Scott Kogan, MD
Professor
Laboratory Medicine
School of Medicine
Education & Training
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- Diversity, Equity, and Inclusion Champion Training University of California 10/2020
- Residency School of Medicine University of California 1994
- M.D. School of Medicine University of California 1991
Websites
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- Clinical Profile at UCSF Benioff Children's Hospital (ucsfbenioffchildrens.org)
- Clinical Profile at UCSF Medical Center (ucsfhealth.org)
- Profile at UCSF Cancer Center (cancer.ucsf.edu)
Grants and Projects
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- Impact of low IL-10 levels at birth and leukemia risk, NIH, 2014-2020
- Center for Integrative Research on Childhood Leukemia and the Environment, NIH, 2009-2019
- Impact of B-Cell Lineage on Progression of B-Acute Lymphoblastic Leukemia, NIH, 2013-2016
- Molecular Mechanisms of Leukemogenesis by PMLRAR alpha, NIH, 2002-2014
- Pathogenesis and Therapy of Acute Promyelocytic Leukemia, NIH, 1999-2004
Publications (180)
Top publication keywords:
Glucosephosphate Dehydrogenase DeficiencyLymphomaTretinoinLeukemia, Myeloid, AcuteLeukemiaLeukemia, B-CellMethemoglobinemiafms-Like Tyrosine Kinase 3Gene Expression Regulation, LeukemicPrecursor Cell Lymphoblastic Leukemia-LymphomaNeoplasm ProteinsOncogene Proteins, FusionPrecursor T-Cell Lymphoblastic Leukemia-LymphomaCell Transformation, NeoplasticLeukemia, Promyelocytic, Acute
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LNK/SH2B3 as a novel driver in juvenile myelomonocytic leukemia.
Haematologica 2023 Wintering A, Hecht A, Meyer J, Wong EB, Hübner J, Abelson S, Feldman K, Kennedy VE, Peretz CAC, French DL, Maguire JA, Jobaliya C, Vasquez MR, Desai S, Dulman R, Nemecek E, Haines H, Hammad M, El … -
Gene-Environment Analyses Reveal Novel Genetic Candidates with Prenatal Tobacco Exposure in Relation to Risk for Childhood Acute Lymphoblastic Leukemia.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 2023 Zhong C, Li S, Arroyo K, Morimoto LM, de Smith AJ, Metayer C, Ma X, Kogan SC, Gauderman WJ, Wiemels JL -
Impact of pinworm infection on the development of murine B-cell leukemia/lymphoma in the presence and absence of ETV6::RUNX1.
Haematologica 2023 Fitch BA, Situ J, Wiemels JL, Kogan SC, Zhou M -
Efficacy of the Allosteric MEK Inhibitor Trametinib in Relapsed and Refractory Juvenile Myelomonocytic Leukemia: A Report from the Children's Oncology Group.
Blood 2023 Elliot Stieglitz, Alex Lee, Steven P. Angus, Christopher Davis, Donald Barkauskas, David Hall, Scott C. Kogan, Julia Meyer, Steven D. Rhodes, Xiaoling Xuei, Kevin Shannon, Mignon L. Loh, Elizabeth Fox… -
Genetic architecture of the acute and persistent immune cell response after radiation exposure.
Cell genomics 2023 He L, Zhong C, Chang H, Inman JL, Celniker SE, Ioakeim-Ioannidou M, Liu KX, Haas-Kogan D, MacDonald SM, Threadgill DW, Kogan SC, Mao JH, Snijders AM
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The SWI/SNF chromatin-remodeling subunit DPF2 facilitates NRF2-dependent antiinflammatory and antioxidant gene expression.
The Journal of clinical investigation 2023 Mas G, Man N, Nakata Y, Martinez-Caja C, Karl D, Beckedorff F, Tamiro F, Chen C, Duffort S, Itonaga H, Mookhtiar AK, Kunkalla K, Valencia AM, Collings CK, Kadoch C, Vega F, Kogan SC, Shiekhattar R, … -
Dapsone-induced methemoglobinemia and hemolysis in a woman without G6PD deficiency presenting with idiopathic urticaria.
Hematology (Amsterdam, Netherlands) 2022 Hu Y, Geere M, Awan M, Leavitt AD, Brown LE, Pearson HJ, Gandelman JS, Kogan SC -
Cytomegalovirus proteins, maternal pregnancy cytokines, and their impact on neonatal immune cytokine profiles and acute lymphoblastic leukemogenesis in children.
Haematologica 2022 Wiemels JL, Wang R, Zhou M, Hansen H, Gallant R, Jung J, Mancuso N, De Smith AJ, Metayer C, Kogan SC, Ma X -
RASA2 ablation in T cells boosts antigen sensitivity and long-term function.
Nature 2022 Carnevale J, Shifrut E, Kale N, Nyberg WA, Blaeschke F, Chen YY, Li Z, Bapat SP, Diolaiti ME, O'Leary P, Vedova S, Belk J, Daniel B, Roth TL, Bachl S, Anido AA, Prinzing B, Ibañez-Vega J, Lange S, … -
Genomic Features of Interstitial Deletions of Chromosome 9q in Acute Myeloid Leukemia.
Cytogenetic and genome research 2022 Qi Z, Wen KW, Ki A, Prakash S, Kogan S, Yu J -
Apixaban Concentrations in Routine Clinical Care of Older Adults With Nonvalvular Atrial Fibrillation.
JACC. Advances 2022 Thomas A, Fang MC, Kogan S, Hubbard CC, Friedman PN, Gong L, Klein TE, Nutescu EA, O'Brien TJ, Tuck M, Perera MA, Schwartz JB -
Clinical characteristics of cytomegalovirus-positive pediatric acute lymphoblastic leukemia at diagnosis.
American journal of hematology 2022 Gallant RE, Arroyo K, Bracci PM, Li S, Metayer C, Kogan SC, Wendt GA, Francis SS, de Smith AJ, Wiemels JL -
Decreased IL-10 accelerates B-cell leukemia/lymphoma in a mouse model of pediatric lymphoid leukemia.
Blood advances 2022 Fitch BA, Zhou M, Situ J, Surianarayanan S, Reeves MQ, Hermiston ML, Wiemels JL, Kogan SC -
Preventing Bleeding With Direct-Acting Oral Anticoagulants.
Journal of the American College of Cardiology 2021 Schwartz JB, Kogan SC, Fang MC -
Nf1 and Sh2b3 mutations cooperate in vivo in a mouse model of juvenile myelomonocytic leukemia.
Blood advances 2021 Morales CE, Stieglitz E, Kogan SC, Loh ML, Braun BS -
Cytokine Levels at Birth in Children Who Developed Acute Lymphoblastic Leukemia.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 2021 Whitehead TP, Wiemels JL, Zhou M, Kang AY, McCoy LS, Wang R, Fitch B, Petrick LM, Yano Y, Imani P, Rappaport SM, Dahl GV, Kogan SC, Ma X, Metayer C -
Epigenetic Biomarkers of Prenatal Tobacco Smoke Exposure Are Associated with Gene Deletions in Childhood Acute Lymphoblastic Leukemia.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 2021 Xu K, Li S, Whitehead TP, Pandey P, Kang AY, Morimoto LM, Kogan SC, Metayer C, Wiemels JL, de Smith AJ -
Anti-factor Xa activity assays of direct-acting oral anticoagulants during clinical care: An observational study.
Research and practice in thrombosis and haemostasis 2021 Sukumar S, Cabero M, Tiu S, Fang MC, Kogan SC, Schwartz JB -
In utero and early-life exposure to thirdhand smoke causes profound changes to the immune system.
Clinical science (London, England : 1979) 2021 Snijders AM, Zhou M, Whitehead TP, Fitch B, Pandey P, Hechmer A, Huang A, Schick SF, de Smith AJ, Olshen AB, Metayer C, Mao JH, Wiemels JL, Kogan SC -
Trends in Acute Lymphoblastic Leukemia Incidence in the United States by Race/Ethnicity From 2000 to 2016.
American journal of epidemiology 2021 Feng Q, de Smith AJ, Vergara-Lluri M, Muskens IS, McKean-Cowdin R, Kogan S, Brynes R, Wiemels JL -
PML-RARα: changing myeloid networks.
Blood 2021 Kogan SC -
KrasP34R and KrasT58I mutations induce distinct RASopathy phenotypes in mice.
JCI insight 2020 Wong JC, Perez-Mancera PA, Huang TQ, Kim J, Grego-Bessa J, Del Pilar Alzamora M, Kogan SC, Sharir A, Keefe SH, Morales CE, Schanze D, Castel P, Hirose K, Huang GN, Zenker M, Sheppard D, Klein OD, … -
The Baf Subunit Dpf2 Regulates Resolution of Inflammation By Controlling Macrophage Differentiation Transcription Factor Networks.
Blood 2020 Gloria Mas Martin, Na Man, Daniel Karl, Concepcion Martinez, Stephanie Duffort, Hidehiro Itonaga, Adnan K Mookhtiar, Daniel Bilbao, Kranthi Kunkalla, Alfredo M Valencia, Clayton Collings, Cigall … -
History of Early Childhood Infections and Acute Lymphoblastic Leukemia Risk Among Children in a US Integrated Health-Care System.
American journal of epidemiology 2020 Morimoto LM, Kwan ML, Deosaransingh K, Munneke JR, Kang AY, Quesenberry C, Kogan S, de Smith AJ, Metayer C, Wiemels JL -
Human pediatric B-cell acute lymphoblastic leukemias can be classified as B-1 or B-2-like based on a minimal transcriptional signature.
Experimental hematology 2020 Fitch B, Roy R, Geng H, Montecino-Rodriguez E, Bengtsson H, Gaillard C, Hiam K, Casero D, Olshen AB, Dorshkind K, Kogan SC -
Abstract A105: Trends in acute lymphocytic leukemia (ALL) incidence in the US from 2000-2016.
Cancer Epidemiology Biomarkers & Prevention 2020 Qianxi Feng, Maria Vergara-Lluri, Ivo Muskens, Roberta McKean-Cowdin, Scott Kogan, Russell Brynes, Adam de Smith, Joseph Wiemels -
Genetic disruption of N-RasG12D palmitoylation perturbs hematopoiesis and prevents myeloid transformation in mice.
Blood 2020 Zambetti NA, Firestone AJ, Remsberg JR, Huang BJ, Wong JC, Long AM, Predovic M, Suciu RM, Inguva A, Kogan SC, Haigis KM, Cravatt BF, Shannon K -
Abstract A23: A second site KrasG12D mutation that impairs PI3K binding rescues embryonic lethality, abrogates myeloproliferative disease, and delays lung tumorigenesis.
Molecular Cancer Research 2020 Jasmine C. Wong, Pedro A. Perez-Mancera, Jangkyung Kim, Kuang-Yu Jen, Scott C. Kogan, Ari J. Firestone, Eric A. Collisson, David A. Tuveson, Kevin Shannon -
Loss of glucocorticoid receptor expression mediates in vivo dexamethasone resistance in T-cell acute lymphoblastic leukemia.
Leukemia 2020 Wandler AM, Huang BJ, Craig JW, Hayes K, Yan H, Meyer LK, Scacchetti A, Monsalve G, Dail M, Li Q, Wong JC, Weinberg O, Hasserjian RP, Kogan SC, Jonsson P, Yamamoto K, Sampath D, Nakitandwe J, Downing … -
Increased neonatal level of arginase 2 in cases of childhood acute lymphoblastic leukemia implicates immunosuppression in the etiology.
Haematologica 2019 Nielsen AB, Zhou M, de Smith AJ, Wang R, McCoy L, Hansen H, Morimoto L, Grønbæk K, Johansen C, Kogan SC, Metayer C, Bracci PM, Ma X, Wiemels JL -
FLT3-ITD impedes retinoic acid, but not arsenic, responses in murine acute promyelocytic leukemias.
Blood 2019 Esnault C, Rahmé R, Rice KL, Berthier C, Gaillard C, Quentin S, Maubert AL, Kogan S, de Thé H -
Identification of IRF8 as a potent tumor suppressor in murine acute promyelocytic leukemia.
Blood advances 2018 Gaillard C, Surianarayanan S, Bentley T, Warr MR, Fitch B, Geng H, Passegué E, de Thé H, Kogan SC -
Dilute Russell viper venom time interpretation and clinical correlation: A two-year retrospective institutional review.
International journal of laboratory hematology 2018 Jacquot C, Wool GD, Kogan SC -
TCEA1 regulates the proliferative potential of mouse myeloid cells.
Experimental cell research 2018 Yang T, Cui H, Wen M, Zuber J, Kogan SC, Wei G -
Abstract 3241: Children with acute lymphoblastic leukemia have increased arginase 2 at birth, implicating immunosuppression in leukemogenesis.
Epidemiology 2018 Amalie B. Nielsen, Mi Zhou, Adam de Smith, Lucie McCoy, Helen Hansen, Paige Bracci, Libby Morimoto, Scott Kogan, Catherine Metayer, Xiaomei Ma, Joseph Wiemels -
Severe Iron Metabolism Defects in Mice With Double Knockout of the Multicopper Ferroxidases Hephaestin and Ceruloplasmin.
Cellular and molecular gastroenterology and hepatology 2018 Fuqua BK, Lu Y, Frazer DM, Darshan D, Wilkins SJ, Dunn L, Loguinov AV, Kogan SC, Matak P, Chen H, Dunaief JL, Vulpe CD, Anderson GJ -
Age-Related Impaired Efficacy of Bone Marrow Cell Therapy for Myocardial Infarction Reflects a Decrease in B Lymphocytes.
Molecular therapy : the journal of the American Society of Gene Therapy 2018 An S, Wang X, Ruck MA, Rodriguez HJ, Kostyushev DS, Varga M, Luu E, Derakhshandeh R, Suchkov SV, Kogan SC, Hermiston ML, Springer ML -
Dual origin of relapses in retinoic-acid resistant acute promyelocytic leukemia.
Nature communications 2018 Lehmann-Che J, Bally C, Letouzé E, Berthier C, Yuan H, Jollivet F, Ades L, Cassinat B, Hirsch P, Pigneux A, Mozziconacci MJ, Kogan S, Fenaux P, de Thé H -
Pml nuclear body disruption cooperates in APL pathogenesis and impairs DNA damage repair pathways in mice.
Blood 2017 Voisset E, Moravcsik E, Stratford EW, Jaye A, Palgrave CJ, Hills RK, Salomoni P, Kogan SC, Solomon E, Grimwade D -
Acute myeloid leukemia with t(14;21) involving RUNX1 and SYNE2: A novel favorable-risk translocation?
Cancer genetics 2017 Foley N, Van Ziffle J, Yu J, Qi Z, Grenert JP, Yeh I, Bastian B, Kogan S, Mannis GN -
In utero cytomegalovirus infection and development of childhood acute lymphoblastic leukemia.
Blood 2016 Francis SS, Wallace AD, Wendt GA, Li L, Liu F, Riley LW, Kogan S, Walsh KM, de Smith AJ, Dahl GV, Ma X, Delwart E, Metayer C, Wiemels JL -
Dilute Russell Viper Venom Time Interpretation and Clinical Correlation: A Two-Year Retrospective Institutional Review.
Blood 2016 Cyril Jacquot, Geoffrey D. Wool, Scott C. Kogan -
Genetic Subtypes of Human Pediatric ALLs Show Gene Expression Differences That Parallel Those Observed in Mouse B1 and B2 Progenitors, Suggesting Divergent Developmental Origins.
Blood 2016 Scott C. Kogan, Huimin Geng, Ritu Roy, Encarnacion Montecino-Rodriguez, Coline M Gaillard, Kamir Hiam, Henrik Bengtsson, David Casero, Adam B Olshen, Kenneth Dorshkind -
Identification of IRF8 As a Potent Tumor Suppressor in Murine Acute Promyelocytic Leukemia.
Blood 2016 Sangeetha Surianarayanan, Coline M Gaillard, Trevor Bentley, Matthew R. Warr, Briana Fitch, Huimin Geng, Emmanuelle Passegue, Hugues de Thé, Scott C. Kogan -
Mechanism of IL-10 Protective Effect in Development of Childhood B Cell Acute Lymphoblastic Leukemia.
Blood 2016 Briana Fitch, Michelle L. Hermiston, Joseph L. Wiemels, Scott C. Kogan -
Pml Nuclear Body Disruption Cooperates in APL Pathogenesis, Impacting DNA Damage Repair Pathways.
Blood 2016 Edwige Voisset, Eva Moravcsik, Eva W Stratford, Amie Jaye, Christopher J Palgrave, Robert K Hills, Paolo Salomoni, Scott C. Kogan, Ellen Solomon, David Grimwade -
Resistant T-Cell Acute Lymphoblastic Leukemias That Emerge after In Vivo Treatment with Dexamethasone Frequently Down-Regulate Glucocorticoid Receptor Protein Expression.
Blood 2016 Anica M. Wandler, Benjamin Huang, Alessandro Scacchetti, Jeff Craig, Hannah Yan, Gabriela Monsalve, Qing Li, Monique Dail, Jasmine C. Wong, Joy Nakitandwe, Olga Weinberg, Robert P. Hasserjian, Scott C… -
Co-operative leukemogenesis in acute myeloid leukemia and acute promyelocytic leukemia reveals C/EBPα as a common target of TRIB1 and PML/RARA.
Haematologica 2016 Keeshan K, Vieugué P, Chaudhury S, Rishi L, Gaillard C, Liang L, Garcia E, Nakamura T, Omidvar N, Kogan SC -
DNMT3A Haploinsufficiency Transforms FLT3ITD Myeloproliferative Disease into a Rapid, Spontaneous, and Fully Penetrant Acute Myeloid Leukemia.
Cancer discovery 2016 Meyer SE, Qin T, Muench DE, Masuda K, Venkatasubramanian M, Orr E, Suarez L, Gore SD, Delwel R, Paietta E, Tallman MS, Fernandez H, Melnick A, Le Beau MM, Kogan S, Salomonis N, Figueroa ME, Grimes HL -
Sustained MEK inhibition abrogates myeloproliferative disease in Nf1 mutant mice.
The Journal of clinical investigation 2016 Chang T, Krisman K, Theobald EH, Xu J, Akutagawa J, Lauchle JO, Kogan S, Braun BS, Shannon K -
Functional evidence implicating chromosome 7q22 haploinsufficiency in myelodysplastic syndrome pathogenesis.
eLife 2015 Wong JC, Weinfurtner KM, Alzamora Mdel P, Kogan SC, Burgess MR, Zhang Y, Nakitandwe J, Ma J, Cheng J, Chen SC, Ho TT, Flach J, Reynaud D, Passegué E, Downing JR, Shannon K -
Transcription and methylation analyses of preleukemic promyelocytes indicate a dual role for PML/RARA in leukemia initiation.
Haematologica 2015 Gaillard C, Tokuyasu TA, Rosen G, Sotzen J, Vitaliano-Prunier A, Roy R, Passegué E, de Thé H, Figueroa ME, Kogan SC -
Mechanisms of clonal evolution in childhood acute lymphoblastic leukemia.
Nature immunology 2015 Swaminathan S, Klemm L, Park E, Papaemmanuil E, Ford A, Kweon SM, Trageser D, Hasselfeld B, Henke N, Mooster J, Geng H, Schwarz K, Kogan SC, Casellas R, Schatz DG, Lieber MR, Greaves MF, Müschen M -
Direct and indirect targeting of MYC to treat acute myeloid leukemia.
Cancer chemotherapy and pharmacology 2015 Brondfield S, Umesh S, Corella A, Zuber J, Rappaport AR, Gaillard C, Lowe SW, Goga A, Kogan SC -
Cooperative loss of RAS feedback regulation drives myeloid leukemogenesis.
Nature genetics 2015 Zhao Z, Chen CC, Rillahan CD, Shen R, Kitzing T, McNerney ME, Diaz-Flores E, Zuber J, Shannon K, Le Beau MM, Spector MS, Kogan SC, Lowe SW -
Aberrant Hematopoietic Stem Cell Function in Mice Haploinsufficient for a 2 Mb Deletion of Chromosome 5A3 Syntenic to a Region of Human 7q22 Frequently Deleted in Myelodysplastic Syndromes.
Blood 2014 Jasmine C. Wong, Kelley Weinfurtner, Pilar Alzamora, Scott C. Kogan, Michael R. Burgess, Yan Zhang, Joy Nakitandwe, Jing Ma, Jinjun Cheng, Shann-Ching Chen, Johanna Flach, Damien Reynaud, Emmanuelle … -
Preclinical Efficacy of MEK Inhibition in Nras Mutant Acute Myeloid Leukemia.
Blood 2014 Michael R. Burgess, Eugene Hwang, Ari J Firestone, Tannie Huang, Jin Xu, Johannes Zuber, Natacha Bohin, Tiffany Wen, Scott C. Kogan, Kevin M. Haigis, Scott W. Lowe, Kevin Shannon, Qing Li -
Preclinical efficacy of MEK inhibition in Nras-mutant AML.
Blood 2014 Burgess MR, Hwang E, Firestone AJ, Huang T, Xu J, Zuber J, Bohin N, Wen T, Kogan SC, Haigis KM, Sampath D, Lowe S, Shannon K, Li Q -
MLL3 is a haploinsufficient 7q tumor suppressor in acute myeloid leukemia.
Cancer cell 2014 Chen C, Liu Y, Rappaport AR, Kitzing T, Schultz N, Zhao Z, Shroff AS, Dickins RA, Vakoc CR, Bradner JE, Stock W, LeBeau MM, Shannon KM, Kogan S, Zuber J, Lowe SW -
Crenolanib is a selective type I pan-FLT3 inhibitor.
Proceedings of the National Academy of Sciences of the United States of America 2014 Smith CC, Lasater EA, Lin KC, Wang Q, McCreery MQ, Stewart WK, Damon LE, Perl AE, Jeschke GR, Sugita M, Carroll M, Kogan SC, Kuriyan J, Shah NP -
CUL4A induces epithelial-mesenchymal transition and promotes cancer metastasis by regulating ZEB1 expression.
Cancer research 2013 Wang Y, Wen M, Kwon Y, Xu Y, Liu Y, Zhang P, He X, Wang Q, Huang Y, Jen KY, LaBarge MA, You L, Kogan SC, Gray JW, Mao JH, Wei G -
Disruption Of PML Nuclear Bodies Cooperates In The Pathogenesis Of Acute Promyelocytic Leukemia.
Blood 2013 Eva Moravcsik, Melanie Joannides, Edwige Voisset, Eva Wessel Stratford, Bernd B. Zeisig, Jo Morris, Ruth Densham, Chris Palgrave, Gordon Stamp, Emma Nye, Robert K. Hills, Paolo Salomoni, Chi Wai Eric … -
The Challenge Of Russell’s Viper Venom Time Interpretation For Lupus Anticoagulant Diagnosis: A Two-Year Retrospective Institutional Review.
Blood 2013 Geoffrey D. Wool, Scott C. Kogan -
Pten loss in the bone marrow leads to G-CSF-mediated HSC mobilization.
The Journal of experimental medicine 2013 Tesio M, Oser GM, Baccelli I, Blanco-Bose W, Wu H, Göthert JR, Kogan SC, Trumpp A -
The histone demethylase PHF8 governs retinoic acid response in acute promyelocytic leukemia.
Cancer cell 2013 Arteaga MF, Mikesch JH, Qiu J, Christensen J, Helin K, Kogan SC, Dong S, So CW -
Initially disadvantaged, TEL-AML1 cells expand and initiate leukemia in response to irradiation and cooperating mutations.
Leukemia 2013 Li M, Jones L, Gaillard C, Binnewies M, Ochoa R, Garcia E, Lam V, Wei G, Yang W, Lobe C, Hermiston M, Passegué E, Kogan SC -
Sustained MEK inhibition abrogates myeloproliferative disease in Nf1 mutant mice.
The Journal of clinical investigation 2012 Chang T, Krisman K, Theobald EH, Xu J, Akutagawa J, Lauchle JO, Kogan S, Braun BS, Shannon K -
Crenolanib (CP-868,596) Is a Potent and Selective Type I FLT3 Inhibitor That Retains Activity Against AC220 Resistance-Causing FLT3 Kinase Domain Mutants.
Blood 2012 Catherine C Smith, Elisabeth Lasater, Melissa Mccreery, Kimberly Lin, Whitney Stewart, Lauren E Damon, Alexander E Perl, Grace R Jeschke, Mayumi Sugita, Martin Carroll, Scott C. Kogan, Neil Shah -
Evaluation of Patients with Bleeding Symptoms Using a Novel Perfusion Chamber Assay (PCA).
Blood 2012 Matthew F. Gorman, Scott C. Kogan, James Huang, Gillian Stephens -
PML-RARa Deregulates an Unexpectedly Small Number of Genes in Pre-Leukemic Promyelocytes.
Blood 2012 Coline M Gaillard, Taku A Tokuyasu, Emmanuelle Passegue´, Scott C. Kogan -
PML-RARα co-operates with Sox4 in acute myeloid leukemia development in mice.
Haematologica 2012 Omidvar N, Maunakea ML, Jones L, Sevcikova S, Yin B, Himmel KL, Tennant TR, Le Beau MM, Largaespada DA, Kogan SC -
A dominantly acting murine allele of Mcm4 causes chromosomal abnormalities and promotes tumorigenesis.
PLoS genetics 2012 Bagley BN, Keane TM, Maklakova VI, Marshall JG, Lester RA, Cancel MM, Paulsen AR, Bendzick LE, Been RA, Kogan SC, Cormier RT, Kendziorski C, Adams DJ, Collier LS -
Genetically mediated Nf1 loss in mice promotes diverse radiation-induced tumors modeling second malignant neoplasms.
Cancer research 2012 Choi G, Huang B, Pinarbasi E, Braunstein SE, Horvai AE, Kogan S, Bhatia S, Faddegon B, Nakamura JL -
An insertional mutagenesis screen identifies genes that cooperate with Mll-AF9 in a murine leukemogenesis model.
Blood 2012 Bergerson RJ, Collier LS, Sarver AL, Been RA, Lugthart S, Diers MD, Zuber J, Rappaport AR, Nixon MJ, Silverstein KA, Fan D, Lamblin AF, Wolff L, Kersey JH, Delwel R, Lowe SW, O'Sullivan MG, Kogan SC, … -
Heterozygous Germ Line Deletion of a 2Mb Interval in Mice That Models Loss of 7q22 in Human Myeloid Malignancies Results in Defective Hematopoietic Stem Cell Function Reminiscent of Premature Aging.
Blood 2011 Jasmine C. Wong, Kelley Weinfurtner, Yan Zhang, Pilar Alzamora, Eugene Hwang, Scott C. Kogan, Kevin M. Shannon -
Control of the senescence-associated secretory phenotype by NF-κB promotes senescence and enhances chemosensitivity.
Genes & development 2011 Chien Y, Scuoppo C, Wang X, Fang X, Balgley B, Bolden JE, Premsrirut P, Luo W, Chicas A, Lee CS, Kogan SC, Lowe SW -
PML-RARα enhances constitutive autophagic activity through inhibiting the Akt/mTOR pathway.
Autophagy 2011 Huang Y, Hou JK, Chen TT, Zhao XY, Yan ZW, Zhang J, Yang J, Kogan SC, Chen GQ -
Abstract A37: A dominantly acting allele of murine Mcm4 causes chromosome instability and promotes leukemiogenesis.
Cancer Genomics 2011 Bruce N. Bagley, Vilena Maklakova, Christina Kendziorski, David J. Adams, Lara S. Collier, Jonathon G. Marshall, Rachael A. Lester, Michelle M. Cancel, Laura G. Bendzick, Thomas Keane, Scott C. Kogan,… -
Donor myocardial infarction impairs the therapeutic potential of bone marrow cells by an interleukin-1-mediated inflammatory response.
Science translational medicine 2011 Wang X, Takagawa J, Lam VC, Haddad DJ, Tobler DL, Mok PY, Zhang Y, Clifford BT, Pinnamaneni K, Saini SA, Su R, Bartel MJ, Sievers RE, Carbone L, Kogan S, Yeghiazarians Y, Hermiston M, Springer ML -
RNAi screen identifies Brd4 as a therapeutic target in acute myeloid leukaemia.
Nature 2011 Zuber J, Shi J, Wang E, Rappaport AR, Herrmann H, Sison EA, Magoon D, Qi J, Blatt K, Wunderlich M, Taylor MJ, Johns C, Chicas A, Mulloy JC, Kogan SC, Brown P, Valent P, Bradner JE, Lowe SW, Vakoc CR -
An integrated approach to dissecting oncogene addiction implicates a Myb-coordinated self-renewal program as essential for leukemia maintenance.
Genes & development 2011 Zuber J, Rappaport AR, Luo W, Wang E, Chen C, Vaseva AV, Shi J, Weissmueller S, Fellmann C, Fellman C, Taylor MJ, Weissenboeck M, Graeber TG, Kogan SC, Vakoc CR, Lowe SW -
A rapid and scalable system for studying gene function in mice using conditional RNA interference.
Cell 2011 Premsrirut PK, Dow LE, Kim SY, Camiolo M, Malone CD, Miething C, Scuoppo C, Zuber J, Dickins RA, Kogan SC, Shroyer KR, Sordella R, Hannon GJ, Lowe SW -
Treatment with 5-azacytidine accelerates acute promyelocytic leukemia leukemogenesis in a transgenic mouse model.
Genes & cancer 2011 Scaglioni PP, Cai LF, Majid SM, Yung TM, Socci ND, Kogan SC, Kopelovich L, Pandolfi PP -
Dose-dependent effects of focal fractionated irradiation on secondary malignant neoplasms in Nf1 mutant mice.
Cancer research 2011 Nakamura JL, Phong C, Pinarbasi E, Kogan SC, Vandenberg S, Horvai AE, Faddegon BA, Fiedler D, Shokat K, Houseman BT, Chao R, Pieper RO, Shannon K -
Hematopoiesis and leukemogenesis in mice expressing oncogenic NrasG12D from the endogenous locus.
Blood 2010 Li Q, Haigis KM, McDaniel A, Harding-Theobald E, Kogan SC, Akagi K, Wong JC, Braun BS, Wolff L, Jacks T, Shannon K -
ABT-737 Targets Leukemic Stem Cells In Mouse Models of Mutant NRASD12/hBCL-2- Mediated Acute Myeloid Leukemia Progression with Increased Survival.
Blood 2010 Rose Ann Padua, Stephanie Beurlet, Patricia Krief, Nader Omidvar, Carole Le Pogam, Didier Auboeuf, Pierre de la Grange, Annie Soulie, Anne Janin, Maria-Elena Noguera, Pascal Merlet, Laure Sarda-Mantel… -
Mutant BCL2 Co-Operates with CBFß/PEBP2ß-MYH11 to Promote Expansion of Leukemia Initiating Cells with a Predominantly Pro-Apoptotic Mechanism Via Recruitment of Ras-GTP In a Mouse Model of Progressive Acute Myeloid Leukemia.
Blood 2010 Nader Omidvar, Carole Le Pogam, Stephanie Beurlet, Maria-Elena Noguera, Ann Janin, Scott C. Kogan, Irving L. Weissman, Marika Pla, Christine Chomienne, Rose Ann Padua -
Gain of MYC underlies recurrent trisomy of the MYC chromosome in acute promyelocytic leukemia.
The Journal of experimental medicine 2010 Jones L, Wei G, Sevcikova S, Phan V, Jain S, Shieh A, Wong JC, Li M, Dubansky J, Maunakea ML, Ochoa R, Zhu G, Tennant TR, Shannon KM, Lowe SW, Le Beau MM, Kogan SC -
PML-RAR{alpha} and Dnmt3a1 cooperate in vivo to promote acute promyelocytic leukemia.
Cancer research 2010 Subramanyam D, Belair CD, Barry-Holson KQ, Lin H, Kogan SC, Passegué E, Blelloch R -
p53 loss promotes acute myeloid leukemia by enabling aberrant self-renewal.
Genes & development 2010 Zhao Z, Zuber J, Diaz-Flores E, Lintault L, Kogan SC, Shannon K, Lowe SW -
Abstract 3427A: Focal fractionated irradiation induces specific malignancies in a dose-dependent manner in Nf1 mutant mice.
Clinical Research 2010 Jean L. Nakamura, Connie Phong, Emile Pinarbasi, Scott C. Kogan, Scott Vandenberg, Andrew E. Horvai, Bruce A. Faddegon, Benjamin T. Houseman, Russell O. Pieper, Kevin Shannon -
Medicine. Poisonous contacts.
Science (New York, N.Y.) 2010 Kogan SC -
Use of chromosome engineering to model a segmental deletion of chromosome band 7q22 found in myeloid malignancies.
Blood 2010 Wong JC, Zhang Y, Lieuw KH, Tran MT, Forgo E, Weinfurtner K, Alzamora P, Kogan SC, Akagi K, Wolff L, Le Beau MM, Killeen N, Shannon K -
Mutant Ikzf1, KrasG12D, and Notch1 cooperate in T lineage leukemogenesis and modulate responses to targeted agents.
Proceedings of the National Academy of Sciences of the United States of America 2010 Dail M, Li Q, McDaniel A, Wong J, Akagi K, Huang B, Kang HC, Kogan SC, Shokat K, Wolff L, Braun BS, Shannon K -
An Insertional Mutagenesis Screen for Genes That Cooperate with Mll-AF9 in Leukemogenesis.
Blood 2009 Rachel Joy Bergerson, Lara S Collier, Sanne Lugthart, Raha Allaei, Molly J Nixon, Kevin A.T. Silverstein, Aaron Sarver, Danhua Flora Fan, Anne-Francoise J Lamblin, Linda Wolff, John H. Kersey, M. … -
Response and resistance to MEK inhibition in leukaemias initiated by hyperactive Ras.
Nature 2009 Lauchle JO, Kim D, Le DT, Akagi K, Crone M, Krisman K, Warner K, Bonifas JM, Li Q, Coakley KM, Diaz-Flores E, Gorman M, Przybranowski S, Tran M, Kogan SC, Roose JP, Copeland NG, Jenkins NA, Parada L, … -
Mouse models of human AML accurately predict chemotherapy response.
Genes & development 2009 Zuber J, Radtke I, Pardee TS, Zhao Z, Rappaport AR, Luo W, McCurrach ME, Yang MM, Dolan ME, Kogan SC, Downing JR, Lowe SW -
Curing APL: differentiation or destruction?
Cancer cell 2009 Kogan SC -
ABT-737 Targets Intrinsic Apoptosis during Cooperation of BCL-2 and Oncogenic NRAS in An in Vivo Progression Model of Myelodysplasia/Acute Myeloid Leukaemia.
Blood 2008 Nader Omidvar, Stephanie Beurlet, Carole Le Pogam, Anne Janin, Christophe Leboeuf, Annie Soulie, Niclas Setterblad, Maria-Elena Noguera, Laure Sarda-Mantel, Pascal Merlet, Marika Pla, Scott C. Kogan, … -
Myc Drives Chromosomal Gain in Acute Myeloid Leukemia.
Blood 2008 Letetia Jones, Sabina Sevcikova, Vernon Phan, Sachi Jain, Angell Shieh, Joshua Dubansky, Min Li, Mei Lin Maunakea, George Zhu, Thelma R Tennant, Scott Lowe, Michelle M. Le, Scott C. Kogan -
Hematopoietic stem cell quiescence is maintained by compound contributions of the retinoblastoma gene family.
Cell stem cell 2008 Viatour P, Somervaille TC, Venkatasubrahmanyam S, Kogan S, McLaughlin ME, Weissman IL, Butte AJ, Passegué E, Sage J -
Fractionated Cranial Irradiation Induces a Distinctive Pattern of Second Malignant Neoplasms in Nf1 Mutant Mice.
International Journal of Radiation Oncology • Biology • Physics 2008 J.L. Nakamura, C. Phong, S. Kogan, S. Vandenberg, R.O. Pieper, K. Shannon -
mTORC1 promotes survival through translational control of Mcl-1.
Proceedings of the National Academy of Sciences of the United States of America 2008 Mills JR, Hippo Y, Robert F, Chen SM, Malina A, Lin CJ, Trojahn U, Wendel HG, Charest A, Bronson RT, Kogan SC, Nadon R, Housman DE, Lowe SW, Pelletier J -
Survival and tumorigenesis in O6-methylguanine DNA methyltransferase-deficient mice following cyclophosphamide exposure.
Mutagenesis 2008 Nagasubramanian R, Hansen RJ, Delaney SM, Cherian MM, Samson LD, Kogan SC, Dolan ME -
The protective effect of KCNMB1 E65K against hypertension is restricted to blood pressure treatment with beta-blockade.
Journal of human hypertension 2008 Kelley-Hedgepeth A, Peter I, Kip K, Montefusco M, Kogan S, Cox D, Ordovas J, Levy D, Reis S, Mendelsohn M, Housman D, Huggins G -
BCL-2 and mutant NRAS interact physically and functionally in a mouse model of progressive myelodysplasia.
Cancer research 2007 Omidvar N, Kogan S, Beurlet S, le Pogam C, Janin A, West R, Noguera ME, Reboul M, Soulie A, Leboeuf C, Setterblad N, Felsher D, Lagasse E, Mohamedali A, Thomas NS, Fenaux P, Fontenay M, Pla M, Mufti … -
Expressing N-RasG12D from the Endogenous Promoter Induces Myeloproliferative Disease (MPD) and Cooperates with Retroviral Insertional Mutagenesis (RIM) To Generate Acute Myeloid Leukemia (AML).
Blood 2007 Qing Li, Kevin Haigis, Andrew McDaniel, Benjamin Huang, Michelle Miller, Angell Shieh, Scott Kogan, Lynda Wolff, Tyler Jacks, Kevin Shannon -
Novel Mll-AF9 Cooperating Genes Identified in a Leukemogenesis Screen Using Retroviral Mutagenesis.
Blood 2007 Rachel J. Bergerson, Lara S. Collier, Raha Allaei, Kevin A. Silverstein, Anne-Francoise F. Lamblin, Linda Wolff, Scott C. Kogan, John H. Kersey, David J. Adams, David A. Largaespada -
PPARgamma-active triterpenoid CDDO enhances ATRA-induced differentiation in APL.
Cancer biology & therapy 2007 Tabe Y, Konopleva M, Kondo Y, Contractor R, Tsao T, Konoplev S, Shi Y, Ling X, Watt JC, Tsutsumi-Ishii Y, Ohsaka A, Nagaoka I, Issa JP, Kogan SC, Andreeff M -
Haploinsufficiency of EGR1, a candidate gene in the del(5q), leads to the development of myeloid disorders.
Blood 2007 Joslin JM, Fernald AA, Tennant TR, Davis EM, Kogan SC, Anastasi J, Crispino JD, Le Beau MM -
Mouse models of acute promyelocytic leukemia.
Current topics in microbiology and immunology 2007 Kogan SC -
Dual treatment with FLT3 inhibitor SU11657 and doxorubicin increases survival of leukemic mice.
Leukemia research 2006 Lee BD, Sevcikova S, Kogan SC -
Acute Promyelocytic Leukemia Stem Cell Derived from Leukemic Progenitor.
Blood 2006 Galit P. Rosen, Scott C. Kogan -
SU11657 Cooperates with Doxorubicin To Increase Survival of Leukemic Mice.
Blood 2006 Sabina Sevcikova, Brian D. Lee, Scott C. Kogan -
Beta common receptor inactivation attenuates myeloproliferative disease in Nf1 mutant mice.
Blood 2006 Kim A, Morgan K, Hasz DE, Wiesner SM, Lauchle JO, Geurts JL, Diers MD, Le DT, Kogan SC, Parada LF, Shannon K, Largaespada DA -
Determinants of sensitivity and resistance to rapamycin-chemotherapy drug combinations in vivo.
Cancer research 2006 Wendel HG, Malina A, Zhao Z, Zender L, Kogan SC, Cordon-Cardo C, Pelletier J, Lowe SW -
New evidence supporting megakaryocyte-erythrocyte potential of flk2/flt3+ multipotent hematopoietic progenitors.
Cell 2006 Forsberg EC, Serwold T, Kogan S, Weissman IL, Passegué E -
CCAAT/enhancer binding proteins alpha and epsilon cooperate with all-trans retinoic acid in therapy but differ in their antileukemic activities.
Blood 2006 Lee YJ, Jones LC, Timchenko NA, Perrotti D, Tenen DG, Kogan SC -
Loss of p53 impedes the antileukemic response to BCR-ABL inhibition.
Proceedings of the National Academy of Sciences of the United States of America 2006 Wendel HG, de Stanchina E, Cepero E, Ray S, Emig M, Fridman JS, Veach DR, Bornmann WG, Clarkson B, McCombie WR, Kogan SC, Hochhaus A, Lowe SW -
Trp53 loss during in vitro selection contributes to acquired Ara-C resistance in acute myeloid leukemia.
Experimental hematology 2006 Yin B, Kogan SC, Dickins RA, Lowe SW, Largaespada DA -
Leukemia with distinct phenotypes in transgenic mice expressing PML/RAR alpha, PLZF/RAR alpha or NPM/RAR alpha.
Oncogene 2006 Rego EM, Ruggero D, Tribioli C, Cattoretti G, Kogan S, Redner RL, Pandolfi PP -
Increased CCAAT enhancer-binding protein epsilon (C/EBPepsilon) expression and premature apoptosis in myeloid cells expressing Gfi-1 N382S mutant associated with severe congenital neutropenia.
The Journal of biological chemistry 2006 Zhuang D, Qiu Y, Kogan SC, Dong F -
Forced retinoic acid receptor alpha homodimers prime mice for APL-like leukemia.
Cancer cell 2006 Sternsdorf T, Phan VT, Maunakea ML, Ocampo CB, Sohal J, Silletto A, Galimi F, Le Beau MM, Evans RM, Kogan SC -
Cbf beta-SMMHC induces distinct abnormal myeloid progenitors able to develop acute myeloid leukemia.
Cancer cell 2006 Kuo YH, Landrette SF, Heilman SA, Perrat PN, Garrett L, Liu PP, Le Beau MM, Kogan SC, Castilla LH -
Investigation of Hematopoietic Stem Cell and Progenitor Populations: Implication for Cell Fate Determination and Lineage Commitment.
Blood 2005 Emmanuelle Passegue, Camilla Forsberg, Thomas Serwold, Scott Kogan, Irving L. Weissman -
Haploinsufficiency of Runx1/AML1 promotes myeloid features and leukaemogenesis in BXH2 mice.
British journal of haematology 2005 Yamashita N, Osato M, Huang L, Yanagida M, Kogan SC, Iwasaki M, Nakamura T, Shigesada K, Asou N, Ito Y -
Opinion: how patients have benefited from mouse models of acute promyelocytic leukaemia.
Nature reviews. Cancer 2005 Lallemand-Breitenbach V, Zhu J, Kogan S, Chen Z, de Thé H -
Therapy-induced malignant neoplasms in Nf1 mutant mice.
Cancer cell 2005 Chao RC, Pyzel U, Fridlyand J, Kuo YM, Teel L, Haaga J, Borowsky A, Horvai A, Kogan SC, Bonifas J, Huey B, Jacks TE, Albertson DG, Shannon KM -
Induction of tumor arrest and differentiation with prolonged survival by intermittent hypoxia in a mouse model of acute myeloid leukemia.
Blood 2005 Liu W, Guo M, Xu YB, Li D, Zhou ZN, Wu YL, Chen Z, Kogan SC, Chen GQ -
Role of O6-alkylguanine-DNA alkyltransferase in protecting against 1,3-bis(2-chloroethyl)-1-nitrosourea (BCNU)-induced long-term toxicities.
The Journal of pharmacology and experimental therapeutics 2005 Hansen RJ, Nagasubramanian R, Delaney SM, Cherian MM, Lin S, Kogan SC, Dolan ME -
Cooperation of Cytokine Signaling with Chimeric Transcription Factors in Leukemogenesis: PML-Retinoic Acid Receptor Alpha Blocks Growth Factor-Mediated Differentiation.
Molecular and Cellular Biology 2005 Vernon T. Phan, David B. Shultz, Bao-Tran H. Truong, Timothy J. Blake, Anna L. Brown, Thomas J. Gonda, Michelle M. Le Beau, Scott C. Kogan -
A sumoylation site in PML/RARA is essential for leukemic transformation.
Cancer cell 2005 Zhu J, Zhou J, Peres L, Riaucoux F, Honoré N, Kogan S, de Thé H -
Conditional MLL-CBP targets GMP and models therapy-related myeloproliferative disease.
The EMBO journal 2005 Wang J, Iwasaki H, Krivtsov A, Febbo PG, Thorner AR, Ernst P, Anastasiadou E, Kutok JL, Kogan SC, Zinkel SS, Fisher JK, Hess JL, Golub TR, Armstrong SA, Akashi K, Korsmeyer SJ -
O-14 A reversible two-step model ofMDS/preleukemia: Transgenic mice expressing inducible BCL2 and mutant NRAS.
Leukemia Research 2005 R.A. Padua, N. Omidvar, S. Kogan, T.-H. Phan, R. West, D. Felsher, I. Weissmann, S. Thomas, J. Whittaker, A. Janin, M. Pla, G. Muftis, J.M. Bishop, C. Chomienne -
Cbfb-MYH11 Induces Expansion of a Lin-Kit+Sca1- Abnormal Progenitor Compartment that Predisposes Acute Myeloid Leukemia in Mice.
Blood 2004 Ya-Huei Kuo, Susan Heilman, Amy Chen, Pu P. Liu, Rachel Gernstein, Scott Kogan, Lucio H. Castilla -
Cooperative Pathways to Acute Myeloid Leukemia Include the Combining of Transcription Factor Alterations: PML-RARa Cooperates with SOX4.
Blood 2004 Scott C. Kogan, Mei Lin Maunakea, Karen L. Himmel, Bin Yin, Michelle M. Le Beau, David A. Largaespada -
Discovery of Genes Involved in Experimental Pre-Leukemia to Leukemia Transition in Mice Using Expression Arrays.
Blood 2004 Igor A. Entin, Scott C. Kogan -
Homodimerization of Retinoic Acid Receptor alpha through its Fusion Partners Underlies Pathogenesis of Acute Promyelocytic Leukemia.
Blood 2004 Scott C. Kogan, Vernon T. Phan, Thomas Sternsdorf, Mei Lin Maunakea, Jastinder Sohal, Angela Silletto, Francesco Galimi, Ronald M. Evans -
Identification of Cooperating Genetic Alterations in RUNX Leukemia Using the Mouse Model for the Human Familial Leukemia, FPD/AML.
Blood 2004 Motomi Osato, Namiko Yamashita, Masatoshi Yanagida, Liqun Huang, Scott Kogan, Masayuki Iwasaki, Takuro Nakamura, Katsuya Shigesada, Norio Asou, Yoshiaki Ito -
Increased DNA Damage and Error-Prone Repair in MPD/MDS Mice with Disease Progression: Key Indicators for Increased Genomic Instability.
Blood 2004 Feyruz V. Rassool, Terry J. Gaymes, Nicola Brady, Nicholas Lea, Marika Pla, Thi Hai Phan, Scott Kogan, Christine Chomienne, Nicholas S. Thomas, Ghulam J. Mafti, Rose Ann Padua -
HOXB6 overexpression in murine bone marrow immortalizes a myelomonocytic precursor in vitro and causes hematopoietic stem cell expansion and acute myeloid leukemia in vivo.
Blood 2004 Fischbach NA, Rozenfeld S, Shen W, Fong S, Chrobak D, Ginzinger D, Kogan SC, Radhakrishnan A, Le Beau MM, Largman C, Lawrence HJ -
Myeloid Malignancies.
Mouse Models of Human Cancer 2004 Scott C. Kogan -
Mouse models of human cancers (part 3).
Comparative medicine 2004 Borowsky AD, Munn RJ, Galvez JJ, Cardiff RD, Ward JM, Morse HC, Kogan SC, Aldape KD, Louis DN, Bosenberg MW -
Survival signalling by Akt and eIF4E in oncogenesis and cancer therapy.
Nature 2004 Wendel HG, De Stanchina E, Fridman JS, Malina A, Ray S, Kogan S, Cordon-Cardo C, Pelletier J, Lowe SW -
Somatic inactivation of Nf1 in hematopoietic cells results in a progressive myeloproliferative disorder.
Blood 2004 Le DT, Kong N, Zhu Y, Lauchle JO, Aiyigari A, Braun BS, Wang E, Kogan SC, Le Beau MM, Parada L, Shannon KM -
The role of p53 in suppression of KSHV cyclin-induced lymphomagenesis.
Cancer research 2004 Verschuren EW, Hodgson JG, Gray JW, Kogan S, Jones N, Evan GI -
Somatic activation of oncogenic Kras in hematopoietic cells initiates a rapidly fatal myeloproliferative disorder.
Proceedings of the National Academy of Sciences of the United States of America 2003 Braun BS, Tuveson DA, Kong N, Le DT, Kogan SC, Rozmus J, Le Beau MM, Jacks TE, Shannon KM -
PML-RARA-targeted DNA vaccine induces protective immunity in a mouse model of leukemia.
Nature medicine 2003 Padua RA, Larghero J, Robin M, le Pogam C, Schlageter MH, Muszlak S, Fric J, West R, Rousselot P, Phan TH, Mudde L, Teisserenc H, Carpentier AF, Kogan S, Degos L, Pla M, Bishop JM, Stevenson F, … -
A PMLRARA transgene results in a retinoid-deficient phenotype associated with enhanced susceptibility to skin tumorigenesis.
Cancer research 2003 Hansen LA, Brown D, Virador V, Tanaka T, Andreola F, Strain K, Dancheck B, Riley R, Arbeit JM, De Luca LM, Kogan S, Yuspa SH -
Cooperation of cytokine signaling with chimeric transcription factors in leukemogenesis: PML-retinoic acid receptor alpha blocks growth factor-mediated differentiation.
Molecular and cellular biology 2003 Phan VT, Shultz DB, Truong BT, Blake TJ, Brown AL, Gonda TJ, Le Beau MM, Kogan SC -
Recurring chromosomal abnormalities in leukemia in PML-RARA transgenic mice identify cooperating events and genetic pathways to acute promyelocytic leukemia.
Blood 2003 Le Beau MM, Davis EM, Patel B, Phan VT, Sohal J, Kogan SC -
A model of APL with FLT3 mutation is responsive to retinoic acid and a receptor tyrosine kinase inhibitor, SU11657.
Blood 2002 Sohal J, Phan VT, Chan PV, Davis EM, Patel B, Kelly LM, Abrams TJ, O'Farrell AM, Gilliland DG, Le Beau MM, Kogan SC -
Bethesda proposals for classification of nonlymphoid hematopoietic neoplasms in mice.
Blood 2002 Kogan SC, Ward JM, Anver MR, Berman JJ, Brayton C, Cardiff RD, Carter JS, de Coronado S, Downing JR, Fredrickson TN, Haines DC, Harris AW, Harris NL, Hiai H, Jaffe ES, MacLennan IC, Pandolfi PP, … -
Recurring chromosomal abnormalities in leukemia in PML-RARA transgenic mice parallel human acute promyelocytic leukemia.
Blood 2002 Le Beau MM, Bitts S, Davis EM, Kogan SC -
Retroviral integration at the Epi1 locus cooperates with Nf1 gene loss in the progression to acute myeloid leukemia.
Journal of virology 2001 Blaydes SM, Kogan SC, Truong BT, Gilbert DJ, Jenkins NA, Copeland NG, Largaespada DA, Brannan CI -
Mouse intestinal goblet cells expressing SV40 T antigen directed by the MUC2 mucin gene promoter undergo apoptosis upon migration to the villi.
Cancer research 2001 Gum JR, Hicks JW, Gillespie AM, Rius JL, Treseler PA, Kogan SC, Carlson EJ, Epstein CJ, Kim YS -
BCL-2 cooperates with promyelocytic leukemia retinoic acid receptor alpha chimeric protein (PMLRARalpha) to block neutrophil differentiation and initiate acute leukemia.
The Journal of experimental medicine 2001 Kogan SC, Brown DE, Shultz DB, Truong BT, Lallemand-Breitenbach V, Guillemin MC, Lagasse E, Weissman IL, Bishop JM -
Patient and clinician vocabulary: how different are they?
Studies in health technology and informatics 2001 Zeng Q, Kogan S, Ash N, Greenes RA -
Acute promyelocytic leukemia: a view from a mouse.
Blood cells, molecules & diseases 2000 Kogan SC -
Leukemia initiated by PMLRARalpha: the PML domain plays a critical role while retinoic acid-mediated transactivation is dispensable.
Blood 2000 Kogan SC, Hong SH, Shultz DB, Privalsky ML, Bishop JM -
Acute promyelocytic leukemia: from treatment to genetics and back.
Oncogene 1999 Kogan SC, Bishop JM -
Images in clinical medicine. Indinavir crystalluria.
The New England journal of medicine 1999 Tsao JW, Kogan SC -
Retinoic acid and arsenic synergize to eradicate leukemic cells in a mouse model of acute promyelocytic leukemia.
The Journal of experimental medicine 1999 Lallemand-Breitenbach V, Guillemin MC, Janin A, Daniel MT, Degos L, Kogan SC, Bishop JM, de Thé H -
The PEBP2betaMYH11 fusion created by Inv(16)(p13;q22) in myeloid leukemia impairs neutrophil maturation and contributes to granulocytic dysplasia.
Proceedings of the National Academy of Sciences of the United States of America 1998 Kogan SC, Lagasse E, Atwater S, Bae SC, Weissman I, Ito Y, Bishop JM -
A PMLRARalpha transgene initiates murine acute promyelocytic leukemia.
Proceedings of the National Academy of Sciences of the United States of America 1997 Brown D, Kogan S, Lagasse E, Weissman I, Alcalay M, Pelicci PG, Atwater S, Bishop JM -
6 The effect of fractionated radiotherapy in glioblastoma depends on P53 function.
International Journal of Radiation Oncology • Biology • Physics 1996 D.A. Haas-Kogan, S.C. Kogan, G. Yount, J. Hsu, W.C. Dewey, T.L. Phillips, M.A. Israel -
Inhibition of apoptosis by the retinoblastoma gene product.
The EMBO journal 1995 Haas-Kogan DA, Kogan SC, Levi D, Dazin P, T'Ang A, Fung YK, Israel MA -
157 P53-dependent G1 arrest and P53-independent apoptosis influence the radiobiologic response of glioblastoma.
International Journal of Radiation Oncology • Biology • Physics 1995 D.A. Haas-Kogan, G. Yount, M. Haas, D. Levi, S.C. Kogan, L. Hu, C. Vidair, D.F. Deen, W.C. Dewey, M.A. Israel -
Genitourinary malformations associated with agenesis of the corpus callosum.
The Journal of urology 1993 Franco I, Kogan S, Fisher J, Rifkinson-Mann S, Reda E, Levitt S, Roseman B -
Amino acid substitutions in conserved domains of factor VIII and related proteins: study of patients with mild and moderately severe hemophilia A.
Human mutation 1992 Diamond C, Kogan S, Levinson B, Gitschier J -
Genetic basis of hemophilia A.
Thrombosis and haemostasis 1991 Gitschier J, Kogan S, Diamond C, Levinson B -
Mutations and a polymorphism in the factor VIII gene discovered by denaturing gradient gel electrophoresis.
Proceedings of the National Academy of Sciences of the United States of America 1990 Kogan S, Gitschier J -
35 GENETIC PREDICTION OF HEMOPHILIA A.
PCR Protocols 1990 Scott C. Kogan, Jane Gitschier -
Accurate prenatal diagnosis with novel polymerase chain reaction primers in a family with sporadic hemophilia A.
Obstetrics and gynecology 1989 Sarkar G, Evans MI, Kogan S, Lusher J, Sommer SS -
Functional dissection and sequence of yeast HAP1 activator.
Cell 1989 Pfeifer K, Kim KS, Kogan S, Guarente L -
Mutations of factor VIII cleavage sites in hemophilia A.
Blood 1988 Gitschier J, Kogan S, Levinson B, Tuddenham EG -
Mutations of factor VIII cleavage sites in hemophilia A.
Blood 1988 J Gitschier, S Kogan, B Levinson, EG Tuddenham -
An Improved Method for Prenatal Diagnosis of Genetic Diseases by Analysis of Amplified DNA Sequences.
Obstetrical & Gynecological Survey 1988 SCOTT C. KOGAN, MARIE DOHERTY, JANE GITSCHIER -
An Improved Method for Prenatal Diagnosis of Genetic Diseases by Analysis of Amplified DNA Sequences.
Obstetrical & Gynecological Survey 1988 SCOTT C. KOGAN, MARIE DOHERTY, JANE GITSCHIER -
An improved method for prenatal diagnosis of genetic diseases by analysis of amplified DNA sequences. Application to hemophilia A.
The New England journal of medicine 1987 Kogan SC, Doherty M, Gitschier J