Scott Tanghe, DO
CLINICAL FELLOW
Radiology
School of Medicine

Publications (9)

Top publication keywords:
Trypanosomiasis, AfricanAntimalarialsTrypanosoma cruziPlasmodium bergheiAscomycotaTrypanosomaAntiprotozoal AgentsTrypanocidal AgentsQuinazolinesGlucokinaseMacrolides14-alpha Demethylase InhibitorsLeishmaniaTrypanosoma brucei bruceiGlucosamine

• Preclinical evaluation of strasseriolides A-D, potent antiplasmodial macrolides isolated from Strasseria geniculata CF-247,251.
  Malaria journal 2021 Annang F, Pérez-Moreno G, Díaz C, González-Menéndez V, de Pedro Montejo N, Del Palacio JP, Sánchez P, Tanghe S, Rodriguez A, Pérez-Victoria I, Cantizani J, Ruiz-Pérez LM, Genilloud O, Reyes F, Vicente…
• Targeting the Hexosamine Biosynthetic Pathway Prevents Plasmodium Developmental Cycle and Disease Pathology in Vertebrate Host.
  Frontiers in microbiology 2019 Gomes PS, Tanghe S, Gallego-Delgado J, Conde L, Freire-de-Lima L, Lima AC, Freire-de-Lima CG, Lima Junior JDC, Moreira O, Totino P, Rodriguez A, Todeschini AR, Morrot A
• Improvement of Aqueous Solubility of Lapatinib-Derived Analogues: Identification of a Quinolinimine Lead for Human African Trypanosomiasis Drug Development.
  Journal of medicinal chemistry 2019 Bachovchin KA, Sharma A, Bag S, Klug DM, Schneider KM, Singh B, Jalani HB, Buskes MJ, Mehta N, Tanghe S, Momper JD, Sciotti RJ, Rodriguez A, Mensa-Wilmot K, Pollastri MP, Ferrins L
• Anilinoquinoline based inhibitors of trypanosomatid proliferation.
  PLoS neglected tropical diseases 2018 Ferrins L, Sharma A, Thomas SM, Mehta N, Erath J, Tanghe S, Leed SE, Rodriguez A, Mensa-Wilmot K, Sciotti RJ, Gillingwater K, Pollastri MP
• Corrigendum to "Optimization of physicochemical properties for 4-Anilinoquinazoline inhibitors of trypanosome proliferation" [Eur. J. Med. Chem. 141 (2017) 446-459].
  European journal of medicinal chemistry 2018 Woodring JL, Bachovchin KA, Brady KG, Gallerstein MF, Erath J, Tanghe S, Leed SE, Rodriguez A, Mensa-Wilmot K, Sciotti RJ, Pollastri MP

Show all (4 more) Hide

• Optimization of physicochemical properties for 4-anilinoquinazoline inhibitors of trypanosome proliferation.
  European journal of medicinal chemistry 2017 Woodring JL, Bachovchin KA, Brady KG, Gallerstein MF, Erath J, Tanghe S, Leed SE, Rodriguez A, Mensa-Wilmot K, Sciotti RJ, Pollastri MP
• Hit-to-Lead Optimization of a Novel Class of Potent, Broad-Spectrum Trypanosomacides.
  Journal of medicinal chemistry 2016 Russell S, Rahmani R, Jones AJ, Newson HL, Neilde K, Cotillo I, Rahmani Khajouei M, Ferrins L, Qureishi S, Nguyen N, Martinez-Martinez MS, Weaver DF, Kaiser M, Riley J, Thomas J, De Rycker M, Read KD,…
• Structure-based approach to the identification of a novel group of selective glucosamine analogue inhibitors of Trypanosoma cruzi glucokinase.
  Molecular and biochemical parasitology 2016 D'Antonio EL, Deinema MS, Kearns SP, Frey TA, Tanghe S, Perry K, Roy TA, Gracz HS, Rodriguez A, D'Antonio J
• Small-molecule xenomycins inhibit all stages of the Plasmodium life cycle.
  Antimicrobial agents and chemotherapy 2014 Erath J, Gallego-Delgado J, Xu W, Andriani G, Tanghe S, Gurova KV, Gudkov A, Purmal A, Rydkina E, Rodriguez A