zamvil SS
• Antibodies in multiple sclerosis oligoclonal bands target debris.
  Proceedings of the National Academy of Sciences of the United States of America 2016 Winger RC, Zamvil SS
• Beginning of the end of two-stage theory purporting that inflammation then degeneration explains pathogenesis of progressive multiple sclerosis.
  Current opinion in neurology 2016 Steinman L, Zamvil SS
• Dimethyl fumarate treatment induces adaptive and innate immune modulation independent of Nrf2.
  Proceedings of the National Academy of Sciences of the United States of America 2016 Schulze-Topphoff U, Varrin-Doyer M, Pekarek K, Spencer CM, Shetty A, Sagan SA, Cree BA, Sobel RA, Wipke BT, Steinman L, Scannevin RH, Zamvil SS
• CNS accumulation of regulatory B cells is VLA-4-dependent.
  Neurology(R) neuroimmunology & neuroinflammation 2016 Lehmann-Horn K, Sagan SA, Winger RC, Spencer CM, Bernard CC, Sobel RA, Zamvil SS
• Glatiramer acetate treatment negatively regulates type I interferon signaling.
  Neurology(R) neuroimmunology & neuroinflammation 2015 Molnarfi N, Prod'homme T, Schulze-Topphoff U, Spencer CM, Weber MS, Patarroyo JC, Lalive PH, Zamvil SS
• Vitamin D in clinically isolated syndrome: evidence for possible neuroprotection.
  European journal of neurology 2015 Mowry EM, Pelletier D, Gao Z, Howell MD, Zamvil SS, Waubant E
• Blood coagulation protein fibrinogen promotes autoimmunity and demyelination via chemokine release and antigen presentation.
  Nature communications 2015 Ryu JK, Petersen MA, Murray SG, Baeten KM, Meyer-Franke A, Chan JP, Vagena E, Bedard C, Machado MR, Rios Coronado PE, Prod'homme T, Charo IF, Lassmann H, Degen JL, Zamvil SS, Akassoglou K
• Unique invariant CD8(+) T cell population persists in MS.
  Neurology(R) neuroimmunology & neuroinflammation 2015 Sabatino JJ, Zamvil SS
• Update on biomarkers in neuromyelitis optica.
  Neurology(R) neuroimmunology & neuroinflammation 2015 Melamed E, Levy M, Waters PJ, Sato DK, Bennett JL, John GR, Hooper DC, Saiz A, Bar-Or A, Kim HJ, Pandit L, Leite MI, Asgari N, Kissani N, Hintzen R, Marignier R, Jarius S, Marcelletti J, Smith TJ, …
• Erratum: The ubiquitin-modifying enzyme A20 restricts ubiquitination of the kinase RIPK3 and protects cells from necroptosis.
  Nature immunology 2015 Onizawa M, Oshima S, Schulze-Topphoff U, Oses-Prieto JA, Lu T, Tavares R, Prodhomme T, Duong B, Whang MI, Advincula R, Agelidis A, Barrera J, Wu H, Burlingame A, Malynn BA, Zamvil SS, Ma A
• Use of Advanced Magnetic Resonance Imaging Techniques in Neuromyelitis Optica Spectrum Disorder.
  JAMA neurology 2015 Kremer S, Renard F, Achard S, Lana-Peixoto MA, Palace J, Asgari N, Klawiter EC, Tenembaum SN, Banwell B, Greenberg BM, Bennett JL, Levy M, Villoslada P, Saiz A, Fujihara K, Chan KH, Schippling S, Paul…
• B lymphocytes in neuromyelitis optica.
  Neurology(R) neuroimmunology & neuroinflammation 2015 Bennett JL, O'Connor KC, Bar-Or A, Zamvil SS, Hemmer B, Tedder TF, von Büdingen HC, Stuve O, Yeaman MR, Smith TJ, Stadelmann C
• The ubiquitin-modifying enzyme A20 restricts ubiquitination of the kinase RIPK3 and protects cells from necroptosis.
  Nature immunology 2015 Onizawa M, Oshima S, Schulze-Topphoff U, Oses-Prieto JA, Lu T, Tavares R, Prodhomme T, Duong B, Whang MI, Advincula R, Agelidis A, Barrera J, Wu H, Burlingame A, Malynn BA, Zamvil SS, Ma A
• B-cell very late antigen-4 deficiency reduces leukocyte recruitment and susceptibility to central nervous system autoimmunity.
  Annals of neurology 2015 Lehmann-Horn K, Sagan SA, Bernard CC, Sobel RA, Zamvil SS
• Update on the autoimmune pathology of multiple sclerosis: B-cells as disease-drivers and therapeutic targets.
  European neurology 2015 von Büdingen HC, Palanichamy A, Lehmann-Horn K, Michel BA, Zamvil SS
• Reduction of CD8(+) T lymphocytes in multiple sclerosis patients treated with dimethyl fumarate.
  Neurology(R) neuroimmunology & neuroinflammation 2015 Spencer CM, Crabtree-Hartman EC, Lehmann-Horn K, Cree BA, Zamvil SS
• Does MOG Ig-positive AQP4-seronegative opticospinal inflammatory disease justify a diagnosis of NMO spectrum disorder?
  Neurology(R) neuroimmunology & neuroinflammation 2015 Zamvil SS, Slavin AJ
• Precision medicine in chronic disease management: The multiple sclerosis BioScreen.
  Annals of neurology 2014 Gourraud PA, Henry RG, Cree BA, Crane JC, Lizee A, Olson MP, Santaniello AV, Datta E, Zhu AH, Bevan CJ, Gelfand JM, Graves JS, Goodin DS, Green AJ, von Büdingen HC, Waubant E, Zamvil SS, Crabtree-…
• Immunodominant T-cell epitopes of MOG reside in its transmembrane and cytoplasmic domains in EAE.
  Neurology(R) neuroimmunology & neuroinflammation 2014 Shetty A, Gupta SG, Varrin-Doyer M, Weber MS, Prod'homme T, Molnarfi N, Ji N, Nelson PA, Patarroyo JC, Schulze-Topphoff U, Fogal SE, Forsthuber T, Sobel RA, Bernard CC, Slavin AJ, Zamvil SS
• MOG transmembrane and cytoplasmic domains contain highly stimulatory T-cell epitopes in MS.
  Neurology(R) neuroimmunology & neuroinflammation 2014 Varrin-Doyer M, Shetty A, Spencer CM, Schulze-Topphoff U, Weber MS, Bernard CC, Forsthuber T, Cree BA, Slavin AJ, Zamvil SS
• Laquinimod, an up-and-coming immunomodulatory agent for treatment of multiple sclerosis.
  Experimental neurology 2014 Varrin-Doyer M, Zamvil SS, Schulze-Topphoff U
• Neither T-helper type 2 nor Foxp3+ regulatory T cells are necessary for therapeutic benefit of atorvastatin in treatment of central nervous system autoimmunity.
  Journal of neuroinflammation 2014 Weber MS, Prod'homme T, Youssef S, Dunn SE, Steinman L, Zamvil SS
• MHC class II-dependent B cell APC function is required for induction of CNS autoimmunity independent of myelin-specific antibodies.
  The Journal of experimental medicine 2013 Molnarfi N, Schulze-Topphoff U, Weber MS, Patarroyo JC, Prod'homme T, Varrin-Doyer M, Shetty A, Linington C, Slavin AJ, Hidalgo J, Jenne DE, Wekerle H, Sobel RA, Bernard CC, Shlomchik MJ, Zamvil SS
• Therapeutic decisions in multiple sclerosis: moving beyond efficacy.
  JAMA neurology 2013 Brück W, Gold R, Lund BT, Oreja-Guevara C, Prat A, Spencer CM, Steinman L, Tintoré M, Vollmer TL, Weber MS, Weiner LP, Ziemssen T, Zamvil SS
• Tob1 plays a critical role in the activation of encephalitogenic T cells in CNS autoimmunity.
  The Journal of experimental medicine 2013 Schulze-Topphoff U, Casazza S, Varrin-Doyer M, Pekarek K, Sobel RA, Hauser SL, Oksenberg JR, Zamvil SS, Baranzini SE
• Developmental maturation of innate immune cell function correlates with susceptibility to central nervous system autoimmunity.
  European journal of immunology 2013 Hertzenberg D, Lehmann-Horn K, Kinzel S, Husterer V, Cravens PD, Kieseier BC, Hemmer B, Brück W, Zamvil SS, Stüve O, Weber MS
• The neonatal CNS is not conducive for encephalitogenic Th1 T cells and B cells during experimental autoimmune encephalomyelitis.
  Journal of neuroinflammation 2013 Cravens PD, Kieseier BC, Hussain R, Herndon E, Arellano B, Ben LH, Timmons BC, Castro-Rojas C, Hartung HP, Hemmer B, Weber MS, Zamvil SS, Stüve O
• Aquaporin 4-specific T cells in neuromyelitis optica exhibit a Th17 bias and recognize Clostridium ABC transporter.
  Annals of neurology 2012 Varrin-Doyer M, Spencer CM, Schulze-Topphoff U, Nelson PA, Stroud RM, Cree BA, Zamvil SS
• Laquinimod, a once-daily oral drug in development for the treatment of relapsing-remitting multiple sclerosis.
  Expert review of clinical pharmacology 2012 Brück W, Zamvil SS
• K+ channel alterations in the progression of experimental autoimmune encephalomyelitis.
  Neurobiology of disease 2012 Jukkola PI, Lovett-Racke AE, Zamvil SS, Gu C
• Laquinimod, a quinoline-3-carboxamide, induces type II myeloid cells that modulate central nervous system autoimmunity.
  PloS one 2012 Schulze-Topphoff U, Shetty A, Varrin-Doyer M, Molnarfi N, Sagan SA, Sobel RA, Nelson PA, Zamvil SS
• Randomized controlled trial of atorvastatin in clinically isolated syndrome: the STAyCIS study.
  Neurology 2012 Waubant E, Pelletier D, Mass M, Cohen JA, Kita M, Cross A, Bar-Or A, Vollmer T, Racke M, Stüve O, Schwid S, Goodman A, Kachuck N, Preiningerova J, Weinstock-Guttman B, Calabresi PA, Miller A, …
• Re-engineering of pathogenic aquaporin 4-specific antibodies as molecular decoys to treat neuromyelitis optica.
  Annals of neurology 2012 Steinman L, Zamvil SS
• B cells in multiple sclerosis: connecting the dots.
  Current opinion in immunology 2011 von Büdingen HC, Bar-Or A, Zamvil SS
• Combining statins with interferon β in multiple sclerosis: think twice, it might not be all right.
  The Lancet. Neurology 2011 Zamvil SS, Steinman L
• Lymph node-derived donor encephalitogenic CD4+ T cells in C57BL/6 mice adoptive transfer experimental autoimmune encephalomyelitis highly express GM-CSF and T-bet.
  Journal of neuroinflammation 2011 Cravens PD, Hussain RZ, Zacharias TE, Ben LH, Herndon E, Vinnakota R, Lambracht-Washington D, Nessler S, Zamvil SS, Eagar TN, Stüve O
• Accelerated central nervous system autoimmunity in BAFF-receptor-deficient mice.
  Journal of the neurological sciences 2011 Kim SS, Richman DP, Zamvil SS, Agius MA
• Glatiramer acetate in the treatment of multiple sclerosis: emerging concepts regarding its mechanism of action.
  CNS drugs 2011 Lalive PH, Neuhaus O, Benkhoucha M, Burger D, Hohlfeld R, Zamvil SS, Weber MS
• Switching multiple sclerosis patients with breakthrough disease to second-line therapy.
  PloS one 2011 Castillo-Trivino T, Mowry EM, Gajofatto A, Chabas D, Crabtree-Hartman E, Cree BA, Goodin DS, Green AJ, Okuda DT, Pelletier D, Zamvil SS, Vittinghoff E, Waubant E
• Proinflammatory role of aquaporin-4 in autoimmune neuroinflammation.
  FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2011 Li L, Zhang H, Varrin-Doyer M, Zamvil SS, Verkman AS
• Repetitive pertussis toxin promotes development of regulatory T cells and prevents central nervous system autoimmune disease.
  PloS one 2010 Weber MS, Benkhoucha M, Lehmann-Horn K, Hertzenberg D, Sellner J, Santiago-Raber ML, Chofflon M, Hemmer B, Zamvil SS, Lalive PH
• Immunodominant T cell determinants of aquaporin-4, the autoantigen associated with neuromyelitis optica.
  PloS one 2010 Nelson PA, Khodadoust M, Prodhomme T, Spencer C, Patarroyo JC, Varrin-Doyer M, Ho JD, Stroud RM, Zamvil SS
• Delivery of myelin peptides through the first line of defense, skin, to counter autoimmunity in multiple sclerosis.
  Annals of neurology 2010 Steinman L, Zamvil SS
• B-cell activation influences T-cell polarization and outcome of anti-CD20 B-cell depletion in central nervous system autoimmunity.
  Annals of neurology 2010 Weber MS, Prod'homme T, Patarroyo JC, Molnarfi N, Karnezis T, Lehmann-Horn K, Danilenko DM, Eastham-Anderson J, Slavin AJ, Linington C, Bernard CC, Martin F, Zamvil SS
• Natalizumab and progressive multifocal leukoencephalopathy: what are the causal factors and can it be avoided?
  Archives of neurology 2010 Warnke C, Menge T, Hartung HP, Racke MK, Cravens PD, Bennett JL, Frohman EM, Greenberg BM, Zamvil SS, Gold R, Hemmer B, Kieseier BC, Stüve O
• TLR-mediated B cell activation results in ectopic CLIP expression that promotes B cell-dependent inflammation.
  Journal of leukocyte biology 2010 Newell MK, Tobin RP, Cabrera JH, Sorensen MB, Huckstep A, Villalobos-Menuey EM, Burnett M, McCrea E, Harvey CP, Buddiga A, Bar-Or A, Freedman MS, Nalbantoglu J, Arbour N, Zamvil SS, Antel JP
• Translational research in neurology and neuroscience 2010: multiple sclerosis.
  Archives of neurology 2010 Stüve O, Kieseier BC, Hemmer B, Hartung HP, Awad A, Frohman EM, Greenberg BM, Racke MK, Zamvil SS, Phillips JT, Gold R, Chan A, Zettl U, Milo R, Marder E, Khan O, Eagar TN
• FTY720 and central memory: out of sight, out of mind.
  Neurology 2010 Slavin AJ, Zamvil SS
• Depletion of B lymphocytes from cerebral perivascular spaces by rituximab.
  Archives of neurology 2009 Martin Mdel P, Cravens PD, Winger R, Kieseier BC, Cepok S, Eagar TN, Zamvil SS, Weber MS, Frohman EM, Kleinschmidt-Demasters BK, Montine TJ, Hemmer B, Marra CM, Stüve O
• Glatiramer acetate increases IL-1 receptor antagonist but decreases T cell-induced IL-1beta in human monocytes and multiple sclerosis.
  Proceedings of the National Academy of Sciences of the United States of America 2009 Burger D, Molnarfi N, Weber MS, Brandt KJ, Benkhoucha M, Gruaz L, Chofflon M, Zamvil SS, Lalive PH
• Genotype-Phenotype correlations in multiple sclerosis: HLA genes influence disease severity inferred by 1HMR spectroscopy and MRI measures.
  Brain : a journal of neurology 2008 Okuda DT, Srinivasan R, Oksenberg JR, Goodin DS, Baranzini SE, Beheshtian A, Waubant E, Zamvil SS, Leppert D, Qualley P, Lincoln R, Gomez R, Caillier S, George M, Wang J, Nelson SJ, Cree BA, Hauser SL…
• Decrease in the numbers of dendritic cells and CD4+ T cells in cerebral perivascular spaces due to natalizumab.
  Archives of neurology 2008 del Pilar Martin M, Cravens PD, Winger R, Frohman EM, Racke MK, Eagar TN, Zamvil SS, Weber MS, Hemmer B, Karandikar NJ, Kleinschmidt-DeMasters BK, Stüve O
• Glatiramer acetate treatment does not modify the clinical course of (NZB x BXSB)F1 lupus murine model.
  International immunology 2008 Borel P, Benkhoucha M, Weber MS, Zamvil SS, Santiago-Raber ML, Lalive PH
• Bench to bedside: tempering antigen-presenting cells in multiple sclerosis.
  Nature medicine 2008 Prod'homme T, Zamvil SS
• Disease-modifying agents for multiple sclerosis: recent advances and future prospects.
  Drugs 2008 Menge T, Weber MS, Hemmer B, Kieseier BC, von Büdingen HC, Warnke C, Zamvil SS, Boster A, Khan O, Hartung HP, Stüve O
• Pharmacological treatment of early multiple sclerosis.
  Drugs 2008 Stüve O, Bennett JL, Hemmer B, Wiendl H, Racke MK, Bar-Or A, Hu W, Zivadinov R, Weber MS, Zamvil SS, Pacheco MF, Menge T, Hartung HP, Kieseier BC, Frohman EM
• Statins and demyelination.
  Current topics in microbiology and immunology 2008 Weber MS, Zamvil SS
• The immunogenicity of disease-modifying therapies for multiple sclerosis: clinical implications for neurologists.
  The neurologist 2007 Fox EJ, Vartanian TK, Zamvil SS
• Mechanism of action of glatiramer acetate in treatment of multiple sclerosis.
  Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics 2007 Weber MS, Hohlfeld R, Zamvil SS
• Neuroimmunotherapeutics comes of age.
  Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics 2007 Ransohoff RM, Zamvil SS
• Statins--treatment option for central nervous system autoimmune disease?
  Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics 2007 Weber MS, Steinman L, Zamvil SS
• Spotlight on statins.
  International MS journal 2007 Weber MS, Stuve O, Neuhaus O, Hartung HP, Zamvil SS
• Type II monocytes modulate T cell-mediated central nervous system autoimmune disease.
  Nature medicine 2007 Weber MS, Prod'homme T, Youssef S, Dunn SE, Rundle CD, Lee L, Patarroyo JC, Stüve O, Sobel RA, Steinman L, Zamvil SS
• Combination therapies for multiple sclerosis: scientific rationale, clinical trials, and clinical practice.
  Current opinion in neurology 2007 Costello F, Stüve O, Weber MS, Zamvil SS, Frohman E
• T effectors outfox T regulators in autoimmunity.
  Nature medicine 2007 Prod'homme T, Weber MS, Zamvil SS
• Inhibition of naive Th1 CD4+ T cells by glatiramer acetate in multiple sclerosis.
  Journal of neuroimmunology 2007 Kantengwa S, Weber MS, Juillard C, Benkhoucha M, Fellay B, Zamvil SS, Gougeon ML, Chofflon M, Lalive PH
• Simvastatin regulates oligodendroglial process dynamics and survival.
  Glia 2007 Miron VE, Rajasekharan S, Jarjour AA, Zamvil SS, Kennedy TE, Antel JP
• Statins in the treatment of central nervous system autoimmune disease.
  Journal of neuroimmunology 2006 Weber MS, Youssef S, Dunn SE, Prod'homme T, Neuhaus O, Stuve O, Greenwood J, Steinman L, Zamvil SS
• How to successfully apply animal studies in experimental allergic encephalomyelitis to research on multiple sclerosis.
  Annals of neurology 2006 Steinman L, Zamvil SS
• Statin therapy and autoimmune disease: from protein prenylation to immunomodulation.
  Nature reviews. Immunology 2006 Greenwood J, Steinman L, Zamvil SS
• Immunomodulatory synergy by combination of atorvastatin and glatiramer acetate in treatment of CNS autoimmunity.
  The Journal of clinical investigation 2006 Stüve O, Youssef S, Weber MS, Nessler S, von Büdingen HC, Hemmer B, Prod'homme T, Sobel RA, Steinman L, Zamvil SS
• A neuropeptide in immune-mediated inflammation, Y?
  Trends in immunology 2006 Prod'homme T, Weber MS, Steinman L, Zamvil SS
• Isoprenoids determine Th1/Th2 fate in pathogenic T cells, providing a mechanism of modulation of autoimmunity by atorvastatin.
  The Journal of experimental medicine 2006 Dunn SE, Youssef S, Goldstein MJ, Prod'homme T, Weber MS, Zamvil SS, Steinman L
• Drug Insight: using statins to treat neuroinflammatory disease.
  Nature clinical practice. Neurology 2005 Weber MS, Prod'homme T, Steinman L, Zamvil SS
• Therapeutic considerations for disease progression in multiple sclerosis: evidence, experience, and future expectations.
  Archives of neurology 2005 Frohman EM, Stüve O, Havrdova E, Corboy J, Achiron A, Zivadinov R, Sorensen PS, Phillips JT, Weinshenker B, Hawker K, Hartung HP, Steinman L, Zamvil S, Cree BA, Hauser S, Weiner H, Racke MK, Filippi M
• Virtues and pitfalls of EAE for the development of therapies for multiple sclerosis.
  Trends in immunology 2005 Steinman L, Zamvil SS
• [Statins for treatment of CNS diseases. Status report from research and clinical practice].
  Der Nervenarzt 2005 Menge T, von Büdingen HC, Zamvil SS, Hartung HP, Kieseier BC, Stüve O
• Evaluation of HMG-CoA reductase inhibitors for multiple sclerosis: opportunities and obstacles.
  CNS drugs 2005 Neuhaus O, Stüve O, Zamvil SS, Hartung HP
• Neutralizing antibodies to disease-modifying agents in the treatment of multiple sclerosis.
  Neurology 2004 Vartanian TK, Zamvil SS, Fox E, Sorensen PS
• Are statins a treatment option for multiple sclerosis?
  The Lancet. Neurology 2004 Neuhaus O, Stüve O, Zamvil SS, Hartung HP
• Mitoxantrone as a potential therapy for primary progressive multiple sclerosis.
  Multiple sclerosis (Houndmills, Basingstoke, England) 2004 Stüve O, Kita M, Pelletier D, Fox RJ, Stone J, Goodkin DE, Zamvil SS
• Statins as potential therapeutic agents in multiple sclerosis.
  Current neurology and neuroscience reports 2004 Stüve O, Prod'homme T, Youssef S, Dunn S, Neuhaus O, Weber M, Hartung HP, Steinman L, Zamvil SS
• The potential therapeutic role of statins in central nervous system autoimmune disorders.
  Cellular and molecular life sciences : CMLS 2003 Stüve O, Youssef S, Dunn S, Slavin AJ, Steinman L, Zamvil SS
• Statins and their potential targets in multiple sclerosis therapy.
  Expert opinion on therapeutic targets 2003 Stüve O, Prod'homme T, Slavin A, Youssef S, Dunn S, Steinman L, Zamvil SS
• Efficient technique for immortalization of murine microglial cells relevant for studies in murine models of multiple sclerosis.
  Journal of neuroscience methods 2003 Olson JK, Zamvil SS, Miller SD
• MRI lesion volume heterogeneity in primary progressive MS in relation with axonal damage and brain atrophy.
  Journal of neurology, neurosurgery, and psychiatry 2003 Pelletier D, Nelson SJ, Oh J, Antel JP, Kita M, Zamvil SS, Goodkin DE
• Diverse targets for intervention during inflammatory and neurodegenerative phases of multiple sclerosis.
  Neuron 2003 Zamvil SS, Steinman L
• Statins as potential therapeutic agents in neuroinflammatory disorders.
  Current opinion in neurology 2003 Stüve O, Youssef S, Steinman L, Zamvil SS
• Transcriptional analysis of targets in multiple sclerosis.
  Nature reviews. Immunology 2003 Steinman L, Zamvil S
• The role of the MHC class II transactivator in class II expression and antigen presentation by astrocytes and in susceptibility to central nervous system autoimmune disease.
  Journal of immunology (Baltimore, Md. : 1950) 2002 Stüve O, Youssef S, Slavin AJ, King CL, Patarroyo JC, Hirschberg DL, Brickey WJ, Soos JM, Piskurich JF, Chapman HA, Zamvil SS
• Approved and future pharmacotherapy for multiple sclerosis.
  The neurologist 2002 Stüve O, Cree BC, von Büdingen HC, Yousef S, Bowen JD, Genain CP, Hauser SL, Steinman L, Zamvil SS
• Single nucleotide polymorphisms in MHC2TA, the gene encoding the MHC class II transactivator (CIITA).
  Genes and immunity 2002 Patarroyo JC, Stuve O, Piskurich JF, Hauser SL, Oksenberg JR, Zamvil SS
• Malignant glioma cells use MHC class II transactivator (CIITA) promoters III and IV to direct IFN-gamma-inducible CIITA expression and can function as nonprofessional antigen presenting cells in endocytic processing and CD4(+) T-cell activation.
  Glia 2001 Soos JM, Krieger JI, Stüve O, King CL, Patarroyo JC, Aldape K, Wosik K, Slavin AJ, Nelson PA, Antel JP, Zamvil SS
• Requirement for endocytic antigen processing and influence of invariant chain and H-2M deficiencies in CNS autoimmunity.
  The Journal of clinical investigation 2001 Slavin AJ, Soos JM, Stuve O, Patarroyo JC, Weiner HL, Fontana A, Bikoff EK, Zamvil SS
• Specific immunotherapy: one size does not fit all.
  Nature medicine 2000 Genain CP, Zamvil SS
• Pathogenesis, diagnosis, and treatment of acute disseminated encephalomyelitis.
  Current opinion in neurology 1999 Stüve O, Zamvil SS
• Differential expression of B7 co-stimulatory molecules by astrocytes correlates with T cell activation and cytokine production.
  International immunology 1999 Soos JM, Ashley TA, Morrow J, Patarroyo JC, Szente BE, Zamvil SS
• Highlights from the Fifth International Congress of the International Society of Neuroimmunology.
  Journal of neuroimmunology 1999 Freedman MS, Ransohoff R, Talbot PJ, Zamvil SS
• Astrocytes express elements of the class II endocytic pathway and process central nervous system autoantigen for presentation to encephalitogenic T cells.
  Journal of immunology (Baltimore, Md. : 1950) 1998 Soos JM, Morrow J, Ashley TA, Szente BE, Bikoff EK, Zamvil SS
• Pathogenesis and treatment of central nervous system demyelinating disease.
  Revue neurologique 1998 Zamvil SS, Soos JM, Weiner HL
• Prior exposure to superantigen can inhibit or exacerbate autoimmune encephalomyelitis: T-cell repertoire engaged by the autoantigen determines clinical outcome.
  Journal of neuroimmunology 1996 Das MR, Cohen A, Zamvil SS, Offner H, Kuchroo VK
• Effect of oral beta interferon on subsequent immune responsiveness.
  Annals of the New York Academy of Sciences 1996 Nelson PA, Akselband Y, Dearborn SM, Al-Sabbagh A, Tian ZJ, Gonnella PA, Zamvil SS, Chen Y, Weiner HL
• B7-1 and B7-2 costimulatory molecules activate differentially the Th1/Th2 developmental pathways: application to autoimmune disease therapy.
  Cell 1995 Kuchroo VK, Das MP, Brown JA, Ranger AM, Zamvil SS, Sobel RA, Weiner HL, Nabavi N, Glimcher LH
• Reciprocal expression of co-stimulatory molecules, B7-1 and B7-2, on murine T cells following activation.
  European journal of immunology 1995 Prabhu Das MR, Zamvil SS, Borriello F, Weiner HL, Sharpe AH, Kuchroo VK
• T cell receptor (TCR) usage determines disease susceptibility in experimental autoimmune encephalomyelitis: studies with TCR V beta 8.2 transgenic mice.
  The Journal of experimental medicine 1994 Kuchroo VK, Collins M, al-Sabbagh A, Sobel RA, Whitters MJ, Zamvil SS, Dorf ME, Hafler DA, Seidman JG, Weiner HL
• 'Lupus-prone' mice are susceptible to organ-specific autoimmune disease, experimental allergic encephalomyelitis.
  Pathobiology : journal of immunopathology, molecular and cellular biology 1994 Zamvil SS, al-Sabbagh A, Nelson PA, Kaul D, Charles MS, Mitchell DJ, Steinman L, Weiner HL, Kuchroo VK
• Localization of an encephalitogenic epitope for the SJL mouse in the N-terminal region of myelin basic protein.
  Journal of neuroimmunology 1990 Fritz RB, Skeen MJ, Chou CH, Zamvil SS
• Lymphotoxin and tumor necrosis factor-alpha production by myelin basic protein-specific T cell clones correlates with encephalitogenicity.
  International immunology 1990 Powell MB, Mitchell D, Lederman J, Buckmeier J, Zamvil SS, Graham M, Ruddle NH, Steinman L
• The T lymphocyte in experimental allergic encephalomyelitis.
  Annual review of immunology 1990 Zamvil SS, Steinman L
• Prevention of experimental encephalomyelitis with peptides that block interaction of T cells with major histocompatibility complex proteins.
  Proceedings of the National Academy of Sciences of the United States of America 1989 Sakai K, Zamvil SS, Mitchell DJ, Hodgkinson S, Rothbard JB, Steinman L
• Polymorphic residues on the I-A beta chain modulate the stimulation of T cell clones specific for the N-terminal peptide of the autoantigen myelin basic protein.
  Journal of immunology (Baltimore, Md. : 1950) 1989 Davis CB, Mitchell DJ, Wraith DC, Todd JA, Zamvil SS, McDevitt HO, Steinman L, Jones PP
• Autoimmune demyelinating disease.
  The Western journal of medicine 1989 Zamvil SS, Steinman L
• Involvement of distinct murine T-cell receptors in the autoimmune encephalitogenic response to nested epitopes of myelin basic protein.
  Proceedings of the National Academy of Sciences of the United States of America 1988 Sakai K, Sinha AA, Mitchell DJ, Zamvil SS, Rothbard JB, McDevitt HO, Steinman L
• Multiple discrete encephalitogenic epitopes of the autoantigen myelin basic protein include a determinant for I-E class II-restricted T cells.
  The Journal of experimental medicine 1988 Zamvil SS, Mitchell DJ, Powell MB, Sakai K, Rothbard JB, Steinman L
• Characterization of a major encephalitogenic T cell epitope in SJL/J mice with synthetic oligopeptides of myelin basic protein.
  Journal of neuroimmunology 1988 Sakai K, Zamvil SS, Mitchell DJ, Lim M, Rothbard JB, Steinman L
• Limited heterogeneity of T cell receptors from lymphocytes mediating autoimmune encephalomyelitis allows specific immune intervention.
  Cell 1988 Acha-Orbea H, Mitchell DJ, Timmermann L, Wraith DC, Tausch GS, Waldor MK, Zamvil SS, McDevitt HO, Steinman L
• Predominant expression of a T cell receptor V beta gene subfamily in autoimmune encephalomyelitis.
  The Journal of experimental medicine 1988 Zamvil SS, Mitchell DJ, Lee NE, Moore AC, Waldor MK, Sakai K, Rothbard JB, McDevitt HO, Steinman L, Acha-Orbea H
• Comparison of antigen specificity, class II major histocompatibility complex restriction, and in vivo behavior of myelin basic protein-specific T cell lines and clones derived from (BALB/c x SJL/J) mice.
  Journal of immunology (Baltimore, Md. : 1950) 1987 Trotter J, Zamvil SS, Steinman L
• T cell specificity for class II (I-A) and the encephalitogenic N-terminal epitope of the autoantigen myelin basic protein.
  Journal of immunology (Baltimore, Md. : 1950) 1987 Zamvil SS, Mitchell DJ, Moore AC, Schwarz AJ, Stiefel W, Nelson PA, Rothbard JB, Steinman L
• T-cell epitope of the autoantigen myelin basic protein that induces encephalomyelitis.
  Nature 1986 Zamvil SS, Mitchell DJ, Moore AC, Kitamura K, Steinman L, Rothbard JB
• Therapy of autoimmune diseases with antibody to immune response gene products or to T-cell surface markers.
  Annals of the New York Academy of Sciences 1986 Steinman L, Waldor MK, Zamvil SS, Lim M, Herzenberg L, Herzenberg L, McDevitt HO, Mitchell D, Sriram S
• Encephalitogenic T cell clones specific for myelin basic protein. An unusual bias in antigen recognition.
  The Journal of experimental medicine 1985 Zamvil SS, Nelson PA, Mitchell DJ, Knobler RL, Fritz RB, Steinman L
• T-cell clones specific for myelin basic protein induce chronic relapsing paralysis and demyelination.
  Nature 1985 Zamvil S, Nelson P, Trotter J, Mitchell D, Knobler R, Fritz R, Steinman L
• Prevention of experimental allergic encephalitis with in vivo administration of anti I-A antibody. Decreased accumulation of radiolabelled lymph node cells in the central nervous system.
  Journal of neuroimmunology 1983 Steinman L, Solomon D, Lim M, Zamvil S, Sriram S
• Murine model for pertussis vaccine encephalopathy: linkage to H-2.
  Nature 1982 Steinman L, Sriram S, Adelman NE, Zamvil S, McDevitt HO, Urich H
• In vitro cellular respiration at elevated temperatures in developing rat cerebral cortex.
  Brain research 1982 Holtzman D, Nguyen H, Zamvil S, Olson J
• Maturation of potassium-stimulated respiration in rat cerebral cortical slices.
  Journal of neurochemistry 1982 Holtzman D, Olson J, Zamvil S, Nguyen H
• Response to the RIF-1 tumor in vitro and in C3H/Km mice to X-radiation (cell survival, regrowth delay, and tumor control), chemotherapeutic agents, and activated macrophages.
  Journal of the National Cancer Institute 1980 Brown JM, Twentyman PR, Zamvil SS