Saurabh Asthana, PhD
Data Scientist
Vice Chanc Research
Chancellor/EVC/FAS

Publications (34)

Top publication keywords:
DiphenylamineDrug Resistance, NeoplasmAdenovirus E1A ProteinsLeukemia, Myeloid, Acutefms-Like Tyrosine Kinase 3INDEL MutationMatrix Metalloproteinases, Membrane-AssociatedTumor MicroenvironmentProtein BiosynthesisClonal Evolutionras ProteinsProto-Oncogene Proteins B-rafProbabilityGenes, Neurofibromatosis 1Censuses

• Discovering dominant tumor immune archetypes in a pan-cancer census.
  Cell 2021 Combes AJ, Samad B, Tsui J, Chew NW, Yan P, Reeder GC, Kushnoor D, Shen A, Davidson B, Barczak AJ, Adkisson M, Edwards A, Naser M, Barry KC, Courau T, Hammoudi T, Argüello RJ, Rao AA, Olshen AB, …
• Functional screening identifies aryl hydrocarbon receptor as suppressor of lung cancer metastasis.
  Oncogenesis 2020 Nothdurft S, Thumser-Henner C, Breitenbücher F, Okimoto RA, Dorsch M, Opitz CA, Sadik A, Esser C, Hölzel M, Asthana S, Forster J, Beisser D, Kalmbach S, Grüner BM, Bivona TG, Schramm A, Schuler M
• Ribosome profiling reveals a functional role for autophagy in mRNA translational control.
  Communications biology 2020 Goldsmith J, Marsh T, Asthana S, Leidal AM, Suresh D, Olshen A, Debnath J
• Synthetic Essentiality of Metabolic Regulator PDHK1 in PTEN-Deficient Cells and Cancers.
  Cell reports 2019 Chatterjee N, Pazarentzos E, Mayekar MK, Gui P, Allegakoen DV, Hrustanovic G, Olivas V, Lin L, Verschueren E, Johnson JR, Hofree M, Yan JJ, Newton BW, Dollen JV, Earnshaw CH, Flanagan J, Chan E, …
• Clonal Selection with RAS Pathway Activation Mediates Secondary Clinical Resistance to Selective FLT3 Inhibition in Acute Myeloid Leukemia.
  Cancer discovery 2019 McMahon CM, Ferng T, Canaani J, Wang ES, Morrissette JJD, Eastburn DJ, Pellegrino M, Durruthy-Durruthy R, Watt CD, Asthana S, Lasater EA, DeFilippis R, Peretz CAC, McGary LHF, Deihimi S, Logan AC, …

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• Translation control of the immune checkpoint in cancer and its therapeutic targeting.
  Nature medicine 2019 Xu Y, Poggio M, Jin HY, Shi Z, Forester CM, Wang Y, Stumpf CR, Xue L, Devericks E, So L, Nguyen HG, Griselin A, Gordan JD, Umetsu SE, Reich SH, Worland ST, Asthana S, Barna M, Webster KR, Cunningham …
• Abstract 3104: Establishment of an oral tongue squamous cell carcinoma cell line from a never-smoking patient.
  Tumor Biology 2018 Steven J. Wang, Saurabh Asthana, Annemieke van Zante, Adam B. Olshen, Frank McCormick, Osamu Tetsu
• A natural killer-dendritic cell axis defines checkpoint therapy-responsive tumor microenvironments.
  Nature medicine 2018 Barry KC, Hsu J, Broz ML, Cueto FJ, Binnewies M, Combes AJ, Nelson AE, Loo K, Kumar R, Rosenblum MD, Alvarado MD, Wolf DM, Bogunovic D, Bhardwaj N, Daud AI, Ha PK, Ryan WR, Pollack JL, Samad B, …
• Heterogeneous resistance to quizartinib in acute myeloid leukemia revealed by single-cell analysis.
  Blood 2017 Smith CC, Paguirigan A, Jeschke GR, Lin KC, Massi E, Tarver T, Chin CS, Asthana S, Olshen A, Travers KJ, Wang S, Levis MJ, Perl AE, Radich JP, Shah NP
• Establishment and characterization of an oral tongue squamous cell carcinoma cell line from a never-smoking patient.
  Oral oncology 2017 Wang SJ, Asthana S, van Zante A, Heaton CM, Phuchareon J, Stein L, Higuchi S, Kishimoto T, Chiu CY, Olshen AB, McCormick F, Tetsu O
• Novel computational method for predicting polytherapy switching strategies to overcome tumor heterogeneity and evolution.
  Scientific reports 2017 Jonsson VD, Blakely CM, Lin L, Asthana S, Matni N, Olivas V, Pazarentzos E, Gubens MA, Bastian BC, Taylor BS, Doyle JC, Bivona TG
• Correction: Whole Exome Sequencing of Growing and Non-Growing Cutaneous Neurofibromas from a Single Patient with Neurofibromatosis Type 1.
  PloS one 2017 Faden DL, Asthana S, Tihan T, DeRisi J, Kliot M
• KRAS Allelic Imbalance Enhances Fitness and Modulates MAP Kinase Dependence in Cancer.
  Cell 2017 Burgess MR, Hwang E, Mroue R, Bielski CM, Wandler AM, Huang BJ, Firestone AJ, Young A, Lacap JA, Crocker L, Asthana S, Davis EM, Xu J, Akagi K, Le Beau MM, Li Q, Haley B, Stokoe D, Sampath D, Taylor …
• Whole Exome Sequencing of Growing and Non-Growing Cutaneous Neurofibromas from a Single Patient with Neurofibromatosis Type 1.
  PloS one 2017 Faden DL, Asthana S, Tihan T, DeRisi J, Kliot M
• Inactivation of Capicua drives cancer metastasis.
  Nature genetics 2016 Okimoto RA, Breitenbuecher F, Olivas VR, Wu W, Gini B, Hofree M, Asthana S, Hrustanovic G, Flanagan J, Tulpule A, Blakely CM, Haringsma HJ, Simmons AD, Gowen K, Suh J, Miller VA, Ali S, Schuler M, …
• Combined chemical-genetic approach identifies cytosolic HSP70 dependence in rhabdomyosarcoma.
  Proceedings of the National Academy of Sciences of the United States of America 2016 Sabnis AJ, Guerriero CJ, Olivas V, Sayana A, Shue J, Flanagan J, Asthana S, Paton AW, Paton JC, Gestwicki JE, Walter P, Weissman JS, Wipf P, Brodsky JL, Bivona TG
• Abstract 4366: Identifying novel recurrent mutations reveals candidate actionable mutations.
  Molecular and Cellular Biology, Genetics 2016 Matthew T. Chang, Sizhi Paul Gao, Tripti Shrestha Bhattarai, Tambudzai Shamu, Cyriac Kandoth, Saurabh Asthana, Jocelyn S. Chapman, JianJiong Gao, Nicholas D. Socci, Adam B. Olshen, David M. Hyman, …
• Identifying recurrent mutations in cancer reveals widespread lineage diversity and mutational specificity.
  Nature biotechnology 2015 Chang MT, Asthana S, Gao SP, Lee BH, Chapman JS, Kandoth C, Gao J, Socci ND, Solit DB, Olshen AB, Schultz N, Taylor BS
• RAS-MAPK dependence underlies a rational polytherapy strategy in EML4-ALK-positive lung cancer.
  Nature medicine 2015 Hrustanovic G, Olivas V, Pazarentzos E, Tulpule A, Asthana S, Blakely CM, Okimoto RA, Lin L, Neel DS, Sabnis A, Flanagan J, Chan E, Varella-Garcia M, Aisner DL, Vaishnavi A, Ou SH, Collisson EA, …
• Clinical Sequencing Contributes to a BRCA-Associated Cancer Rediagnosis That Guides an Effective Therapeutic Course.
  Journal of the National Comprehensive Cancer Network : JNCCN 2015 Chapman JS, Asthana S, Cade L, Chang MT, Wang Z, Zaloudek CJ, Ueda S, Collisson EA, Taylor BS
• NF-κB-activating complex engaged in response to EGFR oncogene inhibition drives tumor cell survival and residual disease in lung cancer.
  Cell reports 2015 Blakely CM, Pazarentzos E, Olivas V, Asthana S, Yan JJ, Tan I, Hrustanovic G, Chan E, Lin L, Neel DS, Newton W, Bobb KL, Fouts TR, Meshulam J, Gubens MA, Jablons DM, Johnson JR, Bandyopadhyay S, …
• The landscape of somatic hypermutation in gynecologic cancer.
  Gynecologic Oncology 2015 J.S. Chapman, M. Chang, S. Asthana, L.M. Chen, N. Schultz, B. Taylor
• The Hippo effector YAP promotes resistance to RAF- and MEK-targeted cancer therapies.
  Nature genetics 2015 Lin L, Sabnis AJ, Chan E, Olivas V, Cade L, Pazarentzos E, Asthana S, Neel D, Yan JJ, Lu X, Pham L, Wang MM, Karachaliou N, Cao MG, Manzano JL, Ramirez JL, Torres JM, Buttitta F, Rudin CM, Collisson …
• GE-15CLONAL EVOLUTION AND INTRATUMORAL HETEROGENEITY OF LOW-GRADE GLIOMA GENOMES.
  Neuro-Oncology 2014 Brett Johnson, Tali Mazor, Chibo Hong, Michael Barnes, Shogo Yamamoto, Hiroki Ueda, Kenji Tatsuno, Koki Aihara, Saurabh Asthana, Manisha Dayal, Sarah Nelson, Joanna Phillips, Andrew Bollen, Akitake …
• The landscape of somatic hypermutation in gynecologic cancer.
  Gynecologic Oncology 2014 Jocelyn S. Chapman, Matthew T. Chang, Saurabh Asthana, Kriti Lall, Nikolaus Schultz, Lee-may Chen, Barry S. Taylor
• Abstract 1836: Erlotinib induces NF-kappa B dependence that promotes EGFR tyrosine kinase inhibitor resistance in lung adenocarcinoma.
  Experimental and Molecular Therapeutics 2014 Collin M. Blakely, Evangelos Pazarentzos, Saurabh Asthana, Victor Olivas, Irena Tan, Timothy Fouts, Jeffrey Meshulam, Trever G. Bivona
• Abstract 4265: The landscape of somatic hypermutation in human cancer.
  Molecular and Cellular Biology 2014 Jocelyn S. Chapman, Matthew T. Chang, Saurabh Asthana, Kriti Lall, Nikolaus Schultz, Barry S. Taylor
• Abstract LB-316: The landscape of actionable genomic lesions in small cell bladder cancer.
  Molecular and Cellular Biology 2014 Matthew T. Chang, Saurabh Asthana, Gopakumar Iyer, Neil Desai, Hikmat Al-Ahmadie, Jocelyn Chapman, Bernard H. Bochner, Jonathan E. Rosenberg, Dean F. Bajorin, David B. Solit, Barry S. Taylor
• Synthetic lethality in ATM-deficient RAD50-mutant tumors underlies outlier response to cancer therapy.
  Cancer discovery 2014 Al-Ahmadie H, Iyer G, Hohl M, Asthana S, Inagaki A, Schultz N, Hanrahan AJ, Scott SN, Brannon AR, McDermott GC, Pirun M, Ostrovnaya I, Kim P, Socci ND, Viale A, Schwartz GK, Reuter V, Bochner BH, …
• Mapping the molecular determinants of BRAF oncogene dependence in human lung cancer.
  Proceedings of the National Academy of Sciences of the United States of America 2014 Lin L, Asthana S, Chan E, Bandyopadhyay S, Martins MM, Olivas V, Yan JJ, Pham L, Wang MM, Bollag G, Solit DB, Collisson EA, Rudin CM, Taylor BS, Bivona TG
• Mutational analysis reveals the origin and therapy-driven evolution of recurrent glioma.
  Science (New York, N.Y.) 2013 Johnson BE, Mazor T, Hong C, Barnes M, Aihara K, McLean CY, Fouse SD, Yamamoto S, Ueda H, Tatsuno K, Asthana S, Jalbert LE, Nelson SJ, Bollen AW, Gustafson WC, Charron E, Weiss WA, Smirnov IV, Song JS…
• Concurrent driver mutations in non-small cell lung cancer (NSCLC) patients (p) on targeted therapy uncovered by comprehensive molecular profiling.
  Journal of Clinical Oncology 2013 Collin M. Blakely, Luping Lin, Saurabh Asthana, Nikoletta Sidiropoulos, Tyrrell Nelson, Boris C. Bastian, Matthew A. Gubens, Barry S. Taylor, Trever Grant Bivona
• Identification and analysis of functional elements in 1% of the human genome by the ENCODE pilot project.
  Nature 2007 ENCODE Project Consortium, Birney E, Stamatoyannopoulos JA, Dutta A, Guigó R, Gingeras TR, Margulies EH, Weng Z, Snyder M, Dermitzakis ET, Thurman RE, Kuehn MS, Taylor CM, Neph S, Koch CM, Asthana S, …
• Predicting protein complex membership using probabilistic network reliability.
  Genome research 2004 Asthana S, King OD, Gibbons FD, Roth FP