Scott Soifer, MD
Professor
Pediatrics
School of Medicine

Education & Training

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• Residency School of Medicine University of California, San Francisco

Websites

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• Clinical Profile at UCSF Benioff Children's Hospital (ucsfbenioffchildrens.org)

Grants and Projects

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• Abnormal Fetal Lung Circulation--Vasoactive Mediators, NIH, 1986-2000
• Pulmonary Hypertension and Lung Disease in the Newborn, NIH, 1983-1985

Publications (61)

Top publication keywords:
Pulmonary CirculationPersistent Fetal Circulation SyndromeNitric OxideAnimals, NewbornVascular ResistanceProstaglandin Endoperoxides, SyntheticSRS-A15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic AcidArginineEndothelium, VascularNitric Oxide SynthaseVasodilationSheepHypertension, PulmonaryEndothelins

• Harnessing Viscous Flow to Simplify the Actuation of Fluidic Soft Robots.
  Soft robotics 2019 Vasios N, Gross AJ, Soifer S, Overvelde JTB, Bertoldi K
• Effect of enalaprilat on postoperative hypertension after surgical repair of coarctation of the aorta.
  Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies 2003 Rouine-Rapp K, Mello DM, Hanley FL, Mohan Reddy V, Soifer S
• Expression of VEGF and its receptors Flt-1 and Flk-1/KDR is altered in lambs with increased pulmonary blood flow and pulmonary hypertension.
  American journal of physiology. Lung cellular and molecular physiology 2003 Mata-Greenwood E, Meyrick B, Soifer SJ, Fineman JR, Black SM
• Cyclic mechanical stretch induces VEGF and FGF-2 expression in pulmonary vascular smooth muscle cells.
  American journal of physiology. Lung cellular and molecular physiology 2002 Quinn TP, Schlueter M, Soifer SJ, Gutierrez JA
• A receptor for vascular endothelial growth factor that stimulates endothelial apoptosis.
  Cancer research 2001 Quinn TP, Soifer SJ, Ramer K, Williams LT, Nakamura MC

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• Altered regulation of the ET-1 cascade in lambs with increased pulmonary blood flow and pulmonary hypertension.
  Pediatric research 2000 Black SM, Bekker JM, Johengen MJ, Parry AJ, Soifer SJ, Fineman JR
• Altered endothelial function in lambs with pulmonary hypertension and acute lung injury.
  Pediatric pulmonology 1999 Fineman JR, Wong J, Mikhailov T, Vanderford PA, Jerome HE, Soifer SJ
• Coordinated regulation of genes of the nitric oxide and endothelin pathways during the development of pulmonary hypertension in fetal lambs.
  Pediatric research 1998 Black SM, Johengen MJ, Soifer SJ
• Increased endothelial NOS in lambs with increased pulmonary blood flow and pulmonary hypertension.
  The American journal of physiology 1998 Black SM, Fineman JR, Steinhorn RH, Bristow J, Soifer SJ
• Increased pulmonary blood flow alters the molecular regulation of vascular reactivity in the lamb.
  Chest 1998 Black S, Fineman J, Johengen M, Bristow J, Soifer S
• Ventilation and oxygenation induce endothelial nitric oxide synthase gene expression in the lungs of fetal lambs.
  The Journal of clinical investigation 1997 Black SM, Johengen MJ, Ma ZD, Bristow J, Soifer SJ
• Nonsustained ventricular tachycardia in severe heart failure. Independent marker of increased mortality due to sudden death. GESICA-GEMA Investigators.
  Circulation 1996 Doval HC, Nul DR, Grancelli HO, Varini SD, Soifer S, Corrado G, Dubner S, Scapin O, Perrone SV
• Expression of neuronal nitric oxide synthase corresponds to regions of selective vulnerability to hypoxia-ischaemia in the developing rat brain.
  Neurobiology of disease 1995 Black SM, Bedolli MA, Martinez S, Bristow JD, Ferriero DM, Soifer SJ
• Endothelinb receptor agonists produce pulmonary vasodilation in intact newborn lambs with pulmonary hypertension.
  Journal of cardiovascular pharmacology 1995 Wong J, Vanderford PA, Winters J, Soifer SJ, Fineman JR
• Regulation of pulmonary vascular tone in the perinatal period.
  Annual review of physiology 1995 Fineman JR, Soifer SJ, Heymann MA
• Developmental effects of endothelin-1 on the pulmonary circulation in sheep.
  Pediatric research 1994 Wong J, Vanderford PA, Fineman JR, Soifer SJ
• Use of ATP-MgCl2 in the evaluation and treatment of children with pulmonary hypertension secondary to congenital heart defects.
  Circulation 1994 Brook MM, Fineman JR, Bolinger AM, Wong AF, Heymann MA, Soifer SJ
• Chronic nitric oxide inhibition in utero produces persistent pulmonary hypertension in newborn lambs.
  The Journal of clinical investigation 1994 Fineman JR, Wong J, Morin FC, Wild LM, Soifer SJ
• HA1004, an intracellular calcium antagonist, selectively attenuates pulmonary hypertension in newborn lambs.
  Journal of cardiovascular pharmacology 1994 Crowley MR, Fineman JR, Soifer SJ
• Diethylamine/nitric oxide (NO) adduct, an NO donor, produces potent pulmonary and systemic vasodilation in intact newborn lambs.
  Journal of cardiovascular pharmacology 1994 Vanderford PA, Wong J, Chang R, Keefer LK, Soifer SJ, Fineman JR
• Disparate temporal expression of the prothrombin and thrombin receptor genes during mouse development.
  The American journal of pathology 1994 Soifer SJ, Peters KG, O'Keefe J, Coughlin SR
• Endothelin-1 produces pulmonary vasodilation in the intact newborn lamb.
  The American journal of physiology 1993 Wong J, Vanderford PA, Fineman JR, Chang R, Soifer SJ
• Pulmonary hypertension: physiologic or pathologic disease?
  Critical care medicine 1993 Soifer SJ
• Hyperoxia and alkalosis produce pulmonary vasodilation independent of endothelium-derived nitric oxide in newborn lambs.
  Pediatric research 1993 Fineman JR, Wong J, Soifer SJ
• Endothelin-1 does not mediate acute hypoxic pulmonary vasoconstriction in the intact newborn lamb.
  Journal of cardiovascular pharmacology 1993 Wong J, Vanderford PA, Winters JW, Chang R, Soifer SJ, Fineman JR
• M&B 22948, a cGMP phosphodiesterase inhibitor, is a pulmonary vasodilator in lambs.
  The American journal of physiology 1993 Braner DA, Fineman JR, Chang R, Soifer SJ
• EDRF inhibition attenuates the increase in pulmonary blood flow due to oxygen ventilation in fetal lambs.
  Journal of applied physiology (Bethesda, Md. : 1985) 1992 Moore P, Velvis H, Fineman JR, Soifer SJ, Heymann MA
• Thrombin receptor expression in normal and atherosclerotic human arteries.
  The Journal of clinical investigation 1992 Nelken NA, Soifer SJ, O'Keefe J, Vu TK, Charo IF, Coughlin SR
• K+ channel pulmonary vasodilation in fetal lambs: role of endothelium-derived nitric oxide.
  Journal of applied physiology (Bethesda, Md. : 1985) 1992 Chang JK, Moore P, Fineman JR, Soifer SJ, Heymann MA
• EDRF inhibition augments pulmonary hypertension in intact newborn lambs.
  The American journal of physiology 1992 Fineman JR, Chang R, Soifer SJ
• L-Arginine, a precursor of EDRF in vitro, produces pulmonary vasodilation in lambs.
  The American journal of physiology 1991 Fineman JR, Chang R, Soifer SJ
• Hemodynamic effects of oleic acid in newborn lambs: role of arachidonic acid metabolites.
  Journal of developmental physiology 1991 Schreiber MD, Soifer SJ
• In vivo attenuation of endothelium-dependent pulmonary vasodilation by methylene blue.
  Journal of applied physiology (Bethesda, Md. : 1985) 1991 Fineman JR, Crowley MR, Heymann MA, Soifer SJ
• N omega-nitro-L-arginine attenuates endothelium-dependent pulmonary vasodilation in lambs.
  The American journal of physiology 1991 Fineman JR, Heymann MA, Soifer SJ
• Effects of vasoactive drugs on thromboxane A2 mimetic-induced pulmonary hypertension in newborn lambs.
  Pediatric research 1991 Crowley MR, Fineman JR, Soifer SJ
• The role of pulmonary vascular endothelium in perinatal pulmonary circulatory regulation.
  Seminars in perinatology 1991 Fineman JR, Soifer SJ, Heymann MA
• Selective pulmonary vasodilation with ATP-MgCl2 during pulmonary hypertension in lambs.
  Journal of applied physiology (Bethesda, Md. : 1985) 1990 Fineman JR, Crowley MR, Soifer SJ
• Leukotrienes C4, D4, and E4 in fetal lamb tracheal fluid.
  Journal of developmental physiology 1990 Velvis H, Krusell J, Roman C, Soifer SJ, Riemer RK, Heymann MA
• Plasma epinephrine concentrations after intraosseous and central venous injection during cardiopulmonary resuscitation in the lamb.
  The Journal of pediatrics 1990 Andropoulos DB, Soifer SJ, Schreiber MD
• Bradykinin produces pulmonary vasodilation in fetal lambs: role of prostaglandin production.
  Journal of applied physiology (Bethesda, Md. : 1985) 1989 Frantz E, Soifer SJ, Clyman RI, Heymann MA
• Leukotriene antagonists attenuate thromboxane-inducible pulmonary hypertension.
  Pediatric research 1989 Soifer SJ, Schreiber MD, Heymann MA
• Cromolyn sodium does not prevent hypoxia-induced pulmonary hypertension in newborn and young lambs.
  Journal of developmental physiology 1988 Frantz EG, Schreiber MD, Soifer SJ
• Respiratory alkalosis attenuates thromboxane-induced pulmonary hypertension.
  Critical care medicine 1988 Schreiber MD, Soifer SJ
• Tricuspid regurgitation in children: a pulsed Doppler, contrast echocardiographic and angiographic comparison.
  Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography 1988 Martin GR, Silverman NH, Soifer SJ, Lutin WA, Scagnelli SA
• Effects of prostaglandin D2 on pulmonary arterial pressure and oxygenation in newborn infants with persistent pulmonary hypertension.
  The Journal of pediatrics 1988 Soifer SJ, Clyman RI, Heymann MA
• Leukotriene synthesis inhibition increases pulmonary blood flow in fetal lambs.
  Chest 1988 Heymann MA, LeBidois J, Soifer SJ, Clyman RI
• Piriprost: a putative leukotriene synthesis inhibitor increases pulmonary blood flow in fetal lambs.
  Pediatric research 1987 Lebidois J, Soifer SJ, Clyman RI, Heymann MA
• Effects of activity on ascending aortic velocity in children with valvar aortic stenosis.
  The American journal of cardiology 1987 Martin GR, Soifer SJ, Silverman NH, Dae MW, Stanger P
• Umbilical cord compression produces pulmonary hypertension in newborn lambs: a model to study the pathophysiology of persistent pulmonary hypertension in the newborn.
  Journal of developmental physiology 1987 Soifer SJ, Kaslow D, Roman C, Heymann MA
• The differential effects of leukotriene C4 and D4 on the pulmonary and systemic circulations in newborn lambs.
  Pediatric research 1987 Schreiber MD, Heymann MA, Soifer SJ
• Infant coarctation: a spectrum in clinical presentation and treatment.
  The Annals of thoracic surgery 1986 Yee ES, Soifer SJ, Turley K, Verrier ED, Fishman NH, Ebert PA
• Increased arterial pH, not decreased PaCO2, attenuates hypoxia-induced pulmonary vasoconstriction in newborn lambs.
  Pediatric research 1986 Schreiber MD, Heymann MA, Soifer SJ
• Contrast echocardiography in the diagnosis of anomalous left coronary artery arising from the pulmonary artery.
  Pediatric cardiology 1986 Martin GR, Cooper MJ, Silverman NH, Soifer SJ
• Thromboxane is not responsible for the high pulmonary vascular resistance in fetal lambs.
  Pediatric research 1985 Clozel M, Clyman RI, Soifer SJ, Heymann MA
• Leukotriene end organ antagonists increase pulmonary blood flow in fetal lambs.
  The American journal of physiology 1985 Soifer SJ, Loitz RD, Roman C, Heymann MA
• Leukotriene inhibition prevents and reverses hypoxic pulmonary vasoconstriction in newborn lambs.
  Pediatric research 1985 Schreiber MD, Heymann MA, Soifer SJ
• Future research directions in persistent pulmonary hypertension of the newborn.
  Clinics in perinatology 1984 Soifer SJ, Heymann MA
• Synthetic patch aortoplasty. A simplified approach for coarctation in repairs during early infancy and thereafter.
  American journal of surgery 1984 Yee ES, Turley K, Soifer S, Ebert PA
• The developmental effects of prostaglandin D2 on the pulmonary and systemic circulations in the newborn lamb.
  Journal of developmental physiology 1983 Soifer SJ, Morin FC, Kaslow DC, Heymann MA
• Prostaglandin D2 reverses induced pulmonary hypertension in the newborn lamb.
  The Journal of pediatrics 1982 Soifer SJ, Morin FC, Heymann MA
• Detection of intracranial arteriovenous fistula by two-dimensional ultrasonography.
  Circulation 1981 Snider AR, Soifer SJ, Silverman NH