Sarat Vatsavayai, PhD
Associate Researcher
Neurology
School of Medicine

Publications (22)

Top publication keywords:
Long-Term Synaptic DepressionSmall-Conductance Calcium-Activated Potassium ChannelsC9orf72 ProteinDNA Repeat ExpansionRNA SplicingFrontotemporal DementiaAmyotrophic Lateral SclerosisFrontotemporal Lobar DegenerationInclusion BodiesTauopathiesHuntington DiseaseTuberous SclerosisProteinsDNA-Binding ProteinsSynapses

• Single-cell transcriptomic atlas of frontoinsular cortex reveals molecular correlates of selective neuronal vulnerability in FTD.
  bioRxiv : the preprint server for biology 2026 Breevoort A, Ivanov D, Horan-Portelance L, Nana A, Vatsavayai S, Miravet ÀT, Wallace JL, Ding JW, Pereira FL, Fernhoff K, Gorno-Tempini ML, Spina S, Yokoyama JS, Rosen HJ, Grinberg LT, Jacobs FMJ, …
• Cryptic splicing in synaptic and membrane excitability genes links TDP-43 loss to neuronal dysfunction.
  Science translational medicine 2026 Guo C, Chen K, Vatsavayai S, Akiyama T, Liu C, Zeng Y, Sianto O, Yang E, Bombosch J, Powell R, Zhen S, Mekhoubad S, Morrie RD, Miller G, Ilic D, Boll M, Parnell E, Penzes P, Lipstein N, Green EM, …
• Neuropathology of Dementia.
  The Behavioral Neurology of Dementia 2025 Eun-Joo Kim, Sarat Vatsavayai, William W. Seeley
• Cryptic splicing in synaptic and membrane excitability genes links TDP-43 loss to neuronal dysfunction.
  bioRxiv : the preprint server for biology 2025 Guo C, Chen K, Vatsavayai SC, Akiyama T, Zeng Y, Liu C, Sianto O, Yang E, Bombosch J, Powell R, Zhen S, Mekhoubad S, Morrie RD, Miller G, Green EM, Petrucelli L, Seeley WW, Gitler AD
• Frontotemporal lobar degeneration targets brain regions linked to expression of recently evolved genes.
  Brain : a journal of neurology 2024 Pasquini L, Pereira FL, Seddighi S, Zeng Y, Wei Y, Illán-Gala I, Vatsavayai SC, Friedberg A, Lee AJ, Brown JA, Spina S, Grinberg LT, Sirkis DW, Bonham LW, Yokoyama JS, Boxer AL, Kramer JH, Rosen HJ, …

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• FTLD targets brain regions expressing recently evolved genes.
  medRxiv : the preprint server for health sciences 2023 Pasquini L, Pereira FL, Seddighi S, Zeng Y, Wei Y, Illán-Gala I, Vatsavayai SC, Friedberg A, Lee AJ, Brown JA, Spina S, Grinberg LT, Sirkis DW, Bonham LW, Yokoyama JS, Boxer AL, Kramer JH, Rosen HJ, …
• Loss of TDP-43 function contributes to genomic instability in amyotrophic lateral sclerosis.
  Frontiers in neuroscience 2023 Fang M, Deibler SK, Nana AL, Vatsavayai SC, Banday S, Zhou Y, Almeida S, Weiss A, Brown RH, Seeley WW, Gao FB, Green MR
• Tuberous sclerosis complex is associated with a novel human tauopathy.
  Acta neuropathologica 2022 Hwang JL, Perloff OS, Gaus SE, Benitez C, Alquezar C, Cosme CQ, Nana AL, Vatsavayai SC, Ramos EM, Geschwind DH, Miller BL, Kao AW, Seeley WW
• TDP-43 represses cryptic exon inclusion in the FTD-ALS gene UNC13A.
  Nature 2022 Ma XR, Prudencio M, Koike Y, Vatsavayai SC, Kim G, Harbinski F, Briner A, Rodriguez CM, Guo C, Akiyama T, Schmidt HB, Cummings BB, Wyatt DW, Kurylo K, Miller G, Mekhoubad S, Sallee N, Mekonnen G, …
• C9orf72-specific phenomena associated with frontotemporal dementia and gastrointestinal symptoms in the absence of TDP-43 aggregation.
  Acta neuropathologica 2019 Sampognaro PJ, Vatsavayai SC, Cosme CG, Hwang JL, Nolan A, Huang EJ, Seeley WW, De May MG
• C9orf72-FTD/ALS pathogenesis: evidence from human neuropathological studies.
  Acta neuropathologica 2018 Vatsavayai SC, Nana AL, Yokoyama JS, Seeley WW
• Suppression of C9orf72 RNA repeat-induced neurotoxicity by the ALS-associated RNA-binding protein Zfp106.
  eLife 2017 Celona B, Dollen JV, Vatsavayai SC, Kashima R, Johnson JR, Tang AA, Hata A, Miller BL, Huang EJ, Krogan NJ, Seeley WW, Black BL
• Neuropathology of dementia.
  The Behavioral Neurology of Dementia 2017 Eun-Joo Kim, Sarat Vatsavayai, William W. Seeley
• Timing and significance of pathological features in C9orf72 expansion-associated frontotemporal dementia.
  Brain : a journal of neurology 2016 Vatsavayai SC, Yoon SJ, Gardner RC, Gendron TF, Vargas JN, Trujillo A, Pribadi M, Phillips JJ, Gaus SE, Hixson JD, Garcia PA, Rabinovici GD, Coppola G, Geschwind DH, Petrucelli L, Miller BL, Seeley WW
• Dysfunctional Dopaminergic Neurones in Mouse Models of Huntington's Disease: A Role for SK3 Channels.
  Neuro-degenerative diseases 2015 Dallérac GM, Levasseur G, Vatsavayai SC, Milnerwood AJ, Cummings DM, Kraev I, Huetz C, Evans KA, Walters SW, Rezaie P, Cho Y, Hirst MC, Murphy KP
• B05 CAG profiling in R6/1 89Q indicates early and progressive expansion in critical neuronal populations and expansion and changes in surrounding glial cell populations.
  Journal of Neurology Neurosurgery & Psychiatry 2012 M Hirst, S Vatsavayai, G Dallerac, A Milnerwood, D Cummings, P Rezaie, K Evans, A Stramek, S Walters, K Murphy
• B24 Dysfunctional dopaminergic neurones and biphasic activity-dependent dopamine release in mouse models of Huntington's disease.
  Journal of Neurology Neurosurgery & Psychiatry 2012 KPSJ Murphy, GM Dallerac, AJ Milnerwood, DM Cummings, SC Vatsavayai, A Stramek, KA Evans, SW Walters, MC Hirst
• Impaired long-term potentiation in the prefrontal cortex of Huntington's disease mouse models: rescue by D1 dopamine receptor activation.
  Neuro-degenerative diseases 2011 Dallérac GM, Vatsavayai SC, Cummings DM, Milnerwood AJ, Peddie CJ, Evans KA, Walters SW, Rezaie P, Hirst MC, Murphy KP
• Abnormal cortical synaptic plasticity in a mouse model of Huntington's disease.
  Brain research bulletin 2006 Cummings DM, Milnerwood AJ, Dallérac GM, Vatsavayai SC, Hirst MC, Murphy KP
• Progressive CAG expansion in the brain of a novel R6/1-89Q mouse model of Huntington's disease with delayed phenotypic onset.
  Brain research bulletin 2006 Vatsavayai SC, Dallérac GM, Milnerwood AJ, Cummings DM, Rezaie P, Murphy KP, Hirst MC
• Aberrant cortical synaptic plasticity and dopaminergic dysfunction in a mouse model of Huntington's disease.
  Human molecular genetics 2006 Cummings DM, Milnerwood AJ, Dallérac GM, Waights V, Brown JY, Vatsavayai SC, Hirst MC, Murphy KP
• Early development of aberrant synaptic plasticity in a mouse model of Huntington's disease.
  Human molecular genetics 2006 Milnerwood AJ, Cummings DM, Dallérac GM, Brown JY, Vatsavayai SC, Hirst MC, Rezaie P, Murphy KP